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7605157 |
Tricyclic tetrahydroquinoline antibacterial agents
The invention includes tetrahydroquinoline and related compounds of formula I and pharmaceutical compositions thereof, that exhibit useful antibacterial activity again a wide range of human and...
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7569563 |
Substituted quinolones II
The invention relates to substituted quinolones of formula (I) and to methods for their preparation as well as their use for the production of medicaments for the treatment and/or prophylaxis of...
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7550458 |
Tricycloundecane compounds useful as modulators of nuclear hormone receptor function
Tricycloundecanes compounds, methods of using such compounds in the treatment of nuclear hormone receptor-associated conditions such as cancer and immune disorders, and pharmaceutical compositions...
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7432372 |
Fluorinated resorufin compounds and their application
The invention provides novel fluorinated resorufin compounds that are of use in a variety of assay formats. Also provided are methods of using the compounds and kits that include a compound of the...
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7429582 |
Dihydro[1,4]oxazino[2,3,4-hi]indazole derivatives as 5-hydroxytryptamine-6 ligands and use thereof in the treatment of attention deficit disorders
The present invention provides a compound of formula I and the use thereof for the treatment of a central nervous system disorder related to or affected by the 5-HT6 receptor
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7425628 |
Methods for the purification of levofloxacin
The invention provides a process for preparing levofloxacin hemihydrate, comprising:
(A) dissolving levofloxacin in a solvent selected from the group consisting of acetonitrile, acetonitrile:H 2...
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7414051 |
Substituted-dihydro[1,4]oxazino[2,3,4-hi]indazole derivatives as 5-hydroxytryptamine-6 ligands
The present invention provides a compound of formula I and the use thereof for the treatment of a central nervous system disorder related to or affected by the 5-HT6 receptor.
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7364804 |
Pyran derivative, method for manufacturing the same, and light-emitting element containing the pyran derivative
A light-emitting compound that has excellent carrier transportation properties and that can exhibit long wavelength light is disclosed. Further, a method for manufacturing the light-emitting...
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7291431 |
Organophotoreceptor with charge transport compound having an epoxy group
This invention relates to a novel organophotoreceptor that comprises an electrically conductive substrate and photoconductive element on the electrically conductive substrate, the photoconductive...
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7276298 |
Substance for intermediate layer of organic electroluminescent device and organic electroluminescent device using the same
The present invention is related to an intermediate layer of an organic electroluminescent device comprising an amine derivative substance which may further comprise a functional group capable of...
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7235550 |
Polycyclic azaindole compounds
The invention relates to compounds of formula (I):
wherein:
G 1 represents an alkylene chain as defined in the description, A represents
R 2 and R 3 represent...
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7220861 |
Processes for preparing quinolonecarboxylate derivatives
Provided is a process for preparing quinolonecarboxylate derivatives under a mild condition in high yield, so as to be favorably applied to a large-scale mass production thereof.
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7208490 |
Tricyclic tetrahydroquinoline antibacterial agents
The invention includes tetrahydroquinoline and related compounds of formula I, and pharmaceutical compositions thereof, that exhibit useful antibacterial activity against a wide range of human and...
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7179805 |
7-amino alkylidenyl-heterocyclic quinolones and naphthyridones
The present invention relates to compounds having a structure according to Formula I
wherein n, m, z, R, R 2 , R 3 , R 4 , R 5 , R 6 , A, E, X, Y, a and b are as defined above;
or an optical...
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7176313 |
Anti acid-fast bacterial agent containing pyridonecarboxylic acids as active ingredient
An anti acid-fast bacterial agent containing, as an active ingredient, a pyridonecarboxylic acid derivative represented by the following general formula (1), a salt thereof, or a hydrate thereof,...
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7169520 |
Organophotoreceptor with charge transport material with a hydrazone group linked to a heterocyclic group
Improved organophotoreceptor comprises an electrically conductive substrate and a photoconductive element on the electrically conductive substrate, the photoconductive element comprising:
...
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7160732 |
Fluorescein-based metal sensors, and methods of making and using the same
The present invention is directed, in part, to fluorescein-based ligands for detection of metal ions, and methods of making and using the same.
