Patents in Class 540/490

Matches 1 - 50 out of 112

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Match	Document	Document Title
1	8158617	Fused heterocyclic compound and use thereof The present invention relates to a serotonin 5-HT2C receptor activator containing a compound represented by the formula wherein ring A is a 5- or 6-membered aromatic heterocycle optionally having...
2	8022058	Agents for preventing and treating disorders involving modulation of the RyR receptors The present invention provides novel compounds of Formula I and salts, hydrates, solvates, complexes, and prodrugs thereof. The present invention further provides methods for synthesizing compounds...
3	8012960	Heterocyclic aspartyl protease inhibitors Disclosed are compounds of the formula I or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein Ar, R1, R2, R3, R4 and R5 are as defined in the specification;...
4	7994160	Pyridazine compounds as glycogen synthase kinase 3 inhibitors Disclosed are pyridazine compounds of the formula I which are useful for inhibiting glycogen synthase kinase 3 (GSK-3), methods of making the compounds, compositions containing the compounds, and...
5	7981879	HIV integrase inhibitors Compounds of Formula I are inhibitors of FHV integrase and inhibitors of FHV replication (I), wherein m, n, X, R1, R2, R3, R4, R5, R6, R7; R8, R9 and R10 are defined herein. The compounds are...
6	7943607	Heteroaryl benzamide derivatives for use as GLK activators in the treatment of diabetes Compounds of formula (I), wherein R1, R4, HET-1 and HET-2 are as described in the specification, and their salts and pro-drugs, are activators of glucokinase (GLK) and are thereby useful in the...
7	7879840	Agents for preventing and treating disorders involving modulation of the RyR receptors The present invention provides compounds of Formula I and salts, hydrates, solvates, complexes, and prodrugs thereof. The present invention further provides methods for synthesizing compounds of...
8	7718645	Substituted bicyclolactam compounds The invention provides compounds of formula (1), and the pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5a, R5b, R5c, R5d, Q, A, Z, and R7 are as described herein; compositions...
9	7704990	Agents for preventing and treating disorders involving modulation of the RyR receptors The present invention provides novel compounds of Formula I and salts, hydrates, solvates, complexes, and prodrugs thereof. The present invention further provides methods for synthesizing compounds...
10	7598237	7-aryl 1,5-dihydro-4,1-benzoxazepin-2(3H)-one derivatives and their use as progesterone receptor modulators This invention provides progesterone receptor modulators having the structure: wherein R1 to R7, X, and Q are as defined in the specification; or a pharmaceutically acceptable salt thereof.
11	7572783	Substituted benzofused heterocycles The present invention relates to the compounds of Formula I, their preparation and pharmaceutical compositions comprising them. The compounds and pharmaceutical compositions are useful, for...
12	7569561	2,4-diaminopyrimidines useful for treating cell proliferation diseases The present invention encompasses compounds of general formula (1) wherein R1 to R6, X and Y are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive...
13	7151097	Bicyclic pyrazolyl and imidazolyl compounds and uses thereof Compounds of Formula (I) are described herein. The compounds have been shown to act as cannabinoid receptor ligands and are therefore useful in the treatment of diseases linked to the mediation of...
14	7122662	Tricyclic compound having spiro union This invention relates to tricyclic compounds having spiro union represented by the following formula (I) or its salt which is useful as a drug, and in particular, as an inhibitor for activated...
15	7109233	Protease inhibitors This invention relates in general to certain substituted substituted 1,1,4-1l6-trioxo[1,2]thiazepan-4-ylamides of formula I as defined herein which are protease inhibitors.
16	7060698	Benzoxazepinone derivatives The invention relates to benzoxazepinone derivatives of formula wherein R1, R2, R3, R4, and n are as defined in the specification and to a pharmaceutically suitable acid addition salt thereof....
17	7030107	Fused bicyclic pyridine derivatives as tachykinin receptor antagonists A novel fused bicyclic pyridine derivative or a salt thereof that acts as a tachykinin receptor antagonist, in particular as an NK1 receptor antagonist, is represented by the following general...
18	7026309	Fused bicyclic pyridine derivative as tachykinin receptor antagonist A fused bicyclic pyridine derivative represented by the following general formula (1), or a salt thereof: wherein the rings A and B are each a benzene ring, which may have 1 to 3 substituents (any...
