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7547777 Penam crystals and process for producing the same  
The present invention provides novel 2α-methyl-2β-[(1,2,3-triazol-1-yl)methyl]penam-3α-carboxy lic acid benzhydryl ester (TMPB)-acetone crystals for use in the production of...
7514553 Process for producing penicillanic acid compound  
A process for preparing a penicillanic acid compound of the formula (2) comprising reacting a halogenated penicillanic acid compound of the formula (1), (a) in the presence of a metal bismuth or...
7459551 Method for preparing cyclic compounds  
The present invention provides a method for preparing a β-lactam compound of the following Formula (3), which comprises the step of reacting a compound of the following Formula (1) with a trialkyl...
7358356 Processes for preparation of organic compounds  
The present invention provides a method for preparing an organic compound, which comprises a dehydration step of distilling off water from a polar organic solvent solution containing the organic...
7273935 Process for the preparation of 3-methylcepham derivatives  
A process for the preparation of 3-methylcepham-4-carboxylate of the formula (I). wherein R 2 and R 3 may be same or different and represent hydrogen, halogen, amino, alkyl, phenacetamido,...
7125986 Penicillanic acid derivative compounds and methods of making  
Compounds of formula I: wherein R 1 , R 2 , R 3 , R 4 and n have any of the values defined in the specification, and their pharmaceutically acceptable salts, are useful for inhibiting...
7112582 Bicyclic 6-alkylidene-penems as β-lactamase inhibitors  
The present invention provides a compound of formula I, pharmaceutical compositions and the use thereof for the treatment of bacterial infection or disease in a patient in need thereof. wherein...
7091197 Beta-lactamase inhibitor prodrug  
Prodrugs of 6-β-hydroxymethylpenicillanic acid sulfone having the structure wherein R is H or methyl, and solvates thereof, are disclosed. Also disclosed are pharmaceutical compositions...
7022691 Inhibitors of serine and metallo-β-lactamases  
Compounds of formula (I): wherein R 1 , R 2 , R 3 , R 4 and n have any of the values defined in the specification, and their pharmaceutically acceptable salts, are useful for inhibiting...
7018997 Tricyclic 6-alkylidene-penems as β-lactamase inhibitors  
The present invention provides a compound of formula I, pharmaceutical compositions and the use thereof for the treatment of bacterial infection or disease in a patient in need thereof. wherein...
6936711 Process for preparation of penam derivatives from cepham derivatives  
The present invention relates to a process for preparing 2α-methyl-2β-substituted methyl penam derivatives from cepham derivatives, more particularly the present invention provides a novel...
6770759 Penicillanic acid derivative compounds and methods of making  
Compound of formula I: wherein R 1 , R 2 , R 3 , R 4 and n have any of the values defined in the specification, and their pharmaceutically acceptable salts, are useful for inhibiting...
6660855 Crystals of penicillin and process for the production thereof  
The crystal of the invention is crystal of diphenylmethyl 2-methyl-2-triazolylmethylpenam-3-carboxylate which is stable substantially without decomposition or degradation of properties even when...
6600035 6-(substituted methylene) penems and intermediates  
Compounds of formula (I) in which: R 1 is hydrogen or an organic substituent group; R 2 is a fused bicyclic heterocyclic ring system of general formula (a) wherein R 4 and R 5 are independently...
6495539 B-lactam-like chaperone inhibitors  
Compounds of the formula and the salts, esters and amides thereof wherein Z is S, SO, SO 2 or O; each of R 1 , R 2 and R 3 is independently H or substituted or unsubstituted alkyl (1-10C),...
6437119 Compounds formed from two or three antibiotics and their processes of preparation  
Processes for preparing compounds having two or three antibiotic functionalities using quinolone derivatives, β-lactams and vancomycin and the like as the starting materials and chloride linking...
6395726 3,6-disubstituted penam sulfone derivatives  
Compounds are provided having the following formulae I and II: wherein n is 0 or 1 and when n=1, R is a 5 or 6 membered heterocyclic ring, hydroxy, halogen, oxo, carbamoyl, alkoxy, or...
6339152 Process for producing exo-methylenepenam compounds  
The present invention is directed to a process for preparing an exo-methylenepenam compound wherein a cephem compound is reduced with a metal having a standard oxidation-reduction potential of up...
