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7534781 |
Crystalline amoxicillin trihydrate powder
The invention relates to crystalline amoxicillin trihydrate powder having a bulk density higher than 0.45 g/ml. The invention also relates to a process for preparing crystalline amoxicillin...
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6103897 |
Production of a crystalline salt of amoxicillin
A process for the production of a crystalline salt of amoxicillin utilizing ethanol as a solvent, and crystallizing the salt of amoxicillin in the presence of a salifying compound.
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6013647 |
Benzoxazinedione derivatives, method of producing them and uses thereof
This invention relates to new benzoxazinedione derivatives corresponding to the formula I: ##STR1## wherein R 1 =H or carboxyalkyl, R 2 =H, alkyl or phenyl, and R 3 represents different acid...
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5599987 |
Integrated process for cyclohexanone oxime production
An integrated process for producing cyclohexanone oxime, a caprolactam precursor, is provided wherein isopropanol is utilized to generate the hydrogen peroxide oxidizing agent. The acetone produced...
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5451701 |
Integrated process for cyclohexanone oxime production
An integrated process for producing cyclohexanone oxime, a caprolactam precursor, is provided wherein a secondary alcohol is utilized to generate the hydrogen peroxide oxidizing agent and as a...
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4918067 |
Heterocyclic substituted penicillin antibiotics
The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt or in-vivo hydrolysable ester thereof: ##STR1## wherein R 1 is a 5 or 6 membered sulphur and/or...
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4877783 |
β-lactam antibacterial agents
β-Lactam antibiotics having an α-formamido substituent on the carbon atom adjacent to the carbonyl group of the β-lactam ring and in particular bicyclic compounds having the partial structure:...
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4866170 |
Stable hydrate of penicillin derivative
A stable trihydrate of (2S, 5R, 6R)-6-{(2R)-2-[(2R)-2-amino-3-(N-methylcarbamoyl)propionamid
o]-2-(p-hydrox yphenyl)acetamido}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.
2.0]heptane-2-c arboxylic...
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4801704 |
Methylene penam and derivatives thereof
There are presented compounds of the formula ##STR1## wherein R 2 , R 3 , R 4 and m are as described herein.
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4769325 |
2-(Allenyl)penicillins
2-(Allenyl)penicillins antibiotics and intermediates thereto are disclosed. A process for making the 2-(allenyl)penicillins and the starting materials for the process are also disclosed.
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4555363 |
Process for the preparation of β-lactam compounds
A process for the preparation of a β-lactam having the partial structure (I): ##STR1## wherein R 1 is an acyl group, which process comprises treating an imine having the partial structure (II):...
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4540689 |
Penicillin derivative
A penicillin derivative having an antibacterial activity similar to a penicillin antibiotic in a living body without affecting the intestinal bacterial colonies, a process for preparing the...
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4524073 |
β-Lactam compounds
A compound of formula (I) or a pharmaceutically acceptable salt or in vivo hydrolysable ester thereof: ##STR1## wherein R represents an alkyl or aralkyl group, substituted on an alkyl carbon atom...
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4481209 |
Penicillin salt
Ampicillin phthalidyl ester naphthalene-2-sulphonate, its preparation, and its use in pharmaceutical compositions to treat infections.
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4444686 |
Crystalline penicillin ester intermediate
Crystalline chloromethyl 6-(alpha-1-methoxycarbonylpropen-2-ylaminophenylacetamido)pe
nicillanate as an intermediate to antibacterial agents.
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4434173 |
Bis-esters of 4,5-di(hydroxymethyl)-2-oxo-1,3-dioxole as antibacterial agents
Derivatives of 4,5-di(hydroxymethyl)-2-oxo-1,3-dioxole in which one hydroxy group has been esterified through the carboxy group of ampicillin or amoxicillin, and the other hydroxy group has been...
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4386089 |
β-Lactam antibiotics and their medicinal use
β-Lactam compounds of the formula ##STR1## in which B denotes an optionally substituted heterocyclic 5-membered or 6-membered ring or an optionally substituted phenyl ring, Z denotes a hydrogen...
