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6197761 |
17β-2-oxo-tetrahydrofuranyl)-carbothioic acid ester, -carboxylic acid ester and -carboxylic acid amide androstane derivatives
Compounds of the androstane series are described having general formula ##STR1## and solvates thereof, in which R 1 represents O, S or NH; R 2 individually represents OC(O)C 1 -6 alkyl; R 3 ...
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6114318 |
17β-(2-oxo-tetrahydrofuranyl)-thio- substituted androstane derivatives
Compounds of the androstane series are described having the formula (I) and solvates thereof in which R 1 and R 2 are the same or different and each represents hydrogen or C 1 -6 alkyl; R 3 and...
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5837698 |
Steroid nitrite and nitrate ester derivatives useful as anti-inflammatory drugs
The present invention relates to a pharmaceutical composition or preparation which comprises hydroxyl containing steroidal hormones and organic nitrite/nitrate or other nitric oxide donating agents.
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5801165 |
Antiinflammatory, immunosuppressive and antialleric 16, 17-alkylidioxy-steroids
Compounds of formula I ##STR1## where R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , n, and are as defined herein, their use as antiinflammatory, immunosuppressive, and antiallergic agents, pharmaceutical...
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5420120 |
Anti-inflammatory glucocorticoid compounds for topical ophthalmic use
Topically administrable C-21 thioether glucocorticoid steroid derivatives are disclosed as effective anti-inflammatory agents for the treatment of ophthalmic inflammatory disorders. These C-21...
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5200518 |
Anti-inflammatory carboxycyclic acetal pregnane derivatives
Compounds of the formula: ##STR1## wherein X is H, F, Cl, or CH 3 and Y is ##STR2## wherein R 1 is H, alkyl of 1-5 carbon atoms, phenyl, or benzyl; R 2 is COOR 6 , R 5 COOR 6 , or R 5 ...
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5116829 |
Steroid compounds
A 21-substituted steroid compound is disclosed. The compound has a structure of formula (I), ##STR1## wherein R 1 is a hydrogen atom, a lower alkyl, lower alkenyl, lower alkoxy, or phenyl group, R...
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4913852 |
Compounds obtained from the associative synthesis of sulfur-containing or sulfur-free amino acids with pregnane derivatives
Compounds obtained from the associative synthesis of sulfur-containing or sulfur-free amino acids with derivatives of Δ-4-pregnene-3,20-dione or with derivatives of Δ-1,4-pregnadiene-3,20-dione...
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4432976 |
Cyclocarbonate esters of 16α,17α, dihydroxy anti-inflammatory steroids
Corticoids of Formula I ##STR1## wherein is a single bond or a double bond, X is hydrogen, fluorine, or chlorine, Y represents two hydrogen atoms or an oxygen atom, and Z is hydrogen or...
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4390533 |
Steroids and process for preparing the same
The present invention relates to 2-chloro-6β-fluoro-pregna-1,4-diene-3,20-diones having good anti-inflammatory activity, to processes for their preparation and pharmaceutical compositions thereof.
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4322349 |
Process for preparing 6-methylene steroids
A process for preparing a 6-methylene-Δ 4 -3-keto steroid of the formula ##STR1## wherein R is hydrogen, alkoxy of up to 6 carbon atoms or acyloxy of up to 6 carbon atoms wherein the acyl group...
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4296109 |
Corticoid 21-sulfopropionates and the salts thereof, a process for the production thereof and pharmaceutical preparations thereof
Corticoid 21-sulfopropionates of the formula ##STR1## wherein St is a steroid nucleus of a corticoid having anti-inflammatory activity, and the salts thereof with physiologically acceptable bases,...
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4267173 |
Use of 6β-fluoro-7α-halogenocorticoids as topical anti-inflammatories and pharmaceutical formulations useful therefor
Described is the use of 6β-fluoro-7α-halogeno-1,4-pregnadiene-17α,21-diol-3,20-di
ones and their esters as topical anti-inflammatory agents, and pharmaceutical formulations thereof useful...
