|
Match
|
Document |
Document Title |
|
|
7611888 |
Rotaxane compound, rotaxane-bonded solid substrate, and biochip using the same
The present disclosure provides a rotaxane compound that can be used to separate molecules within a linkage layer formed on a solid substrate of a biochip by a predetermined distance. The compound...
|
|
|
7592331 |
Macrocyclic factor VIIa inhibitors useful as anticoagulants
The present invention relates generally to novel macrocycles of Formula (I):
or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates, or prodrugs thereof, wherein the variables...
|
|
|
7544798 |
Process for preparing macrocyclic compounds
Disclosed is a multi-step process for preparing a macrocyclic compound of the formula (I):
wherein Q is a radical of the following formula:
and the other variables are as defined herein....
|
|
|
7517882 |
Protein kinase inhibitors
Pyrimidine- and triazine-based chemical compounds that are useful, for example, as protein kinase inhibitors for treating cancer, neurological disorders, autoimmune disorders, and other diseases,...
|
|
|
7507726 |
Peptide deformylase inhibitors
Novel PDF inhibitors and novel methods for their use are provided.
|
|
|
7446102 |
Antibacterial amide macrocycles IV
The invention relates to antibacterial amide macrocycles and processes for their preparation, their use for the treatment and/or prophylaxis of diseases and their use for the manufacture of...
|
|
|
7442558 |
Phthalamide-lanthanide complexes for use as luminescent markers
The present invention provides luminescent lanthanide metal chelates comprising a metal ion of the lanthanide series and a complexing agent comprising at least one phthalamidyl moiety. Also...
|
|
|
7432371 |
Nanofilm and membrane compositions
Nanofilms useful for filtration are prepared from oriented amphiphilic molecules and oriented macrocyclic modules. The amphiphilic species may be oriented on an interface or surface. The nanofilm...
|
|
|
7432088 |
Methods for the production of ansamitocins
A process of the large-scale fermentation of a highly productive ansamitocin-producing strains. A method for isolating crude ansamitocins. A method for purifying ansamitocins.
|
|
|
7429565 |
Antiviral phosphonate analogs
The invention is related to phosphorus substituted compounds with antiviral activity, compositions containing such compounds, and therapeutic methods that include the administration of such...
|
|
|
7404912 |
Salicylamide-lanthanide complexes for use as luminescent markers
The present invention provides luminescent lanthanide metal chelates comprising a metal ion of the lanthanide series and a complexing agent comprising at least one salicylamidyl moiety. Also...
|
|
|
7378411 |
Substituted thienopyrimidinones as a mitotic kinesin inhibitor
The present invention relates to thienopyrimidinone compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for...
|
|
|
7358239 |
Pyrrolidinyl, piperidinyl or homopiperidinyl substituted (benzodioxan, benzofuran or benzopyran) derivatives
The present invention concerns compounds of formula (I)
a stereochemically isomeric form thereof, an N-oxide form thereof or a pharmaceutically acceptable acid addition salt thereof, wherein -Z...
|
|
|
7354922 |
Bridged ring NK1 antagonists
A compound having the general structure shown in Formula (I):
or pharmaceutically acceptable salts and/or solvates thereof are useful in treating diseases or conditions mediated by NK 1 ...
|
|
|
7312225 |
Macrocyclic pyrimidines, their production and use as pharmaceutical agents
Macrocyclic pyrimidine derivatives of general formula I
in which R 1 to R 5 , X, Y, A, B, m and n have the meanings that are contained in the description, as inhibitors of the cyclin-dependent...
|
|
|
7279582 |
Retroviral protease inhibiting compounds
A compound of the formula:
is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.
|
|
|
7268211 |
Removal of ruthenium by-product by supercritical fluid processing
A process for removing ruthenium or ruthenium-containing compounds from a reaction mixture comprising a compound of the following formula I in an organic solvent using supercritical fluid...
|
|
|
7262187 |
Substituted oxazolo- and thizaolopyrimidinones as a mitotic kinesin inhibitor
The present invention relates to azolopyrimidinone compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for...