6274730 Process for producing halogenated β-lactam compound  
A process for preparing halogenated β-lactam compounds, characterized in that a β-lactam amino compound of the formula (1) is reacted with nitrous acid or nitrite in a slurry dispersion state in...
6271222 Penem antibacterial compounds, compositions and methods of treatment  
The present invention relates to penem antibacterial agents in which the releaseable liphophilic aromatic side-chain, tethered to the carbapenem nucleus via a methylene linker, necessary for...
6255479 Process for the preparation of α-oxolactams  
A method for preparing an α-oxolactam comprising, reacting a corresponding α-diazolactam with an oxygen donor, in the presence of a transition metal catalyst, to yield the corresponding...
6160112 Procedure for the preparation of dioxopenicillanic acid derivatives  
Procedure for the preparation of dioxopenicillanic acid derivatives and its salts pharmaceutically acceptable with general formula I, where, R is hydrogen, alkyl group containing 1 to 5 Carbon...
6156745 2β-substituted-6-alkylidene penicillanic acid derivatives as β-lactamase inhibitors  
Compounds of formula I: ##STR1## wherein R 1 , R 2 , R 3 , R 4 and n have any of the values defined in the specification, and their pharmaceutically acceptable salts, are useful for inhibiting...
6150350 Antimicrobial compositions  
The invention relates to antimicrobial compositions comprising a combination of (1) a therapeutically effective amount of a compound of formula I ##STR1## with (2) a second ingredient selected from...
6043356 Process for preparing β-lactam compound  
The present invention provides a process for preparing an exo-methylenepenam compound represented by the general formula (5) characterized in that a β-lactam halide compound represented by the...
5885981 Antibacterial penem esters derivatives  
Antibiotic penem compounds are represented by the following formula: ##STR1## wherein R represents a group of the general formula: ##STR2## in which R 1 is a hydrogen atom or linear or branched C...
5886203 Metalorganic compounds  
A process is provided for the production of metalorganic compounds by reacting a Grignard reagent with a Group II, Group III or Group V metal halide in a tertiary alkyl amine solvent to form a...
5821362 Method of desilylating silylether compounds  
Method of desilylating a silylether compound by reacting a silylether compound of the general formula (I): ##STR1## or a salt thereof with an amine hydrogen fluoride salt or a pyridine hydrogen...
5801242 Process for making quinolonyl lactam antimicrobials and novel intermediate compounds  
The present invention provides processes for making compounds of the structure (Q--L 1 )--L--(L 2 --B) wherein (I) Q is a quinolone moiety; (II) B is a lactam moiety; and (III) L, L 1 ,...
5763603 Crystalline tazobactam, and its production and use  
Crystalline sodium 2α-methyl-2β-(1,2,3-triazol-1-yl) -methylpenam-3α-carboxylate-1,1-dioxide monohydrate (crystalline tazobactam sodium monohydrate) obtainable by adding to a concentrated...
5747483 Penem derivatives, their preparation and pharmaceutical compositions containing them  
Penem derivatives of general formula (I), below, and pharmaceutically acceptable salts thereof are disclosed. ##STR1## wherein: R 1 is H, C 1 -C 6 alkoxy, C 3 -C 7 cycloalkyl, or an optionally...
5703231 Process for making antimicrobial compounds  
The present invention provides a process for making a compound having a structure according to Formula (I) ##STR1## wherein A 1 , A 2 and A 3 are independently carbon or nitrogen and R 1 , R 3 ,...
5703068 Penem compounds  
Antibiotic penem compounds are represented by the following formula: ##STR1## wherein R represents a group of the following formula: ##STR2## in which R 1 is a linear or branched, C 1 -C 6 alkyl...
5686441 Penam sulfones as β-lactamase inhibitors  
Novel 3-(substituted)-3-methyl-4-thia-1-azabicyclo 3.2.0!heptane-2-carboxylate, 4,4-dioxides which are of value for use in combination with β-lactam antibiotics to increase the effectiveness of...
5681951 Metal catalyzed displacement process  
A process for preparing a compound of formula (I'): ##STR1## comprising reacting a compound of formula (II'): ##STR2## with a compound of formula (III'): A'SH ...