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4377590 |
Derivatives of ampicillin and amoxicillin with beta-lactamase inhibitors
Certain beta-lactamase inhibitors which have a beta-lactam ring as well as a carboxy group have been linked through their carboxy group to either the amino group of ampicillin, the amino group of...
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4376767 |
Pyridylmethyl esters of selected bio-affecting carboxylic acids
Novel pharmaceutically useful derivatives of selected known bio-affecting carboxylic acids are disclosed, said derivatives having the structural formula ##STR1## wherein R 1 and R 2 , which can be...
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4344955 |
Penicillin 1,1-dioxides
Anti-bacterially active penicillin 1,1-dioxides of the formula ##STR1## or a salt thereof, in which R 1 denotes a hydrogen atom or an ester-forming radical, R 2 denotes a hydrogen atom or...
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4318852 |
Sodium amoxicillin solvate
The solvate of sodium amoxicillin and N-methyl-2-pyrrolidone and its preparation which is a stable antibiotic from which injectable solutions may be prepared.
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4317775 |
Amoxicillin derivatives
The compound 6-[D(-)alpha-amino-phenylacetamido]penicillanic acid and salts or hydrates thereof wherein the amino group is substituted with a 5 to 6-membered heterocyclic ring, useful as...
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4255330 |
Process for preparing 6-substituted amino-2-substituted-pen-2-em-3-carboxylic acid
Disclosed are 6-substituted amino-2-substituted-pen-2-em-3-carboxylic acids of the following structure: ##STR1## wherein R 1 is hydrogen or acyl, R 2 is hydrogen or methoxyl, and R 3 is, inter...
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4244885 |
α-Substituted-3-(halomethyl)-4-hydroxybenzeneacetic acids
α-Substituted-3-(halomethyl)-4-hydroxybenzeneacetic acids, prepared by the halomethylation of α-substituted-4-hydroxybenzeneacetic acids are new and useful as starting materials for the...
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4241062 |
Antibacterial penicillins
This invention relates to a new class of penicillins (I) and their pharmaceutically acceptable salts and esters which are useful as antibiotics: ##STR1## wherein the stylized radical (hereafter...
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4231927 |
Hydrazono penicillin derivatives
Hydrazono penicillin derivatives of the formula ##STR1## wherein R represents phenyl optionally substituted, 2- or 3- thienyl optionally substituted, or 2- or 3-furyl optionally substituted, R 1 ...
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4197240 |
Penicillin derivatives
New 7-[4-hydroxy-3-(substitutedmethyl)phenyl]acetamido penicillin derivatives are prepared which are useful as antibiotics.
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4162314 |
7[2(Substituted phenyl)2-(amino)acetamido]cephalosporin derivatives
Novel β-lactam antibiotics are compounds of the formula: ##STR1## wherein R is alkyl of up to 6 carbon atoms or, when A is oxygen, R is hydrogen; A is oxygen or --OCO--; Z is ##STR2## R 1 is...
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RE29650 |
Phthalide penicillin ester intermediates
The Phthalide ester of 6-[(D(-)α-aminophenylacetamido] penicillanic acid and intermediates therefor are described . The phthalide penicillin ester is orally administrable to provide high serum...
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4062842 |
Method for preparing 7-substituted cephalosporins and 6-substituted penicillins by replacement of sulfur-containing groups
Disclosed is a method for replacing 7-lower alkylthio and 7-arylthio groups from cephalosporins with lower alkanoyloxy,lower alkoxy, aryloxy, aroyloxy, amino, lower alkylamino and azido moieties,...
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4053360 |
Enzymatic preparation of 6-D-(-)-α-amino-α-(p-hydroxyphenylacetamino)penicillin acid
This invention relates to a novel α-aminoα-(p-acyloxyphenyl)acetamidopenicillanic acid which is useful as an antibacterial agent, and also to a novel process for the production of...
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4036829 |
Lactonyl esters of penicillins
Lactonyl esters of Penicillins of the formula ##STR1## WHEREIN R 1 is an antibacterially active penicillin-completing side chain; R is hydrogen, methyl or phenyl; and Ra, Rb, Rc, Rd are hydrogen,...
