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7625900 |
Sutstituted tetrahydropyrrolopyrazine compounds and the use thereof in the treatment and/or inhibition of pain
Substituted tetrahydropyrrolopyrazine compounds corresponding to the formula I:
processes for their preparation, pharmaceutical compositions comprising these compounds and the use of these...
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7608658 |
Amine-functionalized liquid polyisoprene
This invention discloses a process for manufacturing an elastomeric article by liquid injection molding, said process comprising the steps of: (I) heating a curable composition comprised of (1) a...
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7605261 |
Urea derivatives, method for preparing same, use thereof as medicines, pharmaceutical compositions and novel use
The invention relates to new products of formula (I):
in which: Y represents oxygen or sulphur, Z represents C═CH2, CH—CH3 or CH2, R1 represents hydrogen, morpholinyl or the
radical. In...
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7598248 |
Certain 1H-imidazo[4,5-b]pyrazin-2(3H)-ones and 1H-imidazo[4,5-b]pyrazin-2-ols, compositions thereof, and methods for their use
Provided is at least one chemical entity chosen from compounds of Formula I and compounds of Formula II:
and pharmaceutically acceptable salts thereof, compositions thereof, and methods for...
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7595397 |
Compounds which modulate the CB2 receptor
Compounds are provided which bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, the compounds having the general formula
wherein, R 1 , R 2 , A, Y, X, Ar 1 and Ar 2...
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7595315 |
Morpholine derivatives as norepinephrine reuptake inhibitors
Compounds of the general formula (I)
are inhibitors of the reuptake of norepinephrine. As such, they may be useful for the treatment of disorders of the central and/or peripheral nervous system.
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7592449 |
Structural carotenoid analogs for the inhibition and amelioration of disease
A method for inhibiting and/or ameliorating the occurrence of diseases associated with reactive oxygen species, reactive nitrogen species, radicals and/or non-radicals in a subject whereby a...
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7589197 |
Pyrimidine compounds
This invention relates to a method for treating inflammatory diseases or immune diseases, developmental or degenerative diseases, or tissue injuries. The method includes administering to a subject...
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7589114 |
Derivatives of [6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonyl]-azetidine-carboxylic acids, esters and amides
Derivatives of 6,7-dihydro-5H-imidazo[1,2-α]imidazole-3-sulfonyl]-azetidin
e-carboxylic acids, esters and amides which exhibit good inhibitory effect upon the interaction of CAMs and...
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7589205 |
3-thia-10-aza-phenanthrene derivatives
The compounds of formula I
in which A, R1, R2 and R3 have the meanings as given in the description, are novel effective PDE4 inhibitors.
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7579022 |
Photochromic compounds
Various non-limiting embodiments disclosed herein relate generally to photochromic compounds, which may be thermally reversible or non-thermally reversible, and articles made therefrom. Other...
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7576083 |
Morpholinyl piperidine glycine transporter inhibitors
The present invention is directed to morpholinyl piperidine compounds that inhibit the glycine transporter GlyT1 and which are useful in the treatment of neurological and psychiatric disorders...
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7572793 |
3-Substituted-4-pyrimidone derivatives
A pyrimidone derivative represented by formula (I) or a salt thereof, or a solvate thereof or a hydrate thereof having inhibitory activity against tau protein kinase 1:
wherein R 1 represents...
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7572792 |
Azetidine glycine transporter inhibitors
The present invention is directed to azetidine compounds that inhibit the glycine transporter GlyT1 and which are useful in the treatment of neurological and psychiatric disorders associated with...
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7566716 |
Imidazopyrazines as Raf inhibitor compounds
Compounds of Formula I are useful for inhibiting Raf kinase and for treating disorders mediated thereby. Methods of using compounds of Formula I, and stereoisomers, tautomers, solvates and...
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7563789 |
1-Adamantyl chalcones for the treatment of proliferative disorders
The present invention relates to the compounds of the general formula (I), a composition for and a method of treating breast cancer or other proliferative disorders in a subject using a compound of...
