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7598378 |
Method for the production of 4-(4-aminophenyl)-3-morpholinone
The present invention relates to a process for preparing 4-(4-aminophenyl)-3-morpholinone by reacting 4-(4-nitrophenyl)-3-morpholinone with hydrogen in the presence of a hydrogenation catalyst,...
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7544716 |
Tetrahydro-naphthalene derivatives as vanilloid receptor antagonists
This invention relates to tetrahydro-naphthalene derivatives of formula (I)
in which the variable groups are as defined in the specification and claims, and tautomeric and stereoisomeric forms...
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7514431 |
Piperidinyl cyclopentyl aryl benzylamide modulators of chemokine receptor activity
The present invention is directed to compounds of the formula I: I (wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , X, Z and n are defined herein) which are useful as modulators of chemokine receptor...
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7456195 |
Phenylglycinamide and pyridylglycinamide derivatives useful as anticoagulants
The present invention provides novel phenylglycinamide derivatives of Formula (I) or (IV):
or a stereoisomer, tautomer, pharmaceutically acceptable salt, solvate, or prodrug thereof, wherein...
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7439356 |
Substituted indan derivatives
The present invention relates to intermediates of the formula
useful in the preparation of piperazinyl-substituted indan derivatives, wherein
Y is CONR 2 wherein R 2 is H or C 1 -C 6 alkyl;...
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7414053 |
Dihydropteridione derivatives, process for their manufacture and their use as medicament
Disclosed are new dihydropteridinones of the formula (I)
wherein the groups L, R 1 , R 2 , R 3 , R 4 and R 5 have the meanings provided herein, the isomers thereof, processes for preparing...
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7365197 |
Method for the regioselective preparation of substituted benzo[g]quinoline-3-carbonitriles and benzo[g]quinazolines
This invention relates to a method for the regioselective synthesis of 4,6,7,8-substituted benzo[g]quinoline-3-carbonitriles and 4,6,7,8-substituted benzo[g]quinazolines as well as intermediates...
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7273867 |
Phenyl derivatives
Novel compounds of the formula I in which W, X, Y, T, R 1 and R 2 are as defined in Patent claim 1 , are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or...
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7214714 |
20-hydroxyeicosatetraenoic acid production inhibitors
A hydroxyformamidine compound represented by the following formula or a pharmaceutically acceptable salt thereof
[wherein R 1 represents a substituted morpholino group, a substituted...
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7183302 |
Iminothiazolidinones as inhibitors of HCV replication
Compounds having the structure of formula I are described
wherein R, R′, R 1 , R 2 , and R 3 are as defined in the specification. The compounds can inhibit hepatitis C virus (HCV)...
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7179817 |
Carboxylic acid derivatives and drugs containing the same as the active ingredient
Compounds represented by formula (I), prodrugs thereof and salts thereof, and pharmaceutical compositions comprising the same as an active ingredient (wherein each symbol has the meaning as defined...
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7125997 |
Differential tumor cytotoxicity compounds and compositions
The invention is directed to novel biaryl derivatives, to the uses of these compounds in various medicinal applications, including the treatment, prevention and control of proliferative diseases...
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7105507 |
Cyclohexane derivatives and their use as therapeutic agents
The present invention relates compounds of formula (I), wherein ring A is a phenyl or pyridyl ring; X represents a linker selected from the group consisting of formulae: (a), (b), (c), (d), and...
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7101877 |
Ion channel modulating compounds and uses thereof
Ion channel modulating compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and...
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7053087 |
Aminocycloalkyl cinnamide compounds for arrhythmia and analgesics and anesthetics
Aminocycloalkyl cinnamide compounds (I) are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in...
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6962633 |
Amine azide propellant
A novel family of amine azides having a cyclic structure therein is disclosed. These compounds have attractive properties as rocket propellants.
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6943179 |
Biurethane derivatives
Novel compounds of the formula I in which X, Y, Z, R, R 1 , R 2 and R 3 are as defined in Patent Claim 1 , are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or...
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6878707 |
Carboxamides useful as inhibitors of microsomal triglyceride transfer protein and of apolipoprotein b secretion
Compounds of formula (I) wherein R 2 —C, R 3 —C, R 4 —C or R 5 —C may be replaced by N; and wherein n is 1, 2 or 3; R 1 is aryl, heteroaryl or (aryl or heteroaryl)-lower alkoxy; R 2 , R 3...
