Matches 101 - 150 out of 341 < 1 2 3 4 5 6 7 >
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5972975 Substituted 2-aminopyridines as inhibitors of nitric oxide synthase  
Substituted 2-aminopyridine compounds of Formula (I) and pharmaceutically acceptable salts which have been found useful in the treatment of nitric oxide synthase mediated diseases and disorders....
5869499 Benzyloxyquinuclidines as substance P antagonists  
A compound of chemical formula (I) and its pharmaceutically acceptable salt: ##STR1## wherein X and Y are each hydrogen, halogen, C 1 -C 6 alkyl, halosubstituted C 1 -C 6 alkyl, C 1 -C 6 ...
5824677 Substituted amino alcohol compounds  
Disclosed are compounds having a straight or branched aliphatic hydrocarbon structure of formula I: ##STR1## In formula I, n is an integer from one to four and m is an integer from four to twenty....
5817671 5-HT.sub.1F agonists  
This invention provides 5-HT 1F agonists of Formula I: ##STR1## where A--B, X, and R are as defined in the specification. The invention also encompasses pharmaceutical formulations employing...
5767128 1,3-dihydro-2H-pyrrolo 2,3-b!pyridin-2-one compounds  
The invention relates to a compound selected from those of formula (I): ##STR1## wherein R 1 , W and Y are as defined in the description, its geometric and/or optical isomers, and its...
5760034 Heterocyclic substituted naphthyridinones and methods and compositions employing them  
Nitrogen-containing heterocyclic substituted naphthyridinones and methods and compositions employing such compounds are disclosed.
5750702 Certain pyrrolo pyridine-3-carboxamides; a new class of GABA brain receptor ligands  
The present invention encompasses structures of the formula: ##STR1## or the pharmaceutically acceptable non-toxic salts thereof wherein: ##STR2## wherein: W represents substituted or unsubstituted...
5747486 Thienopyridine or thienopyrimidine derivatives and their use  
This invention provides an anti-inflammatory agent, particularly an agent for treating arthritis, and a bone resorption inhibiting agent, containing a thienopyridine or thienopyrimidine derivative...
5719135 Substituted 3-arylidene-7-azaoxindole compounds and process for their preparation  
The present invention relates to compound of formula (I) ##STR1## wherein A is benzene, naphthalene, 5,6,7,8,-tetrahydronaphthalene, quinoline, isoquinoline, indole or 7-azaindole; R 1 is --H,...
5700757 Triazolopyridine dyes and intermediates therefor  
Triazolopyridine dyes of the formula ##STR1## where R 1 is unsubstituted or substituted C 1 -C 20 -alkyl, unsubstituted or substituted phenyl, unsubstituted or substituted hydroxyl or...
5691356 Disubstituted heterocyclic thrombin inhibitors  
Disubstituted heterocyclic thrombin inhibitors are provided which have the structure ##STR1## wherein G is ##STR2## wherein n is 0, 1 or 2 or 3; m is 0, 1, 2 or 3; Y is NH or S; p is 0, 1 or 2, Q...
5674878 Anellated dihydropyridines and the use thereof for the production of pharmaceutical preparations  
Compound of general formula I ##STR1## wherein A is a benzo or thieno group; R 1 is (C 4 -6)cycloalkyl, (C 4 -6)cycloalkyl-(C 1 -5)alkyl or ##STR2## R 2 , m, R 3 , R 4 , R and u are defined as...
5663346 Substituted azaindolylidene compounds and process for their preparation  
The present invention relates to compounds useful as tyrosine kinase inhibitors, having the following general formula (I) ##STR1## wherein one of the groups X 1 , X 2 , X 3 , X 4 is N and the...
5654298 Amine derivatives  
This invention concerns novel aminopyridinium compounds of the formula I wherein R 1 , R 2 , R 3 , R 5 and R 6 are selected from the following combinations: ##STR1## (a) one of R 2 and R 6 is a...
5643922 Indole cyclohexyl platelet activating factor antagonists  
The present invention provides compounds of formula ##STR1## and the pharmaceutically acceptable salts thereof which are potent antagonists of PAF and are useful in the treatment of PAF-related...
5641777 Substituted heterocyclic compounds and pharmaceutical compositions in which they are present  
The invention relates to neurokinin receptor antagonist compounds of the formula ##STR1## in which: A is a divalent radical selected from: A 1 ) --O--CO-- A 2 ) --CH 2 --O--CO-- A 3 )...
5637595 Cyclic ether acetal PAF antagonists  
Compounds of general formula (I), wherein W represents a 5- or 6-membered aromatic heterocyclic ring containing one or more non-quaternised sp2 nitrogen atoms in its ring, which heterocyclic ring...
