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8105504 |
Stabilization of organic materials
Organic materials which possess outstanding stability to oxidative, thermal or light-induced degradation comprise as stabilizers at least one compound of the formula (I) wherein the general symbols...
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8030482 |
Free cholesterol analogs bearing a boron dipyrromethene difluoro (BODIPY) fluorophore in the side chain and method of preparation and use thereof
The present invention relates to free cholesterol analogs bearing a boron dipyrromethene difluoro (BODIPY) fluorophore in the side chain and methods of preparation. The compounds of the present...
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7635792 |
2,5-linked polyfluorenes for optoelectronic devices
Polyfluorene polymers and copolymers having substantial amounts (10-100%) of fluorenes coupled at the 2 and 5 positions of fluorene are useful as active layers in OLED devices where triplet...
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6620801 |
17β-amino and hydroxylamino-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties
The invention is directed to a novel class of steroids which exhibit potent antiprogestational activity.
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6489081 |
Organosilyl radical generators and their applications
Compounds of formula I wherein R1, R2, and R3 independently of one another are hydrogen; C1-C20alkyl which is unsubstituted or substituted by OH, C1-C4alkoxy, C1-C4alkylthio, phenylthio, F, Cl, Br,...
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6133280 |
Androgen synthesis inhibitors
This invention relates to novel inhibitors of androgen synthesis that are useful in the treatment of prostate cancer and benign prostatic hypertrophy. The present invention also provides methods of...
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5808059 |
Matrix-supported sapphyrins
The invention relates to the field of polymer- and other matrix-supported sapphyrins. Disclosed are silica gel, glass, resin and other polymer- and matrix-supported sapphyrins and...
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5792758 |
Steroid nitrite ester derivatives useful as anti-inflammatory drugs
The present invention discloses novel steroid nitrite ester derivatives, and to their use treating inflammatory diseases.
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5756722 |
Intermediates for the preparation of Δ4,9(11),17(20) -pregnatriene-3-ones
The novel intermediates of the formula ##STR1## wherein L, K and M are as defined in the specification which are useful intermediates for the preparation of Δ4,9(11),16 -pregnatriene-3-ones.
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5741795 |
16-substituted-6-aza-androsten-4-ene-3-ones as 5-α-reductase inhibitors
Compounds of the formula I ##STR1## are inhibitors of 5α-reductase, and are useful for the treatment of hyperandrogenic disorders such as acne vulgaris, seborrhea, female hirsutism, male pattern ...
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5641767 |
Modified bile acids process for their preparation and their use
The invention relates to linker-modified bile acid derivatives of the formula I: ##STR1## wherein the radicals X1, X2, X3 and Y and n are as defined in the claims, and to a process for their...
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5401864 |
Process for preparing 21 acyloxy-Δ4,9(11),16 pregnatrienes 3-20-dione
A process for the preparation of a compound of the formula ##STR1## wherein R1 is acyl of 1 to 8 carbon atoms, by reducing an intermediary to form an alcohol, oxidizing the alcohol to form an...
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5359055 |
Pregnane derivatives and processes for production thereof
There are provided pregnane derivatives represented by formula ##STR1## wherein A1 represents a hydrogen atom or a hydroxyl group, A2 represents a substituent such as a hydroxyl group when A1...
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5359054 |
Initial compounds for the production of 10β-H-steroids and a process for the production of these initial compounds
The invention includes compounds of the following formula ##STR1## where A and B either A and B form an additional double bond and D is a hydrogen atom or B and D form an additional double bond and...
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5352781 |
Process for precursors to calcitriol and related compounds
The process of the invention comprises reacting a C-22-halo-23,24-bisnorsteroid or C-22-halo-23,24-bisnor-9,10-secosteroid with a nickel complex of an electron withdrawing alkene of the formula...
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5336686 |
17 Methylene lactones of steroids
A compound selected from the group consisting of a compound of the formula ##STR1## wherein the substituents are defined as in the application having antiglucocorticoid and antiprogestomimetic...
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5232915 |
9α-hydroxy-19,11β-bridged steroids, their production and pharmaceutical preparations containing these steroids
9α-Hydroxy-19,11β-bridged steroids of general formula I ##STR1## are described. The more detailed meaning of A, B, R1, R2, G, Z, R4 --Y and R4' --Y' follows from the description. The steroids of g...
