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5190938 |
Derivatives of 2-hydroxythiophene and -furan fused with a nitrogen-containing ring and their application in therapy
The invention relates to compounds of formula ##STR1## in which R 1 is selected from the groups R 3 and OR 3 , R is selected from H and a group CHR 2 R', in which R 2 is selected from H, alkyl,...
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5180723 |
Certain sulfonamide heterobicyclic platelet activating factor antagonists
Compounds of general formula I; ##STR1## wherein: A 1 is N--, CH-- or CR 1 --; A 2 is N--, CH-- or CR 2 --; provided that, when one of A 1 and A 2 is a nitrogen atom, the...
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5180418 |
Herbicidally active thiadiazabicyclononanes and nonenes
Cycloalkanecarboxylic acid derivatives of formula I ##STR1## wherein W is ##STR2## and A is CO--R 3 or CN; R 1 is hydrogen or fluorine; R 2 is halogen or cyano; R 3 is chlorine, X--R 5 , amino,...
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5174913 |
Polybasic acid esters as oil field corrosion inhibitors
A corrosion inhibitor with excellent film forming and film persistency characteristics may be produced by first reacting in a condensation reaction a polybasic acid with a polyalcohol to form a...
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5153201 |
Condensed thiazole compounds and use as pharmaceuticals
A novel condensed thiazole derivative of the formula [I]: ##STR1## wherein A is a single bond or CH 2 ; R 1 is hydrogen atom, or an optionally substituted aliphatic, carboxylic acyl or sulfonic...
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5151435 |
Angiotensin II antagonists incorporating an indole or dihydroindole
There are disclosed substituted indoles and dihydroindoles of Formula I which are useful as angiotensin II antagonists. ##STR1##
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5149702 |
Cycloheptenopyridine derivatives, process for preparation thereof and antiulcer agents containing the same
Provided are cycloheptenopyridine derivatives represented by the general formula ##STR1## [wherein R represents a hydrogen atom or lower alkyl group; R 1 represents a hydrogen atom, halogen atom,...
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5130311 |
Oxazolopyridine compounds, compositions and use
The invention relates to the analgesic compounds of general formula (I): ##STR1## in which: R 1 , R 2 , R 3 , R 4 , A, Z and m are as defined in the description, their isomers, epimers and...
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5128327 |
Angiotensin II antagonists incorporating a nitrogen containing six membered ring heterocycle
There are disclosed compounds, containing a pyridine, pyrazine or pyrimidine functionality on the lower ring of Formula I, which are useful as angiotensin II antagonists. ##STR1##
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5126341 |
Anti-inflammatory 1,8-naphthyridin-2-one derivatives
Disclosed are naphthyridine derivatives represented by formula (I) ##STR1## wherein: X represents hydrogen; lower alkyl; aralkyl; substituted or unsubstituted aryl; substituted or unsubstituted...
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5124335 |
Substituted pyrollo-fused 6 membered heterocycles as angiotensin II antagonists
Substituted pyrrolo-fused 6-membered heterocycles of structural formula: ##STR1## wherein A, B, C, and D are independently carbon atoms or nitrogen atoms are angiotensin II antagonists useful in...
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5112821 |
Excitatory amino acid antagonists which are certain thienopyridives
The present invention is directed to a new class of excitatory amino acid antagonists.
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5102890 |
Pyrrole derivatives, their preparation and pharmaceutical compositions which contain them
This invention relates to pyrrole derivatives of formula: ##STR1## in which A forms with the pyrrole ring an isoindoline, 6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine,...
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5103007 |
Lipids
Lipid derivatives represented by the formula: ##STR1## wherein R 1 stands for an optionally substituted higher alkyl group, R 2 stands for an optionally substituted lower alkyl group or an...
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5101028 |
(1,2,4)triazolo[2,3-a]pyridines
Triazolopyridines of the formula ##STR1## where R 1 is C 1 -C 20 -alkyl which may be substituted, phenyl which may be substituted, or hydroxyl, R 2 is hydrogen, formyl, nitroso, cyano or...
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5086051 |
1H, 3H-pyrrolo[1,2-c]thiazole-7-carboxamide derivatives and pharmaceutical compositions containing them
New derivatives of formula (I) in which R 1 =H, halogen, alkyl, alkyloxy, CF 3 , NH 2 , alkylamino, dialkylamino, OH, CH, phenyl or phenoxy, Ar=phenyl, naphthyl, pyridyl, quinolyl, isoquinolyl,...
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5081245 |
Carboxylic acid derivatives
A compound represented by the formula: ##STR1## wherein R represents a hydrogen atom or a lower alkyl group; R 1 represents a higher alkyl group which may be substituted; R 2 represents a...