19	7014981	Benzoindole styryl compounds and their uses in high-density recording media The invention discloses new benzoindole styryl compounds and its use for a high-density optical recording medium. The invention uses the dyes of the new benzoindole styryl compounds to form the...
20	6908934	Therapeutic compounds for treating dyslipidemic conditions Compounds of Formula I and the pharmaceutically acceptable salts and esters thereof, wherein Z is selected from the group consisting of: (a) Formula Ia and(b) Formula Ib are novel LXR agonists and...
21	6846833	Vitronectin receptor antagonist bicyclic compounds, preparation method and compositions containing same Compounds of formula (1): wherein: G represents an optionally substituted phenyl or optionally substituted heterocycle, G1 and G2 being N or C,T1 represents —CH2—CH2—, —CH═CH— or ═CH—CH2—, a...
22	6613761	Benzoxazepine compounds, their production and use This invention provides new benzoxazepine compounds represented by the formula: [wherein R stands for a lower alkyl group optionally substituted with a hydroxyl group, X stands for an optionally...
23	6537987	4,1-benzoxazepines or 4,1-benzothiazepines and their use as squalene synthetase inhibitors This invention relates to certain benzoxazepinones and benzothiazepinones useful as hypocholesterolemic agents, hypotriglyceridemic agents, antiatherosclerosis agents, antifungal agents,...
24	6506744	Benzazepinone-derivatives Compounds of formula I as well as pharmaceutically usable salts and esters thereof, inhibit the binding of adhesive proteins to the surface of different types of cell and accordingly influence...
25	6489320	5, 5-disubstituted-1, 5-dihydro-4, 1-benzoxazepin-2 (3H)-ones useful as HIV reverse transcriptase inhibitors The present invention relates to benzoxazepinones of formula I: or stereoisomeric forms or mixtures, or pharmaceutically acceptable salt forms thereof, which are useful as inhibitors of HIV reverse...
26	6486315	Recrystallization processes Mercaptoalkanoylamino lactam acids are recrystallized by treatment with an agent that minimizes the formation of disulfides. Suitable agents are bismercaptans, phosphine or phosphite reducing...
27	6455522	Cyclic sulfonamide derivatives as metalloproteinase inhibitors The present application describes novel lactams and derivatives thereof of formula I: or pharmaceutically acceptable salt forms thereof, wherein rings ring B is a 4-8 membered cyclic sulfonamide...
28	6423840	Inhibitors of interleukin-1β converting enzyme The present invention relates to novel classes of compounds which are inhibitors of interleukin-1β converting enzyme. The ICE inhibitors of this invention are characterized by specific structural ...
29	6403578	Bicyclic fibrinogen antagonists This invention relates to compounds of the formulae: whereinA1 is O, S, N—R1 or CHR1;A4 is N—R4 or CHR4;R2 is a sidechain containing an acid or ester group;R1, R4 and R5 are substituents such as ...
30	6353099	Substituted ureas as cell adhesion inhibitors Compounds of Formula I are antagonists of VLA-4 and/or α4β7, and as such are useful in the inhibition or prevention of cell adhesion and cell-adhesion mediated pathologies. These compounds may be f...
31	6352982	4,1-benzoxazepines, their analogues, and their use as somatostatin agonists The present invention provides a compound of the formula: wherein ring A is an optionally substituted aromatic hydrocarbon ring or aromatic heterocyclic ring; ring B is an optionally substituted...
32	6340752	Deprotection and recrystallization processes Acylmercaptoalkanoylamino lactam esters or acids are converted to the corresponding mercaptoalkanoylamino lactam ester or acid under basic conditions by including an agent which minimizes the...
33	6204261	Inhibitors of interleukin-1β Converting enzyme inhibitors The present invention relates to pyradazino[1,2-a][1,2]diazepine-1-carboxamide compounds of formula: ##STR1##which compounds are inhibitors of interleukin-1beta converting enzyme.
34	6162913	Preparation of [4S-(4α,7α,10aβ)]-4-amino-octahydro-5-oxo-7H-pyrido[2,1 -b] [1,3]thiazepine-7-carboxylic acid, methyl ester and salts thereof via novel disulfides N-protected-L-homocysteine disulfide of the formula ##STR1## or an activated form thereof is reacted with (S)-2-amino-6,6-dimethoxyhexanoic acid, methyl ester to give the disulfide intermediate of...