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4035359 |
6α, β-Substituted penicillin derivatives
Novel 6-methoxy and 6-thioalkyl-6-acylamido-penicillanic acids and their non-toxic pharmaceutically-acceptable salts, esters and amides which are useful as antibiotics. The products are prepared by...
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4035354 |
Thioamides of beta-lactam antibiotics
The invention relates to compounds of the formula: ##STR1## wherein R stands for Benzyl, Phenoxymethyl, 4-amino-4-carboxy-1-butyl, R 3 o--, r 3 s--, r 3 r 4 n-- wherein R 3 is...
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4031076 |
Methampicillin lysinate and its method of manufacturing
Water soluble Methampicillin Lysinate is disclosed along with a method of making the compound. The compound of the invention has superior stability and, because of its greater solubility, has a...
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4029806 |
Nitro-β-lactam antibiotics and processes for their preparation and use
Penicillin and cephalosporin derivatives characterized by the presence of a nitroalkyl, nitrocycloalkyl, nitrophenylalkyl or nitroanilinoalkyl group in the side chain are antibacterial agents. The...
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4008226 |
Intermediates for preparing semi-synthetic cephalosporins and processes relating thereto
Phosphorylated penicillins and cephalsporins are described which are obtained by reacting a penicillin or cephalosporin with a trivalent or pentavalent phosphorus halide and treating the thus...
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4005214 |
Water-soluble amoxicillin salts
Choline and N-methyl-D-glucamine salts of amoxicillin, processes for their preparation and pharmaceutical compositions containing the salts as the active antibacterial component are disclosed.
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3994875 |
Antibiotics
Novel cephalosporin and penicillin antibiotic derivatives.
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3991046 |
Penicillin antibiotics
The invention provides novel antibiotic compounds which are 6β-acylamidopenam-3-carboxylic acids and non-toxic derivatives thereof, characterized in that the acylamido group has the structure...
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3980793 |
Carbonate esters of penicillins and compositions and methods for treatment of bacterial infections
New carbonate esters of penicillins, having the formula ##EQU1## wherein R 1 is substituted or unsubstituted alkyl, alkenyl, aryl, aryloxy or heterocyclic group, R 2 is ##EQU2## in which formula...
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3975376 |
Pencillins having a 6β-(α-etherified oximino) acylamido group
The invention provides novel antibiotic compounds which are 6β-acylamidopenam-3-carboxylic acids, and nontoxic derivatives thereof, characterized in that the acylamido group has the structure...
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3971776 |
Thio-β-lactam penicillins
Thio-β-lactam penicillins of the general formula ##EQU1## wherein R is hydrogen, lower alkyl, phenyl-lower alkyl, trihaloethyl, alkali metal or alkaline earth metal; R 1 is hydrogen, lower alkyl,...
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3962228 |
3-Benzoylpropionamido cephalosporanic derivatives
The antibacterial agents of this invention present the following structural formula: ##SPC1## In which R 1 is --OH, alkoxycarbonyloxy of 2 to 6 carbon atoms, arylsulfonyl of 6 to 10 carbon...
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3948904 |
Isothiourea substituted cephalosporin derivatives
Novel cephalosporin and penicillin antibiotic derivatives.
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RE28744 |
Crystalline p-hydroxyampicillin and salts thereof
Derivatives of 6-Aminopenicillanic Acid possessing antibacterial activity are disclosed.
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3941774 |
Aminoalkyl esters of penicillins
Novel substituted amino methyl esters of penicillins and cephalosporins for oral administration which are much better absorbed than the parent compounds.
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3935202 |
3-(4-BIPHENYLYLCARBONYL)PROPIONAMIDO CEPHALOSPORIN DERIVATIVES
The antibacterial agents of this invention present the following structural formula: ##SPC1## In which A is a member selected from the group consisting of ##EQU1## M is a member selected from...
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3932385 |
Penicillins having a 6β-(α-etherified oximino) acylamido group
The invention provides novel antibiotic compounds which are 6β-acylamidopenam-3-carboxylic acids, and non-toxic derivatives thereof, characterized in that the acylamido group has the structure...
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3928325 |
Alpha-hydrazi nobenzylpenicillins
A new class of semisynthetic penicillins of the formula: ##EQU1## wherein R is H or a C 1 -C 6 alkyl group.
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