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7410961 2,6-disubstituted piperiddines as modulators  
The present invention is further directed to compounds of formula (I): wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 , R 16 , R 17 , R 18 , R 19 , R 20 , R 21 and R 22 are as...
7390798 Carboxamide spirolactam CGRP receptor antagonists  
The present invention is directed to compounds of Formula I: I (where variables A 1 , A 2 , B, J, K, m, n, R 4 , R 5a , R 5b and R 5c are as defined herein) useful as antagonists of CGRP...
7375100 2-amino-pyridine derivatives useful for the treatment of diseases  
The invention relates to compounds of formula (1) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives....
7368444 N-carbamoyl nitrogen-containing fused ring compounds and drugs containing these compounds as the active ingredient  
The present invention relates to the compound presented by formula (I) (wherein all symbols in formula (I) are the same mean as the description shown in the specification.), mitocondorial...
7365196 Sulphonamido-substituted bridged bicycloalkyl derivatives  
A class of compounds is disclosed, comprising sulphonamido-substituted bridged bicycloalkyl structures. The compounds are inhibitors of gamma-secretase, and hence are useful in the treatment of...
7304051 Quinoxaline compounds  
Amidophenyl-sulfonylamino-quinoxaline compounds of formula (I) are CCK2 modulators useful in the treatment of CCK2 mediated diseases.
7304050 Antibacterial agents  
Compounds of formula I and methods for their preparation are disclosed. Further disclosed are methods of making biologically active compounds of formula I as well as pharmaceutically acceptable...
7288651 Preparation of quinoxaline compounds  
Certain methods are disclosed that are useful in the preparation of CCK2 active amidophenyl-sulfonylamino-quinoxaline compounds of the formula: wherein R 1 , R 2 , R a and R b are defined.
7262185 Benzazepine derivative, process for producing the same, and use  
The present invention provides a novel benzazepine derivative represented by formula: wherein, R 1 is a 5- or 6-membered aromatic ring, R 2 is lower alkyl group, etc., Y is an optionally...
7238685 Benzo-fused heterocycles as endothelin antagonists  
The invention relates to novel benzo-fused heterocycles and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including...
7192950 Benzazepines and related heterocyclic derivatives which are useful as orexin receptor antagonists  
The invention relates to novel benzazepines and related heterocyclic derivatives (I) and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also...
7183271 4,4-difluoro-1,2,3,4-tetrahydro-5h-1-benzazepine derivative or salt thereof  
A novel 4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepine derivative or a pharmaceutically acceptable salt thereof, which is useful as an agent for treating or preventing nocturia and/or diabetes...
7176195 Fused azepine derivatives and their use as antidiuretic agents  
Compounds according to general formulae (1 and 2), wherein G 1 is an azepine derivative and G 2 is a group according to general formulae (9–11) are new. Compounds according to the invention are...
7169772 4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepine derivatives or salts thereof  
4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepine derivatives, which have excellent arginine vasopressin V 2 activity and are useful for a drug for the treatment of central diabetes insipidus...
7141562 Substituted benzoxazinones and uses thereof  
Compound of the Formula: and pharmaceutically acceptable salts or prodrugs thereof, wherein: X is CH or N, Y is C or S, Z is —SO 2 — or —(CR a R b ) r —, n is 1 or 2, R 2 is aryl or...
7101869 2,4-diaminopyrimidine compounds useful as immunosuppressants  
Novel compounds according to the formula and pharmaceutically acceptable salts, solvates, or hydrates thereof; wherein each occurrence of A is independently selected from CH or N; X is...
7091352 Compounds substituted with bicyclic amino groups  
Compounds of the formula (I) below, or pharmacologically acceptable salts, esters or other derivatives thereof: wherein A is furan, thiophene, pyrazole, imidazole, isoxazole or isothiazole; R 1...
