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9040562 Macrocyclic inhibitors of hepatitis C virus  
Inhibitors of HCV replication of formula (I) and the N-oxides, salts, and stereoisomers, whereineach dashed line represents an optional double bond;X is N, CH and where X bears a double bond it is...
9040520 Noribogaine salt ansolvates  
Stable noribogaine salt ansolvates are useful for preparing pharmaceutical compositions and for alleviating nociceptive pain in a patient. Such ansolvates can be prepared by slurrying solvated...
9040689 Compounds useful as ligands and particularly as organic chromophores for complexing lanthanides and applications thereof  
The invention relates to the use of compounds comprising at least one 2-(1H-tetrazol-5-yl)pyridine unit, of formula (I) below: as ligands for lanthanides and, more especially, as organic...
9040687 Process for the preparaton of novel porphyrin derivatives and their use as PDT agents and fluorescence probes  
The present invention provides novel porphyrin derivatives represented by the general formula 1 and/or pharmaceutically acceptable derivatives thereof as NIR sensitizers for photodynamic...
9040524 Antifungal 5,6-dihydro-4H-pyrrolo[1,2-a][1,4]-benzodiazepines and 6H-pyrrolo[1,2-a][1,4]benzodiazepines substituted with bicycle benzene derivatives  
The present invention is concerned with novel antifungal 5,6-dihydro-4H-pyrrolo-[1,2-a][1,4]benzodiazepines and 6H-pyrrolo[1,2-a][1,4]benzodiazepines substituted with bicyclic benzene derivatives...
9040518 Chemical compounds  
Compounds of Formula I and methods for treating metabolic disorders are disclosed.
9040517 Compounds as diacylglycerol acyltransferase inhibitors  
This invention relates to novel compounds which are inhibitors of acyl coenzymeA: diacylglycerol acyltransferase 1 (DGAT-1), to pharmaceutical compositions containing them, to processes for their...
9040523 Antifungal 5,6-dihydro-4H-pyrrolo[1,2-α][1,4]-benzodiazepines and 6H-pyrrolo[1,2-α][1,4]benzodiazepines substituted with benzene derivatives  
The present invention is concerned with novel antifungal 5,6-dihydro-4H-pyrrolo-[1,2-a][1,4]benzodiazepines and 6H-pyrrolo[1,2-a][1,4]benzodiazepines of Formula (I) wherein R1, R2, R3, R4, R5 and...
9040688 Intermediates in the preparation of 1,4-diphenyl azetidinone  
The process of the present invention relates to a method for the synthesis of a 1,4-diphenylazetidinone of formula (VIII) by using novel oxime intermediates.
9040519 Fused tetracyclic pyrido [4,3-B] indole and pyrido [3,4-B] indole derivatives and methods of use  
This disclosure is directed to fused tetracyclic pyrido[4,3-b>]indole and pyrido[3,4-b]indole derivatives. Pharmaceutical compositions comprising the compounds are also provided, as are methods of...
9040522 6-(5-hydroxy-1H-pyrazol-1-yl)nicotinamide inhibitors of PHD  
The present invention provides compounds of the formula: which are useful as inhibitors of PHD and pharmaceutical compositions thereof.
9034861 MEK inhibitors useful in the treatment of diseases  
The invention pertains to compound of Formula (I) wherein X, Y, Z, R1, R2, R3, R4, A and A′ are as described hereinabove. Formula (I) and (II) compounds can be used in pharmaceutical compositions,...
9035042 Sulfonamide derivatives of polycyclic dyes used for analytical applications  
The invention concerns the production of quinoline compounds containing sulfonic acid groups, the said quinoline compounds and their conversion into dyes containing sulfonic acid groups. The dyes...
9034892 Forms of rifaximin and uses thereof  
The present invention relates to Rifaximin polymorphic, salt, hydrate, and amorphous forms, to their use in medicinal preparations and to therapeutic methods using them.
