|
Match
|
Document |
Document Title |
|
|
7700766 |
Methanesulfonate salts of abiraterone-3-esters and recovery of salts of abirater one-3-esters from solution in methyl tert-butyl ether
A salt of a compound of formula (I) may be made with methanesulfonic acid. The salt and salts with other acids may be prepared by recovering from methyl tert-butyl ether (MTBE).
|
|
|
5721227 |
17-aryl and 17-heterocyclyl-14β-5α-androstane, androstene and androstadiene derivatives active on the cardiovascular system, processes for their preparation and pharmaceutical compositions containing same
17-Aryl -5α,14β-androstane, androstene and androstadiene derivatives of formula (I): ##STR1## wherein the symbol --- represents a single or a double bond; when the double bond is not present in t...
|
|
|
5695738 |
Steroidal C-glycosides
Compositions of sterodial glycosides are described wherein the glycoside is linked directly, or indirectly to a desired steroidal compound via a carbon, or similar stable linkage, and methods of...
|
|
|
5679788 |
11 beta-substituted-19 nor-steroids
Intermediate compounds of a formula selected from the group consisting of ##STR1## which are useful intermediates for the preparation of final products of the formula ##STR2## wherein the...
|
|
|
RE35517 |
Method, compositions, and compounds for modulating brain excitability
Method, compositions, and compounds for modulating brain excitability to alleviate stress, anxiety, and seizure activity using certain steroid derivatives that act at a newly identified site on the...
|
|
|
5618807 |
Method for preparing 17-substituted steroids useful in cancer treatment
Compounds of the general formula (1) ##STR1## wherein X represents the residue of the A, B and C rings of a asteroid, R represents a hydrogen atom or an alkyl group of 1 to 4 carbon atoms, R14...
|
|
|
5604213 |
17-substituted steroids useful in cancer treatment
Compounds of the general formula (1) ##STR1## wherein X represents the residue of the A, B and C rings of a steroid, R represents a hydrogen atom or an alkyl group of 1 to 4 carbon atoms, R14...
|
|
|
5593983 |
Substituted 2β-morpholino-androstane derivatives
The invention is related to substituted 2β-morpholino-androstane derivatives, bonded at their 2β-position to the nitrogen of a group of formula I ##STR1## wherein R represents one to four s...
|
|
|
5591733 |
Methods, compositions, and compounds for allosteric modulation of the gaba receptor by members of the androstane and pregnane series
Method, compositions, and compounds for modulating brain excitability to alleviate stress, anxiety, insomnia and seizure activity using certain steroid derivatives that act at a newly identified...
|
|
|
5567697 |
17-(4-pyridazinyl) -5β, 14β-androstane derivatives active on the cardiovascular system, processes for their preparation and pharmaceutical compositions containing same
Present invention relates to a group of 17-(4-pyridazinyl)-5β,14β-androstane derivates active on the cardiovascular system and to pharmaceutical compositions containing same.
|
|
|
5536828 |
(E)-20 (22)-dehydrodiels-alder compounds
The invention discloses Diels-Alder adducts of the following structure: ##STR1## The compounds are useful as intermediates in the production of (E)-20(22)-Dehydrovitamin D compounds.
|
|
|
5521167 |
Cyclopentanperhydrophenanthren-17β-(hydroxy or alkoxy)-17α-(Aryl or heterocyclyl)-3β-derivatives active on the cardiovascular system, and pharmaceutical compositions containing same
The present invention relates to new cyclopentanperhydrophenanthren-17-(hydroxy or alkoxy)-17-(aryl or heterocyclyl)-3β-derivatives, active on the cardiovascular system, to a process for their ...
|
|
|
5449795 |
Process for synthesis of steroidal allylic tert. alcohols
A method for the preparation of a steroidal allylic tertiary alcohol is disclosed which involves the deprotonation of a sulfoxide with a strong base which is capable of deprotonating the methine...
|
|
|
5418226 |
Monoquaternary 2,16-bispiperidinylandrostane derivatives
Monoquaternary 2,16-bispiperidinylandrostane neuromuscular blocking derivatives having the formula: ##STR1## wherein R1 is ethyl; R2 is methyl or allyl; and X- is a pharmaceutically acceptable...