7091199 Thienoisoxazole phenoxy unsubstituted ethyl and propyl derivatives useful as d4 antagonists  
The compounds are of the class of thienoisoxazole phenoxy unsubstituted ethyl and propyl derivatives, useful as D 4 antagonists. Said compounds are useful for the treatment of medical conditions...
7074781 Condensed azepines as vasopressin agonists  
This invention provides novel compounds according to general formula (1) wherein A is a bicyclic or tricyclic azepine derivative, V 1 and V 2 are both H, OMe or F, or one of V 1 and V 2 is Br,...
7067513 Phenylpiperazines  
The invention relates to a novel group of phenylpiperazines having interesting pharmacological properties such as a high affinity for the dopamine D 2 receptor and/or the serotonin reuptake site,...
7008938 Benzene-fused heteroring derivatives and pharmaceutical agents comprising the same as active ingredient  
A benzene-fused heteroring derivative of formula (I) wherein all symbols are the same as described in the specification, and a non-toxic salt thereof. The compound of formula (I) has an...
6995154 Heterocyclic topoisomerase poisons  
The invention provides compounds of formula I: wherein R 1 to R 5 have any of the values defined in the specification, as well as pharmaceutically acceptable salts of the compounds,...
6972286 Oxazolidinones having a benzannulated 6- or 7-membered heterocycle  
The present invention provides oxazolidinones having a benzannelated 6- or 7-membered heterocycle as antibacterial agents.
6953787 5HT2C receptor modulators  
The present invention relates to novel compounds of Formula (I): which act as 5HT 2C receptor modulators. These compounds are useful in pharmaceutical compositions whose use includes the...
6936602 Benzazepine derivatives, process for the preparation of the same and uses thereof  
Compounds of the general formula (I): or salts thereof, which exhibit CCR5 antagonism and exert preventive and therapeutic effects against HIV infections: wherein R 1 is a 5- to 6-membered...
6924280 Dipeptide derivatives  
This invention is directed to compounds of the formula and the pharmaceutically-acceptable salts thereof, where the substituents are as defined in the Specification, which are growth hormone...
6919332 N-substituted-heteroaryloxy-aryloxy-pyrimidine-2,4,6-trione metalloproteinase inhibitors  
The present invention relates to N-substituted-heteroaryloxy-aryloxy-2,4,6-trione metalloproteinase inhibitors of the formula wherein X, A, Y, B, G, and R 1 are as defined in the...
6903091 Biphenyl vasopressin agonists  
A compound of the formulae (I) or (II): wherein: Y is a moiety selected from NR or —(CH 2 ) n ; wherein R is hydrogen or (C 1 -C 6 ) lower alkyl, and n is 1; represents: (1) a...
6864367 Process for producing cyclic compound  
A process suitable for safely mass-producing, through a short step, cyclic compounds useful in medicines, agricultural chemicals, foods, cosmetics, and chemical products or as intermediates...
6855708 N-arylsulfonyl aza-bicyclic derivatives as potent cell adhesion inhibitors  
Compounds of Formula I are antagonists of VLA-4 and/or alpha4/beta7, and as such are useful in the inhibition or prevention of cell adhesion and cell-adhesion mediated pathologies. These compounds...
6815451 1,2,3,4-Tetrahydroisoquinolines derivatives as urotensin II receptor antagonists  
The invention relates to novel 1,2,3,4-tetrahydroisoquinoline derivatives of formula (I) and related compounds and their use as active ingredients in the preparation of pharmaceutical compositions....
6815440 Cyclic and heterocyclic N-substituted α-iminohydroxamic and -carboxylic acids  
Cyclic and heterocyclic N-substituted α-iminohydroxamic and -carboxylic acids Compounds of the formula I are suitable for preparing pharmaceuticals for the treatment of disorders in the course...
6809092 Benezene-fused heteroring derivatives and pharmaceutical agents comprising the same as active ingredient  
A benzene-fused heteroring derivative of formula (I) wherein all symbols are the same as described in the specification, and a non-toxic salt thereof. The compound of formula (I) has an...
