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4804658 Imidazopyridine derivatives and pharmaceutical compositions  
This invention relates to novel imidazopyridine derivatives useful in the treatment of diseases or disorders mediated by platelet-activating factor. This invention further relates to pharmaceutical...
4801715 Certain 4-thienyl-dihydropyridines  
Blood sugar levels are reduced by administration of novel 4-thienyl-dihydropyridines of the formula ##STR1## in which R 1 represents 1 or 2 halogen atoms, or represents straight-chain, branched or...
4786641 Dihydropyridine compounds and their use in reducing blood sugar  
Blood-sugar-lowering dihydropyridines of the formula ##STR1## in which R 1 represents phenyl, naphthyl, thienyl, pyridyl, chromenyl or thiochromenyl, it being possible for the radicals mentioned...
4777167 Pharmaceutically useful substituted thiacycloalkeno [3,2-b]pyridines, compositions and method of use  
Novel substituted thiacycloalkeno [3,2-b]pyridines are described. These compounds are useful as calcium channel antagonists with cardiovascular, antiasthmatic and antibronchoconstrictor activity.
4772600 Fused imidazoheterocyclic compounds and pharmaceutical compositions  
Imidazoheterocyclic compounds having the formula: ##STR1## wherein the A ring is pyridine in any of its four positions; B is carbonyl, thioxomethyl or hydroxymethylene; Z is hydrogen, halogen,...
4766213 1,4-dihydropyridines  
Compounds of the formula ##STR1## are disclosed wherein the variables are herein described. These compounds are intermediates to compounds which influence the influx of calcium into the cell.
4753933 Anxiolytic amides derived from certain 1,8-naphthyridine-2-amines  
The invention provides new substituted amides of formula: R--CONH--Het in which: either R is cycloalkyl (3 to 6 carbons), cyclohexadienyl, phenyl, substituted phenyl or a heterocyclic systems...
4754033 Process for producing pyridine-2,3-dicarboxylic acid derivatives; and novel 1-amino-1,2,3,4-tetrahydropyridine-2,3-dicarboxylic acid derivatives and 1,4-dihydropyridine-2,3-dicarboxylic acid derivatives  
A process for producing pyridine-2,3-dicarboxylic acid derivatives of the formula ##STR1## is described. The process is based on the cleavage of HNR 10 R 11 from...
4740510 Derivatives of alpha-(2-oxo 2,4,5,6,7,7a-hexahydro thieno[3,2-c]5-pyridyl) phenyl acetic acid, and their use as platelet and thrombotic aggregation inhibitors  
The present invention relates to novel derivatives of alpha-(2-oxo 2,4,5,6,7,7a-hexahydro thieno [3,2-c] 5-pyridyl) phenyl acetic acid corresponding to the following general formula: ##STR1## their...
4723014 Process for the preparation of 2-substituted-1,4-dihydropyridines  
The present invention provides a process for preparing a 2-substituted-1,4-dihydropyridine by providing a regiospecific bromine containing intermediate which is then reacted with a nucleophile to...
4711882 Octahydro-6-azaindole compounds, compositions and use  
A series of novel octahydro-6-azaindole dipeptide derivatives have been prepared, including their pharmaceutically acceptable salts and bioprecursors therefor. These particular compounds are...
4705785 Substituted thiacycloalkeno (3,2-b) pyridines and pharmaceutical compositions and method of use  
Novel substituted thiacycloalkeno [3,2-b] pyridines are described. These compounds are useful as calcium channel antagonists with cardiovascular, antiasthmatic and antibronchoconstrictor activity.
4698341 Use of 1,6-naphthyridinone derivatives in treating pulmonary thrombosis  
New 1,6-naphthyridinone derivatives of the formula I ##STR1## are herein described wherein R 1 represents an unsubstituted or substituted aromatic or heteroaromatic ring; R 2 is hydrogen, a...
4690924 1,7-Naphthyridine derivatives and medicinal preparations containing same  
Certain 1,7-naphthyridine derivatives and their acid addition salts have strong anticholinergic effects, cardiotonic effects, diuretic effects, bronchodilation effects, anti-acetylocholine effects,...
4687853 Imidazo[1,5-A]pyridylmethanes  
Hetarylmethane leuco dyestuffs of the formula ##STR1## wherein R denotes halogen, alkyl, alkoxy, aryl or aryloxy, A denotes an aromatic-carbocyclic or -hetero-cyclic radical, B denotes...
4684727 Zwitterionic 1,8-naphthyridine and pyrazino[2,3-b]pyridine containing compounds useful as anti-allergic, anti-inflammatory and cycloprotective agents  
Zwitterionic bicyclic compounds are disclosed which are useful as anti-allergic, anti-inflammatory and/or cytoprotective agents. Pharmaceutical compositions and methods of treatment employing such...
4670444 7-amino-1-cyclopropyl-4-oxo-1, 4-dihydro-quinoline-and naphthyridine-3-carboxylic acids and antibacterial agents containing these compounds  
The invention relates to 7-amino-1-cyclo-propyl-4-oxo-1, 4-dihydro-naphthyridine (or quinoline)-3-carboxylic acids of Formula I as defined in the specification. Also included in the invention is a...
