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7459553 |
Process for the preparation of carboxamide compounds
A process for preparing 5H-dibenz[b,f]azepine-5-carboxamide of the general formula:
wherein R 1 , R 2 , R 3 and R 4 are the same or different and can be hydrogen, halogen, nitro, cyano,...
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7241745 |
Pyridyl alkene and pyridyl alkine acid amides as cytostatics and immunosupressives
The invention relates to a new pyridyl alkene and pyridyl alkine acid amides according to the general formula (I)
as well as methods for their production, medicaments containing these compounds...
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7241886 |
Method for preparation of 10,11-dihydro-10-hydroxy-5h-dibenz/b, f/azepine-5-carboxamide and 10,11-dihydro-10-oxo-5h-dibenz/b, f/azepine-5-carboxamide
A method for the preparation of 10,11-dihydro-10-hydroxy-5H-dibenz/b,f/azepine-5-carboxamide
and 10,11-dihydro-10-oxo-5H-dibenz/b,f/azepine-5-carboxamide from carbamazepine via a three-step...
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7189846 |
Method for racemization of (S)-(+)- and (R)-(−)-10,11-dihydro-10-hydroxy-5h-dibenz[B,F]azepine-5-carboxamide and optically enriched mixtures thereof
A high-yielding method and a useful intermediate, 10-chloro-10,11-dihydro-5H-dibenz/b,f/azepine-5-carboxamide (VII) is disclosed. Also disclosed are methods for the racemization of optically pure...
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7183272 |
Crystal forms of oxcarbazepine and processes for their preparation
The present invention provides for new crystal forms of oxcarbazepine, more particularly oxcarbazepine Forms B, C, D and E. The present invention further provides processes for preparation of these...
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7125987 |
Process for the preparation of oxcarbazepine and related intermediates
A process for preparing Oxcarbazepine III
comprising:
a) reacting oximinostilbene IV
with chlorosulfonyl isocyanate in an inert organic solvent and isolating compound V...
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7119197 |
Method for preparation of (s)-(+)-and(r)-(-)10,11-dihydro-10-hydrodoxy-5h-dibenz/b,f/azephine-5-carboxamide
An efficient and high-yielding method for the preparation of optically pure (S)-(+) -10,11-dihydro-10-hydroxy-5H-dibenz/b,f/azepine-5-carboxamid
e and...
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7112673 |
Dibenzo [b,f]azepine intermediates
The invention relates to new processes for the preparation of the pharmaceutical oxcarbazepine, as well as novel intermediates prepared by or used for said processes, and the preparation of said...
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7091339 |
Method of preparing a 5H-dibenz(b,f)azepine-5-carboxamide
The present invention provides a method of preparing a 5H-dibenz[b,f]azepine-5-carboxamide of formula (1)
wherein R 1 , R 2 , R 3 , and R 4 are independently selected from the group consisting...
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7074782 |
Carbamate caspase inhibitors and uses thereof
This invention provides caspase inhibitors of formula I:
wherein Z is oxygen or sulfur; R 1 is hydrogen, —CHN 2 , R, CH 2 OR, CH 2 SR, or —CH 2 Y; Y is an electronegative leaving group; R 2...
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7056911 |
Dibenz[B,F]azepine compounds, pharmaceutical compositions comprising same and methods of use thereof
The invention relates to pharmaceutically active compounds, and methods of treatment and pharmaceutical compositions that utilize or comprise one or more such compounds. Compounds of the invention...
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7015322 |
Process for producing carbamazepine
The invention concerns a process for producing 5H-dibenz[b,f]azepine-5-carboxamide (carbamazepine) by reacting iminostilbene with an alkali cyanate in acetic acid or a mixture of acetic acid with...
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6670472 |
Process for the preparation of 10-methoxycarbamazepine
A process for the preparation of 10-methoxycarbamazepine, an important intermediate in the preparation of 10-oxo-10, 11-dihydro-5H-dibenz(b,f)azepine-5-carboxamide(oxcarbazepine
) from...
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6468998 |
Pyrrolidine compounds and medicinal utilization thereof
The present invention provides a pyrrolidine compound of the formula (I) wherein each symbol is as defined in the specification, an optically active compound thereof and a pharmaceutically...
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6245908 |
Process for preparing carbamazepine from iminostilbene
A process for preparing carbamazepine from iminostilbene is disclosed. The iminostilbene is reacted with urea in a protonating medium. This process results in improvements over prior art processes...
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5998399 |
Guanidine derivatives useful in therapy as inhibitors of nitric oxide synthetase
Method of treating or reducing the risk of human disease or condition in which the synthesis or oversynthesis of nitric oxide forms a contributory part wherein a therapeutically effective amount of...
