|
Match
|
Document |
Document Title |
|
|
7625892 |
Pharmaceutical compositions for the treatment of diseases related to neurotrophines
The present invention refers to pharmaceutical preparations including as active compounds 3-aza-bicyclo[3.2.1]octane derivatives of general formula (I) and/or their dimers of general formula (II)...
|
|
|
7585863 |
Therapeutic amides
The invention provides compounds of the formula:
wherein A, X, Y, and Z are as defined in the specification. The compounds are effective anti-tumor agents. The invention also provides...
|
|
|
7541355 |
Conversion process for 2,3-benzodiazepine enantiomers
Methods for the racemization of an enantiomer of a 2,3-benzodiazepine molecule into the corresponding racemic mixture under either basic or acidic conditions are described. Furthermore, the...
|
|
|
7498433 |
Process and intermediates for the preparation of olanzapine
The invention provides an improved process for preparing Olanzapine as well as intermediates therefor.
|
|
|
7459414 |
Herbicides
Compounds of formula
wherein the substituents have the meanings given in claim 1 , and agronomically tolerable salts, isomers and enantiomers of those compounds, are suitable for use as...
|
|
|
7427613 |
7-aryl-3,9-diazabicyclo(3.3.1)non-6-ene derivatives and their use as renin inhibitors in the treatment of hypertension, cardiovascular or renal diseases
The invention relates to novel 3,9-diazabicyclo[3.3.1]nonene derivatives of formula (I) and related compounds and their use as active ingredients in the preparation of pharmaceutical compositions....
|
|
|
7407950 |
N-(heteroaryl)-1H-indole-2-carboxamide derivatives and their use as vanilloid TRPV1 receptor ligands
The invention concerns compounds of general formula (I), wherein n, X 1 , X 2 , X 3 , X 4 , Z 1 , Z 2 , Z 3 , Z 4 , Z 5 and W are as defined herein.
Said compounds are ligands of the TRPV 1 ...
|
|
|
7265106 |
Method for isolating (R)-tofisopam
(R)-tofisopam, substantially free of the (S)-enantiomer of tofisopam, is obtained by separating the enantiomers of tofisopam by chromatography employing a chiral separation medium comprising (i)...
|
|
|
7189711 |
2, 3-benzodiazepine derivatives and pharmaceutical compositions containing the same as the active ingredient
The invention refers to novel 2,3-benzodiazepine derivatives of formula (I) and pharmaceutical compositions containing the same as the active ingredient. The novel compounds antipasmodic, muscle...
|
|
|
7183274 |
Piperidine-2,6-diones heterocyclically substituted in the 3-position
Piperidine-2,6-diones heterocyclically substituted in the 3-position corresponding to formula I
Also the production and use of such compounds in pharmaceutical formulations and related methods...
|
|
|
7176195 |
Fused azepine derivatives and their use as antidiuretic agents
Compounds according to general formulae (1 and 2), wherein G 1 is an azepine derivative and G 2 is a group according to general formulae (9–11) are new. Compounds according to the invention are...
|
|
|
7153958 |
Farnesyl transferase inhibiting benzoheterocyclic derivatives
This invention comprises the novel compounds of formula (I)
wherein r, s, t, X, Z, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 and R 7 have defined meanings, having farnesyl transferase inhibiting...
|
|
|
7141562 |
Substituted benzoxazinones and uses thereof
Compound of the Formula:
and pharmaceutically acceptable salts or prodrugs thereof, wherein: X is CH or N, Y is C or S, Z is —SO 2 — or —(CR a R b ) r —, n is 1 or 2, R 2 is aryl or...
|
|
|
7129235 |
Amides useful for treating pain
The present invention relates to compounds of formula (I-VII)
or a pharmaceutically acceptable salt or prodrug thereof, in which A, L, R 6 , R 7 and R 8 are defined herein. The present...
|
|
|
7101869 |
2,4-diaminopyrimidine compounds useful as immunosuppressants
Novel compounds according to the formula
and pharmaceutically acceptable salts, solvates, or hydrates thereof; wherein each occurrence of A is independently selected from CH or N; X is...
|
|
|
7015214 |
Cyanamide, alkoxyamino, and urea derivatives of 1,3-benzodiazepine as HIV reverse transcriptase inhibitors
The present invention relates to 1,3-benzodiazepin-2-ones and 1,3-benzoxazepin-2-ones of formula I:
or stereoisomeric forms, stereoisomeric mixtures, or pharmaceutically acceptable salt forms...
|
|
|
6995154 |
Heterocyclic topoisomerase poisons
The invention provides compounds of formula I:
wherein R 1 to R 5 have any of the values defined in the specification, as well as pharmaceutically acceptable salts of the compounds,...
|
|
|
6930104 |
Heterocyclic derivatives
The object of the present invention is to provide soluble β-amyloid precursor protein secretory stimulators, which are effective in treating neurodegenerative diseases as well as cerebrovascular...
