Patents in Class 540/598

Matches 1 - 50 out of 295

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Match	Document	Document Title
1	8173638	Compounds which modulate the CB2 receptor Compounds of formula (I) are disclosed. Compounds according to the invention bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, and are useful for treating inflammation....
2	8013156	Tie-2 modulators and methods of use The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration...
3	7951807	Substituted oxindol derivatives and medicaments containing the same The present invention relates to novel oxindole derivatives of the general formula (I), wherein the substituents A, B, R1, R2 and R3 are as defined in Claim 1, and medicaments containing the same...
4	7919618	Synthesis of piperazines, piperidines and related compounds Novel methods of synthesizing piperazines, piperidines and related compounds are disclosed, as are compounds useful for their preparation.
5	7888384	Heterocyclic derivatives for modulation of calcium channels Heterocyclic derivatives act as Ca channel antagonists. The compositions are useful for treating or relieving Ca channel mediated conditions.
6	7829560	1,4-disubstituted naphthalenes as inhibitors of P38 MAP kinase 1,4 disubstituted napthylenes, of formula (I), are disclosed. These compounds may be useful in treating cell-proliferative diseases.
7	7727989	4-benzimidazol-2-yl-pyridazine-3-one-derivatives, production and use thereof in medicaments The present invention relates to kinase inhibitor compounds and derivatives thereof as well as compositions comprising them consisting of the structure of formula I: Wherein R1, R2, A, B, D and E...
8	7709466	Pyridazinone derivatives, methods for their production and their use as pharmaceuticals The present invention relates to pyridazinone compounds and their derivatives according to the general formula (I), with the substituents X, R1 and R2 defined herein, as well as their...
9	7709467	Apoptosis promoters Compounds which inhibit the activity of anti-apoptotic family protein members, compositions containing the compounds and methods of treating diseases during which occur expression one or more than...
10	7704995	Protein kinase modulators and methods of use This invention relates to compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and...
11	7514424	Substituted 4-(4-piperidin-4-yl-piperazin-1-yl)-azepane derivatives and their use as neurokinin antagonists The invention concerns substituted 4-(4-piperidin-4-yl-piperazin-1-yl)-azepane derivatives having neurokinin antagonistic activity, in particular NK˜antagonistic activity, their preparation, ...
12	7432255	1H-indol-5-yl-piperazin-1-yl-methanone derivatives The present invention relates to compounds of formula I and their pharmaceutically acceptable salts wherein in formula I is: wherein R1 to R4 are as defined in the description and claims. The...
13	7427612	Benzoyl-piperazine derivatives A compound of formula wherein the substituents are as described in the specification for the treatment of psychoses, pain, neurodegenerative disfunction in memory and learning, schizophrenia,...
14	7405209	Protease inhibitors The present invention provides 4-amino-azepan-3-one protease inhibitors and pharmaceutically acceptable salts, hydrates and solvates thereof which inhibit proteases, including cathepsin K,...
15	7393845	Heteroaryl derivates, their preparation and use A heteroaryl derivative having the formula (I). The compounds of the invention are considered useful for the treatment of affective disorders such as general anxiety disorder, panic disorder,...
16	7348425	Inhibitors of HCV replication Indole compounds of Formula I are described. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV. Different forms and compositions...
17	7244722	Amino-substituted 1H-pyrazin-2-ones and 1H-quinoxalin-2-ones Compounds of the general formula (I): wherein m, n, R1, R2, R3 and R4 are as described in the specification. Further included are pharmaceutical compositions comprising the compounds, processes for...
18	7238688	Piperidine compounds Disclosed are novel compounds of the formula Also disclosed are pharmaceutical compositions comprising the compounds of Formula I.Also disclosed are methods of treating various diseases or...
19	7186827	Dipeptide synthesis Disclosed are processes of making dipeptide compounds of formula(I) as further described in the detailed description section:
20	7071184	Protease inhibitors The present invention provides C1-6alkyl-4-amino-azepan-3-one protease inhibitors and pharmaceutically acceptable salts, hydrates and solvates thereof which inhibit proteases, including cathepsin...
