Patents in Class 540/327

Matches 1 - 50 out of 78

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Match	Document	Document Title
1	RE33778	1,3-dithietane-2-carboxylic acid penicillin and cephalosporin derivatives Substituted 1,3-dithietane-2-carboxylic acid derivatives useful as intermediates for the preparation of highly effective penicillin and cephalosporin derivatives and the preparation thereof.
2	4912211	Method for producing pure crystalline antibiotic products A process is described for producing pure crystalline products, in particular penicillin and cephalosporin, wherein the desired product, prepared according to a known method, is treated with...
3	4711956	Penicillin derivatives The invention relates to penicillin derivatives of Formula I, and a method of synthesis; the derivatives having high antimicrobial activity against gram-positive and gram-negative microorganisms....
4	4609652	Methods of using β-lactam antibacterial agents β-Lactam antibiotics having an α-formamido substituent on the carbon atom adjacent to the carbonyl group of the β-lactam ring and in particular bicyclic compounds having the partial structure: ##...
5	4555363	Process for the preparation of β-lactam compounds A process for the preparation of a β-lactam having the partial structure (I): ##STR1## wherein R1 is an acyl group, which process comprises treating an imine having the partial structure (II): ...
6	4517124	Process for preparing penem derivatives The present invention provides a process for the preparation of a compound of the formula (IV): ##STR1## or salt or ester thereof wherein R1 and R2 are independently hydrogen; an organic radical...
7	4410458	Process for providing an oxidized penam This invention relates to a process for preparing an oxidized penam derivative of the formula: ##STR1## wherein R1 represents an amino or protected amino radical, and R3 represents a radical...
8	4389407	1,3-Thiazolidin-4-yl-carboxylic acid derivatives and antibacterial compositions thereof New derivatives of 1,3-thiazolidin-4-yl carboxylic acid of the general formula I ##STR1## wherein: R represents hydrogen, (C1 -4)alkyl, aralkyl, phenyl, phenyl substituted by a halogen atom or a...
9	4381307	Soft tertiary amine esters of bio-affecting carboxylic acids Novel derivatives of known bio-affecting carboxylic acids R-COOH are disclosed, said derivatives having the structural formula ##STR1## wherein Y and Y' are each H or C1 -C4 alkyl; n is 0 or 1; R1...
10	4347183	Process for the synthesis of penems and carbapenems Described is a novel process for the preparation of penems and carbapenems useful as antibacterial agents which comprises the reaction of an appropriate 4-substituted-azetidine-2-one with an acid...
11	4344939	Penicillin 1,1-dioxides, compositions thereof and methods of use New penicillin 1,1-dioxides of the formula ##STR1## or a salt thereof, in which R1 denotes a hydrogen atom or an ester-forming radical, R2 denotes a hydrogen atom, R3 denotes a hydrogen atom, R4...
12	4344955	Penicillin 1,1-dioxides Anti-bacterially active penicillin 1,1-dioxides of the formula ##STR1## or a salt thereof, in which R1 denotes a hydrogen atom or an ester-forming radical, R2 denotes a hydrogen atom or optionally...
13	4255330	Process for preparing 6-substituted amino-2-substituted-pen-2-em-3-carboxylic acid Disclosed are 6-substituted amino-2-substituted-pen-2-em-3-carboxylic acids of the following structure: ##STR1## wherein R1 is hydrogen or acyl, R2 is hydrogen or methoxyl, and R3 is, inter alia,...
14	4230849	Process for the activation of carboxylic acids A process for the activation of carboxylic acids which is useful for the subsequent conversion of said carboxylic acids into their corresponding amides or esters, based on reacting a...
15	4217274	Methoxyethoxymethyl esters of penicillins β-Methoxyethoxymethyl esters of cephalosporins and penicillins are exemplified by such esters of hetacillin and heta-amoxicillin were synthesized and found to exhibit advantageous biological ...