|
|
|
6887867 |
5H-2,3-benzodiazepine antagonists of excitatory amino acid receptors
Substituted benzodiazepine compositions are provided which are active as non-NMDA ionotropic excitatory amino acid (EAA) receptor antagonists. The compounds are generally 7- or 8-mono substituted...
|
|
|
6858605 |
Substituted 2,3-benzodiazepine derivatives
The invention relates to new 2,3-benzodiazepine derivatives of formula (I), isomers and acid addition salts thereof and to pharmaceutical compositions containing the same, as well as to...
|
|
|
6667302 |
Heterocyclic topoisomerase poisons
The invention provides compounds of formula I: wherein R 1 to R 5 have any of the values defined in the specification, as well as pharmaceutically acceptable salts of the compounds,...
|
|
|
6566357 |
Spirocyclic-6,7-dihydro-5H-pyrazolo&lsqb 1,2-a&rsqb pyrazol-1-ones which control inflammatory cytokines
The present invention relates to compound which are capable of preventing the extracellular release of inflammatory cytokines, said compounds, including all enantiomeric and diasteriomeric forms...
|
|
|
6407095 |
1,4-diazabicylo&lsqb 3,2,2&rsqb nonane derivatives, their preparation and their therapeutic application
The invention relates to 1,4-diazabicyclo[3.2.2]nonane derivatives, to pharmaceutical compositions containing them, and to methods for the treatment or prevention of disorders associated with a...
|
|
|
6369221 |
Thiazolobenzoheterocycles, preparation and medicines containing same
Disclosed are thiazolobenzoheterocycles of the general formula Including their isomers, racemates, enantioners and salts thereof, as well as processes for preparing these compounds and...
|
|
|
6274577 |
Benzodiazepines
Benzodiazapine derivatives of formula (1) are described: ##STR1## wherein Ar 1 is an aromatic or heteroaromatic group; L 1 is a linker atom or group; Ar 2 is an optionally substituted...
|
|
|
6200970 |
2,3-benzodiazepine derivatives and their use as AMPA-receptor inhibitors
A compound of formula I ##STR1## in which X means hydrogen or halogen, Y means --NR 3 -- or --N, R 1 and R 2 are the same or different and mean hydrogen, C 1 -C 6 alkyl, nitro,...
|
|
|
6177565 |
Process for synthesizing piperazic acid
The invention relates to a process for synthesizing piperazic acid and similar, ring-containing acids. The invention also relates to a process for simultaneously N(2)-acylating piperazic acid or an...
|
|
|
6121258 |
1,5-heterocyclic metalloprotease inhibitors
The invention provides compounds of formula ##STR1## as described in the claims, or an optical isomer, diastereomer or enantiomer thereof, or a pharmaceutically-acceptable salt, or biohydrolyzable...
|
|
|
6075018 |
1-[2-(substituted vinyl)]-3,4-dihydro-4-dihydro-5H-2,3-benzodiazepine derivatives
The invention relates to new 1-[2-(substituted vinyl)]-3,4-dihydro-5H-2,3-benzodiazepine derivatives, a process for the preparation thereof and pharmaceutical compositions comprising them. The new...
|
|
|
5985869 |
Benzoheterocyclic compounds
Novel benzoheterocyclic compounds of the formula: ##STR1## wherein R 1 is H, halogen, alkyl, optionally substituted amino, alkoxy; R 2 is H, halogen, alkoxy, phenylalkoxy, OH, alkyl, optionally...
|
|
|
5942506 |
1- 2-(substituted vinyl)!-5H-2,3-benzodiazepine derivatives
This invention relates to new 1- 2-(substituted vinyl)!-5H-2,3-benzodiazepine derivatives, a process for the preparation thereof, pharmaceutical compositions comprising the same, to the use of the...
|
|
|
5854239 |
Diazabicyclic neuokinin antagonists
The present invention relates to diazabicyclic compounds and, specifically, to compounds of the formula ##STR1## wherein A, G, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , and R 7 are as defined in the...
|
|
|
5834463 |
Condensed heterocyclic compounds, their production and use
Compounds represented by the formula: ##STR1## wherein ring A is benzene; Ar is aromatic group; R 1 , R 2 and R 3 each stands for H, acyl, hydrocarbon or heterocyclic, or R 2 and R 3 , taken...
|
|
|
5807851 |
2,3-Benzodiazepine Derivatives as non-competitive AMPA
Derivatives of 2,3-benzodiazepine are substituted by one or two halogen atom(s) and have the general formula ##STR1## These derivatives are non-competitive AMPA antagonists and are used in...
|
|
|
5750690 |
Asymmetric hydrogenation process using ruthenium-diphosphine complexe
A process for the asymmetric hydrogenation of a compound of the formula ##STR1## wherein each R, independently, is alkyl, arylmethyl, aryl, alkoxy, arylmethoxy or aryloxy or both R's, taken...