21	6960575	Thiazine derivatives A compound having 3-oxo-3, 4-dihydro-2H-1, 4-thiazine 4-tetrahydropyrazine as a main skeleton. The compound is a chymase inhibitor and is represented by the following formula [I] and salts thereof:...
22	6890921	Arylsubstituted piperazines useful in the treatment of benign prostatic hyperplasia This invention relates to a series of arylsubstituted piperazines, of Formula I pharmaceutical compositions containing them and intermediates used in their manufacture. The compounds of the...
23	6887864	Azepane derivatives This invention provides novel azepane derivatives or pharmaceutically acceptable salts thereof, according to the general formula (I) wherein the symbols are defined in the specification, as well as...
24	6846827	Pyrimidine derivatives The invention concerns pyrimidine derivatives of Formula (I) wherein m is 0-3 and each R1 is a group such as hydroxy, halogeno, trifluoromethyl and cyano; R3 is hydrogen, halogeno or (1-6C)alkyl; n...
25	6821965	Amidobenzamide derivatives which are useful as cytokine inhibitors The invention concerns amide derivatives of the Formula (I) wherein R3 is (1-6C)alkyl or halogeno; Q is aryl or heteroaryl which optionally bears 1, 2, 3 or 4 substituents such as hydroxy,...
26	6800636	Farnesyl protein transferase inhibitors Disclosed are compounds of the formula: wherein R8 represents a cyclic moiety to which is bound an imodazolylalkyl group; R9 represents a carbamate, urea, amide or sulfonamide group; and the...
27	6767907	4-aryl-1-(indanmethyl dihydrobenzofuranmethyl or dihydrobenzothiophenemethyl) piperidines tetrahydropyridines or piperazines 4-Aryl-1-(indanmethyl, dihydrobenzofuranmethyl or dihydrobenzothiophenemethyl)piperidine, -tetrahydropyridine or -piperazine compounds of general formula (I), wherein one of X and Y is CH2 and the...
28	6743788	Carbamate and oxamide compounds Disclosed are novel aromatic compounds of the formula(I) described herein, wherein G, E, W, Ar, X, Y and Z are disclosed herein. The compounds are useful for treating cytokine mediated diseases or...
29	6713472	Thiazine or pyrazine derivatives A compound which is a chymase inhibitor and which is represented by a formula [I] and salts thereof. In the formula [I], X is R6—(A2)n—N, R1 and R2 are H, alkyl, cycloalkyl or aryl, R3 and R4 are...
30	6710042	Human NK3 receptor-selective antagonist compounds, method for obtaining them and pharmaceutical compositions containing them Compounds of formula (I) are useful as human NK3 receptor antagonists.
31	6699856	Pyrazinones, compositions containing such compounds and methods of use Compounds represented by formula I: as well as pharmaceutically acceptable salts, esters, N-oxides and hydrates thereof are disclosed. Pharmaceutical compositions and methods of use are also...
32	6699864	Substituted phenyl-piperazine derivatives, their preparation and use The present invention provides compounds of the formula: wherein R1-R8, X, Y, Z, n and m are defined in the application.The compounds of the invention have affinity for the 5-HT1A receptor.
33	6639070	N-substituted perhydrodiazine N-substituted perhydro-2,3-diazines of the formula I in which the variables Z, R, m and RA are as defined in claim 1, a process for their preparation and the use of the compounds of the formula I...
34	6583136	Antifungal ethers The present invention concerns compounds of formula the N-oxide forms, the salts, the quaternary amines and stereochemically isomeric forms thereof, whereinD represents a tetrahydrofuran or...
35	6455520	Benzamide derivatives and their use as cytokine inhibitors The invention concerns amide derivatives of formula (I) wherein R3 is (1-6C)alkyl or halogeno; m is 0-3, p is 0-2 and q is 0-4; each of R1 and R2 is a group such as hydroxy, halogeno,...
36	6420395	Azacyclooctane and heptane derivatives, their preparation and use in therapy The present invention discloses compounds of formula (1) or (2), any of its enantiomers or any mixture thereof, or a pharmaceutically acceptable salt thereof; wherein n is 0, or 1; R is hydrogen,...
