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7667056 |
Process and new intermediates for the preparation of steroids with a progestogen activity
The present invention relates to a new process of synthesis and to some new intermediates for the preparation of steroids with progestogen activity, more particularly, for the preparation of...
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6043235 |
11β-aryl-17, 17-spirothiolane-substituted steroids
The invention is directed to 11β-aryl-17,17-spirothiolane substituted steroid compounds of formula (I) exhibiting binding to the progestin receptor. ##STR1## Also disclosed are methods of using ...
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5003063 |
Conversion of steroidal 17-cyanohydrins to corticoids
The invention involves a two step chemical transformation of a steroidal 17-cyanohydrin (II) ##STR1## to a 17α-hydroxy-21-halo-20-keto steroid (IV) ##STR2## intermediate which can readily be ...
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4948533 |
11a-hydroxy steroid diester
The present invention relates to 21-(3-carboxy-1-oxopropoxy) -17α-hydroxy-11α-(3,3-dimethyl-1-oxobutoxy)pregna-1,4-dien
e-3, 20 dione and pharmaceutically acceptable salts thereof which are u...
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4912097 |
Novel 11 β-alkynylphenyl-10-nor-steroids
Novel 11β-alkynylphenyl-19-nor-steroids of the formula ##STR1## wherein R1 is alkynyl of 2 to 8 carbon atoms optionally substituted with at least one member of the group consisting of --OH ...
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4645763 |
6α-methyl corticoids, their production and use
6α-Methyl corticoids of formula I ##STR1## wherein is a single bond or a double bond, R is acyloxy of up to 8 carbon atoms, and X is chlorine, hydroxy, or acyloxy of up to 8 carbon atoms, are ...
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4602009 |
Corticoid derivatives and process for production thereof
Novel corticoid 17α-alkoxycarbonyl carboxylate derivatives are disclosed. These derivatives have strong topical anti-inflammatory activity and extremely weak systemic adverse reactions and are ...
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4587236 |
Novel 6α-methylprednisolone derivatives, their preparation, and their use
6α-Methylprednisolone derivatives of Formula I ##STR1## wherein R1 is 1-oxoalkyl of 2-6 carbon atoms or benzoyl and R2 is 1-oxoalkyl of 2-6 carbon atoms, are pharmacologically efficacious ...
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4567172 |
6α-Methylprednisolone derivatives
A 6α-methylprednisolone derivative of the general formula: ##STR1## wherein R1 is a hydrogen atom or stands for the grouping ##STR2## where R3 is a straight or once-branched chain C1-4 alkyl ...
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4511511 |
Prednisolone derivatives
Novel prednisolone derivatives modified at C-17,C-20 and/or C-21 positions. Many of the compounds are anti-inflammatory agents which do not significantly suppress the pituitary-adrenal axis.
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4390533 |
Steroids and process for preparing the same
The present invention relates to 2-chloro-6β-fluoro-pregna-1,4-diene-3,20-diones having good anti-inflammatory activity, to processes for their preparation and pharmaceutical compositions thereof.
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4340538 |
Process for producing 6α-fluoro-Δ1,4 -3-keto steroids
Two processes are disclosed (one-pot and two-pot) for the transformation of a 6β-fluoro-Δ1,4 -3-keto steroid (IV) to a 6α-fluoro-Δ1,4 -3-keto steroid (VI). These processes permit the int...
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4323564 |
Esters of 6-chloro-11β, 17α,21-trihydroxypregna-1,4,6-triene-3,20-dione
The 17-butyrate, 17-benzoate, 17,21-methyl orthobutyrate, 17,21-methyl orthobenzoate, and 17,21-dibutyrate esters of cloprednol (6-chloro-11β, 17α, 21-trihydroxy-pregna-1,4,6-triene-3,20-dione) a...