|
|
|
5416079 |
21-chloro-pregnane derivative
The invention is related to a 21-chloro-pregnane derivative of the formula ##STR1## or pharmaceutically acceptable salts thereof. The compound has intravenous anaesthetic activity, short onset time...
|
|
|
5382661 |
Pyrazinylpiperazinyl steroids
Disclosed are amino substituted steroids (XI) which contain a pyrazinylpiperazinyl group attached to the terminal carbon atom of the C17 -side chain which are useful as pharmaceutical agents for...
|
|
|
5380840 |
Triazinylpiperazinyl steroids
Disclosed are amino substituted steroids (XI) which contain 4-[1,3,5-triazin-2-yl]- or 4-[1,2,4-triazin-3-yl]- 1-piperazinyl group attached to the terminal carbon atom of the C17 -side chain which...
|
|
|
5373095 |
Steroid compounds
Provided are cyclic hydrocarbons of Formula I ##STR1## with an aminoalkyl sidechain that are useful for treating phospholipase A2 mediated conditions, diabetes, and obesity.
|
|
|
5319115 |
Method for making 3α-hydroxy, 3β-substituted-pregnanes
This invention provides a simplified method for converting pregnan-3,20-dione compounds to 3α-hydroxy,3β-substituted-pregnanes. By selective use of reagents the unprotected dione is converted c...
|
|
|
5175281 |
Pharmaceutically active pyrimidinylpiperazinylsterioids
Disclosed are Δ9(11) -steroids (VI) and amino substituted steroids (XI) which contain an amino group attached to the terminal carbon atom of the C17 -side chain, more particularly amino steroids ...
|
|
|
5017568 |
Steriod 5-alpha-reductase inhibitors
Invented are substituted acrylate analogues of steroidal synthetic compounds, pharmaceutical compositions containing these compounds, and methods of using these compounds to inhibit steroid...
|
|
|
4975537 |
Δ9(11) -angiostatic steroids
Disclosed are Δ9(11) -steroids of the formula ##STR1## which have been found to be angiostatic and therefore are useful in the control of embryogenesis, inflammatory conditions, tumor growth as ...
|
|
|
4970205 |
Sulfonic acid substituted aromatic steroids as inhibitors of steroid 5-α-reductase
Invented are sulfonic acid substituted analogues of steroidal synthetic compounds, pharmaceutical compositions containing these compounds, and methods of using these compounds to inhibit steroid...
|
|
|
4946834 |
Phosphonic acid substituted steroids as steroid 5α-reductase inhibitors
Invented are substituted acrylate analogues of steroidal synthetic compounds, pharmaceutical compositions containing the compounds, and methods of using these compounds to inhibit steroid...
|
|
|
4937237 |
Phosphinic acid substituted aromatic steroids as inhibitors of steroid 5-60 -reductase
Invented are phosphinic acid substituted analogues of steroidal synthetic compounds, pharamaceutical compositions containing these compounds, and methods of using these compounds to inhibit steroid...
|
|
|
4891366 |
Novel 2β,16β-diamino-androstanes
2β,16β-diamino-3α,17α-oxygenated androstanes having one quaternized group, process for the preparation of these compounds and pharmaceutical compositions comprising such compounds as the active ing...
|
|
|
4882319 |
Phosphonic acid substituted aromatic steroids as inhibitors of steroid 5-α-reductase
Invented are phosphonic acid substituted analogues of steroidal synthetic compounds, pharmaceutical compositions containing these compounds, and methods of using these compounds to inhibit steroid...
|
|
|
4774236 |
17α-(substituted-methyl)-17β-hydroxy/esterified hydroxy steroids and pharmaceutical compositions containing them
Steroids of the formula: ##STR1## which are characterized by a 17α-cyanomethyl, azidomethyl, methoxymethyl, phenylmethyl, or ethynylmethyl substituent and a 17β-hydroxy/esterified hydroxy s...
|
|
|
4548749 |
Process for the preparation of 21-hydroxy-20-keto-Δ16 -steroids and new intermediate compounds formed in this process
A novel process for the preparation of 21-hydroxy-20-keto-Δ16 -steroids comprising reacting a 17-(isocyanosulfonylmethylene)-steroid with an aldehyde and an alcohol to form a ...