|
|
|
7262186 |
Substituted pyrazolo[3,4-d] pyrimidinones as a mitotic kinesin inhibitor
The present invention relates to azolopyriniidinone compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for...
|
|
|
7253160 |
Depeptidized inhibitors of hepatitis C virus NS3 protease
The present invention discloses novel depeptidized compounds which have HCV protease inhibitory activity as well as pharmaceutical compositions comprising such compounds and methods of using them...
|
|
|
7244723 |
Substituted furopyrimidinones as a mitotic kinesin inhibitors
The present invention relates to furanopyrimidinone compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for...
|
|
|
7230021 |
Potent, simplified derivatives of pateamine A
The present invention provides a compound of Formula I, all of its related stereoisomers, and their pharmaceutically acceptable salts, wherein A—B, K, Q, X, Y, Z, R and R1 are as defined in Claim...
|
|
|
7211572 |
Nitrogen-containing fused ring compound and use thereof as HIV integrase inhibitor
The present invention relates to a nitrogen-containing fused ring compound represented by the following formula [I]
wherein each symbol is as defined in the specification, or a pharmaceutically...
|
|
|
7208595 |
Peptide deformylase inhibitors as novel antibiotics
A macrocyclic peptide deformylase (PDF) inhibitor comprising a peptide or peptide mimetic having three residues, P1′, P2′, and P3′, wherein P2′ connects P1′ and P3′, wherein P1′ and...
|
|
|
7192949 |
Substituted bicyclic pyrimidinones as a mitotic kinesin KSP inhibitors
The present invention relates to cycloalkylpyrimidinone compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for...
|
|
|
7192750 |
Mutant Actinosynnema pretiosum strain with increased maytansinoid production
A microorganism that is a mutant bacterial strain of the species Actinosynnema pretiosum , designated PF4-4, (ATCC PTA-3921), being capable of producing maytansinoid ansamitocins such as...
|
|
|
7189844 |
Ring-closing metathesis process in supercritical fluid
Disclosed is a process for preparing a compound of formula I comprising cyclizing a diene compound of formula III in the presence of a ruthenium catalyst in a suitable organic solvent, wherein the...
|
|
|
7183374 |
Method of removing transition metals
A process for diminishing the concentration of a metal complex from a solution containing said complex by the addition of an optionally fused and/or optionally substituted heterocyclic compound....
|
|
|
7179908 |
Water-and organic-soluble cucurbituril derivatives, their preparation methods, their separation methods and uses
Provided are cucurbituril derivatives having the formula (1), their preparation methods and uses:
where X is O, S or NH; R 1 and R 2 are each independently selected from the group consisting...
|
|
|
7163935 |
Scorpionate-like pendant macrocyclic ligands, complexes and compositions thereof, and methods of using same
Substituted 1,4,7-triazacyclononane-N,N′,N″-triacetic acid compounds with a pendant donor amino group, metal complexes thereof, compositions thereof, and methods of use in diagnostic imaging...
|
|
|
7160466 |
Uses of cucurbituril devices
Uses of cucurbituril derivatives are disclosed. The cucurbituril derivatives have the formula (1)
where X is O, S or NH; R 1 and R 2 are independently selected from the group consisting of...
|
|
|
7151096 |
Cyclic compounds and compositions as protein kinase inhibitors
The invention provides a novel class of cyclic compounds, pharmaceutical compositions comprising such cyclic compounds and methods of using such compounds to treat or prevent diseases and disorders...
|
|
|
7148347 |
Process for preparing macrocyclic compounds
Disclosed is a process for preparing a macrocyclic compound of the formula (I):
which is carried out using an intermediate of the formula (II):
wherein W, R 1 through R 4 , D, A and R 12 ...
|
|
|
7081452 |
Scorpionate-like pendant macrocyclic ligands, complexes and compositions thereof, and methods of using same
Substituted 1,4,7-triazacyclononane-N,N′,N″-triacetic acid compounds with a pendant donor amino group, metal complexes thereof, compositions thereof, and methods of use in diagnostic imaging...
|
|
|
7064119 |
Fused bicyclic pyrimidine derivatives
A novel fused bicyclic pyrimidine derivative or a salt thereof that acts as a tachykinin receptor antagonist and, in particular, as an NK1 receptor antagonist is represented by the following...