16	4198339	1,3-Dithietane-2-carboxylic acids and the preparation thereof Substituted 1,3-dithietane-2-carboxylic acid derivatives useful as intermediates for the preparation of highly effective penicillin and cephalosporin derivatives and the preparation thereof.
17	4155905	6-Substituted penicillanic acid and derivatives thereof Disclosed herein are penicillanic acids and derivatives thereof which are substituted in the 6-position, processes for preparing such compounds and the utility thereof. The compounds of the...
18	4067993	Antimicrobial 2-nitro-3-phenylbenzofurancarboxylic acids Optionally substituted 2-nitro-3-phenylbenzofurancarboxylic acids which are active as antimicrobial agents, processes for their preparation and intermediates therefor are described.
19	4036829	Lactonyl esters of penicillins Lactonyl esters of Penicillins of the formula ##STR1## WHEREIN R1 is an antibacterially active penicillin-completing side chain; R is hydrogen, methyl or phenyl; and Ra, Rb, Rc, Rd are hydrogen,...
20	4015000	6-Acylamino-penam-3-carboxylic and 7-acylamino-3-cephem-4-carboxylic acids 6-Acylamino-penam-3-carboxylic acids and 7-acylamino-3-cephem-4-carboxylic acids in which the acyl group has the formula ##STR1## IN WHICH R1 is hydrogen, R2 is optionally substituted phenyl,...
21	3997532	Intermediates for producing semi-synthetic cephalosporins Novel 6-APA, 7-ACA, and 7-ADCA derivatives are described which comprise phosphorylated derivatives of 6-APA, 7-ACA, or 7-ADCA and the corresponding acylated derivatives thereof. The novel compounds...
22	3980793	Carbonate esters of penicillins and compositions and methods for treatment of bacterial infections New carbonate esters of penicillins, having the formula ##EQU1## wherein R 1 is substituted or unsubstituted alkyl, alkenyl, aryl, aryloxy or heterocyclic group, R2 is ##EQU2## in which formula R3...
23	3971776	Thio-β-lactam penicillins Thio-β-lactam penicillins of the general formula ##EQU1## wherein R is hydrogen, lower alkyl, phenyl-lower alkyl, trihaloethyl, alkali metal or alkaline earth metal; R1 is hydrogen, lower alkyl, ...
24	3965093	6-Arylthio penicillanic acid and derivatives thereof Disclosed herein are penicillanic acids and derivatives thereof which are substituted in the 6-position, processes for preparing such compounds and the utility thereof. The compounds of the...
25	3963704	Penicillin esters This invention relates to a novel class of esters of penicillins and cephalosporins which, upon oral administration are absorbed into the bloodstream where they are split by enzymic action to...
26	3951957	Chloromethyl ester of penicillins New penicillin esters and their salts together with methods for, and intermediates in the preparation thereof, the esters having the formula: ##EQU1## in which formula the asterisk indicates the...
27	3951953	Pharmaceutical compositions Complexes of a semi-synthetic penicillin and an anion exchange resin cross-linked less than 4% and wherein the penicillin, with or without a non-complexed additional penicillin, is absorbed onto...
28	3947465	3-Alkylsilyl-2-oxazolidonone compounds and synthesis thereof Silylating agents, such as 3-alkylsilyl-2-oxazolidinones, are useful for the preparation of penicillins and cephalosporins at low temperatures and in a short time. The process for preparing these...
29	3935193	Diacyl penicillins and methods for their production Novel diacyl penicillins of the formula ##EQU1## wherein R is alkyl, cycloalkyl, aryl, aralkyl, phenoxyalkyl, heterocyclic carboxyl excepting isoxazole carboxyl derivatives, or ##SPC1##In which...
30	3912720	β- Ketoacyl derivatives of 6-aminopenicillanic acid and process thereof β-Ketoacyl derivatives of 6-aminopenicillanic acid of the formula: ##SPC1## Are disclosed. In the above structure R1 is hydrogen, alkyl, halogen, alkoxy, cyano, trifluoromethyl and the like; Z is ...