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4267173 |
Use of 6β-fluoro-7α-halogenocorticoids as topical anti-inflammatories and pharmaceutical formulations useful therefor
Described is the use of 6β-fluoro-7α-halogeno-1,4-pregnadiene-17α,21-diol-3,20-di
ones and their esters as topical anti-inflammatory agents, and pharmaceutical formulations thereof useful th...
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4242334 |
Corticoid 17-(alkyl carbonates) and processes for their preparation
What is disclosed is corticoid 17-(alkyl carbonates) of the formula ##STR1## as defined in the specification, which compounds can be used in veterinary therapy and human therapy, in the form of...
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4201778 |
6-Acyloxy-1,4,6-pregnatrienes, their use as anti-inflammatory agents, methods for their manufacture, and 6-oxo-1,4-pregnadiene intermediates
Novel 6-acyloxy-3,20-dioxo-1,4,6-pregnatrienes and 6-acyloxy-3,20-dioxo-4,6-pregnadienes, useful anti-inflammatory agents, are prepared by reaction of the corresponding...
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4181720 |
Corticosteroid antiinflammatory agents
22-Optionally substituted steroids of the corticoid series are prepared from the corresponding 21-methylene steroids through the 20,21-dione steroid intermediates. These compounds have utility as...
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4124707 |
7α-Halogeno-3,20-dioxo-1,4-pregnadienes, methods for their manufacture, their use as anti-inflammatory agents, and pharmaceutical formulations useful therefor
Novel 3,20-dioxo-7α-halogeno-1,4-pregnadienes are described and their use as anti-inflammatory agents. Preferred are 7α-bromo- and 7α-chloro- derivatives, particularly 7α-bromo- and 7α-...
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4113680 |
Method for preparing 17 α-ester-21-halo pregnanes
One-step method for preparing 17 α-ester-21-halo pregnanes by reacting 17 α, 21-cyclic orthoesters of 17 α, 21-dihydroxy pregnanes with a halo compound in the presence of an organic polar so...
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4069322 |
Pro-drugs for the improved delivery of certain selected anti-inflammatory steroids
Transient, pro-drug forms of conventional anti-inflammatory steroids are disclosed.
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4021459 |
Process for the preparation of 21-halogeno-21-desoxy-17α-acyloxy 20-keto-pregnenes
21-Halogeno-17α-acyloxy-20-keto-4-pregnenes having physiological properties are prepared by the reaction of a 17α,21-dihydroxy-20-keto-4-pregnene 17α,21-orthoester with a triphenylmethyl halide in...
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3992422 |
Process for the preparation of 21-halogeno-21-desoxy-17α-acyloxy-20-keto-pregnenes
21-Halogeno-17α-acyloxy-20-keto-4-pregnenes having physiological properties are prepared by the reaction of a 17α,21-dihydroxy-20-keto-4-pregnene 17α,21-orthoester with a halide reagent selected fr...
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3956349 |
Process for preparing 3-enol ethers of 11β-hydroxy-Δ4 -pregnene-3-ones and derivatives thereof
3-enol ethers of 11β-hydroxy-Δ4 -pregnene-3-ones are prepared by reacting triethylorthoacetate with an 11β-hydroxy-Δ4 -pregnene-3-one in a solvent which is at least 40% by weight or more eth...
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3933799 |
11β-Halo-9,12-unsubstituted-C19 -steroids
11β-Halo-9α,12-unsubstituted-C19 -steroids having hormonal activity and a process for preparing same by reacting the corresponding 11α-hydroxy steroid with a compound of the formula ##EQU1## wh...
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3900467 |
Process for the manufacture of β13-oxo-7α-acetylthio-17 βhydroxy 4-androstene-17αyl)-propionic acidγ-lactone
A process for preparing spironolactone, ##SPC1## By reacting certain 17-oxo steroids with certain organo-metallic propionaldehyde acetals, semi-thioacetals, or thioacetals to form the corresponding...