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7560549 |
Sulfonyloxy derivatives
A compound having the formula (I)
wherein R 1 is a substituted phenyl, R 2 is a phenyl substituted with halogen atoms, R 3 is a substituted phenyl, D is an oxygen or a methylene, and n is 0...
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7538130 |
Hindered amine light stabilizer, methods of making, and compositions
A compound
in which n is 0, 1, 2, or 3; R 1 , R 2 , R 7 , and R 8 are each independently alkyl group, including cycloalkyl, an alkylaryl group, or an aryl group, optionally with one or more...
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7534880 |
Clear photopolymerizable systems for the preparation of high thickness coatings
The present invention relates to clear photopolymerisable systems for the preparation of high thickness coatings, to a procedure for their application and to the solid surfaces coated with them.
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7531651 |
Benzenesulphonate salt of a morpholine urea derivative for use as a CCR-3 antagonist in the treatment of inflammatory conditions
Compounds of formula (I):
wherein A − represents the benzenesulphonate (besylate) anion;.
R represents H or C 1-6 alkyl; and
n is a number from 0.8 to 2.2 are CCR3 antagonists and...
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7528131 |
Substituted morpholinyl compounds
This disclosure relates to novel substituted morpholinyl compounds and their derivatives, pharmaceutically acceptable salts, solvates, and hydrates thereof. This disclosure also provides...
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7524874 |
Vanilloid receptor ligands and their use in treatments
Compounds having the general structure
and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster...
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7521449 |
4-arylmorpholin-3-one derivatives, their preparation and therapeutic use thereof
The invention relates to compounds corresponding to formula (I):
in which:
Ar represents a mono- or disubstituted phenyl; R 1 represents an unsubstituted or substituted phenyl; R 2 ...
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7514432 |
Compounds and methods of treating cell proliferative diseases, retinopathies and arthritis
The present invention relates to compounds and their uses, particularly in the pharmaceutical industry. The invention discloses compounds having anti-proliferative and antiangiogenic activities, as...
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7514430 |
Piperizinones as modulators of chemokine receptor activity
The present application describes modulators of CCR3 of formula (I):
or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma and other allergic diseases.
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7511168 |
Processes and intermediates for the preparations of prostaglandins
The present invention provides novel processes for the preparation of a cyclopentanone of Formula II and a lactone of Formula I, which are useful in the production of prostaglandins:
wherein Z,...
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7507817 |
Prostaglandin prodrugs
Novel compounds, and therapeutic methods, compositions and medicament related thereto are disclosed herein.
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7501516 |
Quinoline derivatives and their use as tyrosine kinase inhibitors
The invention concerns quinoline derivatives of Formula (I) wherein each of Z, m, R 1 , n and R 3 have any of the meanings defined in the description; processes for their preparation,...
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7498329 |
Salt form of dopamine agonist
This invention relates to a novel salt form of dopamine agonist 5-[(2R,5S)-5-methyl-4-propylmorpholin-2-yl]pyridin-2-amine (I):
More particularly, this invention relates to...
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7498354 |
Pyrrolo[2,3-D]imidazoles for the treatment of hyperproliferative disorders
or a pharmaceutically acceptable salt or N-oxide thereof, are useful in the treatment of tumors and cancers.
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7488728 |
Pyridinylmorpholine derivatives
The invention relates to compounds of formula (I):
wherein R, R 1 , R 2 and X are defined herein, their preparation, and their use as pharmaceuticals.
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7479491 |
Azanthranylalkyl and -cycloalkyl amides and their use as VEGF receptor inhibitors
The invention relates to substituted anthranylalkyl and -cycloalkyl amides of general formula (I) and to their use as medicaments for treating diseases caused by persistent angiogenesis.
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7476672 |
Acetylenic compounds useful in treating inflammatory disorders
This invention is directed to acetylenic compounds as inhibitors of a nicotinamide adenine dinucleotide oxidase hydride donor useful in treating or ameliorating a reactive oxygen species mediated...
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7470795 |
Synthesis of 6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonic acid amides
Disclosed is a multi-step process for preparing a compound of Formula I:
wherein R 1 to R 3 are as defined herein. The compounds of formula I inhibit the binding of human intercellular...