4663457 1-cyclopropyl-6,7-dihalo-1,4-dihydro-4-oxo-1,8-naphthyridine -3-carboxylic acid and their esters, useful as intermediates for preparing the 7-amine substituted naphthyridines  
1-cyclopropyl-6,7-dihalo-1,4-dihydro-4-oxo-1,8-naphthyridine -3-carboxylic acids and their esters, which are useful as intermediates for the preparation of compounds which are useful as...
4663329 Thienopyridinone derivatives and anti-bacterial compositions containing them  
Thienopyridinone derivatives of the general formula: ##STR1## in which Y represents hydrogen or a lower alkyl group and X represents: a hydroxy, lower alkanoyloxy, lower alkoxy unsubstituted or...
4647568 Circulation-active hydroxy-tetra-hydropyridinelactones  
Hydroxytetrahydropyridinelactones of the formula ##STR1## in which R represents a phenyl, naphthyl, thienyl, furyl, pyrryl, pyrazolyl, imidazolyl, oxazolyl, isoxazolyl, thiazolyl, pyridyl,...
4624956 Ulcer and gastric secretion inhibiting 4,5,6,7-tetrahydrothiazole[5,4-c]pyridine derivatives  
A compound of formula I: ##STR1## wherein either (i) each of R 1 and R 2 independently represents a hydrogen atom or an organic group, or (ii) R 1 and R 2 linked together form a heterocyclic...
4621088 N-acyl derivatives of amino acids and their esters, and drugs in which they are present  
The present invention relates to new N-acyl derivatives of amino acids. These derivatives correspond to the general formula I below: ##STR1## in which A represents a linear or branched, saturated...
4616019 Naphthyridine antibacterial compounds  
Naphthyridine compounds having the formula: ##STR1## wherein Z is an amine or an aliphatic heterocyclic group, R is a phenyl group or an aromatic heterocyclic group and R 1 is hydrogen or a...
4582837 Imidazo[4,5-b] and [4,5-c]pyridine derivatives having cardiotonic activity  
There are disclosed novel imidazole derivatives of the formula ##STR1## and derivatives of the formula ##STR2## the tautomers thereof, and non-toxic, pharmacologically acceptable addition salts...
4577024 Oxoindolizine and oxoindolizinium compounds useful as dyes  
Oxoindolizine and oxoindolizinium dyes are novel compounds useful in imaging, such as laser recording and reading. These dyes are formed by (1) the reaction of a cyclopropenone and a pyridine...
4574123 4,4'-Alkylenedipiperidine derivatives  
A 4,4'-alkylenebis[piperidine-1-(N-amidinoamidine)] derivative of the formula: ##STR1## or a tautomeric form thereof, wherein each of R 1 , R 2 , R 3 and R 4 , which may be the same or different,...
4555512 Circulation-active novel chromone- and thiochromone-substituted 1,4-dihydropyridine-lactones  
Dihydropyridines of the formula ##STR1## in which R 1 , R 2 , R 5 and R 6 can be hydrogen or various halogen or organic radicals, R 4 is an optionally substituted hydrocarbon radical, A is...
4551534 Aralkyl or aryloxyalkyl 1,7-naphthyridine-3-carboxylic acid esters  
7-(Substituted)-1,4,5,6,7,8-hexahydro-2-alkyl-4-aryl-5-oxo-1 ,7-naphthyridin e-3-carboxylic acid esters and pharmaceutically acceptable acid addition salts thereof are useful antihypertensive agents.
4550106 4-Phenyl-4,5,6,7-tetrahydro-thieno[2,3-c]pyridines and salts thereof, compositions and use  
Compounds of the formula ##STR1## wherein R 1 is amino, acetylamino, hydroxymethyl, methoxymethyl or ##STR2## R 2 and R 3 , which may be identical to or different from each other, are each...
4529596 Thieno [3,2-c] pyridine derivatives and their therapeutic application  
This invention relates to new thieno [3,2-c] pyridine derivatives having the formula: ##STR1## in which: Y represents the OH group or an OR group in which R is a straight or branched lower alkyl...
4508897 Preparation of chromogenic azaphthalides  
Chromogenic azaphthalides of the formula ##STR1## wherein R 1 and R 2 independently of each other are hydrogen, C 1 -C 12 alkyl which is unsubstituted or substituted by halogen, hydroxyl, cyano...
4501745 Anxiolytic imidazo[1,2-a]pyridine derivatives  
Imidazo[1,2-a]pyridine derivatives of the general formula: ##STR1## wherein n represents 2, 3 or 4, Y represents a hydrogen or halogen atom or a C 1 -4 alkyl radical, Z represents a naphthyl...
4500525 Pharmacologically active pyrazolo/4,3-c/pyridines  
The present invention is directed to new pyrazolo/4,3-c/pyridines, the process for their preparation, the pharmaceutical compositions containing them and their use as pharmocologically active...
