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7462616 |
Pyrrolo-triazine aniline compounds useful as kinase inhibitors
Compounds having the formula (I),
and pharmaceutically acceptable salts, prodrugs, and solvates thereof, are useful as kinase inhibitors, wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , X and Z are...
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7425561 |
3-substituted-2(arylalkyl)-1-azabicycloalkanes and methods of use thereof
The present invention relates to 3-substituted-2-(arylalkyl)-1-azabicycloalkanes, methods of preparing the compounds and methods of treatment using the compounds. The azabicycloalkanes generally...
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7371750 |
Compounds and compositions as protein kinase inhibitors
The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated...
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7307077 |
Heterocyclic compound and antitumor agent containing the same as effective ingredient
The present invention relates to heterocyclic compounds represented by the formula I or pharmaceutically acceptable salts thereof and antitumor agents containing the heterocyclic compounds as...
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7153853 |
Heterocyclic compounds and antitumor drugs containing the same as the active ingredient
The present invention relates to heterocyclic compounds represented by the formula I
wherein X represents nitrogen atom or CH; R 1 represents halogen atom or hydroxyl; R 2 represents hydrogen...
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7071189 |
Heterocyclic compound and antitumor agent containing the same as active ingredient
The present invention relates to heterocyclic compounds represented by the formula I or pharmaceutically acceptable salts thereof and antitumor agents containing the heterocyclic compounds as...
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7022705 |
Isoxazoline derivatives useful as antimicrobials
Compounds of the formula (I), or a pharmaceutically-acceptable salt, or an in-vivo-hydrolysable ester thereof,
wherein, for example,
HET is an N-linked 5-membered, fully or partially...
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6998483 |
Process for the preparation of sulphonamide-substituted imidazotriazinones
The present invention relates to a process for the preparation of sulphonamide-substituted imidazotriazinones of the general formula (I)
characterized in that compounds of the formula (II)
...
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6974812 |
Benzamide inhibitors of the P2X7 Ereceptor
The present invention provides benzamide inhibitors of the P2X 7 receptor of the formula:
wherein R 1 -R 3 are as defined herein. The compounds of the invention are useful in the treatment...
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6943158 |
Diazinopyrimidines
Compounds of formula I are p38 inhibitors:
or a pharmaceutically acceptable salt thereof,
wherein
R 1 is hydrogen or alkyl; R 2 alkyl, haloalkyl, aryl, aralkyl, heteroaryl,...
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6908916 |
C-5 modified indazolylpyrrolotriazines
The present invention provides compounds of formula I
and pharmaceutically acceptable salts thereof.
The formula I compounds inhibit tyrosine kinase activity of growth factor receptors such...
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6894046 |
IL-5 inhibiting 6-azauracil derivatives
The present invention is concerned with the compounds of formula
the N-oxides, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein p is 0 to...
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6890922 |
2-phenyl substituted imidazotriazinones as phosphodiesterase inhibitors
The 2-phenyl-substituted imidazotriazinones having short, unbranched alkyl radicals in the 9-position are prepared from the corresponding 2-phenyl-imidazotriazinones by chlorosulphonation and...
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6878708 |
Imidazotriazinones and the use thereof
Novel imidazotriazinones of general formula (I), a method for the production and the pharmaceutical use thereof are disclosed.
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6867207 |
IL-5 inhibiting 6-azauracil derivatives
The present invention is concerned with the compounds of formula
the N-oxides, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, p and q are 0, 1,...
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6803365 |
Imidazo&lsqb 1,3,5&rsqb triazinones and the use thereof
The invention relates to imidazo[1.3.5]triazinones, a method for their production and methods of use, in particular as inhibitors of cyclic GMP metabolizing phosphodiesterases.
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6774127 |
Pyrazole and pyrazoline substituted compounds
Novel pyridyl and pyrimidinyl substituted pyrazole and pyrazoline compounds and compositions for use in therapy.
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6683081 |
Triazolotriazinones and the use thereof
The invention relates to novel triazolotriazinones of the general formula (I), to a method for their production and to the pharmaceutical use thereof.
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6680315 |
Triazine compounds
This invention relates to triazine compounds of formula (I): R 1 is, aryl, or heteroaryl; each of R 2 , R 4 , and R 5 , independently, is R c , halogen, nitro, nitroso, cyano, azide,...
