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7582280 |
Conjugates of antioxidants with metal chelating ligands for use in diagnostic and therapeutic applications
The invention provides radiopharmaceuticals for diagnostic and therapeutic applications, conjugates of antioxidants with metal chelating ligands, intermediate compounds, methods of making such...
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7488820 |
Naphthofluorescein-based metal sensors, and methods of making and using the same
The present invention is directed, in part, to naphthofluorescein-based ligands for detection of metal ions, and methods of making and using the same.
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7470469 |
Medical device having surface modification with superoxide dismutase mimic
A medical device comprising a substrate having a plasma polymerized functionality bonded to at least a portion of the substrate. A superoxide dismutase mimic agent having a complimentary functional...
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7432371 |
Nanofilm and membrane compositions
Nanofilms useful for filtration are prepared from oriented amphiphilic molecules and oriented macrocyclic modules. The amphiphilic species may be oriented on an interface or surface. The nanofilm...
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7414065 |
Methods to modulate conditions mediated by the CXCR4 receptor
The present invention is drawn to novel antiviral compounds, pharmaceutical compositions and their use. More specifically this invention is drawn to derivatives of monocyclic polyamines which have...
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7390828 |
Aminoderivatives of biotin and their conjugates with macrocyclic chelating agents
Formula (I) compounds are described where the groups are as defined here below, processes for their preparation, and their uses for the preparation of conjugates with radionuclides for use in human...
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7385054 |
Trimeric, macrocyclically substituted halo-benzene derivatives
The metal complexes of general formula I
in which Hal stands for bromine or iodine, and A 1 and A 2 have different meanings, are suitable as contrast media.
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7368100 |
Backbone-substituted bifunctional DOTA ligands, complexes and compositions thereof, and methods of using same
Backbone-substituted 1,4,7,10-tetraaza cyclododecane-N,N′,N″,N′″-tetraacetic acid compounds, metal complexes thereof, compositions thereof, conjugates thereof, and methods of use in...
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7351389 |
Aminocarboxylate ligands having substituted aromatic amide moieties
Novel metal-chelate complexes comprising aminocarboxylate ligands including substituted aromatic amide moieties, such as those having the formula
wherein R 13 , A 1 , R 1 and R 2 are as...
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7335629 |
Support-fixed bleaching catalyst complex compounds suitable as catalysts for peroxygen compounds
The present invention relates to support-fixed bleaching catalyst(s)suitable or the catalysis of peroxide compounds, characterized in that the support-fixed bleaching catalyst(s) is/are covalently...
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7332149 |
Vitronectin receptor antagonist pharmaceuticals
The present invention describes novel compounds of the formula:
(Q) d —L n —C h ,
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7312327 |
Method of preparing nitrogen macrocycles
The invention relates to a method of preparing nitrogen macrocycles having formula (I). The inventive method comprises a step involving the reaction of compounds (II) and (III) in order to form a...
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7267994 |
Element-coded affinity tags
The present invention provides compositions and methods for detecting, analyzing, and identifying biomolecules. More particularly, the invention provides Element Coded Affinity Tags comprising a...
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7211241 |
Cascade polymer complexes, process for their production and pharmaceutical agents containing said complexes
Described are new cascade polymer complexes, compositions containing them and use of the complexes in diagnosis and therapy, particularly for magnetic resonance imaging and computer tomography...
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7208140 |
Trimeric macrocyclic substituted benzene derivatives
The metal complexes of general formula I
in which Hal stands for bromine or iodine and A 1 and A 2 have different meanings, are suitable as contrast media.
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7164016 |
Macrocyclic metal complexes and their use for the production of conjugates with biomolecules
The invention relates to macrocyclic metal complexes and their production and use for the production of conjugates with biomolecules. The conjugates are suitable as contrast media in NMR diagnosis...
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7160872 |
Methods to treat conditions mediated by chemokine receptors
The present invention is drawn to novel antiviral compounds, pharmaceutical compositions and their use. More specifically this invention is drawn to derivatives of monocyclic polyamines which have...
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7132513 |
Bifunctional chelating agent
The invention concerns a ligand comprising wherein n is an integer from 1 to 5, X represents —NO 2 , —NH 2 , —NCS, —NHCOCH 2 -Z. NHCO—W—COCNHS, —NH-Q, —NHCS-Q, —NHCOCH 2 -Q, or...
