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7615549 Substituted pyrrolidinones, their manufacture and their use as medicaments  
The present invention relates to new substituted pyrrolidinones of general formula wherein A, X, B and R 1 to R 9 are as defined above, or a tautomer or salt thereof, particularly the...
7569561 2,4-diaminopyrimidines useful for treating cell proliferation diseases  
The present invention encompasses compounds of general formula (1) wherein R 1 to R 6 , X and Y are defined as in claim 1 , which are suitable for the treatment of diseases...
7566778 (Pyrido/thieno)-[f]-oxazepine-5-one derivatives  
The present invention relates to (pyrido/thieno)-[f]-oxazepine-5-one derivatives having the general Formula I wherein R 1 , R 2 and R 3 are independently H or (C 1-4 )alkyl; Ar represents a...
7550453 2-alkoxy-3,4,5-trihydroxy-alkylamides, preparation thereof, compositions containing them and use thereof  
The invention relates particularly to 2-alkoxy-3,4,5-trihydroxy-alkylamides, preparation thereof, compositions containing them and use thereof as a medicament, particularly as anti-cancer agents.
7361648 Heterocyclylakylamines as muscarinic receptor antagonists  
This invention relates to compounds which are generally muscarinic M2/M3 receptor antagonists and which are represented by Formula I: wherein X, Y, and Z are O, S or NR 5 , and the other...
7314930 Process for preparing dibenzothiazepine derivatives  
A process for preparing a dibenzothiazepine derivative such as dibenzo[b,f][1,4]thiazepin-11-one employable as a starting material for the preparation of...
7307073 Benzoxazepines derivatives and their use as AMPA receptor stimulators  
The present invention relates to benzoxazepine derivative having the general formula I, wherein X represents CO or SO 2 ; R 1 , R 2 , R 3 and R 4 are independently selected from H, (C 1-4 )alkyl,...
7294622 Lactams and uses thereof  
Compounds having the formula (I) pharmaceutical compositions containing them and their methods of use for the treatment of neurological disorders related to amyloid β protein production and...
7279582 Retroviral protease inhibiting compounds  
A compound of the formula: is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.
7229984 Dibenzoxazepinone derivatives and uses thereof  
Compounds of the Formula I: wherein m, n, k, A, X, Y, Z, Ar, R 1 , R 2 , R 3 , and R 4 are as defined herein. The compounds are useful as 5-HT6 receptor antagonists. Also provided are...
7214793 Method of preparing 10H-dibenzo[b,f][11,4]thiazepin-11-one  
Disclosed is a method of preparing 10H-dibenzo[b,f][1,4]thiazepin-11-one, including reacting dithiosalicylic acid with 1-chloro-2-nitrobenzene in a basic aqueous solution in the presence or absence...
7208487 Compounds, compositions and methods  
Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed.
7205292 CGRP receptor antagonists  
The present invention is directed to compounds of Formula I and Formula II: (where variables R1, R2, R3, R4, R6, A, B, G, J, W, X and Y are as defined herein) useful as antagonists of CGRP...
7157442 Antibacterial compound  
The present invention relates to a compound of formula (I) (wherein R 1 and R 2 represent an aryl group, a heterocyclic group, an alkyl group, an alkenyl group and the like which are optionally...
7109233 Protease inhibitors  
This invention relates in general to certain substituted substituted 1,1,4-1l 6 -trioxo[1,2]thiazepan-4-ylamides of formula I as defined herein which are protease inhibitors.
7045621 Process for producing dibenzothiazepine derivatives  
A process for preparing a dibenzothiazepine derivative such as dibenzo[b,f] [1,4]thiazepin-11-one employable as a starting material for the preparation of...
7015212 Thiazepine inhibitors of HIV-1 integrase  
The present invention discloses non-catechol compounds, such as thiazolothiazepines, and analogs and derivatives thereof, which are anti-integrase inhibitors. The compounds, which are useful as...