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5071846 |
Anti-hystaminic [(bicyclic heterocyclyl) methyl and --hetero] substituted hexahydro-1H-azepines and pyrrolidines
[(Bicyclic heterocyclyl)methyl and --hetero] substituted hexahydro--1H--azepines and pyrrolidines and their pharmaceutically acceptable acid addition salts having anti--histaminic properties,...
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5071986 |
Chromogenic phthalides and azaphthalides
Chromogenic phthalides and azaphthalides of the formula ##STR1## in which V 1 and V 2 are each, independently of the other, hydrogen, halogen, lower alkyl, lower alkoxy, (lower)alkoxycarbonyl or...
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5049181 |
Novel herbicidally active n-phenyl-azoles
The invention relates to novel phenyl substituted pyrazoles, 4,5,6,7-tetrahydro-indazoles, 2,4,5,6-tetrahydro-cyclopenta[c]pyrazoles, octahydroimidazo[1,5-a]pyridin-1,3-diones,...
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5043443 |
Aminomethyloxooxazolidinyl arylbenzene derivatives
Novel aminomethyloxooxazolidinyl arylbenzene derivatives, wherein the aryl includes the phenyl, substituted phenyl, pyridyl, and substituted pyridyl groups, such as (l)-N-{3-[4-...
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5028710 |
Process for the preparation of derivatives of sulfonyl indolizine and their use as synthetic intermediates
The object of the invention is a process for the preparation of derivatives of 3-sulfonyl indolizine of general formula: ##STR1## in which: R is selected from hydrogen, alkyl, cycloalkyl,...
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5026700 |
Certain quinolines and thienopyridines as excitatory amino acid antagonists
The present invention is directed to a new class of excitatory amino acid antagonists. The compounds contain quinoline or thieno pyridine moieties.
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5026711 |
4-amino quinolines and naphthyridines and their use as medicines
Compounds represented by the general formula: ##STR1## in which R 1 and R 2 are selected from hydrogen, C 1 -C 6 alkyl or C 2 -C 6 alkenyl , phenyl or benzyl or R 1 and R 2 form together...
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5025011 |
Fused pyridines active on the cardiovascular system
Compounds of the formula ##STR1## (wherein Ar, R, R 1 , R 2 , R 3 , R 4 , X and m have the meanings given in the description), their preparation and pharmaceutical compositions containing them. The...
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5011838 |
Pharmacologically active 2-substituted 3-(2-ethoxyethyl) imidazo[4,5-b]pyridines and pharmaceutical compositions containing them
2-substituted 3-(2-ethoxyethyl)imidazo[4,5-b] pyridine derivatives of the formula ##STR1## wherein n is an integer of from 1 to 5 inclusive R 1 and R 2 represent each a saturated or...
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4999426 |
Preparation of 4-azasaccharines
Compounds of formula I ##STR1## in which R is H, or an aliphatic or aromatic radical, R 1 is alkyl, R 2 is alkyl, alkoxy, aryl, aryloxy, aralkyl, alkaryl, aralkyloxy, alkaryloxy, alkaralkyl or...
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4990506 |
3-(acylaminomethyl)imidazo[1,2-a]pyridine derivatives and their application in therapy
A compound which is a 3-(acylaminomethyl)imidazo[1,2-a]pyridine derivative of formula (I) ##STR1## in which R 1 denotes hydrogen; linear or branched C 1 -C 4 alkyl; or benzyl; R 2 denotes...
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4973590 |
Process for the preparation of quinolonecarboxylic acids which can be administered parenterally
Known quinolone carboxylic acid derivatives of the formula ##STR1## are treated so as to become readily administrable parenterally, the treatment comprising dissolving the active compound using an...
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4954507 |
1-tertiary-alkyl-substituted naphthyridine carboxylic acid antibacterial agents
There are disclosed new naphthyridine- and quinoline-carboxylic acids having a 1-tertiary-alkyl substituent, compositions containing them, and their use in treating bacterial infections in...
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4943580 |
Anti-histaminic benzimidazole, imidazopyridine and purine derivatives
Novel 1-alkyl substituted benzimidazole derivatives and their pharmaceutically acceptable acid addition salts having anti-histaminic properties, compositions containing the same, and methods of...
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4935425 |
4H-quinolizin-4-ones for treatment of diseases associated with immunoglobulin e-antibody formation
This invention provides novel 4H-quinolizin-4-one compounds which exhibit a selective inhibitory activity against IgE-antibody formation, and have utility for treatment of diseases associated with...
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4925481 |
Substituted bicyclic triazole herbicides
The invention relates to new heterocyclic substituted bicyclic triazoles of general formula I ##STR1## in which X, Y, Z, R 1 , n and m have the meanings given in the description, processes for...
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4908056 |
Heterocyclic acyl sulfonamides
This invention relates to novel heterocyclic carbonyl sulfonamides which are particularly useful as agricultural chemicals.