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7081472 |
Substituted bis-indole derivatives useful as contrast agents, pharmaceutical compositions containing them and intermediates for producing them
Metal-complexable substituted bis-indole derivatives comprising the structure shown in formula (I) hereunder: enantiomers and pharmaceutically acceptable salts thereof and metal complexes thereof,...
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7078013 |
Pretargeting methods and compounds
Methods, compounds, compositions and kits that relate to pretargeted delivery of diagnostic and therapeutic agents are disclosed. In particular, methods for radiometal labeling of biotin and for...
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7060818 |
Synthesis of macrocyclic tetraamido compounds and new metal insertion process
An improved method of synthesizing a macrocyclic tetraamido compound includes protecting the amino portion of an amino carboxylic acid to form a protected amino carboxylic acid; exposing the...
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7045606 |
Bifunctional chelating agent for actinium
The invention concerns a ligand comprising (I) wherein n is an integer from 1 to 5 Y is CO2H or PO3H2T represents —X or -phenyl-X, wherein X represents NO2, NH2, NCS, NHCOCH2-Z,...
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7022843 |
β,β′-dihydroxy meso-substituted chlorins, isobacteriochlorins, and bacteriochlorins
Improved β,β′-dihydroxy meso-substituted chlorin, bacteriochlorin or isobacteriochlorin compounds are provided as photosensitizers. Pharmaceutical compositions and photodynamic therapy...
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7012140 |
Selection of coordination geometry to adjust water exchange rates of paramagnetic metal ion-based macrocyclic contrast agents
The present invention is directed, in general, to a contrast agent comprising a tetraazacyclododecane ligand and comprising a macrocyclic ring and a paramagnetic metal ion coordinated to the...
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6962690 |
Tissue specific fluorescent chelates possessing long wavelength UV excitation
Fluorescent chelates of lanthanide, terbium, europium and dysprosium with tetraazamacrocyclic compounds are discussed which can be used as fluorescent in vitro or in vivo diagnostic agents. These...
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6942966 |
Methods for processing chemical compounds having reactive functional groups
Novel macrocyclic compounds are constructed to include large cyclic structures that are interrupted by at least one ring system. Each interrupting ring system includes two bridgehead atoms....
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6936189 |
Cyclic tertiary amine compound and organic electroluminescent device containing the compound
A cyclic tertiary amine compound represented by a formula (1) and an organic luminescent device are disclosed. Use of the cyclic tertiary amine compound as a hole transport material, a hole...
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6902891 |
Process for labeling a nucleic acid
A process of fragmenting and labeling a synthetic or natural nucleic acid, comprising the steps of providing a mixture containing a nucleic acid, a labeling agent containing a detectable label, and...
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6897209 |
Labelled factor XIIIa substrates
A complex of a radiometal or paramagnetic metal ion with a metal chelating agent such as a diaminedioxime has attached thereto a substituent of formula (Y) m -A-NHR) k can function as a substrate...
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6894151 |
Lithium complexes of N-(1-hydroxymethyl-2,3-dihydroxypropyl)-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane, their production and use
The invention relates to crystalline lithium complexes of N-(1-hydroxymethyl-2,3-dihydroxypropyl)-1,4,7-triscarboxymet
hyl-1,4,7,10 tetraazacyclododecane, their production and the recovery of the...
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6872714 |
Methods to modulate conditions mediated by the CXCR4 receptor
The present invention is drawn to novel antiviral compounds, pharmaceutical compositions and their use. More specifically this invention is drawn to derivatives of monocyclic polyamines which have...
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6852854 |
Preformed carboxylated active ester for labeling biomolecules
The present invention is directed, in general, to a method for making high yields of functionalized cyclic or acyclic tertiary amine-containing compounds, termed active esters, the functionalized...
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6838557 |
Process for making a chelating agent for labeling biomolecules using preformed active esters
The present invention is directed, in general, to a method for making high yields of functionalized cyclic or acyclic tertiary amine-containing compounds, termed active esters, the functionalized...
