Patents in Class 544/122

Matches 1 - 50 out of 461

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Match	Document	Document Title
1	7605159	Cathepsin cysteine protease inhibitors and their use The present invention relates to compounds and compositions for treating diseases associated with cysteine protease activity. The compounds are reversible inhibitors of cysteine proteases S, K, F,...
2	7601714	Pyrimidine derivatives useful as inhibitors of PKC-theta Disclosed are novel compounds of formula (I): wherein X, Y, R 1 , R 2 and R 3 are as defined herein, which are useful as inhibitors of PKC-theta and are thus useful for treating a variety of...
3	7592450	Piperazinyl-, piperidinyl- and morpholinyl-derivatives as inhibitors of histone deacetylase This invention comprises the novel compounds of formula (I) wherein t, R 1 , R 2 , L, Q, X, Y, Z and (a) have defined meanings, having histone deacetylase inhibiting enzymatic activity; their...
4	7579349	4-(pyrazol-3-ylamino) pyrimidine derivatives for use in the treatment of cancer A compound of Formula (I); wherein the substituents are as defined in the text for use in modulating insulin-like growth factor 1 receptor activity in a warm blooded animal such as man.
5	7547782	Met kinase inhibitors The present invention is directed to compounds having the formula I or II: including salts thereof, and methods for using them for the treatment of cancer.
6	7531536	Pyrazole compounds useful as protein kinase inhibitors This invention describes novel pyrazole compounds of formula IIIa: wherein R 1 is T-Ring D, wherein Ring D is a 5-7 membered monocyclic ring or 8-10 membered bicyclic ring selected from aryl,...
7	7531532	Pyridine derivative and pyrimidine derivative A compound represented by the following formula, a salt thereof or a hydrate of the foregoing has an excellent hepatocyte growth factor receptor (HGFR) inhibitory activity, and exhibits anti-tumor...
8	7507733	11b-HSD1 inhibitors for the treatment of diabetes Compounds of the formula (I): as well as pharmaceutically acceptable salts and esters thereof, wherein R 1 to R 5 have the significance given in claim 1 can be used in the form of...
9	7504396	Substituted heterocyclic compounds and methods of use The present invention relates to pyrimidine or pyridine carboxamides or pharmaceutically-acceptable salts thereof. Also included is a method of treatment of inflammation, inhibition of T cell...
10	7501407	Pyrimidine A_2Bselective antagonist compounds, their synthesis and use The subject invention provides compounds having the structure: wherein R 1 is substituted or unsubstituted phenyl or a 5-6 membered heterocyclic or heteroaromatic ring containing from 1 to 5...
11	7491732	Compositions and methods for inhibition of the JAK pathway The invention encompasses compounds having formula I-V and the compositions and methods using these compounds in the treatment of conditions in which modulation of the JAK pathway or inhibition of...
12	7491730	Compositions useful as inhibitors of GSK-3 The present invention provides a compound of formula I: or a pharmaceutically acceptable derivative thereof. These compounds are inhibitors of protein kinases, particularly inhibitors of GSK3...
13	7485638	Pyrimidine compounds Compounds of the formula (I), wherein R 1 , R 2 , R 3 , R 4 , R 5 and p are as defined within and a pharmaceutically acceptable salts and in vivo hydrolysable esters are described. Also described...
14	7470689	4-benzimidazol-2-ylpyridazin-3-one derivatives Disclosed are compounds of the general formula (I), where the definition of the substituents A, B, D, E, R 1 and R 2 are detailed in the description, and the physiologically tolerated salts...
15	7470686	Method of inhibiting the expression and/or the activity of JNK The present invention is related to benzazole derivatives notably for use as pharmaceutically active compounds, as well as to pharmaceutical formulations containing such benzazole derivatives. Said...
16	7465728	Derivatives of 4-(imidazol-5-yl)-2-(4-sulfoanilino)pyrimidine with CDK inhibitory activity Compounds of the formula (I): wherein R 1 , R 2 , R 3 , R 4 , R 5 and p are as defined within and a pharmaceutically acceptable salts and in vivo hydrolysable esters are described. Also described...