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5218109 |
Steroid compounds
Steroid compounds of the following general formulas (I), (II) and (III) are provided: ##STR1## In the above formulas, R1 and R2 each is a hydrogen atom or a hydroxyl-protecting group, R is a group...
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5187273 |
Δ4,9(11),17(20) -pregnatriene-3-ones
A compound of the formula ##STR1## wherein Hal is chlorine or bromine, R is selected from the group consisting of alkyl of 1 to 6 carbon atoms, aralkyl of 7 to 15 carbon atoms and a silylated...
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5182381 |
Intermediates for 3-keto-19-nor-Δ4,9 -steroids
Novel 3-keto-19-nor-Δ4,9 -steroids of the formula ##STR1## and their non-toxic, pharmaceutically acceptable acid addition salts possessing a remarkable antiglucocorticoidal activity.
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5144032 |
Preparation of tertiary amine borane adducts
An improved curing agent for use in coatings, laminates, moldings, castings and adhesives comprising the use of an amine-boron adduct component along with anhydride and epoxy component mixtures....
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5010202 |
Novel silicon-organic compounds, containing an oxazolidine group
Novel silicon-organic compounds containing an oxazolidine group are defined by the general formula (I): ##STR1## wherein R1, R2, R3, R4, R5, X, n and y have the meanings reported in the...
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4977255 |
Steroidal 17α-silyl ethers and process to corticoids and progesterones
17β-Cyano-17α-hydroxy steroids (I) are transformed to 17α-halo silyl ethers (II) which are intermediates useful in the production of progesterones (V), 17-hydroxyprogesterones (VI), corticoids (V...
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4977291 |
Process of producing a silanic or siloxanic compound containing at least one cycloalkyl ring
A process of producing a silanic or siloxanic compound containing at least one cycloalkyl ring by the hydrogenation of a corresponding compound containing at least one aromatic ring, in the...
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4975536 |
Conversion of a delta16-steroid to a delta17(20)-20-silyl ether
The present invention is a process for conversion of Δ16 -steroids (I) ##STR1## to the corresponding Δ17(20) -20-silyl ether (III) ##STR2## by reaction with (1) a preformed copper hydride or a m...
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4954414 |
Photosensitive composition containing a transition metal coordination complex cation and a borate anion and photosensitive materials employing the same
A composition including a cationic transition metal coordination complex and a borate anion, wherein said composition is capable of absorbing actinic radiation and producing free radicals which can...
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4921638 |
17β-cyano-9α,17α-dihydroxyandrost-4-en-3-one
The invention is the compound 17β-cyano-9α, 17α-dihydroxyandrost-4-en-3-one (I) which is particularly useful as an intermediate in the production of the 17α-halo silyl ethers (II).
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4912097 |
Novel 11 β-alkynylphenyl-10-nor-steroids
Novel 11β-alkynylphenyl-19-nor-steroids of the formula ##STR1## wherein R1 is alkynyl of 2 to 8 carbon atoms optionally substituted with at least one member of the group consisting of --OH ...
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4898694 |
17-Hydroxy-steroids
Compounds of the formulae: ##STR1## are useful as anti-cancer, anti-obesity, anti-diabetic, anti-coronary agents, anti-aging agents, anti-hypolipidemic agents and anti-autoimmune agents.
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4891426 |
16α-methyl-17α 20-epoxysteroid and process
C16 -unsaturated corticoids are readily transformed to the corresponding 16α-methyl-17α-hydroxy corticoids by use of a Δ17(20)-20-silyl ether.
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4758383 |
Ergosta-1,5,7,22-tetraen-3β-ol and its use as an intermediate for 1α-hydroxy vitamin D2
New processes for preparing new steroid derivatives including ergosta-1,5,7,22-tetraen-3β-ol, 1α-hydroxyergosteryl diacetate, etc. which are useful intermediates in the synthesis of 1α-hydroxy vi...
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4634695 |
Steroid derivatives
Novel 19-nor steroids and 19-nor-D-homo-steroids of the formula ##STR1## wherein R1 is an organic radical of 1 to 18 carbon atoms containing at least one atom selected from the group consisting of...
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4614616 |
Process for preparing 3β7β-dihydroxy-Δ5 -steroids
A process for preparing a 3β,7β-dihydroxy-Δ5 -steroid of the formula ##STR1## wherein Q is ##STR2## and R1 is hydrogen, trimethylacetyl, tert-butyldimethylsilyl, dimethyl-2-(3-methylbutyl)silyl or...
