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7479486 |
Sulphur analogues of 21-hydroxy-6,19-oxidoprogesterone (21OH-6OP) for treating excess of glucocorticoids
The present invention is related to novel 21-hydroxy-6,19-oxidoprogesterone (21OH-6OP) analogues, their use as antiglucocorticoids for the treatment and/or prophylaxis of disease associated to an...
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7071328 |
Method for the preparation of 21-hydroxy-6,19-oxidoprogesterone (21 oh-6op)
The present invention relates to a novel method for preparing 21-hydroxy-6,19-oxidopro-gesterone (21OH-6OP) and/or its 21-acetate, 21-propionate, 21-hemisuccinate, 21-phosphate, 21-oleate...
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5776922 |
Corticoid derivatives and pharmaceutical and cosmetic compositions
1. A corticoid derivative of the general formula ##STR1## wherein R represents hydrogen, hydroxy, methyl or methylene; inclusive of the acylation product thereof where the 17-position of the...
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5646272 |
Bile acid conjugates of proline hydroxylase inhibitors
Bile acid derivatives of the formula I W--X--Gin which G is a bile acid radical, W is an active compound moiety of a medicament and X is a bonding member between a bile acid radical and active...
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5506354 |
Imidazolylpiperazinyl steroids
Disclosed are amino substituted steroids (XI) which contain an imidazolylpiperazinyl group attached to the terminal carbon atom of the C17 -side chain which are useful as pharmaceutical agents for...
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5462933 |
Modified bile acid conjugates, and their use as pharmaceuticals
Bile acid derivatives, processes for their preparation and use as pharmaceuticals Bile acid derivatives of the formula I W--X--Gin which G is a bile acid radical, W is an active compound moiety of...
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5428181 |
Bisphosphonate derivative
A compound represented by the general formula: ##STR1## wherein A-O-denotes a residue of a compound having an estrogenic activity; R1 denotes H or a C1 -C6 alkyl group; X denotes a single bond, a...
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5215972 |
Steroids
Steroids of the formula ##STR1## wherein R1 to R4, X and n have the significance given in the description, which lower the intestinal resorption of cholesterol and plasma cholesterol and a process...
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5183815 |
Bone acting agents
Described are new agents for treating bone disorders associated with a reduction in bone mass and abnormalities in bone resportion or bone formation including osteoporosis. Paget's disease, bone...
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5116830 |
Stereoisomerically pure 17α-ethynyl-estra-2-en-17β-ol and the 17β esters thereof, methods of preparation and uses
This invention relates to a stereoisomerically pure Δ2 compound of the formula (I): ##STR1## wherein: R1 is hydrogen or --(CO)--R2, wherein: R2 is an organic substituent selected from the group co...
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5026882 |
Phosphinic acid substituted steroids as inhibitors of steroid 5α-reductase
The invention relates to 3-phosphinic acid steroidal compounds, pharmaceutical compositions containing these compounds, and methods of using these compounds to inhibit steroid 5α-reductase.
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4946834 |
Phosphonic acid substituted steroids as steroid 5α-reductase inhibitors
Invented are substituted acrylate analogues of steroidal synthetic compounds, pharmaceutical compositions containing the compounds, and methods of using these compounds to inhibit steroid...
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4939128 |
Ester of ascorbic acid 2-phosphate and pharmaceutical use
The present invention relates to a compound of the formula: ##STR1## wherein R1 is a hydrogen atom, carboxylic acid acyl or carbamoyl which may be substituted; R is an aliphatic hydrocarbon group...
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4634695 |
Steroid derivatives
Novel 19-nor steroids and 19-nor-D-homo-steroids of the formula ##STR1## wherein R1 is an organic radical of 1 to 18 carbon atoms containing at least one atom selected from the group consisting of...
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4584136 |
Process for preparing Estracyt compounds having a carcinostatic bound thereto
An Estracyt compound having a carcinostatic bound thereto is obtained by reacting an Estracyt compound with a carcinostatic having one or more radicals selected from among COOH, Cl, NH2 and OH,...
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4550163 |
Ligand analog-irreversible enzyme inhibitor conjugates
The present invention encompasses a method for determining ligands in test samples comprising intermixing with the test sample a ligand analog-irreversible enzyme inhibitor conjugate and a binding...
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4501695 |
Spironalactone process
The present invention relates to processes for the conversion of a 3-protected steroidal 17-ketone to a 17-spiro-γ-lactone having the appropriate 17-stereochemistry for spironolactone. Novel ...
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4472393 |
3,20-Dioxo-1,4-pregnadiene-17α-ol 17-aromatic heterocycle carboxylates
This invention relates to novel 3,20-dioxo-1,4-pregnadiene-17α-ol 17-aromatic heterocyclic carboxylates, to pharmaceutical formulations thereof, and their use in the treatment and control of ...
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4447424 |
Steroid derivatives
Novel 19-nor steroids and 19-nor-D-homo-steroids of the formula ##STR1## wherein R1 is an organic radical of 1 to 18 carbon atoms containing at least one atom selected from the group consisting of...
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4438033 |
Steroidal chiral phosphines, methods for their preparation, catalytic systems containing them and catalytic processes in which they are used
New steroidal chiral phosphines of formula ##STR1## wherein R represents a phosphorated group selected between ##STR2## methods for their preparation; catalytic systems comprising metal complexes...
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4390533 |
Steroids and process for preparing the same
The present invention relates to 2-chloro-6β-fluoro-pregna-1,4-diene-3,20-diones having good anti-inflammatory activity, to processes for their preparation and pharmaceutical compositions thereof.