17	7449456	Diaminopyrimidinecarboxamide derivative A compound which may be used for the prevention or treatment of respiratory diseases in which STAT 6 is concerned, particularly asthma, chronic obstructive pulmonary disease and the like is...
18	7449462	Triazole derivatives which inhibit vasopressin antagonistic activity Compounds of formula (I), or pharmaceutically acceptable derivatives thereof, wherein: Het represents 2-pyridinyl or 2-pyrimidinyl; R 1 represents H, C 1-3 alkyl or a...
19	7442699	Anilinopyrimidine derivatives as IKK inhibitors and compositions and methods related thereto Compounds having activity as inhibitors of IKK are disclosed, particularly IKK-2. The compounds of this invention are anilinopyrimidine derivatives having the following structure: wherein R 1 ...
20	7442698	Substituted heterocyclic compounds and methods of use The present invention relates to pyrimidine or pyridine carbamate compounds having the general Formula I: and pharmaceutically acceptable salts or derivatives thereof. Also included are methods...
21	7442697	4-imidazolyl substituted pyrimidine derivatives with CDK inhibitory activity Compounds of the formula (I): wherein R 1 , R 2 , R 3 , R 4 , R 5 and p are as defined within and a pharmaceutically acceptable salts and in vivo hydrolysable esters are described. Also described...
22	7432260	Pyrimidine compounds The present invention relates to substituted pyrimidines of formula I, their preparation, pharmaceutical compositions containing them and their use as inhibitors of cyclin-dependent kinases (CDKs)...
23	7427618	Ethynyl derivatives as factor Xa inhibitors Novel compounds of the formula (I), in which R 1 , R 2 , R 3 , X and Y have the meaning indicated in Patent claim 1, are inhibitors of coagulation factor Xa and can be employed for the...
24	7427626	2-Anilino-4-(imidazol-5-yl)-pyrimidine derivatives and their use as cdk (cdk2) inhibitors Compounds of the formula (I), and pharmaceutically acceptable salts and in vivo hydrolysable esters thereof are described. Also described are processes for their preparation and their use as...
25	7365069	Pyrimidone derivatives The present invention relates to novel pyrimidones of the general formula (I), their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their hydrates, their...
26	RE40245	Gyrase inhibitors and uses thereof The present invention relates to compounds of the formula I: or a pharmaceutically acceptable derivative or prodrug thereof. The compounds are useful as inhibitors of bacterial gyrase...
27	7351700	Aminomethylpyrimidines as allosteric enhancers of the GABA_B receptors The present invention relates to compounds of formula wherein X is —S— or —NH—; R 3 /R 4 together with the N-atom to which they are attached form a non aromatic 5, 6 or 7...
28	7323464	Pyridine and pyrimidine derivatives Compounds of formula (1) are described in which R a and R b is each independently a hydrogen atom or a group R c , or R a and R b together form an oxo (═O) or thio (═S) group; X is a N atom...
29	7320975	2-(2-pyridyl)-5-phenyl-6-aminopyrimidine, method and intermediate products for the production and use thereof for combating noxious fungi The invention relates to 2-(2-pyridyl)-5-phenyl-6-aminopyrimidines of formula I, wherein the substitutes and the index have the following meaning: R 1 represents halogen, hydroxy, hyano, hxo,...
30	7312216	N-phenyl-2-pyrimidine-amine derivatives The invention relates to N-phenyl-2-pyrimidine-amine derivatives of formula I wherein the substituents are defined as indicated in the description, to processes for the preparation thereof, to...
31	7312215	Benzimidazole C-2 heterocycles as kinase inhibitors Benzimidazole derivatives having the general formula I are provided. These compounds are useful as tyrosine kinase inhibitors, especially for the treatment of cancer.
32	7282504	Kinase inhibitors The invention relates to inhibitors of kinases, compositions comprising the inhibitors, and methods of using the inhibitors and inhibitor compositions. The inhibitors and compositions comprising...