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4904657 |
4H-quinolizin-4-one compounds exhibiting therapeutic activities
This invention provides novel 4H-quinolizin-4-one compounds which exhibit a selective inhibitory activity against IgE-antibody formation, and have utility for treatment of diseases associated with...
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4902693 |
Anti-allergic esters, acetal ethers, thioethers and nitrogen substituted derivatives of bicyclic compounds
Esters, acetal ethers, thioethers and nitrogen substituted derivatives of certain bicyclic compounds are disclosed which are useful as anti-allergic, anti-inflammatory and/or cytoprotective agents...
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4897401 |
N-(4-piperidinyl) bicyclic condensed 2-imidazolamine derivatives useful in treating allergic diseases
Novel N-(4-piperidinyl)bicyclic condensed 2-imidazolamine derivatives and their pharmaceutically acceptable acid addition salts having anti-histaminic properties, compositions containing the same,...
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4889933 |
4-azasaccharines, 4-aza-dihydro- or -tetrahydro-saccharines
Compounds of formula I ##STR1## in which R is H, or an aliphatic or aromatic radical, R 1 is alkyl, R 2 is alkyl, alkoxy, aryl, aryloxy, aralkyl, alkaryl, aralkyloxy, alkaryloxy, alkaralkyl or...
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4889861 |
Substituted imidazo[1,5-a]pyridine derivatives and other substituted bicyclic derivatives and their use as aromatase inhibitors
Disclosed are compounds of formula I ##STR1## wherein R 1 represents hydrogen, lower alkyl, substituted lower alkyl, nitro, halogen, free, etherified or esterified hydroxy, free, etherified,...
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4879384 |
Preparation of thiocycloalkno [3,2-b] pyridines
Novel substituted thiacycloalkeno [3,2-b] pyridines are described. These compounds are useful as calcium channel antagonists with cardiovascular, antiasthmatic and antibronchoconstrictor activity.
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4874760 |
4,7-dihydroisothiazolo(5,4-b)pyridine derivatives and cardiovascular treating agents containing said derivatives
A 4,7-dihydroisothiazole[5,4-b]pyridine derivative represented by the general formula ##STR1## wherein R 1 represents an alkyl group which may be substituted, R 2 represents a hydrogen atom, a...
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4873337 |
N-substituted derivatives of 2-(pyridylalkenesulfinyl) benzimidazoles as gastric antisecretory agents
The present invention provides novel N-substituted derivatives 2-(pyridylalkylenesulfinyl)benzimidazoles with gastric acid inhibiting effects.
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4845225 |
Substituted thiacycloalkeno [3,2-b] pyridines
Novel substituted thiacycloalkeno [3,2-b] pyridines are described. These compounds are useful as calcium channel antagonists with cardiovascular, antiasthmatic and antibronchoconstrictor activity.
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RE32975 |
4-Pyridone-3-carboxylic acids and/or derivatives thereof
The invention provides 4-pyridone-3-carboxylic acids and derivatives thereof together with a method for their preparation. Also included in the invention are compositions containing said...
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4845118 |
Substituted thienoimidazole derivatives, pharmaceutical compositions containing them, and their use as inhibitors of gastric acid secretion
The invention relates to compounds of the formula ##STR1## in which A represents ##STR2## T denotes --S--, --SO-- or --SO 2 --, and R 1 to R 9 have the meanings given in the description, to a...
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4843074 |
1-azabicyclo[2.2.2]octan-3-yl 2-aryl-3-azacyclo-2-hydroxypropionates and their quaternary salts
Novel 1-azabicyclo[2.2.2]octan-3-yl 2-aryl-3-azacyclo-2-hydroxypropionates and their quaternary salts and their use as antimuscarinic agents having antisecretory activity selective for the...
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4835161 |
Anti-histaminic compositions containing n-heterocyclyl-4-piperidinamines
Anti-allergic compositions containing one or more pharmaceutical carriers and as active ingredient at least one compound which is a N-heterocyclyl-4-piperidinamine and methods of treating allergic...
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4818754 |
Certain anti-inflammatory pyrazolo [4,3-b] pyridine 7-amines
A compound of the formula (1) or a salt or solvate thereof: ##STR1## in which: R 0 is hydrogen or C 1 -6 alkyl; R 1 and R 2 are both hydrogen; or R 1 is hydrogen, C 1 -6 alkyl; and R 2 ...
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4808718 |
Fused polycyclic and bridged compounds useful as calcium channel blockers
Novel fused polycyclic and bridged compounds are disclosed which are useful as calcium entry blockers.
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4808595 |
Furopyridine sulfonamides and their opthalmological compositions
Furopyridine sulfonamides are carbonic anhydrase inhibitors useful in the treatment of elevated intraocular pressure and disorders associated therewith such as glaucoma.
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