|
|
|
5698691 |
Condensed cyclic compounds and their use
Disclosed is a squalene synthetase inhibitor which comprises the compound represented by the formula ##STR1## wherein R 1 is hydrogen or an optionally substituted hydrocarbon group; R 2 is...
|
|
|
5639745 |
Fused-bicyclic lactams as interleukin-1β converting enzyme inhibitors
Disclosed are compounds, compositions and methods for inhibiting interleukin-1β protease activity. The compounds, bicyclic derivatives of aldehydes and α-substituted methyl ketones, have the...
|
|
|
5631372 |
Process for the manufacture of 1-substituted-4-fluoro-1,4-diazoniabicyclo[2.] octane salts
A process for producing 1-substituted-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane salts having the formula ##STR1## wherein the Z substituent is OH, OR, OC(O)R, SO 3 , SO 2 R, NO 2 , NO, or PO(OR) 2...
|
|
|
5624922 |
Aryl-fused and hetaryl-fused-2,4-diazepine and 2,4-diazocine antiarrhythmic agents
Aryl-fused- and hetaryl-fused-2,4-diazepines of formula XXXVI, benzodiazocines of formula XXX, benzodiazepines of formula II ##STR1## δ-aminoamides of formula III and aryldimethanamines of formula...
|
|
|
5534633 |
Aminoketone sensitizers for photopolymer compositions
Aminoketone-substituted coumarin sensitizers having tethered tertiary amino groups are described which have extremely good photosensitivity. The sensitizers of the instant invention have the...
|
|
|
5510346 |
4-heteroaryl-1,3-benzodiazepines and 2-substituted-gamma-(heteroaryl)benzeneethanamines
Novel 4,5-dihydro-4-heteroaryl-3H-1,3-benzodiazepines, intermediates, processes for the preparation thereof, and methods for treating depression, inhibiting convulsions and treating anxiety...
|
|
|
5489681 |
Method for the preparation of 4-phenyl-1,3-benzodiazepins
A compound of the formula ##STR1## is prepared by reacting an N-acylated-o-toluidine of the formula ##STR2## with n-alkyllithium to form a dilithio intermediate of the formula ##STR3## which can...
|
|
|
5292760 |
4-heteroaryl-1,3-benzodiazepines and 2-substituted-α-(heteroaryl)benzeneethanamines
Novel 4,5-dihydro-4-heteroaryl-3H-1,3-benzodiazepines, intermediates, processes for the preparation thereof, and methods for treating depression, inhibiting convulsions and treating anxiety...
|
|
|
5288863 |
Process for the preparation of high-purity 1-(3-chloro-phenyl)-4-methyl-7,8-dimethoxy-5H-2,3-benzodiazepine
The invention relates to a process for the preparation of 1-(3-chlorophenyl)-4-methyl-7,8-dimethoxy-5 H-2,3-benzodiazepine of formula (I) ##STR1## in high purity and in a quality suitable for...
|
|
|
5212301 |
Substituted fluorobenzenes
Introduction of a fluoro substituent into an aromatic ring adjacent an electron donating group is difficult producing mixed isomers and low yields of desired products. A process for the...
|
|
|
5204343 |
5H-benzodiazepin derivative
The invention relates to the new 1-(3-chlorophenyl)-4-hydroxymethyl-7,8-dimethoxy-5H-2,3-benz
odiazepine of formula (I) ##STR1## and pharmaceutically acceptable acid addition salts thereof,...
|
|
|
5036153 |
Preparation of 2,5-diazabicyclo[2.2.1]heptanes and intermediates
(R,R)-2,5-Diazabicyclo[ 2.2.1]heptanes are prepared from a compound of the formula ##STR1## wherein X and R 2 are as defined herein, by heating with tosylchloride in pyridine, reacting the formed...
|
|
|
5008263 |
Diazepine antiallergy agents
Platelet activating factor antagonists of formula (I), (II) or (III): ##STR1## where A is optionally substituted benzene, pyridine, naphthalene, quinoline, thiophene, benzothiophene, pyrazole or...
|
|
|
4977155 |
1,2,3-triazolo compounds
Heterocyclic dihydroxyquinoxaline compounds having the formula ##STR1## wherein R 2 is hydrogen, NO 2 , NH 2 , CN, halogen, or SO 2 NH 2 ; --X--Y--Z-- is selected from --NN--N 3 --,--NR 3 ...
|
|
|
4906630 |
Method of increasing cardiac contractility using pharmaceutical compositions comprising benzodiazinone- pyridazinone or hydroxy-pyrazolyl compounds
A method for increasing cardiotonic contractility in humans or other animals using a class of benzodiazinone-pyridazinone and hydroxy-pyrazolyl compounds and pharmaceutical compositions including...
|