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7153851 |
10-(3-cyclopropylaminomethyl-1-pyrrolidinyl)pyridobenzoxazinecarboxylic acid derivative effective against resistant bacterium
A compound as represented by the general formula (I) shown below exhibits high antibacterial activity against gram-positive bacteria, in particular, such drug-resistant bacteria as mRNA, PRSP and...
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7141566 |
Benzoxazine and benzothiazine derivatives and the use thereof in medicaments
The invention relates to compounds of formula (I), the tautomeric and isomeric forms and salts thereof, in addition to a method for production and use thereof in medicaments.
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7135468 |
Antibacterial compounds
Bacterial protein synthesis-inhibiting compounds having formula (I)
and salts, prodrugs, salts of prodrugs, and metabolites thereof, processes for making the compounds and intermediates in the...
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7060821 |
Osteoclast differentiation inhibitors
A compound represented by formula (I); a process for producing a compound (substance F-1490) of formula (I), wherein X represents —O— and R represents a hydroxyl group, by using a microorganism...
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7049437 |
Synthetic process and crystal form of condensed imidazopyridine derivatives
The present invention provides a process of a compound of the formula (I):
wherein R is heteroaryl or the like, ring A is a heteroalicyclic group or the like comprising reacting a compound of...
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7015219 |
3-aryl-hydroxybenzoxazines and 3, 4-dihydro-3-aryl-hydroxybenzoxazines as selective estrogen receptor beta modulators
Substituted benzoxazine and 3,4-dihydrobenzoxazine derivatives possessing activity as estrogen receptor beta (ERβ) modulators are provided which have the structure of formula I
wherein...
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6919334 |
Antidepressant azaheterocyclymethyl derivatives of 4,5-dihydroimidazo[1,4,5-de][1,4]benzoxazine
Compounds of the formula:
are useful for the treatment of depression (including but not limited to major depressive disorder, childhood depression and dysthymia), anxiety, panic disorder,...
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6914059 |
Benzoxazine and benzothiazine derivatives and the use thereof in medicaments
Compounds of formula I, their tautomeric and isomeric forms and salts,
as well as the process for their production and their use in pharmaceutical agents are described.
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6887868 |
Therapeutic 5-HT ligand compounds
The present invention provides compounds of Formula (I):
wherein: R 1 , R 2 , R 3 , R 4 , R 5 , R 6 R 7 , R 8 , n, m, and X have any of the values defined in the specification, as well as...
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6858607 |
7,8-fused 4H-chromene and analogs as activators of caspases and inducers of apoptosis and the use thereof
The present invention is directed to substituted 4H-chromene and analogs thereof, represented by the general Formula I:
or pharmaceutically acceptable salts or prodrugs thereof, wherein:
...
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6841550 |
Benzoxazine and benzothiazine derivatives and their use in medicines
The invention relates to compounds of formula (I) and their tautomeric and isomeric forms and salts, as well as to a method for producing said compounds and their use in medicines.
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6821969 |
Thioxazinoquinolones as antiviral agents
The present invention provides a compound of formula I These compounds are useful as antiviral agents, in particular, as agents against viruses of the herpes family.
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6770596 |
Fused tricyclic compounds, process for their preparation, and herbicidal compositions containing them
Novel fused tricyclic compounds represented by formula (I) are described. Q, Y, —L—X—, A, A′, B, E, D, n and m are as defined in the disclosure. Also described are the processes for the...
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6699989 |
Antiviral and antimicrobial guanidine or biguanidine derivatives
Disclosed are guanidine and biguanidine derivatives which have anti-viral and anti-bacterial activity. Also disclosed are pharmaceutical compositions containing such compounds as an active...
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6673793 |
Oxazinoquinolones useful for the treatment of viral infections
The present invention provides a compound of formula I which is useful as antiviral agents, in particular, as agents against viruses of the herpes family.
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6624159 |
Heterocycle carboxamides as antiviral agents
The present invention provides a compound of formula I which is useful as antiviral agents, in particular, as agents against viruses of the herpes family.
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6608055 |
Crystalline anticholinergic, processes for preparing it and its use for preparing a pharmaceutical composition
The invention relates to crystalline anhydrous (1α,2β,4β,5α,7β)-7-[(hydroxydi-2-thienylacetyl)oxy]-9,9
-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.02 2,4 ]nonane-bromide, processes for preparing it...