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5885985 |
Guanidine derivatives useful in therapy
Guanidine derivatives of formula I ##STR1## wherein R 8 represents hydrogen, halogen, alkyl C1 to 6, nitro, trifluoromethyl, thioalkyl C1 to 6, hydroxy, alkoxy C1 to 6, or a group selected from...
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5866566 |
Derivatives of 10, 11-Dihydro-10-OXO-5H-Dibenz/B,F/Azepine-5-carboxamide
Compounds of general formula I are described ##STR1## as is a process for their preparation which consists of reacting a compound of formula II ##STR2## with hydroxylamine or its derivatives of...
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5811547 |
Method for inducing crystalline state transition in medicinal substance
This invention has for its object to provide a method of inducing a transition in crystalline state of a crystallizable medicinal substance with great ease and improved efficiency and uniformity on...
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5753646 |
Substituted dihydrodibenzo/b,f/azepines, method of their preparation, their use in the treatment of some central nervous system disorders, and pharmaceutical compositions containing them
New compounds of general formula I, including all possible stereoisomers, are described ##STR1## wherein: R is hydrogen, alkyl, aminoalkyl, halogenalkyl, aralkyl, cycloalkyl, cycloalkylalkyl,...
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5466683 |
Water-soluble analogs of carbamazepine
The present invention relates to novel water-soluble analogs of carbamazepine and compositions containing them. The novel compositions are particularly suited for intravenous administration. The...
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5395933 |
Carbamazepine hapten analogues
New carbamazepine hapten analogues are described comprising: (A) an active ester group; (B) a carbamazepine nucleus; and (C) a linking chain (i) linking the carboxamide group of the carbamazepine...
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5391740 |
Fluoresence polarization immunoassay
This disclosure relates to a method and reagents for determining ligands in biological fluids such as serum, plasma, spinal fluid, amnionic fluid and urine. In particular, this disclosure relates...
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5348955 |
N,N-diacylpiperazines
Diacylpiperazines of general structural formula: ##STR1## are: angiotensin II (A-II) antagonists with affinity for both AT 1 and AT 2 receptors useful in the treatment of hypertension, congestive...
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5185443 |
Method for preparing 5-carbamoyl-5H-dibenz[b,f]azepine
A process for producing carbamazepine ##STR1## by (i) optionally purifying a solution of CCDA ##STR2## in an anhydrous, aromatic solvent; (ii) if required distilling off water in the solution;...
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5116974 |
3-carbalkoxyamino-5-aminoacyl-5H-dibenz[b,f]azepines, and methods for making
New 3-carbalkoxyamino-5-aminoacyl-5H-dibenz[b,f]azepines and their pharmaceutically acceptable acid addition salts, and methods for their synthesis are described. These compounds are useful as...
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5110923 |
Method for preparing 5-chlorocarbonyl-5H-dibenz(b,f)azepine
The invention is directed to a process for the synthesis of 5-chlorocarbonyl-5H-dibenz[b,f]azepine, which is the precursor for the industrial scale synthesis of 5-carbamoyl-5H-dibenz[b,f]azepine....
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4952691 |
Fluorescence polarization immunoassay
This disclosure relates to a method and reagents for determining ligands in biological fluids such as serum, plasma, spinal fluid, amnionic fluid and urine. In particular, this disclosure relates...
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4847374 |
Process for the manufacture of N,N-(Dibenzohexatrienylene)ureas
N,N-(dibenzohexatrienylene)urea medicaments can be manufactured in a smooth one-step reaction by reacting a corresponding N,N-(dibenzohexatrienylene)amine with cyanic acid.
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4659817 |
Reporter compounds containing boron
Compounds and methods featuring, in one aspect, compositions containing an organic boronic acid and one or more reporter groups.
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4559174 |
Process for the manufacture of 5-carbamoyl-10-oxo-10,11-dihydro-5H-dibenz[b,]azepine
The invention relates to a process for the manufacture of the known 5-carbamoyl-10-oxo-10,11-dihydro-5H-dibenz[b,f]azepine of the formula III which is characterized in that, for example,...
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4540514 |
5-Cyano- and 5-carbamoyl-10-nitro-5H-dibenz[b,f]azepine
The invention relates to a process for the manufacture of the known 5-carbamoyl-10-oxo-10,11-dihydro-5H-dibenz[b,f]azepine of the formula III which is characterized in that, for example,...
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4436660 |
Process for the production of 5-cyano-and 5-carboxamido-5H-dibenz[b,f]azepines
The invention relates to a novel and technically advanced process for producing 5-cyano-5H-dibenz[b,f]azepine by reacting 5H-dibenz[b,f]azepine with a halocyanogen in the presence of strongly polar...