9034856 17-(1′propenyl)-17-3′-oxidoestra-4-en-3-one derivative, use thereof, and medicament containing said derivative  
The invention relates to 17-(1′-propenyl)-17-3′-oxidoestra-4-en-3-one derivatives with the general chemical formula I, where the residues Z, R4, R6a, R6b, R7, R15, R16a, R16b and R18 have the...
9035046 Rifaximin derivative and uses thereof  
25-desacetyl rifaximin or a pharmaceutically acceptable salt thereof is provided. Methods of treatment of bowl related disorders using isolated and/or purified 25-desacetyl rifaximin or a...
9034095 Greenish blue pigment, colorant composition containing said pigment, and image recording material  
An object is to overcome the drawbacks of conventional blue phthalocyanine pigments upon the formation of images, and to develop a blue pigment that can satisfactorily exhibit a greenish blue...
9029356 Substituted indazole derivatives active as kinase inhibitors  
Substituted indazole derivatives of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification; the compounds of the invention may be useful in therapy in the...
9029358 Aminodihydrothiazine derivatives  
A composition having BACE 1 inhibitory activity containing a compound represented by the formula (I): wherein ring A is an optionally substituted carbocyclic group or an optionally substituted...
9029355 Solid ganaxolone compositions and methods for the making and use thereof  
In certain embodiments, the invention is directed to composition comprising stable particles comprising ganaxolone, wherein the volume weighted median diameter (D50) of the particles is from about...
9029360 Pyrazolopyrimidines as metabotropic glutamate 5 receptor antagonists  
This invention relates to novel pyrazolopyrimidines and their use as metabotropic glutamate 5 receptor antagonists (mGlu5 receptor antagonists), pharmaceutical compositions containing the same,...
9029361 Agents for treating pain and uses thereof  
This invention relates to: (a) compounds and salts thereof that, inter alia, treat pain; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such...
9024014 Phosphorus-containing compounds and uses thereof  
This disclosure concerns a new family of phosphorus-containing compounds of Formula (I): and pharmaceutically acceptable derivatives thereof. Compositions containing such compounds and uses...
9023808 Macrocyclic inhibitors of hepatitis C virus  
Inhibitors of HCV replication of formula (I) and the N-oxides, salts, or stereoisomers thereof, wherein the dashed line, X, R1, R2, R3, R4, R5, R6, and R7 have defined meanings; the preparation...
9024013 Method for purifying rocuronium bromide  
Provided is a method for purifying rocuronium bromide, which comprises: formulating crude rocuronium bromide to be purified into an aqueous solution, distilling off excess residue solvents at...
9026203 Photosensitizing compositions  
The invention relates to pharmaceutically acceptable salts of amphiphilic photosensitizing agents which have a water solubility of at least 0.5 mg/ml and to their use in methods of photochemical...
9023842 Benzodiazepine bromodomain inhibitor  
The present invention relates to a benzodiazepine compound of formula (I), processes for its preparation, pharmaceutical compositions containing such a compound and to its use in therapy.
9024015 Process for preparing tolvaptan intermediates  
The present invention provides a novel process for the preparation of 7-chloro-2,3,4,5-tetrahydro-1H-1-benzazepin-5-one. The present invention also provides an improved process for the preparation...
9017826 Visible/near-infrared porphyrin-tape/C60 organic photodetectors  
Porphyrin compounds are provided. The compounds may further comprise a fused polycyclic aromatic hydrocarbon or a fused heterocyclic aromatic. Fused polycyclic aromatic hydrocarbon s and fused...
9018373 Method for preparing temsirolimus  
A method for preparing temsirolimus, the method including: using a substituted aromatic aldehyde to protect 2,2-dimethylol propionic acid to produce intermediate II; carrying out reaction between...
9018197 Tetradecahydro-1H-cyclopenta[a]phenanthrene compounds, compositions, and related methods of use  
Chemical entities that are bufalin derivatives, pharmaceutical compositions and methods of treatment of cancer are described.
9018318 Catalysts for the preparation of carbonates from epoxides and CO2  
A macrocycle based on β-diketimines, a process for preparing the inventive macrocycle, an uncharged macrocyclic dimetallic complex based on the inventive macrocycle, and a process for preparing...