5618819 1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one and oxazolo[4,5-b]pyridin-2-(3H)-one compounds  
The invention relates to a compound selected from those of formula (I): ##STR1## wherein R 1 , W and Y are as defined in the description, its geometric and/or optical useful as anti-algies.
5616710 Triazolopyridine dyes  
Triazolopyridine dyes of the formula ##STR1## where one of the two radicals A and E is nitrogen and the other is a radical of the formula C-R 1 , where R 1 is unsubstituted or substituted C 1 -C...
5614518 Morpholine derivatives as dopamine receptor subtype ligands  
A class of substituted morpholine derivatives of formula ##STR1## wherein Y represents an optionally substituted bicyclic heteroaromatic ring system containing one or two nitrogen atoms, the ring...
5597916 1 substituted oxindoles and azaoxindoles  
Compounds of Formula I have been shown to enhance the release of the neurotransmitter acetylcholine, and thus may be useful as chemical intermediates and as pharmacological agents in the treatment...
5593943 Heteroaromatically condensed hydroxypyridonecarboxamides, their preparation and use as herbicides  
Heteroaromatically condensed hydroxypyridonecarboxamides of the structure I ##STR1## where the substituents and the ring Q have the following meanings: R 1 hydrogen, hydroxyl, substituted or...
5567711 Indole-3-carbonyl and indole-3-sulfonyl derivatives as platelet activating factor antagonists  
The present invention provides compounds of formula ##STR1## and the pharmaceutically acceptable salts thereof which are potent antagonists of PAF and are useful in the treatment of PAF-related...
5561146 Modified guanidino and amidino thrombin inhibitors  
Thrombin inhibitors are provided which have the formula ##STR1## wherein Z is a thrombin inhibitor substructure containing distal and proximal binding site residues; and R 1 is cyano, hydroxyl,...
5554625 Substituted biphenylmethylimidazopyridines  
Biphenylmethylimidazopyridines of the structure (I) are angiotensin (II) antagonists and therefore useful in the treatment of hypertension and related cardiovascular disorders and ocular...
5552090 Photochromic naphthopyran compounds  
Described are novel reversible photochromic naphthopyran compounds, examples of which are compounds substituted at the 3 position of the pyran ring with (i) an aryl substituent and (ii) a phenyl...
5502187 Pharmaceutically active bicyclic-heterocyclic amines  
The pharmaceutically active bicyclic heterocyclic amines (XXX) ##STR1## where W 1 is --N or --CH; W 3 is --N or --CH; W 5 is --N or --CR 5 -- with the proviso that W 5 is --CR 5...
5494916 Imidazo[4,5-C]pyridin-4-amines  
Imidazo[4,5-c]pyridin-4-amines that induce interferon (α) biosynthesis in human cells. Also disclosed are pharmaceutical compositions containing such compounds and methods of inducing interferon...
5491161 Pyrroloimidazolyl and imidazopyridinyl substituted 1H-benzimidazole derivatives  
Pyrroloimidazolyl and imidazopyridinyl substituted 1H-benzimidazole derivatives having the formula ##STR1## wherein n is 0 or 1; R 1 is hydrogen, nitro, amino, mono- or di(C 1 -6 alkyl)amino,...
5464781 Amino naphthyridine compounds as anti-rhoumatic agents  
This invention relates to compounds of formula I and pharmaceutically acceptable salts thereof ##STR1## in which R 1 represents hydrogen, alkyl, hydroxy, carboxyalkenyl, alkoxycarbonyalkenyl,...
5457104 Quinolone- and naphthyridonecarboxylic acid derivatives  
The invention relates to new quinolone- and naphthyridonecarboxylic acid derivatives which have hydrogen in the 6-position, to processes for their preparation, and to antibacterial compositions and...
5446153 Intermediates for imidazo[4,5-c]pyridin-4-amines  
Imidazo[4,5-c]pyridin-4-amines that induce interferon (α) biosynthesis in human cells. Also disclosed are pharmaceutical compositions containing such compounds and methods of inducing interferon...
5438063 Imidazopyridines as angiotensin II antagonists  
Novel imidazopyridine derivatives of formula I ##STR1## wherein ##STR2## and R 1 , R 2 , R 3 , R 4 , X and Y are as defined herein, and their salts, exhibit antagonistic properties toward...
5428035 1-substituted azaoxindoles and pharmaceutical compositions  
Compounds of Formula I have been shown to enhance the release of the neurotransmitter acetylcholine, and thus may be useful as chemical intermediates and as pharmacological agents in the treatment...