4499094 Derivatives of arene and hetero-arene carboxamides and their use as medicaments  
Compounds with the formula: ##STR1## in which R 1 and R 2 represent independently, a linear or branched alkyl, cycloalkyl, phenylalkyl or cycloalkylalkyl group. R 1 and R 2 may also represent...
4492702 1-Phenyl-1,8-naphthridin-2(1H)-ones  
Certain substituted 1,8-naphthyridines and 1,5,8-azanaphthyridines are useful for treating allergic reactions in mammals. Certain of the compounds may also be utilized to treat chronic obstructive...
4492695 Therapeutically useful imidazo[1,2-a]pyridine derivatives  
An imidazo[1,2-a]pyridine derivative of the formula: ##STR1## wherein Y represents a hydrogen or halogen atom or a C 1 -4 alkyl radical, Z represents a furan-2-yl, thien-2-yl or pyridin-2-yl...
4469696 Substituted 2-amino-pyridine derivative compounds, their production and their medicinal use  
The invention relates to 4-,5-and 6-substituted 2-amino pyridines of Formula (I) and methods for their preparation. Also included in the invention are compositions containing said 2-amino pyridines...
4409226 Imidazo[1,5-a]pyridines  
The invention relates to imidazo[1,5-a]pyridine derivatives which are useful in the treatment of peptic ulcer diseases.
4382938 Imidazo[1,2-a] pyridine derivatives and their application as pharmaceuticals  
Imidazo[1,2-a] pyridines of the formula: ##STR1## and their acid addition salts in which Y represents a hydrogen or halogen atom or a C 1 -4 alkyl radical, Z represents a naphthyl radical or a...
4365063 Antihypertensive agents  
1,4,5,6,7,8-Hexahydro-2-alkyl-4-pentafluorophenyl-5-oxo-1,7- naphthyridine-3 -carboxylic acid esters and pharmaceutically acceptable salts thereof are useful antihypertensive agents.
4363808 N-(3-Phenoxy-2-hydroxypropyl)benzimidazole-1-alkanamines  
3-Phenoxy-2-hydroxypropylamines having an N-benzimidazolyalkyl substituent and similar compounds are described herein. They are obtained by the reaction of the appropriate imidazole-1-alkanamine...
4359578 Naphthyridine derivatives and salts thereof useful as antibacterial agents  
This invention relates to 1,8-naphthyridine compounds of the formula ##STR1## wherein X is a halogen atom especially fluorine atom, R 1 is an ethyl group or a vinyl group, and R 2 is a...
4353833 Cationic dyes  
Compounds of the general formula I ##STR1## where the radicals A, A 1 and B are identical or different and A is unsubstituted or substituted benzene or heteroaromatic, A 1 , if n=1, is...
4352803 Novel naphthyridine derivatives, intermediates thereof, processes for preparation thereof, and use thereof  
This invention relates to 1,8-naphthyridine compounds of the formula ##STR1## wherein X is a halogen atom especially fluorine atom, R 1 is an ethyl group or a vinyl group, and R 2 is a...
4336374 Quaternary ammonium substituted N-cinnamylpiperidines  
2-Hydroxymethyl-3,4,5-trihydroxypiperidines bearing a quaternary ammonium-substituted cinnamyl group on the piperidine nitrogen atom and their acid addition salts are antihyperglycemic agents. A...
4324893 4-Amino-3-carboxy or cyano-1,2-dihydro-2-oxo-1,8-naphthyridine derivatives  
4-Amino-3-carboxy or cyano-1,2-dihydro-2-oxo-1,8-naphthyridine derivatives are anti-secretory agents for use in the treatment of peptic ulcer disease.
4323566 Triazole acylamines, pharmaceutical compositions thereof and method of use thereof  
The invention relates to compounds of the general formula (I) ##STR1## and physiologically acceptable salts, hydrates and bioprecursors thereof, in which R 1 and R 2 , which may be the same of...
4317909 Preparation of 1,3-dihydro-5-(pyridinyl)-2H-imidazo[4,5-b]pyridin-2-ones  
1,3-Dihydro-3-R-5-PY-2H-imidazo[4,5-b]pyridin-2-ones or 2-thiones of pharmaceutically-acceptable acid-addition salts thereof, which are useful as cardiotonic agents, where R is hydrogen,...
4315938 4-Phenyl-4,5,6,7-tetrahydro-pyrrolo [2,3-c] pyridines and salts thereof  
Compounds of the formula ##STR1## wherein R 2 is hydrogen, chlorine, bromine, formyl, acetyl, alkyl of 1 to 4 carbon atoms, nitro, cyano or --CH 2 --A; where A is (alkyl of 1 to 2 carbon...
4309537 Production of imidazo[4,5-b]pyridin-2-ones or thiones  
1,3-Dihydro-1-R 1 -3-R 3 -6-PY-5-Q-2H-imidazo[4,5-b]pyridin-2-ones or -2-thiones or pharmaceutically-acceptable acid-addition salts thereof, which are useful as cardiotonic agents, where Q is...
Matches 201 - 250 out of 342 < 1 2 3 4 5 6 7 >