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4221787 |
Esteramide prodrugs of anti-inflammatory corticosteroids
Transient, C-21 and/or C-17 esteramide prodrugs of the anti-inflammatory corticosteroids, prepared by esterification of hydroxy steroids, are disclosed.
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4201778 |
6-Acyloxy-1,4,6-pregnatrienes, their use as anti-inflammatory agents, methods for their manufacture, and 6-oxo-1,4-pregnadiene intermediates
Novel 6-acyloxy-3,20-dioxo-1,4,6-pregnatrienes and 6-acyloxy-3,20-dioxo-4,6-pregnadienes, useful anti-inflammatory agents, are prepared by reaction of the corresponding...
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4198403 |
17 Beta-thiocarboxylic acid esters of 4-halo-3-oxoandrost-4-enes
Certain 3-oxoandrost-4-ene and 3-oxoandrosta-1,4-diene 17 beta-thiocarboxylic acid esters substituted at the 4-position with a fluoro, chloro or bromo and optionally substituted at the six position...
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4188385 |
Thioetianic acid derivatives
Certain 3-oxoandrost-4-ene and 3-oxoandrosta-1,4-diene 17 beta-thiocarboxylic acid esters are useful as antiinflammatory steroids. These compounds are optionally substituted at the 6 alpha-position...
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4187301 |
17 Beta-thiocarboxylic acid esters of 6 alpha, 6 beta-difluoro-3-oxoandrost-4-enes
Certain 3-oxoandrost-4-ene and 3-oxoandrosta-1,4-diene 17 beta-thiocarboxylic acid esters substituted at the 6 alpha, 6 beta-positions with fluorine substituents are useful as anti-inflammatory...
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4011316 |
Cyclohexa-2,5-diene-1-thiones
Compounds of the general formula ##STR1## are provided wherein the substituents R, which may be the same or are different, represent hydrogen atoms or hydrocarbyl groups and the groups R 1 ...
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4011315 |
21-Acetals and mixed acetals of steroidal 21-aldehydes, intermediates and methods of preparation
21-ACETALS AND MIXED ACETALS OF STEROIDS OF THE CORTICOID SERIES ARE PREPARED FROM THE CORRESPONDING 21-HYDROXY STEROIDS AND HAVE UTILITY AS ANTI-INFLAMMATORY AGENTS.
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3996359 |
Novel stereoisomeric component A of stereoisomeric mixtures of 2'-unsymmetrical 16,17-methylenedioxy steroid 21-acylates, compositions thereof, and method of treating therewith
A process for the resolution of stereoisomeric mixtures of certain steroids obtained by synthesis into its components, comprising subjecting the stereoisomeric mixture to gel filtration, the...
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3984544 |
Retinoic acid esters of steroids of the pregnane series, their use in the treatment of acne and pharmaceutical formulations useful therefor
Novel retinoic acid esters of anti-inflammatory steroids of the pregnane series are described and their use in the treatment and control of acne vulgaris via the topical or intralesional route. A...
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3963707 |
Novel N-nitroso compounds, compositions containing such compounds, processes for their preparation and methods of treatment therewith, and novel intermediates
This invention relates to novel N-halogenoalkyl-N-nitroso carbamates and N 4 halogenalkyl-N 4 -nitroso allophanates of steroid compounds, having an anti-tumor activity, and to the preparation...
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3929768 |
Steroids, processes for their manufacture and preparations containing same
Novel steroids having the general formula: ##SPC1## Wherein X and Y are independently selected from hydrogen and fluorine, X being selected from hydrogen and fluorine when Y is hydrogen and X being...
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3928326 |
Process for the separation of stereoisomeric mixtures into their components and components obtained hereby
A process for the resolution of stereoisomeric mixtures of certain steroids obtained by synthesis into its components, comprising subjecting the stereoisomeric mixture to gel filtration, the...
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3886145 |
NEW DERIVATIVE OF TRIAMCINOLONE
A novel triamcinolone derivative 21-(β-benzoylaminoisobutyryl) -16α, 17α - (p-dimethylaminobenzyliden) triamcinolone is disclosed. It is prepared by ketalizing or acetalizing the 16α and 17α...