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6827927 |
Gadolinium complex tetramides and use in medical imaging
The invention concerns a racemic compound of the pair of enantiomers of formula (III) wherein R represents an alkyl group or a phenyl group optionally substituted.
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6774228 |
Tetra-aza macrocycles and metal complexes thereof
1,4,7,10-Tetrazacyclododecanes carrying a side chain terminating in a group capable of reacting with an antibody, and their complexes with a di- or tripositive metal having a coordination number of...
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6756391 |
Antiviral compounds
The present invention is drawn to novel antiviral compounds, pharmaceutical compositions and their use. More specifically this invention is drawn to derivatives of monocyclic polyamines which have...
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6746662 |
pH sensitive MRI contrast agents
A composition and method is disclosed for providing a magnetic resonance imaging contrast agent that is sensitive to pH, the compound and salts thereof including, a tetraaza base having a spacer at...
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6746595 |
Ammonium ionophore, an ammonium ion selective matrix, an ammonium ion-selective sensor, and a method for detecting ammonium ions in a fluid sample
An ammonium selective ionophore for use in ion selective electrodes.
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6730666 |
Pharmaceutical compositions comprising porphyrins and some novel porphyrin derivatives
Tertrapyrrolic macrocycles selected from 5,10,15,20-tetraaryl-porphyrins and 5,10,15-triaryl-corrloes, wherein said aryl radical is a carboaryl, a heteroaryl or a mixed carboaryl-heteroaryl radical...
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6719958 |
Polychelants, their complexes with metal ions, their preparation and their uses
A new class of polychelants, their chelates with metal ions and their physiologically acceptable salts, useful, either as they are or in association or formulation with other components, for...
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6699989 |
Antiviral and antimicrobial guanidine or biguanidine derivatives
Disclosed are guanidine and biguanidine derivatives which have anti-viral and anti-bacterial activity. Also disclosed are pharmaceutical compositions containing such compounds as an active...
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6693190 |
Enhanced relaxivity monomeric and multimeric compounds
Metal chelates capable of exhibiting an immobilized relativity between about 60 and 200 mM −1 s −1 /metal atom are useful as magnetic resonance imaging agents. Additionally, a compound which is...
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6676928 |
Perfluoroalkyl-containing complexes with polar radicals, process for their production and their use
Perfluoroalkyl-containing complexes with polar radicals of general formula I (K) 1 -G-(Z-R f ) m (R) p (I) in which R means the polar radical, R f means a perfluorinated carbon chain, K is a...
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6670354 |
Methods to enhance white blood cell count
Methods to elevate white blood cell counts in animal subjects using compounds of formula (1) are disclosed. These compounds have the formula Z-linker-Z′ (1) or pharmaceutically acceptable salt...
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6656450 |
Macrocyclic magnetic resonance imaging contrast agents
The invention relates to novel magnetic resonance imaging contrast agents.
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6653470 |
Process for the preparation of 1,4,7,10-tetraazacyclododecane
1,4,7,10-Tetraazacyclodecane, a precursor for the synthesis of macrocylic chelating agents for metal ions such as gadolinium, is prepared efficiently as a highly pure product on an industrial scale.
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RE38329 |
Chelated complexes of paramagnetic metals with low toxicity
Compounds of formula (I) and (II) wherein the R, R 1 , R 2 , R 3 and R 4 groups have the meanings defined in the disclosure, are useful chelants for metal ions. The complexes of compounds (I)...
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6646122 |
Ligand and complex for catalytically bleaching a substrate
The invention relates to ligands or complexes useful as catalysts for catalytically bleaching substrates with atmospheric oxygen, and as catalysts in the of treatment of textiles such as laundry...
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6641797 |
Perfluoroalkyl-containing complexes with sugar radicals, process for their production and their use
Perfluoroalkyl-containing complexes with sugar radicals of general formula I in which R represents a monosaccharide or oligosaccharide radical that is bonded via the 1-OH position or 1-SH...
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6576760 |
Processes for synthesis of cyclic and linear polyamine chelators containing N-monosubstituted coordinating arms
Polyamines containing at least two nitrogen atoms monosubstituted with pendant arms capable of coordinating metal cations, or with precursors of such pendant arms, all nitrogen atoms of the...
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