9018225 Rifaximin crystalline forms and methods of preparation thereof  
The present invention is directed to methods for preparation of a composition comprising mixed crystalline polymorphs rifaximin α and rifaximin β. For example, practice of a method of the...
9012630 Method for producing bridged manganese complexes of triazacyclononane  
The invention relates to a method for producing manganese complex compounds of the general formula (1), wherein M, X, L, z, Y and q are defined as in claim 1. The method is characterized by the...
9012627 Method to produce uretonimine-modified isocyanate composition  
A method to produce uretonimine-modified isocyanate composition comprises Providing an organic isocyanate composition having two or more isocyanate groups;Reacting, in the presence of a suitable...
9012628 Crystalline form of ertapenem sodium and preparation method therefor  
Provided is a crystalline form E of ertapenem sodium. Further provided is a method for preparing a crystalline form E of ertapenem sodium, characterized by using an aqueous ertapenem sodium...
9012629 Methods for the acylation of maytansinol  
Disclosed is a method of preparing an amino acid ester of maytansinol by reacting maytansinol with an N-carboxyanhydride of an amino acid (NCA) in the presence of a drying agent. Also disclosed is...
9012441 Therapeutic compounds  
Compounds of formula I: or salts thereof are disclosed. Also disclosed are pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I,...
9006423 Process for making a 4-amino-4-oxobutanoyl peptide cyclic analogue, an inhibitor of viral replication, and intermediates thereof  
The invention provides a process of preparing 4-amino-4-oxobutanoyl peptides and cyclic analogues thereof of Compound I and pharmaceutically acceptable salts thereof.
9006424 Process for the manufacture of ivabradine and of intermediates of synthesis thereof  
The invention concerns a new process for the resolution of ivabradine and of intermediates of synthesis thereof.
9006421 Cephalosporin compositions and methods of manufacture  
Provided herein is a method for the synthesis of cephalosporin antibiotic compounds comprising the conversion of a protected 7-amino group into a 7-carboxamide moiety in a single step.
9006454 Dihydroorotate dehydrogenase inhibitors  
The invention relates to compounds of formula (I) wherein R1, R2, X1, X2, Y, Ra, Rb, Q have the meanings given in claim 1. The compounds are useful e.g. in the treatment of autoimmune disorders,...
9006232 Pyrimidone derivatives  
A compound represented by the formula (I) or a pharmaceutically acceptable salt thereof: wherein Z represents nitrogen atom or C—X; X represents hydrogen atom or fluorine atom; R1 is hydrogen atom...
9006422 Oxidation process for preparing 3-formyl-cephem derivatives  
The present invention relates to an improved process for oxidizing 3-hydroxy-methyl-cephem derivatives to the corresponding 3-formyl-cephem derivatives. In particular this oxidation process is for...
9006231 Cephalotaxus esters, methods of synthesis, and uses thereof  
The present invention provides novel cephalotaxus esters, syntheses thereof, and intermediates thereto. The invention also provides pharmaceutical compositions comprising a compound of the present...
9006233 Gabaergic receptor subtype selective ligands and their uses  
Described herein are α3 or α2 or α2/α3 GABAergic receptor subtype selective ligands, pharmaceutical compositions, and methods of use of such ligands and compositions in treatment of anxiety...
9006316 Organometallic compositions and coating compositions  
The present invention is directed to novel organometallic complexes as catalysts for the reaction of compounds with isocyanate and hydroxyl functional groups to form urethane and/or polyurethane...
9006276 Substituted oxindole derivatives, medicaments containing said derivatives and use thereof  
The invention relates to novel oxindole derivatives of general formula (I), wherein the substituents R1, R2, A, B, and Y are defined as in claim 1. The invention further relates to medicaments...
9006230 1,6-diazabicyclo [3,2,1] octan-7-one derivatives and their use in the treatment of bacterial infections  
Compounds of Formula (I), their preparation and use in preventing or treating bacterial infections are disclosed.
9000150 Process for the preparation of pure meropenem trihydrate  
The present invention relates to a process for the preparation of pure meropenem trihydrate.