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6479491 |
Disubstituted morpholine, oxazepine or thiazepine derivatives, their preparation and their use as dopamine d4 receptor antagonists
The present invention relates to compounds of formula (I), any of it enantiomers, or any mixture thereof, or a pharmaceutically acceptable acid addition salt thereof, wherein R 1 , R 2 , R 3 , R 4...
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6462042 |
Hydroxamic acid derivatives as matrix metalloproteinase (mmp) inhibitors
Compounds having therapeutic utility are of formula (I) wherein B 1 , B 2 , R 1 and R 2 are each various sub-stituents, or R 1 and R 2 together form a ring.
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6420556 |
Acyl isothiocyanate resins and their use in solid-supported synthesis of guanidines
The subject invention involves novel acyl isothiocyanate resins of formula (I) and processes for making them: (a) starting with a phenyl carboxy resin, treating the resin with any reagent that...
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5990309 |
2-chloro-5-fluoro-4-morpholinonitrobenzene and 2-chloro-5-fluoro-4-morpholinoaniline
The present invention relates to a process for the preparation of N-carboxyalkyl-3-fluoro-4-dialkylaminoanilines, which comprises reacting, in a first step, an ortho-nitrochlorobenzene of the...
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5917037 |
Process for the preparation of n-carboxyalkyl-3-fluoro-4-dialkylaminoanilines
The present invention relates to a process for the preparation of N-carboxyalkyl-3-fluoro-4-dialkylaminoanilines, which comprises reacting, in a first step, an orthonitrochlorobenzene of the...
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5880151 |
Pentafluorobenzenesulfonamides and analogs
The invention provides methods and compositions relating to novel pentafluorophenylsulfonamide derivatives and analogs and their use as pharmacologically active agents. The compositions find...
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5607953 |
Butenoic or propenoic acid derivative
A butenoic or propenoic acid derivative having the following formula in which G is an aryl or a heterocyclic ring, R11 and R12 are hydroben or an alkyl, X is sulfur or oxygen, R2 and R3 are...
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5374724 |
Process for the preparation of substituted acetic acids
A process for the preparation of a substituted acetic acid of the Formula (2): ##STR1## wherein --X--Z is an optionally substituted aromatic or heteroaromatic optionally substituted amino radical;...
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5223498 |
Phenylamidine and phenylguanidine derivatives and their use as antidiabetic agents
Compounds of formula I ##STR1## and their salts in which n=0 or 1, R 1 and R 2 are each aliphatic or cycloalkyl or NR 1 R 2 is an optionally substituted heterocyclic ring, R 3 is alkyl,...
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5130329 |
Benzocyclohexanes and benzocycloheptanes useful as analgesics
Novel all possible enantiomeric and diastereoisomeric forms of compounds of the formula ##STR1## wherein R 1 is selected from the group consisting of hydrogen, halogen, alkyl and alkoxy of 1 to 5...
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5082840 |
Morpholine compounds and treatment
A method for increasing the weight gain and/or improving the feed utilization efficiency and/or increasing the lean body mass and/or decreasing birth mortality rate and increasing post-natal...
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5068244 |
Benzocyclohexanes and analgesic compositions thereof
Novel all possible enantiomeric and diastereoisomeric forms of compounds of the formula ##STR1## wherein R 1 is selected from the group consisting of hydrogen, halogen, alkyl and alkoxy of 1 to 5...
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5047417 |
Butenoic or propenoic acid derivatives
A butenoic or propenoic acid derivative having the following formula in which G is an aryl or a heterocyclic ring, R11 and R12 are hydrogen or an alkyl, X is sulfur or oxygen, R2 and R3 are...
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5021571 |
Cyclohexyl EDTA monoanhydride
The present invention relates to new rigid chelating structures, to methods for preparing these materials, and to their use in preparing radiometal labeled immunoconjugates. These new chelates...
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4914202 |
Morpholine compounds
A method for inceasing the weight gain and/or improving the feed utilization efficiency and/or increasing the lean body mass and/or decreasing birth mortality rate and increasing post-natal...
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4888355 |
Indanes and their use as antiarrhythmic agents
A compound selected from the group consisting of all enantiomeric and diastereoisomeric forms possible of compounds of the formula ##STR1## wherein X is selected from the group consisting of...