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3691214 |
17-VALERATE ESTER OF 6α,9α-DIFLUOROPREDNISOLONE, ITS COMPOSITIONS AND USE AS AN ANTI-INFLAMMATORY AGENT
This invention relates to the new 6α,9α-difluoroprednisolone 17-valerate and to pharmaceutical compositions for topical and systemic use of said compound in the treatment of inflammatory conditions.
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3665017 |
PROCESS FOR PREPARATION OF 6-AZIDO-4, 6-BIS-DEHYDRO-STEROIDS
6-Azido-4,6-bis-dehydro-steroids are prepared by treating a 6β-azido-7α-acyloxy-4-dehydro-steroid which is saturated at C-1 and C-2, with a tetraalkylammonium halide in an aprotic solvent. P...
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3621014 |
17α,21-ORTHOCARBONATES OF STEROID DERIVATIVES
The present invention relates to 17α,21-orthocarbonates of steroid ivatives. 5 Claims, No Drawings
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3641070 |
HALOGEN-PREGNADIENES
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3784603 |
6-AZIDO-21-OXYGENATED-STEROIDS OF THE PREGNANE SERIES,METHODS FOR THEIR MANUFACTURE AND INTERMEDIATES PRODUCED THEREBY
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3557160 |
1,2 - METHYLENE - 6,7 - DIFLUOROMETHYLENE AND 1,2,6,7 - BIS(DIFLUOROMETHYLENE) PREGNANES AND PROCESSES FOR THEIR PREPARATION
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3832366 |
PROCESS FOR PREPARING 21-CHLORO-17-ACYLOXY-20-KETOSTEROIDS
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3766223 |
DISTEROIDYL ETHERS
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3707537 |
4-CHLORO-4,6-DIENE-6-HALO OR LOWER ALKYL STEROIDS
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3580935 |
PROCESS FOR THE PREPARATION OF 3-ENOL ETHERS OF 3-KETO-DELTA**4 - 6-(N-DISUBSTITUTED) AMINOMETHYL STEROIDS
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3707484 |
PROCESS FOR THE PREPARATION OF 6-AZIDO-11BETA-HYDROXY-4,6-PREGNADIENES AND NOVEL INTERMEDIATES PRODUCED THEREBY
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3702848 |
PROCESS FOR THE CONVERSION OF 3-ENOL ETHERS OF 3-KETO-DELTA**4-STEROIDS UNSUBSTITUTED AT C4 AND C6 TO THE CORRESPONDING 3 - KETO - DELTA**4-6BETA - (N-DISUBSTITUTED)AMINOMETHYL COMPOUNDS
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3803182 |
DISTEROIDYL-ETHERS
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3828081 |
STEROIDYL-ESTRATRIENES
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3651049 |
17ALPHA 21 ALKENYLIDENE DIOXY DERIVATIVES OF PREGNANE AND PROCESS FOR PREPARATION THEREOF
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3845085 |
STEROIDS OF THE PREGNANE SERIES
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3438977 |
6,7-METHYLENE AND 6,7-HALOMETHYLENE PREGNANES AND 19-NORPREGNANES AND PROCESS FOR THEIR PREPARATION
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3423405 |
PREPARATION OF 1,3,5(10),9(11) STEROIDS AND NOVEL INTERMEDIATES THEREOF
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3422193 |
17-MONO ESTERS OF CORTICOIDS
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3409610 |
9alpha-difluoromethyl and 9alpha-trifluoromethyl pregnenes
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3376293 |
Fluoro steroids and methods of preparing the same
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3312590 |
Topically active anti-inflammatory 17-mono- and 17,21-diesters of betamethasone and its 9-chloro-analogs, compositions and use thereof
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3312591 |
Topical compositions of 17alpha,21-ortho esters of betamethasone having topical anti-inflammatory activity and their use
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3280159 |
Process for preparing 21-methyl-20-keto-17alpha, 21-dihydroxy steroids
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3228933 |
3-enol ethers of 6-methyl-3-oxo-deta4-steroids and process for preparing same
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