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6608048 |
Tricyclic protein kinase inhibitors
This invention provides compounds of Formula (I), where A″, Z, X and n are defined herein, or a pharmaceutically acceptable salt thereof which are useful as antineoplastic agents and in the...
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6573260 |
Cycloalkyl-substituted aminomethylpyrrolidine derivatives
This invention provides a quinolone derivative which exerts strong antibacterial action upon various bacteria and has high safety, and it relates to a compound having a structure of formula (I),...
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6552018 |
Pyrazole derivatives
The present invention relates to cis- and trans-forms of pyrazole derivatives, salts thereof, or agents containing the same, and represented by the general formula (I): wherein G represents a...
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6514984 |
Treatment for alzheimer's disease
A method is disclosed for the prevention and treatment of Alzheimer's disease by administering to a human in need thereof an effective amount of a substituted tricyclic sPLA 2 inhibitor.
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6468996 |
Substituted hetero-polycyclic compounds as PPARα and PPAR&ggr activators
The present invention relates to compounds of the general formula (I) The compounds are useful in the treatment and/or prevention of conditions mediated by nuclear receptors, in particular the...
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6462038 |
Androgen receptor modulator compounds and methods
Compounds, pharmaceutical compositions, and methods for modulating processes mediated by steroid receptors. In particular, preparation and methods of use of non-steroidal compounds and compositions...
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6448241 |
Thiazolobenzoheterocycles, their preparation and medicaments containing them
Compounds of formula (I): their racemates, enantiomers, diastereoisomers and inorganic acid salts and organic acid salts thereof, processes for preparing them and the medicaments containing them...
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6444812 |
Intermediate compounds in the preparation of farnnesyl transferase inhibiting 1,8-annelated quinolinone derivatives substituted with N-or C linked imidazoles
This invention concerns intermediates in the preparation of compounds of formula the pharmaceutically acceptable acid addition salts and the stereochemically isomeric forms thereof, wherein the...
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6426416 |
Anthraquinone and condensed anthraquinone colorants having sulfonamido linked poly (oxyalkylene) moieties and their preparation
The process for chemically modifying metal-free, colored anthraquinone or condensed anthraquinone compounds or the compounds prepared by said process for improving one or more properties thereof...
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6376488 |
Benzoxazine α-1 adrenergic compounds
The present invention relates to compounds having formula I and to pharmaceutically acceptable salts thereof. Compounds of formula I inhibit α 1 adrenoreceptors and may be useful for treating...
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6316618 |
Process for preparing (-)pyridobenzoxazine carboxylic acid derivatives
Disclosed is a process for preparing optically active (-)pyridobenzoxazine carboxylic acid derivative and pharmaceutically acceptable salt thereof by employing a starting material of (+)ethyl...
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6288081 |
Use of 7-(1-aminomethyl-2-oxa-7-aza-bicyclo[3.3.0]oct-7-yl)-quinolone carboxylic acid and naphthyridone carboxylic acid derivatives for treating Helicobacter pylori infections and the gastroduodenal diseases associated therewith
The invention relates to the use of quinolone- and naphthyridonecarboxylic acid derivatives which are substituted in position 7 by a 1-aminomethyl-2-oxa-7-azabicyclo[3.3.0]oct-7-yl radical, and of...
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6191129 |
Bicyclic amine derivative
A pyridobenzoxazine derivative having a bicyclic amine derivative as its substituent, represented by the formula (I): ##STR1## exhibiting antimcrobial activity, and useful in treating infectious...
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6187786 |
Farnesyl transferase inhibiting 1,8-annelated quinolinone derivatives substituted with N- or C-linked imidazoles
This invention concerns compounds of formula ##STR1## the pharmaceutically acceptable acid addition salts and the stereochemically isomeric forms thereof, wherein the dotted line represents an...
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6080752 |
Tricyclic amine derivatives
A compound of formula (I): ##STR1## wherein R 1 represents a group of formula (A) or (B): ##STR2## R 2 , R 3 , Ar, Y Ar 1 are as defined herein; or a pharmaceutically acceptable salt thereof,...
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6057317 |
Heterocyclic compounds
Compound of formula (I): ##STR1## wherein: Y, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 and n are as defined in the description, and medicinal products containing the same which are useful as...
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