35	6140320	5,5-disubstituted-1,5-dihydro-4,1-benzoxazepin-2 (3H)-ones useful as HIV reverse transcriptase inhibitors The present invention relates to benzoxazepinones of formula I: ##STR1## or stereoisomeric forms or mixtures, or pharmaceutically acceptable salt forms thereof, which are useful as inhibitors of...
36	6114522	Process of production of 4-substituted-3-halogeno-1,4-benzoxazepine derivative and salts thereof A process for producing 4-substituted-3-halogeno-1,4-benzoxazepin derivative or the salt thereof comprising: deprotonizing a benzoxazepine derivative having the formula (II): ##STR1## with a base;...
37	6110909	Benzoxazepine compounds, their production and use as lipid lowering agents This invention provides new benzoxazepine compounds represented by the formula: ##STR1## [wherein R stands for a lower alkyl group optionally substituted with a hydroxyl group, X stands for an...
38	6069114	2-amino-4-bicycloamino-1,3,5-Triazines, their preparation, and their use as herbicide and plant growth regulators Compounds of the formula (I) and their salts ##STR1## in which R1 to R6, Y1, to Y2, Y3, m and n are as defined in claim 1 are suitable as herbicides and plant growth regulators. They can be...
39	6008214	Bicyclic compounds This invention relates to compounds of the formula: ##STR1## or a pharmaceutically acceptable salt thereof, which are effective for inhibiting platelet aggregation and bone resorption,...
40	5965553	Squalene synthetase inhibitors This invention relates to certain benzoxazepinones and benzothiazepinones useful as hypocholesterolemic agents, hypotriglyceridemic agents, antiatherosclerosis agents, antifungal agents,...
41	5770594	Naphthyl-benzoxazepines or -benzothiazepines as squalene synthetase inhibitors This invention relates to certain benzoxazepinones and benzothiazepinones useful as hypocholesterolemic agents and antiatheroscierosis agents.
42	5726306	4,1-benzoxazepin derivatives and their use N-containing, condensed heterocyclic compounds and salts thereof are disclosed which are useful for inhibiting squalene synthetase and fungal growth, and which are useful for treating or preventing...
43	5698691	Condensed cyclic compounds and their use Disclosed is a squalene synthetase inhibitor which comprises the compound represented by the formula ##STR1## wherein R1 is hydrogen or an optionally substituted hydrocarbon group; R2 is hydrogen,...
44	5677298	Benzoxazepine-2-one compounds and their use Disclosed is a squalene synthetase inhibitor which comprises the compound represented by the formula (I) ##STR1## wherein R1 stands for H or an optionally substituted hydrocarbon group; R2 and R3...
45	5674865	Nonpeptidyl integrin inhibitors having specificity for the GPIIb IIIa A benzodiazepinedione derivative which acts as a nonpeptidyl platelet aggregation inhibitor is provided. This inhibitor potently inhibits fibrinogen binding to the GPIIb IIIa receptor and is...
46	5672599	Compounds containing a fused bicycle ring Compounds of the formula ##STR1## wherein X is O or S--(O)t ; n is one; m is zero or one; Y is CH2, O, or S--(O)t provided that Y is O or S--(O)t only when m is one; and A is ##STR2## are dual...
47	5654294	Spiro lactam dual action inhibitors Compounds of the formula ##STR1## are disclosed as possessing inhibotory activity against angiotensin converting enzyme (ACE) and neutral endopeptidase (NEP) and thus being useful as cardiovascular...
48	5646276	Diazepine containing dual action inhibitors Compounds of the formula ##STR1## wherein X1 is ##STR2## are disclosed as possessing inhibotory activity against angiotensin converting enzyme (ACE) and neutral endopeptidase (NEP) and thus being...
49	5635502	Mercaptoacetylamide bicyclic lactam derivatives useful as inhibitors of enkephalinase and ACE The present invention relates to certain novel mercaptoacetylamide bicyclic lactam derivatives useful as inhibitors of enkephalinase and of ACE.These mercaptoacetylamide bicyclic lactam derivatives...
50	5627278	Process for preparing compounds containing a fused bicyclic ring A process for preparing compounds of the formula ##STR1## wherein X is O or S; n is one or two; m is zero or one; Y is CH2, O, or S provided that Y is O or S only when m is one; and A is ##STR2##...

Matches 1 - 50 out of 112

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