31	3897445	5-EPI-penicillins 5-Epi-penicillin esters and acids, the acids being useful as inhibitors of β-lactamase type enzymes, a process for preparing such compounds by reacting an ester of a ...
32	3875152	INTERMEDIATES FOR PRODUCING SEMI-SYNTHETIC CEPHALOSPORINS AND METHODS OF PRODUCTION Novel 6-APA, 7-ACA, and 7-ADCA derivatives are described which comprise phosphorylated derivatives of 6-APA, 7-ACA, or 7-ADCA and the corresponding acylated derivatives thereof. The novel compounds...
33	3865857	Tri-substituted aluminum salts or di-substituted aluminum salts of carboxyl group-containing, pharmaceutically effective compounds, and process for preparation thereof A process for the preparation of di- or tri-substituted aluminum salts of carboxyl group-containing, pharmaceutically effective compounds which comprises reacting up to three types of carboxyl...
34	3860585	PENICILLIN KETENIMINE INTERMEDIATES FOR PREPARING OXACILLIN Phenyl- and phenoxyketene-N-6-penicillanic acid-imine esters as useful intermediates in the preparation of oxacillin.
35	3859298	MIXED PHOSPHORUS ANHYDRIDES AND PHOSPHORUS AMIDES OF 6-AMINO-PENICILLANIC ACID Novel 6-APA, 7-ACA, and 7-ADCA derivatives are described which comprise phosphorylated derivatives of 6-APA, 7-ACA, or 7-ADCA and the corresponding acylated derivatives thereof. The novel compounds...
36	3839323	AMINO ACID DERIVATIVES OF 6-AMINOPENICILLANIC ACID Novel penicillins having the formula ##SPC1## Are disclosed along with methods for the preparation of these compounds.
37	3714150	6-(2,5-DIOXO-4-PHENYL-N-SUBSTITUTED-4-IMIDAZOLINECARBOXAMIDO)P ENICILLANIC ACIDS Novel 6-(2,5-dioxo-4-phenyl-N-substituted-4-imidazolidinecarboxami do)penicillani c acids and intermediates are described which are useful as antibacterial agents.
38	3668200	PROCESS FOR THE PRODUCTION OF ISOXAZOLYL PENICILLINS A chemical process for the production of isoxazolyl penicillins and nontoxic salts and lower alkyl esters thereof having the formula requires no microbiological deacylation or fermentation to...
39	3609141	MAGNESIUM SLAT OF 5-METHYL-3-(2,6-DICHLOROPHENYL)-4-ISOXAZOLYL-PENICILLIN Magnesium salt of 5-methyl-3-(2,6-dichlorophenyl)-4-isoxazolyl-penicillin demonstrates antimicrobial activity.
40	3534020	ISOXAZOLE PENICILLINS
41	3498995	ISOTHIAZOLE SYNTHESIS
42	3494917	SYNTHETIC PENICILLINS AND PROCESS FOR THEIR PREPARATION
43	3850908	AMINOACYLOXYMETHYL ESTERS OF PENICILLINS
44	3567715	SULFANILAMIDOPYRIMIDINYLSULFONAMIDES
45	3704291	PENICILLINS DERIVED FROM THE REACTION OF ENAMINES WITH 6-ISOCYANATO PENICILLANIC ACID
46	3658792	DIACYL PENICILLINS AND METHODS FOR THEIR PRODUCTION
47	3576797	BIOLOGICALLY ACTIVE DERIVATIVES OF 6-AMINOPENICILLANIC ACID AND THEIR PRODUCTION
48	3704292	SEMICARBAZIDOPENICILLINS
49	4010175	Thio-{62 -lactam penicillins Thio- beta -lactam penicillins of the general formula wherein R is hydrogen, lower alkyl, phenyl-lower alkyl, trihaloethyl, alkali metal or alkaline earth metal; R1 is hydrogen, lower alkyl,...
50	3736318	6-(2-SUBSTITUTED-3-PHENYL-2H-ISOINDOLE-1-CARBOXAMIDO)PENICILLANIC ACIDS

Matches 1 - 50 out of 78

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