33	7279576	Anti-cancer medicaments Novel compounds and methods of using those compounds for the treatment of oncological conditions are provided. In a preferred embodiment, modulation of the activation states of abl or bcr-abl...
34	7279475	Fluorinated di-aryl urea compounds Disclosed are compounds of formula(I): wherein R 1 , R 2 , W and X of formula(I) are defined herein. The compounds inhibit production of cytokines involved in inflammatory processes and are...
35	7276502	Thiazoles useful as inhibitors of protein kinases The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of...
36	7262200	Indazolinone compositions useful as kinase inhibitors The present invention provides compounds of formula I: These compounds, and pharmaceutically acceptable compositions thereof, are useful generally as kinase inhibitors, particularly as...
37	7259162	Benzazole derivatives and their use as JNK modulators The present invention is related to benzazole derivatives notably for use as pharmaceutically active compounds, as well as to pharmaceutical formulations containing such benzazole derivatives. Said...
38	7226919	Compositions useful as inhibitors of protein kinases The present invention provides a compound of formula (I): or a pharmaceutically acceptable salt thereof. These compounds are inhibitors of protein kinases, particularly inhibitors of...
39	7220736	Pyrimidine compounds A cyclic compound of the formula (I) or a pharmacologically acceptable salt thereof, wherein X is ═CH— or ═N—, Y is —NH—, —NR 4 —, —S—, —O—, —CH═N—,...
40	7217712	4-Substituted-5-cyano-1H-pyrimidin-6-(thi)ones as GSK-3 inhibitors The present invention relates to compounds of formula I that are useful as GSK-3 inhibitors. The invention also relates to methods of using compounds of formula I or pharmaceutical compositions...
41	7205297	Substituted 5-alkynyl pyrimidines having neurotrophic activity The present invention relates to a series of novel substituted 5-alkynyl pyrimidines, pharmaceutical compositions which contain them, methods for their preparation, and their use in therapy,...
42	7199120	Pyrazolo-pyridine derivatives as antiherpes agents The present invention provides compounds of formula (I): wherein all variables are as defined herein, pharmaceutical compositions containing the same, processes for preparing the same and their...
43	7189717	Medicinal compositions promoting bowel movement The present invention provides a medicament having a gentle but strong defecation-promoting action without causing diarrhea. That is, it provides a defecation-promoting agent comprising a compound...
44	7186714	Imidazo[1,2-α]pyridine derivatives for the prophylaxis and treatment of herpes viral infections The present invention provides compounds of formula (I) wherein all variables are as defined herein, pharmaceutical compositions containing the same, processes for preparing the same and their use...
45	7179806	Δ1-pyrrolines used as pesticides The invention relates to novel Δ 1 -pyrrolines of the formula (I) in which R 1 , R 2 , R 3 , m, and Q have the meanings given in the disclosure, to a plurality of processes for preparing these...
46	7173028	Pyrimidine derivatives The present invention relates to trisubstituted pyrimidines of formula (I) wherein 0R a to R e are defined as in claim 1, which are suitable for the treatment of illnesses characterised by...
47	7169781	Imidazole derivatives and their use as pharmaceutical agents Compounds of the general formula (I) are presented which arevaluable therapeutics for the treatment of cancer and cancer related diseases.
48	7166599	Trisubstituted pyrimidines The present invention relates to trisubstituted pyrimidines of formula wherein R a to R e are defined as in claim 1, which are suitable for the treatment of illnesses in which β-amyloid...
49	7166597	Fused pyrazole derivatives being protein kinase inhibitors Compounds of Formula (I): salts or solvates or physiologically functional derivatives thereof, wherein Z is CH or N, and R 1 , R 2 , and R 4 are various substituent groups, are protein kinase...
50	7163940	Pyrazolopyridinyl pyrimidine therapeutic compounds The present invention provides compounds of formula (I): wherein all variables are as defined herein, pharmaceutical compositions containing the same, processes for preparing the same and their...

Matches 1 - 50 out of 461

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