7009047 Ethane-1,2-diaminium bis[(2R)-2-bromo-3-phenylpropanoate], processes for its preparation and its use  
The present invention relates to ethane-1,2-diaminium bis[(2R)-2-bromo-3-phenyl-propanoate], the preparation of ethane-1,2-diaminium bis[(2R)-2-bromo-3-phenyl-propanoate] from...
6924277 Cyclized benzamide neurokinin antagonists for use in therapy  
Compounds having the general formula wherein R 1a , R 1b , R 1c , X 1 , X 2 , R 2 , R 3 , R 4 , R 5 , R 6 , n, Y and Z are as defined in the specification, methods of using such compounds for...
6921759 Aza- and polyaza-naphthalenyl carboxamides useful as HIV integrase inhibitors  
Aza- and polyaza-naphthalenyl carboxamide derivatives including certain quinoline carboxamide and naphthyridine carboxamide derivatives are described. These compounds are inhibitors of HIV...
6919328 Tricyclic compounds with NOS activity  
The present invention provides novel tricyclic compounds, compositions comprising these compounds and methods of using these compounds as neuroprotectants. In particular, the compounds of the...
6916807 Triaryl-oxy-aryl-spiro-pyrimidine-2,4,6-trione metalloproteinase inhibitors  
The present invention relates to triaryl-oxy-aryl-spiro-pyrimidine-2,4,6-trione metalloproteinase inhibitors of the formula wherein said ring X is a 5-7 membered heterocyclic ring, and wherein...
6900201 N-substituted-heteroaryloxy-aryl-spiro-pyrimidine-2,4,6-trione metalloproteinase inhibitors  
The present invention relates to N-substituted-heteroaryloxy-aryl-spiro-pyrimidine-2,4,6-trio ne metalloproteinase inhibitors of the formula wherein ring X is a 5-7 membered heterocyclic ring,...
6864250 N-acylated lipophilic amino acid derivatives  
Compounds of structural Formula (I) where A is a lipophilic group including an aliphatic bridging group, B is a lipophilic group, D is a group having at least one amino or substituted amino group...
6852713 Lactam derivatives and methods of their use  
Lactam derivatives of the general formula are disclosed. Pharmaceutical compositions containing the compounds and methods for their use are also disclosed.
6828439 Compounds, composition, and methods for photodynamic therapy  
Disclosed are novel compounds, compositions, and methods that are particularly useful in photodynamic therapy. In particular, the inventive compounds, compositions, and methods relate to the...
6815463 Laulimalide derivatives  
Laulimalide compounds, intermediates thereto and methods for their preparation, and methods for their use in the treatment of diseases characterized by cellular hyperproliferation.
6806267 Apoptosis-inducing compounds  
The present invention relates to pyrrolobenzoxazepines, pyrrolobenzthiazepines and related compounds having the ability to induce apoptosis, to pharmaceutical compositions comprising these...
6767907 4-aryl-1-(indanmethyl dihydrobenzofuranmethyl or dihydrobenzothiophenemethyl) piperidines tetrahydropyridines or piperazines  
4-Aryl-1-(indanmethyl, dihydrobenzofuranmethyl or dihydrobenzothiophenemethyl)piperidine, -tetrahydropyridine or -piperazine compounds of general formula (I), wherein one of X and Y is CH 2 and...
6686349 Substituted tetracyclic pyrroloquinolone derivatives useful as phosphodiesterase inhibitors  
The invention relates to novel tetracyclic pyrroloquinolone derivatives of the formula (I) or (II): wherein all variables are as herein defined, pharmaceutical compositions containing the...
6667301 Heterocyclylalkylamines as muscarinic receptor antagonists  
This invention relates to compounds which are generally muscarinic M2/M3 receptor antagonists and which are represented by Formula I: wherein X, Y, and Z are O, S or NR 5 , and the other...
6656911 Serine protease inhibitors  
The present invention relates to certain substituted oxadiazole, thiadiazoles and triazole peptoids which are useful as inhibitors of serine proteases. Compounds of the invention are useful for...
6635759 Luminescent 4-trifluoromethyl 1-2-quinolones with long wave UV absorption and the use thereof  
The invention relates to a substituted 4-trifluoromethyl carbostyril according to formula (I) and is characterised in that the 4-trifluoromethyl carbostyril is provided with an absorption maximum...