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7465811 |
Indoline compounds
Sulfonylindoline compounds of formula I,
wherein R1 through R4, Y and Z have defined meanings, a process for preparation of such compounds, and the use as pharmaceutically active substances,...
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7462637 |
Derivatives of [6,7-dihydro-5H-imidazo[1,2--a]imidazole-3-sulfonyl]-pyrrolidine-2-carboxylic acid amide
Derivatives of 6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonyl]-pyrrolidi
ne-2-carboxylic acid amide which exhibit good inhibitory effect upon the interaction of CAMs and Leukointegrins and are...
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7449573 |
Photosensitive composition, compound for use in the photosensitive composition, and method of pattern formation with the photosensitive composition
A compound which generates a sulfonic acid having one or more —SO 3 H groups and one or more —SO 2 — bonds upon irradiation with an actinic ray or a radiation; a photosensitive composition...
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7442716 |
2-(phenyl or heterocyclic)-1H-phenantrho[9,10-d]imidazoles as mPGES-1 inhibitors
The invention encompasses novel compounds of Formula I
or pharmaceutically acceptable salts thereof. These compounds are inhibitors of the microsomal prostaglandin E synthase-1 (mPGES-1) enzyme...
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7435744 |
Piperidine derivatives as NMDA receptor antagonists
The present invention relates to a compound of formula (I):
wherein: V and U are hydrogen, halogen, C 1 -C 4 alkylamino, or together form a group that contains one or more heteroatoms, and...
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7429589 |
Mono-nitration of aromatic compounds via nitrate salts
A method of nitrating a compound selected from the group consisting of
is provided.
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7425555 |
Heteroaryl substituted biphenyl derivatives as p38 kinase inhibitors
Compounds of formula (I):
are inhibitors of p38 kinase and are useful in the treatment of conditions or disease states mediated by p38 kinase activity or mediated by cytokines produced by the...
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7425572 |
Use of dioxindoindazoles and dioxoloindazoles for treating glaucoma
Novel dioxinoindazole compounds and dioxoloindazole compounds are disclosed. Also disclosed are methods for the lowering and controlling of normal or elevated intraocular pressure as well as a...
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7423147 |
Pyridine compounds as histamine H3 modulators
Certain non-imidazole heterocyclic compounds are Histamine H 3 modulators in the treatment of Histamine H 3 receptor mediated diseases.
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7414054 |
3-(arylamino)methylene-1, 3-dihydro-2H-indol-2-ones as kinase inhibitors
The present invention relates to organic molecules capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation.
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7414067 |
Ophthalmic compositions for treating ocular hypertension
This invention relates to the use of potent potassium channel blockers or a formulation thereof in the treatment of glaucoma and other conditions which leads to elevated intraoccular pressure in...
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7405262 |
Preparation of functionalized anionic polymerization initiators
A process for preparing a functionalized polymerization initiator, the process comprising combining a functionalized styryl compound and an organolithium compound.
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7402675 |
Process for the synthesis of amine ethers from secondary amino oxides
An amine ether of formula A
wherein a is 1 or 2; and when a is 1, E is E′; when a is 2, E is L;
E′ is C 1 -C 36 alkyl; C 3 -C 18 alkenyl; C 2 -C 18 alkinyl; C 5 -C 18 cycloalkyl;...
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7388007 |
Gamma-lactams as beta-secretase inhibitors
There is provided a series of novel substituted gamma-lactams of Formula (I)
or a stereoisomer; or a pharmaceutically acceptable salt thereof, wherein R 1 , R 2 , R 4 , R 5 and R 6 as defined...
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7378521 |
Preparation of 2-(2-arylmorpholin-2-yl) ethanol derivatives and intermediates
The invention relates to a process for the preparation of substituted 2-vinyl-2-arylmorpholine derivatives as described herein. This invention also relates to 2-vinyl-2-arylmorpholine derivatives...
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7371749 |
Benzothiazole derivatives
The present invention relates to compounds of formulae IA and IB
wherein
R 1 and R 2 are each independently lower alkyl or —(CH 2 ) m —O-lower alkyl, or together with the N atom to which...
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