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6670357 |
Methods of treating p38 kinase-associated conditions and pyrrolotriazine compounds useful as kinase inhibitors
Methods of treating one or more conditions associated with p38 kinase activity are disclosed comprising administering to a patient in need thereof at least one compound having the formula (I): ...
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6642381 |
Pyrimido&lsqb 5,4-e&rsqb &lsqb 1,2,4&rsqb triazine-5,7-diamine compounds as protein tyrosine phosphatase inhibitors
The invention relates to pyrimido[5,4-e][1,2,4]triazine-5,7-diamine compounds which are useful for inhibiting protein tyrosine phosphatases, particularly PTP1B.
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6608004 |
Substituted 2-aryl-1,2,4-triazine-3,5-di(thi)ones
The invention relates to novel substituted 2-aryl-1,2,4-triazine-3,5-di(thi)ones of the general formula (I), in which Q 1 , Q 2 , R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are each as defined in the...
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6458950 |
Compounds and pharmaceutical compositions containing the same
A compound shown by the formula II, wherein Het is a mono- or polycyclic heterocyclic group comprising one or more hetero atoms selected from the group consisting of N, O and S which may be the...
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6417187 |
1,2,4-triazole based compounds that can be used as insecticides or acaricides and processes
3-(Substituted aryl)-5-{substituted aryl-(alkynyl-aryl)}-[1,2,4]- triazole compounds are useful as insecticides and acaricides. New synthetic procedures and intermediates for preparing the...
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6362178 |
2-phenyl substituted imidazotriazinones as phosphodiesterase inhibitors
The 2-phenyl-substituted imidazotriazinones having short, unbranched alkyl radicals in the 9-position are prepared from the corresponding 2-phenyl-imidazotriazinones by chlorosulphonation and...
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6235738 |
Diphenyl-substituted heterocycles with 6-membered ring, processes for the preparation thereof and the use thereof as medicaments
The invention relates to novel diphenyl-substituted heterocycles with 6-membered ring of general formula (I) ##STR1## in which A, X and the residues R 1 , R 2 , R 3 , R 4 and R 5 are as defined...
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6218391 |
Triazinones and derivatives thereof
Corticotropin releasing factor (CRF) antagonists of Formula (I) ##STR1## and their use in treating psychiatric disorders and neurological diseases including major depression, anxiety-related...
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6096886 |
Morpholino end-capped, hindered amine substituted aminotriazine
Novel morpholino end-capped polyamino-1,3,5-triazines, methods for their use as light stabilizers for materials which are subject to degradation (for example, by actinic radiation), stabilizer...
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5470984 |
1-dimethylcarbamoyl-3-substituted-5-substituted-1H-1,2,4-triazoles
This invention relates to 1-dimethylcarbamoyl-3-substituted-5-substituted-1H-1,2,4-tri
azoles as defined herein, compositions containing those compounds and methods of use.
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5420099 |
Sulfanomide herbicides
A compound having the formula ##STR1## wherein A is CR 7 ; and R 1 through R 7 are substituents such as hydrogen, halogen, branched and straight chain hydrocarbons, cyclic hydrocarbons,...
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5290931 |
Water-insoluble naphthalic acid imide dyestuffs
Water-insoluble naphthalic acid imide dyestuffs of the following formula: ##STR1## wherein D is ##STR2## wherein R 1 is C 1 -C 8 alkyl which may be substituted, R 2 is hydrogen, halogen, lower...
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5256667 |
Quinazolinones and pyridopyrimidinones
Substituted quinazolinones and pyridopyrimidines of structural formula I ##STR1## are angiotensin II antagonists useful in the treatment of disorders related to the renin-angiotensin system (RAS)...
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5188832 |
Agents directed against parasites of fishes and insects
A method of using certain triazine-dione compounds for the control of endo- and ectoparasites of fish and/or insects. The compounds may be combined with aids to form an agent for controlling the...
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5175287 |
Process for preparing 1,2,4-benzotriazine oxides
A method of using 1,2,4-benzotriazine oxides, some of which are novel compounds, as radiosensitizers and selective cytotoxic agents is disclosed. These compounds are shown to specifically...
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5043443 |
Aminomethyloxooxazolidinyl arylbenzene derivatives
Novel aminomethyloxooxazolidinyl arylbenzene derivatives, wherein the aryl includes the phenyl, substituted phenyl, pyridyl, and substituted pyridyl groups, such as (l)-N-{3-[4-...