6610697 Substituted 2-aryl-3-(heteroaryl)-imidazo&lsqb 1,2-a&rsqb pyrimidines, and related pharmaceutical compositions and methods  
This invention relates to a series of imidazopyrimidines of Formula I, and pharmaceutical compositions containing them. The compounds of the invention inhibit the production of a number of...
6544978 Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds  
Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions...
6541466 Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds  
Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions...
6537987 4,1-benzoxazepines or 4,1-benzothiazepines and their use as squalene synthetase inhibitors  
This invention relates to certain benzoxazepinones and benzothiazepinones useful as hypocholesterolemic agents, hypotriglyceridemic agents, antiatherosclerosis agents, antifungal agents,...
6503897 Antibacterial agents  
Compounds of formula (I) are antibacterial agents wherein: R 3 and R 4 , taken together with the carbon atoms to which they are respectively attached, form an optionally substituted saturated...
6489320 5, 5-disubstituted-1, 5-dihydro-4, 1-benzoxazepin-2 (3H)-ones useful as HIV reverse transcriptase inhibitors  
The present invention relates to benzoxazepinones of formula I: or stereoisomeric forms or mixtures, or pharmaceutically acceptable salt forms thereof, which are useful as inhibitors of HIV...
6472529 Retroviral protease inhibiting compounds  
A compound of the formula: is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.
6472384 Antimicrobial compounds  
The present invention relates to ester, ether and N-alkylcarbamoyl derivatives of compound (Ia) and pharmaceutically acceptable salts thereof. These compounds exhibit excellent antibacterial...
6468996 Substituted hetero-polycyclic compounds as PPARα and PPAR&ggr activators  
The present invention relates to compounds of the general formula (I) The compounds are useful in the treatment and/or prevention of conditions mediated by nuclear receptors, in particular the...
6444809 Therapeutic heterocycles  
Compounds of formula I wherein G, J, L, M, m and D have any of the meanings given in the specification, their N-oxides, and their pharmaceutically acceptable salts are nonpeptide antagonists of...
6416922 Azomethine dye precursor, image-forming material, and image-forming method  
The present invention related to an azomethine dye precursor represented by the following general formula (1) and the image-forming material and image-forming method using the azomethine dye...
6399598 Diheterocyclic metalloprotease inhibitors  
The invention provides compounds of formula as described in the claims, or an optical isomer, diastereomer or enantiomer thereof, or a pharmaceutically-acceptacle salt, or biohydrolyzable amide,...
6297232 Triazolo[4,5-D]pyrimidinyl derivatives and their use as medicaments  
The invention relates to triazolo[4,5-d]pyrimidin-3-yl derivatives which are useful in the treatment of platelet aggregation disorders.
6218394 4-Aryl-1-(indanmethyl, dihydrobenzofuranmethyl or dihydrobenzothiophene-methyl) piperazines  
4-Aryl-1-(indanmethyl, dihydrobenzofuramethyl or dihydrobenzothiophenemethyl) piperidine, -tetrahydropyridine or -piperazine compounds of general formula (I) ##STR1## wherein one of X and Y is CH 2...
6140320 5,5-disubstituted-1,5-dihydro-4,1-benzoxazepin-2 (3H)-ones useful as HIV reverse transcriptase inhibitors  
The present invention relates to benzoxazepinones of formula I: ##STR1## or stereoisomeric forms or mixtures, or pharmaceutically acceptable salt forms thereof, which are useful as inhibitors of...
5972237 Use of heterocyclic compounds as activators for inorganic peroxy compounds  
Heterocyclic compounds I R 1 --X--L (I) where L is a cyclic carbamate residue, a lactonoxy residue or a lactam residue, X is an...
5965553 Squalene synthetase inhibitors  
This invention relates to certain benzoxazepinones and benzothiazepinones useful as hypocholesterolemic agents, hypotriglyceridemic agents, antiatherosclerosis agents, antifungal agents,...
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