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4876269 |
Benoz-fused cycloalkane trans-1,2-diamine derivatives
Benzo-fused cycloalkane and oxa- and thia-cycloalkane trans-1,2-diamine compounds of the formula: ##STR1## wherein A, B, C, D, n, X, Y, R, R 1 , R 2 and R 3 are as defined in the specification,...
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4859206 |
Hair dye preparations containing nitrodiphenylamine derivative
This invention encompasses compounds of the formula ##STR1## wherein R 1 and R 2 independently are hydrogen, C 1 -4 alkyl, or C 2 -4 hydroxyalkyl; one of R 3 to R 7 is --SO 3 H or --COOH; and...
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4735959 |
Carboxylic acid amides and pharmaceutical compositions containing them
There are described novel carboxylic acid derivatives of the formula ##STR1## and derivatives of the formula ##STR2## and the addition salts thereof, which exhibit an effect on the intermediary...
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4656267 |
Substituted 2(1H)-quinazolinone-1-alkanoic acids and esters
The synthesis of substituted 2(1H)-quinazolinone-1-alkanoic acids and their esters is described. The novel quinazolinones are renal vasodilators and as such reduce vascular resistance to renal...
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4619666 |
Hair dyes containing amino-nitrobenzoic acid or amino-nitrobenzene sulfonic acids as substantive dyes
Hair coloring preparations containing substantive hair dyes corresponding to the following general formula ##STR1## in which A is an SO 3 H group or a COOH group, and R 1 and R 2 are hydrogen or...
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4494953 |
2,4-Dihydroxydiphenylamines and hair dyeing compositions and method
This invention pertains to compounds suitable for dyeing keratin fibers, especially human hair. The compounds have the formula: ##STR1## or an acid addition salt thereof, in which formula R 1 and...
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4377522 |
Benzodiazepine derivatives
There are presented novel benzodiazepine derivatives of the formula ##STR1## wherein R 1 is lower alkyl, lower hydroxyalkyl or lower dialkylaminoalkyl, R 2 and R 3 each are lower alkyl, R 4 is...
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4325959 |
Hypoglycemic 4-(((1,3,4, thiadiazolyl)thio)methyl)benzoic acids, ester and amides
4-(((Heterocyclo)thio)methyl)benzoic acids, esters, amides and pharmaceutically-acceptable salts thereof having hypoglycemic activity in mammals, including a method of use and...
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4297127 |
Herbicidal use of 2,6-dinitroaniline herbicides
The invention is the use of substituted 2,6-dinitroaniline compounds as preemergence herbicides and compositions employing the substituted 2,6-dinitroaniline compounds.
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4263213 |
2,4-Dihydroxy-4'-(substituted amino)-diphenylamines
New compounds suitable for dyeing keratin fibres, especially human hair, are described. The compounds have the formula: ##STR1## or an acid addition salt thereof, in which formula either R 1 and R...
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4260749 |
Quaternary diaminobenzoquinones
2,5-diamino-1,4-benzoquinones are used in the production of hair dye compositions and can be prepared by condensing a corresponding 3-amino-4-methoxy phenol derivative on one of a corresponding...
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4215215 |
9-Phenyl-nonate traene compounds
Novel 9-phenyl 5,6-dimethyl-nona-2,4,6,8-tetraenoic acid, tetraenal or tetraenol derivatives useful as anti-tumor agents.
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4204059 |
Diaminobenzoquinones
2,5-diamino-1,4-benzoquinones are used in the production of hair dye compositions and can be prepared by condensing a corresponding 3-amino-4-methoxy phenol derivative on one of a corresponding...
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4168151 |
O-Amidophenylmorpholine compounds
o-Amidophenylmorpholine compounds having a halo, haloalkyl, lower alkylsulfonyl, halo-lower alkylsulfonyl, or lower alkyl substituent on the aromatic ring para to the morpholino nitrogen. The...
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4133672 |
(Aminophenyl)morpholines and use thereof
(2-Aminophenyl)morpholine compounds having a haloalkyl, lower alkylsulfonyl, halo-lower alkylsulfonyl, or branched-chain alkyl substituent on the aromatic ring para to the morpholino nitrogen. The...
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4123251 |
O-Amidophenylmorpholine compounds and method of use
o-Amidophenylmorpholine compounds having a halo, haloalkyl, lower alkylsulfonyl, halo-lower alkylsulfonyl, or lower alkyl substituent on the aromatic ring para to the morpholino nitrogen. The...
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