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4267173 |
Use of 6β-fluoro-7α-halogenocorticoids as topical anti-inflammatories and pharmaceutical formulations useful therefor
Described is the use of 6β-fluoro-7α-halogeno-1,4-pregnadiene-17α,21-diol-3,20-di
ones and their esters as topical anti-inflammatory agents, and pharmaceutical formulations thereof useful th...
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4239755 |
Steroidal cyclotriphosphazenes
Steroidal cyclotriphosphazenes of the formula ##STR1## wherein R is the residue of a 3- or 17-hydroxysteroid and R2 is alkyl, are hydrolytically labile compounds adapted for slow release in vivo of...
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4201778 |
6-Acyloxy-1,4,6-pregnatrienes, their use as anti-inflammatory agents, methods for their manufacture, and 6-oxo-1,4-pregnadiene intermediates
Novel 6-acyloxy-3,20-dioxo-1,4,6-pregnatrienes and 6-acyloxy-3,20-dioxo-4,6-pregnadienes, useful anti-inflammatory agents, are prepared by reaction of the corresponding...
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4124707 |
7α-Halogeno-3,20-dioxo-1,4-pregnadienes, methods for their manufacture, their use as anti-inflammatory agents, and pharmaceutical formulations useful therefor
Novel 3,20-dioxo-7α-halogeno-1,4-pregnadienes are described and their use as anti-inflammatory agents. Preferred are 7α-bromo- and 7α-chloro- derivatives, particularly 7α-bromo- and 7α-...
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4097477 |
Steroid compounds and processes thereof
Novel steroids of the formula ##STR1## Also there are provided processes for preparing such compounds. The new compounds are useful as intermediates in the preparation of known cardenolides;...
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4024131 |
16-Methyl-9α-halo steroid esters, ethers and preparation thereof
New 16-methyl-9α-halo corticosteroid esters and ethers having high topical anti-inflammatory potency and low systemic activity and the manner in which they can be produced are described.
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3996359 |
Novel stereoisomeric component A of stereoisomeric mixtures of 2'-unsymmetrical 16,17-methylenedioxy steroid 21-acylates, compositions thereof, and method of treating therewith
A process for the resolution of stereoisomeric mixtures of certain steroids obtained by synthesis into its components, comprising subjecting the stereoisomeric mixture to gel filtration, the...
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3929768 |
Steroids, processes for their manufacture and preparations containing same
Novel steroids having the general formula: ##SPC1## Wherein X and Y are independently selected from hydrogen and fluorine, X being selected from hydrogen and fluorine when Y is hydrogen and X being...
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3928326 |
Process for the separation of stereoisomeric mixtures into their components and components obtained hereby
A process for the resolution of stereoisomeric mixtures of certain steroids obtained by synthesis into its components, comprising subjecting the stereoisomeric mixture to gel filtration, the...
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3627789 |
3-OXO-STEROID-OXIMES
3-Oxosteroid-oximes of the formula ##SPC1## In which R1 represents a free, esterified or etherified hydroxyl group, R2 a free or esterified hydroxyl group, R3 and R4 a hydrogen or fluorine atom...
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3534024 |
STEROID PHOSPHITES AND PROCESSES FOR THEIR PREPARATION
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3530117 |
DELTA**4 AND DELTA**4,6 - 17 - HYDROXY - STEROIDAL PYRAZOLES OF THE PREGNANE SERIES
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3514446 |
LOWER ALKOXYTETRAHYDROPYRANYL ETHERS OF PROGESTATIONAL STEROIDS
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3798214 |
PROCESS FOR THE MANUFACTURE OF NEW STEROID EPOXIDES OF THE 19-NORPREGNENE SERIES
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3784603 |
6-AZIDO-21-OXYGENATED-STEROIDS OF THE PREGNANE SERIES,METHODS FOR THEIR MANUFACTURE AND INTERMEDIATES PRODUCED THEREBY
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3704295 |
STEROIDO(3,2-C)PYRAZOLES AND PREPARATION THEREOF
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3803130 |
2-(2'-CYCLOPROPYLPHENOXYMETHYL)-2-IMIDAZOLINE AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF
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3707537 |
4-CHLORO-4,6-DIENE-6-HALO OR LOWER ALKYL STEROIDS
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3832345 |
17-DESOXY STEROIDAL PYRAZOLES AND PROCESSES OF PREPARING THEM
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3842075 |
ETHERS OF THE PREGNANE SERIES
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3487077 |
PROCESS FOR THE PREPARATION OF 21-PHOSPHATE STEROIDS
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3484436 |
BICYCLO(2.2.2)OCTANE - 1 - -CARBOXYLATE ESTERS OF DELTA**4 - PREGNENE CORTICOID STEROIDS
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3475418 |
11 - DESOXY - 16ALPHA,17ALPHA-DIHYDROXY - 20 - OXO - 4-PREGNENO- AND 4,6 - PREGNADIENO-PYRAZOLES AND 16ALPHA,17ALPHA - ACETALS AND KETALS THEREOF
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3435057 |
16ALPHA,17ALPHA-ETHYLENE AND SUBSTITUTED ETHYLENE PREGNANE DERIVATIVES AND PROCESS
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3376291 |
17alpha-dihalopregneno[3, 2-c]pyrazoles and process for their preparation
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3364206 |
16alpha-alkoxy-10alpha, 9beta-unsaturated pregnene derivatives
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3338928 |
Fused halocyclopropyl steroids
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3332967 |
3-hydroxy-1, 5-bis-dehydro steroids and methods for their manufacture
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3324110 |
Method of phosphorylation and novel intermediates produced thereby
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