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4994448 |
Condensed quinolinium and isoquinolinium derivatives
The new compounds of the general Formula I ##STR1## (wherein R 1 stands for C 1 -4 alkyl or aralkyl; and R 2 represents hydroxy; or R 1 and R 2 together form a valency bond; R 3 is...
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4987146 |
N-hetaryl imidazole derivatives
N-hetaryl imidazole derivatives of general Formula I ##STR1## are disclosed in which Het represents an optionally substituted monocyclic or bicyclic heteroaromate, R 3 represents hydrogen, a...
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4939140 |
Heterocyclic oxophthalazinyl acetic acids
A heterocyclic oxophthalazinyl acetic acid having aldose reductast inhibitory activity of the formula ##STR1## wherein X is oxygen or sulfur; Z is a covalent bond, O, S, NH or CH 2 or CHR 5 Z is...
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4921527 |
Herbicidal sulfonamides
The invention relates to sulfonylurea compounds with a substituted or unsubstituted bicyclic nine-membered ring having one to five heteroatoms which are preemergent and/or postemergent herbicides...
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4916129 |
Combination β-blocking/angiotensin II blocking antihypertensives
Imidazole compounds such as ##STR1## which have angiotensin II antagonizing properties as well as β-adrenoceptor antagonizing properties are useful as antihypertensives and for treatment of...
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4908056 |
Heterocyclic acyl sulfonamides
This invention relates to novel heterocyclic carbonyl sulfonamides which are particularly useful as agricultural chemicals.
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4908364 |
Substituted 3-phenyl-7H-thiazol[3,2-b][1,2,4]-triazin-7-ones
Novel substituted 3-phenyl-7H-thiazolo[3,2-b][1,2,4]-triazin-7-ones of the formula I are disclosed ##STR1## in which R 1 , R 2 and R 3 have the meaning recited in the specification. The compounds...
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4898862 |
1,2,4-triazinone derivatives, their preparation and use
Compounds of formula (I): ##STR1## (in which: R 1 is hydrogen or alkl; R 2 is a variety of groups or atoms; R 3 is optionally substituted hydroxy or --(NH) n --NR 5 R 6 , wherein R 5 and R 6 ...
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4892946 |
Agricultural sulfonamides
N-(heterocyclicaminocarbonyl)arylsulfonamides in which the aryl radical is substituted in the 2-position by a carboxy radical, ester, thioester, or amide thereof; e.g....
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4870174 |
Imidozopyrionidines and their use in pharmaceutical preparations
The synthesis of 7-n-alkyl-imidazolium[4,5-d]-pyrimidines, 6-substituted-3n-alkyl-benzimidazolium- and 3n-alkyl-5,6-substituted-benzthiazolium salts are described. There N + -surfactants having a...
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4853394 |
N-('-B-hydroxyethylpiperid-4-yl esters and amides
Compounds of formula (I) and pharmaceutically acceptable salts thereof: Ar--CO--X--Y--Z--OR 1 (I) wherein: Ar is a group of formula (a): ##STR1## wherein either...
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4795755 |
Heterocyclic derivatives
This invention relates to heterocyclic derivatives which are histamine H-2 antagonists and which inhibit gastric acid secretion. According to the invention there is provided a guanidine derivative...
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4782056 |
2-phenylhexahydro-1,2,4-triazine-3-,5-diones
Compounds of the formula I ##STR1## with n=1-3, R=H, Hal, CF 3 , alkyl, cycloalkyl, alkyloxy, alkylthio, alkylsulfinyl, alkylsulfonyl, benzylsulfinyl, benzylsulfonyl, nitro, cyano, amino,...
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4698352 |
4-oxo-1,4-dihydronicotinic acid derivatives, salts thereof, and antibacterial agents containing the same
This invention relates to a novel 4-oxo-1,4-dihydronicotinic acid derivative ##STR1## or a salt thereof, wherein R 1 is hydrogen or carboxyl-protecting group; R 2 is substituted phenyl and...
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4689414 |
2-(substituted imino)-6-aryl-3,6-dihydro-4-substituted-1,5(2H)-pyrimidinecarboxylic acids and analogs
Cardiovascular activity is exhibited by compounds having the formula ##STR1## and pharmaceutically acceptable salts thereof, wherein R 1 is alkyl, cycloalkyl, aryl, heterocyclo, --(CH 2 ) n --Y 2...
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