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4261893 |
Bis-phthalimide intermediates
Bis-phthalimide intermediates of the formula: ##STR1## wherein one of R 9 and R 10 is hydrogen and the other is --NR 11 R 12 ; R 11 is hydrogen or straight stain alkyl containing 1-4 carbon...
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4255329 |
Double receptor fluorescent immunoassay
A novel sensitive method for determining qualitatively and quantitatively the presence of a wide variety of physiologically active organic compounds (ligand) and their receptors is provided. The...
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4235895 |
Substituted 5H-dibenz[b,f]azepine
The substituted 5H-dibenz[b,f]azepine of the formula ##STR1## a process for its manufacture, pharmaceutical compositions which contain the novel compound, and a method of treating epilepsy which...
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4226993 |
Amino-functionalized phthalhydrazides
Amino-functionalized phthalhydrazides of the formula: ##STR1## wherein one of R 5 and R 6 is hydrogen and the other is --NR 7 R 8 ; R 7 is hydrogen or straight chain alkyl containing 1-4...
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4181655 |
5(3-Substituted aminopropyl)-10-trifluoromethoxy-5H-dibenz[b,f]azepines
Novel compounds of general formula ##STR1## (where R 1 and R 2 , which may be the same or different, are hydrogen atoms or alkyl groups; and R 3 and R 4 , which may be the same or different,...
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4124583 |
5-Substituted derivatives of 5H-dibenz (b,f)-azepine and method for obtaining the same
The invention covers the following compounds: 5-(N-benzoylthiocarbamoyl)-5H-dibenz [b, f] azepine, 5-thiocarbamoyl-5H-dibenz [b,f] azepine, 5-(S-methylisothiocarbamoyl)-5H-dibenz [b,f]-azepine and...
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4076707 |
N-(2-hexamethyleniminoethyl)-5H-dibenz[b,f]-azepine-5-carboxamides and quaternary ammonium derivatives thereof
N-(hexamethyleniminoalkyl)-5H-dibenz[b,f]-azepine-5-carboxam
ides having anti-arrhythmic activity are described herein. The subject compounds can be prepared by reacting a...
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4076812 |
10-Halogeno- or 10,11-dihalogeno derivatives of 5H-dibenz[b,f]azepine
The present invention relates to new derivatives of 5H-dibenz[b,f]azepine having the formula I ##STR1## wherein Hal represents halogen with an atomic number up to 35 and R represents hydrogen or...
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3931151 |
Dibenzo (b,f) azepines
Novel dibenzo (b,f) azepines of the formula ##SPC1## Wherein R is alkyl of 1 to 4 carbon atoms, R 1 is selected from the group consisting of hydrogen and alkyl of 1 to 4 carbon atoms, n is 0, 1 or...
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3925369 |
New tricyclic ureas processes for their production and pharmaceutical compositions
This invention relates to tricyclic compounds bearing on the nitrogen atom of the medium ring an 3-amino 2-hydroxy propylamino carbonyl side chain and their physiologically compatible acid addition...
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3905957 |
3-Aryl-5-oxo-2-pyrazoline-4-carboxanilides and process therefor
Novel products selected from the group consisting of compounds of the formula ##EQU1## wherein X is selected from the group consisting of ethylene, vinylene, oxygen and sulfur and R is alkyl of 1...
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3624072 |
DERIVATIVES OF 5H-DIBENZ[b,f] AZEPINE-4-CARBOXYLIC ACIDS
5H-Diebenz[b,f]azepines-4-carboxylic acid, the 10,11-dihydro and other substituted derivatives thereof are antiinflammatory agents. They can be prepared, among other ways, through treatment of the...
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3544558 |
SUBSTITUTED DIAZOCINODIBENZOAZEPINES
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3523944 |
IMINODIBENZYLS AND A PROCESS FOR THEIR PREPARATION
Anti-depressant pharmaceutical composition containing N-[3,4-di(alkoxycarbonyl)cinnamyl]iminodibenzyl of the formula: WHEREIN R is a lower alkyl group, or a non-toxic acid addition salt thereof as...
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3518268 |
SUBSTITUTED 5-CARBONYL- OR 5-THIOCARBONYL-DIBENZO(B,F)AZEPINES
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3510476 |
DIBENZAZEPINE-5-HYDROXAMIC ACID AND DERIVATIVES THEREOF
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3475412 |
DIBENZAZEPINE COMPOUNDS USEFUL AS STABILIZERS FOR OXIDIZABLE ORGANIC COMPOSITIONS
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