|
|
|
7060290 |
Phosphocholine linked prodrug derivatives
Disclosed are compounds of general formula (I) that function as prodrugs, thereby increasing bioavailabilities of the linked therapeutic agents, wherein the LINKER is (i) substituted or...
|
|
|
7056912 |
Heteroaryl derivatives and their use as medicaments
The invention relates to novel quinoline derivatives of the formula 1, to their preparation and to their use as medicaments, in particular for treating tumors.
|
|
|
7018850 |
Salicylamide-lanthanide complexes for use as luminescent markers
The present invention provides luminescent lanthanide metal chelates comprising a metal ion of the lanthanide series and a complexing agent comprising at least one salicylamidyl moiety. Also...
|
|
|
6992184 |
Macrocyclic tetraamido ligands as bleaching catalysts and synthesis thereof
The invention relates to a novel synthetic route for a group of ligands and to an improved catalyst containing the ligand. The invention also provides use of a ligand for inhibiting dye transfer.
|
|
|
6984734 |
Cyclo[n]pyrroles and methods thereto
The present invention provides an oxidative coupling procedure that allows efficient synthesis of novel cyclo[n]pyrrole macrocycles. Therefore, the present invention provides cyclo[n]pyrroles where...
|
|
|
6962690 |
Tissue specific fluorescent chelates possessing long wavelength UV excitation
Fluorescent chelates of lanthanide, terbium, europium and dysprosium with tetraazamacrocyclic compounds are discussed which can be used as fluorescent in vitro or in vivo diagnostic agents. These...
|
|
|
6946459 |
CRYSTALLINE FORMS OF 1S-[1ALPHA(2S*,3R*), 9ALPHA]6, 10-DIOXO-N-(2-ETHOXY-5-OXO-TETRAHYDRO-3-FURANYL)-9[[(1-ISOQUINOLYL) CARBONYL]AMINO]OCTAHYDRO-6H-PIRIDAZINO[1,2-A][1,2]DIAZEPIN-1-CARBOXAMIDE
Two new crystalline forms of 1S-[1alpha(2S*, 3R*), 9alpha]6, 10-dioxo-N-(2-ethoxy-5-oxo-tetrahydro-3-furany1)-9 [[(1-isoquinolyl) carbony1]amino]octahydro-6H-pyridazino...
|
|
|
6943157 |
Reverse-turn mimetics and composition and methods relating thereto
Conformationally constrained compounds that mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins having the following structure are disclosed:
...
|
|
|
6924305 |
Diazocine derivatives and their use as tryptase inhibitors
Compounds of the formula I, in which B1, B2, R1, R2, R6, R7, K1 and K2 are as defined in the description are novel effective tryp-tase inhibitors.
|
|
|
6916805 |
Quinoxalinones as serine protease inhibitors
This invention discloses quinoxalinones which display inhibitory effects on serine proteases such as factor Xa, thrombin, and/or factor VIIa. The invention also discloses pharmaceutically...
|
|
|
6900222 |
Pyrrolidinyl, piperdinyl or homopiperidinyl substituted (benzodioxan, benzofuran or benzopyran) derivatives
The present invention concerns compounds of formula (I)
a stereochemically isomeric form thereof, an N-oxide form thereof or a pharmaceutically acceptable acid addition salt thereon wherein...
|
|
|
6867208 |
Vitronectin receptor antagonists, their preparation and their use
The present invention relates to compounds of the formula I
A—B—D—E—F—G (I)
|
|
|
6818764 |
Process for preparing substance GM-95
A method of manufacturing substance GM-95 having general formula [I], comprising (a) deprotecting a macrocyclic compound having general formula [II] (wherein, R 1 's are the same or different and...
|
|
|
6793839 |
Cucurbiturils and method for synthesis
A method for producing cucurbit[n]urils, where n is from 4 to 12, comprising mixing substituted and/or unsubstituted glycoluril with an acid and a compound that can form methylene bridges between...
|
|
|
6680311 |
Cryptophycin compounds
The present invention provides cryptophycin compounds of Formula I that are useful in the treatment of neoplasms.
|