|
|
|
4519946 |
Steroids
Novel 19-nor steroids and 19-nor-D-homo-steroids of the formula ##STR1## wherein R1 is an organic radical of 1 to 18 carbons atoms containing at least one atom selected from the group consisting of...
|
|
|
4447425 |
Mono- and bisquaternary ammonium derivatives of 2β,16β-di-amino-5α-androstane derivatives and pharmaceutical preparations containing same
This invention relates to novel mono- and bisquaternary ammonium derivatives of 5α-androstanes having the formula: ##STR1## wherein: R1 =H or alkyl (1-4 C); R2 and R3 each are alkyl (1-4 C) or ...
|
|
|
4447424 |
Steroid derivatives
Novel 19-nor steroids and 19-nor-D-homo-steroids of the formula ##STR1## wherein R1 is an organic radical of 1 to 18 carbon atoms containing at least one atom selected from the group consisting of...
|
|
|
4268441 |
Prodrugs for improved bioavailability of certain Δ4 -3-ketosteroidal sex hormones
Transient, orally active thiazolidine type prodrug forms of conventional, natural and synthetic ketosteroidal sex hormones, e.g., of progesterone, testosterone, and the like, are disclosed. The...
|
|
|
4252719 |
Steroid conversion method and products produced thereby
Method for the removal of selected tertiary hydrogen atoms from 5 α-steroids of the cholestane, androstane and pregnane series by chlorination of 5 α-steroids esterified with selected iodoaryl s...
|
|
|
4213978 |
Anti-acne and anti-seborrhea prodrug derivatives of progesterone
Transient, topically active thiazolidine type prodrug forms of progesterone are disclosed.
|
|
|
4203981 |
Novel 17 α-aryl-steroids
Novel steroids of the formula ##STR1## wherein R1 is selected from the group consisting of hydrogen and acyl of an organic carboxylic acid of 1 to 18 carbon atoms, R2 is selected from the group...
|
|
|
4177190 |
Diamino-androstanes and a process for the preparation of the said compounds
Curare-type salts of the formula ##STR1## wherein Ac is an alkyl carbonyl group containing 1 to 4 carbon atoms in the alkyl moiety and one of R1 and R2, is a methylene group and the other is a...
|
|
|
4110326 |
Acylated diepoxy-androstane and a process for the preparation thereof
A compound of the formula (I) ##STR1## wherein X is a halogen, Z1 and Z2 are both hydrogen, or Z1 is hydroxy and Z2 is chlorine, or Z1 and Z2 together stand for an α-epoxy group.
|
|
|
4000125 |
Novel cardiotonic steroids, process for their preparation and therapeutical use
The invention relates to novel steroid compounds having the formula ##STR1## and their glycoside derivatives containing a pyridazine ring, in which particularly the substituent R4 is a hydroxy...
|
|
|
3912722 |
Novel 6β-amino-steroids and production thereof
Novel 6β-amino-steroids of the formula: ##SPC1## Wherein R1 is a hydrogen atom or an acyl group, R2 is a hydrogen atom or an aliphatic hydrocarbon group, R3 and R4 are each a hydrogen atom or an ...
|
|
|
3872091 |
New 2β, 16β-diamino-androstanes and their preparation
The invention relates to novel 2β,16β-diamino-17-unsubstituted-androstanes, to acid addition salts and quaternary ammonium derivatives of these compounds and to processes for their preparation. T...
|
|
|
3530120 |
NOVEL PROCESS FOR PREPARATION OF ENAMINES
|
|
|
3553211 |
QUATERNARY AMMONIUM STEROIDS
|
|
|
3553212 |
2-BETA,16-BETA-DIAMINO-ANDROSTANES
|
|
|
3637668 |
N-SUBSTITUTED 4-AMINOSTEROIDS
|
|
|
3402172 |
3-lower alkoxy-17alpha-(3-substituted-5-isoxazolyl) estra-1, 3, 5(10)-trien-17beta-ols
|
|
|
3378551 |
16beta-amino-3beta, 17alpha-dihydroxypregn-5-en-20-one 20-ketals and acyl derivatives thereof
|
|
|
3328387 |
Steroidguanylhydrazones and their production
|
|
|
3317520 |
Steroido[20, 21-c]pyrazoles and intermediates
|
|
|
3313809 |
Steroido[21, 20-d]isoxazoles
|