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3728335 |
METHODS OF PREPARING 21-FLUORO-16,17-ALKYLIDENEDIOXY-3,20-DIKETO-PREGNANES
A fluorination method for preparing 21-fluoro-pregnanes and also methods of preparing 9α,11β-dichloro-6α,21-difluoro-16α,17α-alkyli denedioxy-pregna-1,4-diene-3,20-dione and...
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3687942 |
21-MERCAPTO-STEROIDS OF THE PREGNANE SERIES
21-Mercapto-steroids of the pregnane series of the general formula ##SPC1## Wherein R 1 = h or an acyl radical R 2 = h or free or esterified hydroxyl R 3 = ch 3 or α-hydroxy, free or...
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3681338 |
C-21 LOWER ALKYSULFINYL ESTERS OF CERTAIN 6α-FLUORO-21-HYDROXYCORTICOSTEROIDS
C-21 Lower alkylsulfinyl esters of certain 6α-fluoro-21-hydroxycorticosteroids are good antiinflammatory agents which have both topical and systemic activities. These compounds are best prepared...
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3673179 |
C-21 LOWER ALKYLSULFINYL ESTERS OF CERTAIN 21-HYDROXYCORTICOSTEROIDS
C-21 Lower alkylsulfinyl esters of certain 21-hydroxycorticosteroids are good antiinflammatory agents which have both topical and systemic activities. These compounds are best prepared by a 2-step...
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3665017 |
PROCESS FOR PREPARATION OF 6-AZIDO-4, 6-BIS-DEHYDRO-STEROIDS
6-Azido-4,6-bis-dehydro-steroids are prepared by treating a 6β-azido-7α-acyloxy-4-dehydro-steroid which is saturated at C-1 and C-2, with a tetraalkylammonium halide in an aprotic solvent....
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3541086 |
6-HALO-9,11,21-TRICHLORO - 16,17-ALKYLIDENEDIOXYPREGNANES AND DERIVATIVES AND COMPOSITIONS THEREOF
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3513161 |
CYANO-STEROIDS
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3496199 |
PROCESS FOR THE PREPARATION OF 9BETA,10ALPHA-STEROIDS
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3487077 |
PROCESS FOR THE PREPARATION OF 21-PHOSPHATE STEROIDS
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3480623 |
3-(2'-CHLOROETHYLTHIO)-6-FORMYL-9ALPHA-FLUORO-STEROIDS
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3471550 |
20BETA-ALKANOYLOXY-5-OXO-3,5-SECO-A-NOR-PREGNAN-3-OIC ACIDS
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3462423 |
CYANO-DERIVATIVES OF STEROIDS
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3442891 |
STEROIDAL 4,6-DIEN-3-ONES HAVING C6 SUBSTITUENTS AND PROCESS FOR PREPARING SAME
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3409613 |
6alpha, 21-difluoro-9alpha, 11beta-dichloro-16alpha, 17alpha-alkylidene-dioxypregn-4-ene-3, 20 diones
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3349085 |
Acetals and ketals of 6-alkyl-16, 17-dihydroxyprogesterone and intermediates therefor
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3311617 |
6-cyano steroidal enol ethers and process for preparing same
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3275621 |
19-amino-delta4-pregnenes and-10alpha-pregnenes and process for their preparation
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3274180 |
Method of preparing pregnapentaenes
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3249602 |
19-substituted-20-keto-10alpha-pregnenes
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3242169 |
6alpha-dimethylaminomethyl-3-oxo-delta4-steroids and method for producing same
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3234095 |
21-methyl and 21-hydroxymethyl steroid compounds
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3226383 |
21-desoxy-16,17-cyclic acetals
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3211727 |
9, 11, 21-trichloro-16alpha, 17alpha-isopropylidene steroids of the pregnane series
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3186985 |
Novel 6-keto-4-dehydro-steroids and processes for their manufacture
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