6770668 Pharmaceutically active compounds and methods of use  
The present invention relates to pharmaceutically acceptable compounds, including certain substituted indolinyl and derivatives thereof, 1,2,3,4-tetrahydroquinolinyl and derivatives thereof,...
6762178 Acetylenic aryl sulfonamide and phosphinic acid amide hydroxamic acid TACE inhibitors  
Hydroxamic acids having the formula are useful in treating disease conditions mediated by TNF-α, such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis, multiple...
6686351 Compounds and methods for modulation of estrogen receptors  
Compounds that modulate the estrogen receptor (ER) are disclosed, as well as pharmaceutical compositions containing the same. In a specific embodiment, the compounds are selective modulators for...
6667302 Heterocyclic topoisomerase poisons  
The invention provides compounds of formula I: wherein R 1 to R 5 have any of the values defined in the specification, as well as pharmaceutically acceptable salts of the compounds,...
6642223 Benzoheterocyclic derivatives  
A benzoheterocyclic derivative of the following formula [1]: and pharmaceutically acceptable salts thereof, which show excellent anti-vasopressin activity, vasopressin agonistic activity and...
6630463 Heterocycle-containing carboxylic acid derivative and drug containing the same  
Described is a heterocycle-containing carboxylic acid derivative represented by the following formula (I): wherein A represents, for example, a heteroaryl group which contains at least one...
6608079 Indole derivatives and their use as 5-HT1F agonists  
The present invention relates to a compound of formula (I), or a pharmaceutical acid addition salt thereof, which are useful for activating 5-HT 1F receptors and inhibiting neuronal protein...
6602864 Sulfonic acid or sulfonylamino N-(heteroaralkyl)-azaheterocyclylamide compounds  
The compounds of formula I herein exhibit useful pharmacological activity and accordingly are incorporated into pharmaceutical compositions and used in the treatment of patients suffering from...
6596869 Nitrosation process  
A process for preparing compounds of formula (I), by nitrosating compounds of formula (II), compounds of formula (I) having pharmaceutical activity.
6586422 Pyrazine and triazine derivatives of 1,2,4,5-tetrahydro-Benzo or Thieno &lsqb d&rsqb azepine  
The invention relates to compounds which are represented by the formula wherein R 1 , R 2 , R 3 , R 4 , X and Y are as defined in the specification, as well as pharmaceutically acceptable salts...
6562828 Amidine compounds  
A compound of the formula [I] wherein R 1 , R 2 and R 3 are the same or different and each is hydrogen atom, wherein each symbol is as defined in the specification, a salt thereof or a prodrug...
6562809 3-bicycloindole compounds  
Described herein are compounds selective for a 5-HT1D receptor, which have the general formula:
6534650 Benzisoxazole and 4-amidino-3-hydroxyphenyl chemical intermediates  
This invention relates to compounds of Formula V H—Y—G—R V and Formula VI (wherein f, X, Y, G and R have the values defined in the description) which are useful as intermediates for the...
6534496 Thermogenic composition and benzazepine thermogenics  
The object of the present invention is to provide a prophylactic and/or therapeutic drug for obesity and obesity-associated diseasestor diabetes with a reduced risk for central side effects and...
6514964 Fused cycloheptane and fused azacycloheptane compounds and their methods of use  
The invention comprises novel compounds that are effective in the prophylaxis and treatment of diseases, such as integrin receptors mediated diseases, in particular, diseases or conditions mediated...
6498158 Il-5 inhibiting 6-azauracil derivatives  
The present invention is concerned with the compounds of formula the N-oxides, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein p is 0 to...
6495542 Benzamide derivatives as vasopressin antagonists  
A compound of formula (I): wherein A is an optionally substituted heterocyclic group, R is a lower alkoxy; Z is C═O or CH 2 ; and B is benzazapinyl, which may be optionally substituted, or a...
Matches 1 - 50 out of 263 1 2 3 4 5 6 >