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4599330 |
Method of treating milk fever
The present invention relates to a method of preventing milk fever which comprises administering to a preparturient female ruminant an effective amount of...
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4568492 |
Δ16-20-Keto steroid conversion to 17α-hydroxy-20-keto steroids
Δ16-20-keto steroids (I) are converted to 17α-hydroxy-20-keto steroids (III) in 2 steps, hydrosilylation followed by peracid oxidation.
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4550163 |
Ligand analog-irreversible enzyme inhibitor conjugates
The present invention encompasses a method for determining ligands in test samples comprising intermixing with the test sample a ligand analog-irreversible enzyme inhibitor conjugate and a binding...
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4548748 |
Cyanohydrin process
Using cyanohydrin intermediates, 17-keto steroids are transformed to corticoids and 17α-acyl progesterones.
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4519946 |
Steroids
Novel 19-nor steroids and 19-nor-D-homo-steroids of the formula ##STR1## wherein R1 is an organic radical of 1 to 18 carbons atoms containing at least one atom selected from the group consisting of...
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4447424 |
Steroid derivatives
Novel 19-nor steroids and 19-nor-D-homo-steroids of the formula ##STR1## wherein R1 is an organic radical of 1 to 18 carbon atoms containing at least one atom selected from the group consisting of...
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4421690 |
Process for the preparation of 24,24-difluoro-1α,25-dihydroxy vitamin D3 and intermediates obtained therefrom
The present invention relates to a process and intermediates for the preparation of 24,24-difluoro-1α,25-dihydroxycholecalciferol from the readily-available 1α,3β-dihydroxyandrost-5-en-17-one wh...
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4407753 |
8α-Oestra-1,3,5(10)-triene derivatives, processes for their preparation and pharmaceutical compositions
The invention relates to new 8α-oestra-1,3,5(10)-triene derivatives having the formula: ##STR1## in which R1 =H or a free, esterified or etherified hydroxy group; R2 =H or a free, esterified or ...
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4401596 |
Novel 17-oxazoline-steroids
Novel 17-oxazoline-steroids of the formula ##STR1## wherein R1 is selected from the group consisting of hydrogen, alkyl of 1 to 4 carbon atoms optionally substituted with a member of the group...
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4336193 |
Process for preparing vitamin D-lactones
The invention provides methods for preparing the various isomeric forms of 25-hydroxyvitamin D3 -26,23-lactone utilizing cyanohydrin formation with readily prepared steroid materials followed by...
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4322349 |
Process for preparing 6-methylene steroids
A process for preparing a 6-methylene-Δ4 -3-keto steroid of the formula ##STR1## wherein R is hydrogen, alkoxy of up to 6 carbon atoms or acyloxy of up to 6 carbon atoms wherein the acyl group is ...
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4287129 |
Synthesis of 1α-hydroxy-7-dehydrosteroids
Enol acetylation is carried out on a variety of 1,4,6-trien-3-ones to form 1,3,5,7 tetraene structures from which 1α-hydroxy-7-dehydro steroids are obtained.The compounds are intermediates used in ...
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4272530 |
Δ1,3,5(10) -Estratrienes
Novel 11β -substituted-Δ 1,3,5(10) -estratrienes of the formula ##STR1## wherein R1 is selected from the group consisting of optionally substituted unsaturated alkyl of 2 to 8 carbon atoms, o...
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4243608 |
3-(4-Hydroxyphenyl)pentanedioic acid, monohydrazide, derivatives and analogs
Compounds having the formula ##STR1## and acid-addition salts thereof, wherein R is hydrogen or alkyl of 1 to 3 carbon atoms and n is 0,1,2,3 or 4 are useful reagents for derivatizing organic...
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4239681 |
Androst-4-en-19-ols
Derivatives of androst-4-en-19-ol are useful for enhancing libido and related psychic attitudes.
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4233296 |
11β-Substituted-Δ4,9 -estradienes
Novel steroids of the formula ##STR1## wherein R1 is linear or branched alkyl of 1 to 12 carbon atoms, unsaturated alkyl of 2 to 8 carbon atoms optionally substituted, optionally substituted aryl...
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4222940 |
Cyclization substrates, cyclization process and related 11β-axially-substituted steroids
There are disclosed substrates of the formula: ##STR1## wherein: (a) R1 is H or C1 -C4 alkyl; (b) R2 is H or C1 -C4 alkyl with the proviso that R1 is H when R2 is alkyl, and with the proviso that...
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