37	6372440	Method for detecting deficient cellular membrane tightly bound magnesium for disease diagnoses This invention relates to methods for detecting the deficiency of magnesium tightly bound to cellular membranes, i.e. magnesium binding defect, which deficiency is associated with certain abnormal...
38	6355640	Pyrazolopyridine adenosine antagonists The present invention relates to a novel pyrazolopyridine compound of the following formula: whereinR1 is aryl, andR2 is cyclo(lower)alkyl which may have one or more suitable substituent(s),...
39	6352981	Substituted AZA- and diazacycloheptane and -cyclooctane Aza- and diazacyclohexane and -cyclooctane compounds of the following formula: Ar1—A—B—Ar2 (I)where Ar1, A, B and Ar2 have the meanings stated in the description have a high affinity for the dopam...
40	6329380	SRC kinase inhibitor compounds Pyrimidine compounds (Formula I), or their pharmaceutically acceptable salts, hydrates, solvates, crystal forms and individual diastereomers, and pharmaceutical compositions including the same,...
41	6316444	SRC kinase inhibitor compounds Pyrimidine compounds (Formula I), or their pharmaceutically acceptable salts, hydrates, solvates, crystal forms and individual diastereomers, and pharmaceutical compositions including the same,...
42	6303594	*WITHDRAWN PATENT AS PER THE LATEST USPTO WITHDRAWN LIST* Arylsubstituted piperazines useful in the treatment of benign prostatic hyperplasia This invention relates to a series of arylsubstituted piperazines, of Formula I ##STR1##pharmaceutical compositions containing them and intermediates used in their manufacture. The compounds of the...
43	6288059	Acylated hetero-alicyclic derivatives A compound of formula (I), a pharmaceutically acceptable salt or ester or other derivative thereof: ##STR1##R1 is optionally substituted cycloalkyl or optionally substituted saturated heterocyclic...
44	6265348	Alkylidenehydrazinophenylsulfonylureas, processes for their preparation and their use as herbicides and plant growth regulators Compounds of the formula (I) and salts thereof ##STR1##in which R1 to R6, W, X, Y and Z are defined as in claim 1, have herbicidal or plant growth-regulatory properties.They can be prepared by...
45	6255302	1,4-piperazine derivatives Compounds of the formula ##STR1##are useful for the treatment of disorder of the central nervous system including anxiety, depression, panic, alcohol and drug addiction, sexual dysfunction, sleep...
46	6221858	Pyridyl-and pyrimidyl-piperazines in the treatment of substance abuse disorders
47	6218394	4-Aryl-1-(indanmethyl, dihydrobenzofuranmethyl or dihydrobenzothiophene-methyl) piperazines 4-Aryl-1-(indanmethyl, dihydrobenzofuramethyl or dihydrobenzothiophenemethyl) piperidine, -tetrahydropyridine or -piperazine compounds of general formula (I) ##STR1##wherein one of X and Y is CH2,...
48	6174940	Synergistic stabilizer mixture based on polyalkyl-1-oxa-diazaspirodecane compounds The present invention relates to mixtures comprising the compound I in a proportion of 65-95% by weight, the compound II in a proportion of 5-35% by weight and the compound III in a proportion of...
49	6127357	N-((phenyl, benzodioxinyl or N-heteroarylpiperazinyl)alkyl)-N-(N-heteroaryl)substituted carboxamides Piperazine derivatives of formula I ##STR1## and their pharmaceutically acceptable acid addition salts are 5-HT1A binding agents, particularly 5-HT1A antagonists and may be used, for example, as...
50	6069114	2-amino-4-bicycloamino-1,3,5-Triazines, their preparation, and their use as herbicide and plant growth regulators Compounds of the formula (I) and their salts ##STR1## in which R1 to R6, Y1, to Y2, Y3, m and n are as defined in claim 1 are suitable as herbicides and plant growth regulators. They can be...

Matches 1 - 50 out of 295

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