5401736 4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid amide  
Disclosed herein are 4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid amide derivatives having a high antagonistic activity against angiotensin II and a high specificity to...
5378700 Fused pyrimidine derivative, process for preparation of same and pharmaceutical preparation comprising same as active ingredient  
Disclosed is a fused pyrimidine of the formula [I] ##STR1## wherein R 1 , R 2 , and R 3 are as defined in the specification, Y represents a linking group of the formula ##STR2## wherein n is an...
5354749 Sulfonylbenzyl-substituted benzo- and pyridopyridones  
Sulfonylbenzyl-substituted benzo- and pyridopyridones are prepared by reacting corresponding benzo- and pyridopyridones with sulphonylbenzyl compounds. The sulphonylbenzyl-substituted benzo- and...
5334719 Bicyclic(azaaromatic)indoles as inhibitors of leukotriene bisynthesis  
Compounds having the formula I: ##STR1## are inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They...
5334598 Six-membered ring fused imidazoles substituted with phenoxyphenylacetic acid derivatives  
Phenoxyphenylacetic acids and derivatives of general structural formula I have endothelin ##STR1## antagonist activity and are therefore useful in treating cardiovascular disorders, such as...
5284661 Fused thiophene derivatives, their production and use  
Novel fused thiophene derivatives of the formula (I): ##STR1## wherein W is ##STR2## R 1 and R 2 which may be same or different, are each independently hydrogen, halogen, cyano, nitro, acylamino,...
5273972 [(2-diakylaminomethyl)-3-quinuclidinyl]-benzamides and benzoates  
This invention provides novel 2-substituted-3-quinuclidinyl arylcarboxamides and arylthiocarboxamides and corresponding arylcarboxylates which have utility as therapeutic agents which exhibit...
5266576 N-myristoyl transferase inhibitors  
The invention relates to a compound of formula (I): ##STR1## which can be used as N-myristoyltransferase inhibitors, in which R 1 represents hydrogen, substituted or unsubstituted (C 1 -C 6 )...
5262426 N,N'-cycloalkyl/alkyl carboxamide 4H-imidazo-[4,5-b]pyridine compounds as PAF antagonists  
A class of N,N'-cycloalkyl/alkyl benzamides of certain 4H-imidazo[4,5-b]pyridine compounds is described for treating cardiovascular and immuno-inflammatory related disorders mediated by platelet...
5235050 Thiadiazolopyridines  
The process according to the invention for the preparation of herbicidal pyridylsulfonylureas of the formula (I) ##STR1## in which R 1 to R 5 and X are as defined in claim 1 comprises the...
5223499 6-amino substituted imidazo[4,5-bipyridines as angiotensin II antagonists  
Substituted imidazo[4,5-b]pyridines of structural formula: ##STR1## are angiotensin II antagonists useful in the treatment of hypertension and congestive heart failure.
5204359 Insecticidally active nitro compounds  
Insecticidally active nitro compounds of the formula ##STR1## wherein R 1 is hydrogen, cyano or alkyl, R 2 is hydrogen or an organic radical, R 3 is ##STR2## R 4 is an organic radical, R...
5200407 Azole derivatives and anti-ulcerative composition containing same  
Compounds of the general formula (I): ##STR1## and pharmaceutically acceptable salts thereof, in which A, B, C and D each represent --CH or --N, with the proviso that at least one of them is...
5198434 Angiotensin II antagonizing fused pyridinyloxy containing derivatives  
The invention concerns pharmaceutically useful compounds of the formula I, in which R 1 , R 2 , R 3 , R 4 , n, m, X, Y and Z have the various meanings defined herein, and their non-toxic salts, and...
5194605 Cyclic renin inhibitors containing 2-substituted (3S,4S)-4-amino-5-cyclohexyl-3-hydroxy pentanoic acid, 2-substituted (3S,4S)-5-cyclohexyl-3,4-di-hydroxy pentanoic acid or 2-substituted (4S,5S)-5-amino-6-cyclohexyl-4-hydroxyhexanoic acid or its analogs  
Compounds of the formula ##STR1## are disclosed. These compounds inhibit the angiotensinogen-cleaving action of the natural proteolytic enzyme, renin, are useful in treating, preventing or managing...
5190938 Derivatives of 2-hydroxythiophene and -furan fused with a nitrogen-containing ring and their application in therapy  
The invention relates to compounds of formula ##STR1## in which R 1 is selected from the groups R 3 and OR 3 , R is selected from H and a group CHR 2 R', in which R 2 is selected from H, alkyl,...
Matches 101 - 150 out of 341 < 1 2 3 4 5 6 7 >