5644053 Penam derivatives  
The present invention discloses compounds having the formula ##STR1## wherein one of R 1 and R 2 is --COR 4 , --CN, --CH 2 R 5 , halogen, --CHCHR 6 or Q and the other is hydrogen or lower...
5625059 Process for the manufacture of 4-acetoxy-3-hydroxyethyl-azetidinone  
The invention relates to a novel process for the manufacture of 4-acetoxy-3-hydroxyethyl-azetidinone of the formula ##STR1## especially 4(R)-acetoxy-3(R)-(1'(R)-hydroxyethyl)-2-azetidinone, from...
5621096 Process for preparing penems  
The invention provides a process for the preparation of the compound of formula I ##STR1## wherein R is carboxy group or a carboxylate anion, by enzymatic hydrolysis with a lipase or an acylase in...
5599925 Penam derivatives  
A penam derivative of the general formula ##STR1## wherein R 1 means hydrogen, halogen, amino or protected amino; R 2 means hydrogen, halogen, lower alkoxy, lower acyl, lower alkyl, hydroxy- or...
5541317 Azetidinone compounds useful in the preparation of carbapenem antibiotics and process for preparing carbapenem and penem compounds  
Compounds of formula (I): ##STR1## wherein: R 1 is hydrogen or a hydroxy-protecting group; R 2 is alkyl, alkoxy, halogen, optionally substituted phenyl or optionally substituted phenoxy; R 3 is...
5538962 Antibiotic penem compounds  
The present invention provides a compound of the formula (I) ##STR1## wherein: R 1 is 1-hydroxyethyl, 1-fluoroethyl or hydroxymethyl; R 2 is hydrogen or C 1 -4 alkyl; Z is carboxy, sufonic...
5539102 Production method for sulfamide  
The method for producing a sulfamide according to the present invention includes the step of reacting an alcohol and an oxycarbonylsulfamide compound in the presence of a trivalent phosphorus...
5506225 Antibacterial penem compounds  
Antibiotic penem compounds are represented by the following formula: ##STR1## wherein R represents a physiological-hydrolyzable, ester-forming group. The physiologically hydrolyzable, ester-forming...
5492903 Crystalline esters of (+)-(5R, 6S)-6-[(R)-1-hydroxyethyl]-3-(3-pyridyl)-7-oxo-4-thia-1-azabicyclo[3.2.0]h e  
Crystalline acetoxymethyl and pivaloyloxymethyl esters of (+)-(5R, 6S)-6-[(R)-1-hydroxyethyl]-3-(3-pyridyl)-7-oxo-4-thia-1-azab icyclo-[3.2.0] hept-2-ene-carboxylic acid can be obtained by adding a...
5488106 Process for preparing 6-[(isoxazolinyl)methyl]penicillanic acid 1,1-dioxide compounds  
The invention provides a novel class of 6-(isoxazolinyl)methyl penicillanic acid 1,1-dioxide compounds having the formula: ##STR1## wherein M, X, R 2 , R 3 , R 4 and R 5 are described in the...
5480880 Penem derivatives  
The invention provides compounds of the general formula I ##STR1## wherein R 1 is a hydrogen atom, a negative charge or an ester residue; R is: a) --(CH 2 ) n --A--CO 2 H, --(CH 2 )n--A--SO 3...
5474993 Lactam inhibitors of cholesterol esterase  
The present invention is related to compounds which inhibit pancreatic cholesterol esterase. The compounds have the formula: ##STR1## wherein R 1 is H or C 1 -6 alkyl; R 2 is H or C 1 -6...
5464616 6β-substituted penicillanic acids as beta-lactamase inhibitors  
A 6β-substituted penicillanic acid of the formula XII: ##STR1## or a pharmaceutically acceptable salt or ester thereof, wherein A and B are each hydrogen wherein the carbon atoms to which A and...
5457193 Hydroxy protecting group removal in penems  
The present invention relates the removal of t-butyldimethylsilyl protecting groups in the preparation of penems which are useful antibiotics. The invention provides a process for preparing a...
5442058 Conversion of penicillins and cephalosporins to 1-(S)-sulfoxides  
The present application discloses a process for the conversion of penicillin-1-(R)-sulfoxide(s) and/or cephalosporin-1-(R)-sulfoxides in solution, to their corresponding 1-(S)-sulfoxides comprising...
Matches 1 - 50 out of 293 1 2 3 4 5 6 >