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6620801 |
17β-amino and hydroxylamino-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties
The invention is directed to a novel class of steroids which exhibit potent antiprogestational activity.
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6472382 |
4-halogenated steroids, their preparation process and intermediates, their use as medicaments and the pharmaceutical compositions containing them
A subject of the invention is the compounds of formula (I): in which X is a halogen atom, D represents the remainder of an optionally substituted pentagonal or hexagonal ring and optionally...
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6365582 |
S-substitute 11β-benzaldoxime-estra-4, 9-diene-carbonic acid thiolesters, method for the production thereof and pharmaceutical preparations containing these compounds
Thiol esters of S-substituted 11β-benzaldoxime-estra-4,9-dien-carboxylic acids of the formula I their pharmaceutically acceptable salts, a method for their synthesis and pharmaceutical ...
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6057473 |
Synthesis of aryl serines
Anthraquinone chiral ligands (AQN) are used in asymmetric aminohydroxylation addition reactions of cinnamate based olefins for synthesizing aryl serines. The anthraquinones impart a reverse...
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6015805 |
17β-nitro-11β-arylisteroids and their derivatives having agonist or antagonist hormonal properties
The invention is directed to 11β-arylsteroids of formula II: ##STR1## wherein R1, R6, R8, R12 and X are as defined by the specification. The compounds exhibit potent antiprogestational activity ...
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5194602 |
9α-hydroxy-17-methylene steroids, process for their preparation and their use in the preparation of corticosteroids
New 9α-hydroxy-17-methylene steroids are prepared by the introduction of a substituted 17-methylene group in 9α-hydroxyandrost-4-ene-3, 17-dione.The resulting compounds are useful starting c...
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5087752 |
Synthesis of nitroxides using dioxiranes
The subject invention relates to a method of synthesizing nitroxides from secondary amines. This method uses a suitable dioxirane compound such as dimethyldioxirane (DMD), which is relatively...
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5001233 |
Synthesis of hydroxylamines using dioxiranes
The subject invention relates to a method of synthesizing hydroxylamines from secondary amines. This method uses a dioxirane compound such as dimethyldioxirane (DMD, which is relatively stable and...
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4987128 |
Novel 10β-alkynyl-steroids
Novel 10β-alkynyl-steroids of the formula ##STR1## wherein R is selected from the group consisting of hydrogen, optionally substituted alkyl and alkoxy of 1 to 8 carbon atoms, optionally ...
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4912097 |
Novel 11 β-alkynylphenyl-10-nor-steroids
Novel 11β-alkynylphenyl-19-nor-steroids of the formula ##STR1## wherein R1 is alkynyl of 2 to 8 carbon atoms optionally substituted with at least one member of the group consisting of --OH ...
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4898859 |
2-Oxa-isocephem compounds and compositions containing same
A 2-oxa-isocephem compound of the formula (1): ##STR1## wherein R1, R2, R3 and R4 are as defined, pharmaceutically acceptable salts thereof, composition containing the same and processes for...
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4601854 |
Process for the production of prednisone 17.21-diacylates
A novel process for the preparation of prednisone derivatives of the formula ##STR1## wherein R1 is alkyl of 1 to 4 carbon atoms and R2 is selected from the group consisting of hydrogen and...
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4536401 |
11β-aryl estradienes, processes for their production and pharmaceutical preparations containing them
Compounds of the formula I ##STR1## wherein R1 is ##STR2## wherein RI and RII each independently is alkyl of 1-4 carbon atoms, or RI and RII together with the connecting N-atom form a 5- or...
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4401596 |
Novel 17-oxazoline-steroids
Novel 17-oxazoline-steroids of the formula ##STR1## wherein R1 is selected from the group consisting of hydrogen, alkyl of 1 to 4 carbon atoms optionally substituted with a member of the group...
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4397782 |
Antiinflammatory 17-spiroandrostenes
Topical antiinflammatory activity is exhibited by steroids having the formula ##STR1## and the 1,2-dehydro and 15,16-dehydro derivatives thereof, wherein R1 is hydrogen, alkyl, carboxyl, or...
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4342754 |
Steroid-spiro-oxathiazolidine derivatives and a process for the preparation thereof
New steroid-spiro-oxathiazolidine derivatives pharmaceutical compositions containing the same, and to a process for the preparation thereof are disclosed.The new compounds have antimineral...
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4328221 |
Substituted steroid-spiro-oxazolidinone derivatives and a process for the preparation thereof
Compounds of the formula (I) having aldosterone-antagonizing activity are disclosed ##STR1## wherein R3 and R4 are each C1 to C3 alkyl; and Z is one of the following groups ##STR2## wherein R1 is...
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4279900 |
Prodrugs for the improved delivery of halogen-containing glucocorticosteroids
Novel 3,2'-spiro(1',3'-thiazolidine) compounds which are transient prodrug forms of known 6- and/or 9-haloglucocorticosteroids are described. The subject prodrugs provide improved delivery of the...
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4268441 |
Prodrugs for improved bioavailability of certain Δ4 -3-ketosteroidal sex hormones
Transient, orally active thiazolidine type prodrug forms of conventional, natural and synthetic ketosteroidal sex hormones, e.g., of progesterone, testosterone, and the like, are disclosed. The...
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4239757 |
Thiazolidine prodrugs for the improved delivery of anti-inflammatory corticosteroids
Novel 3,2'-spiro(1',3'-thiazolidine) compounds which are transient prodrug forms of known anti-inflammatory corticosteroids are disclosed. The subject compounds can be prepared by known methods,...
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4218446 |
Substituted steroid-spiro-oxazolidinone derivatives and a process for the preparation thereof
Diuretic pharmaceutically active steroid-spiro-oxazolidinone compounds of the formula (I), ##STR1## wherein R1 is hydrogen or methyl, R2 is C1-4 alkyl, R3 is hydrogen, C1-4 alkyl or C2-4 alkenyl,...
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4213978 |
Anti-acne and anti-seborrhea prodrug derivatives of progesterone
Transient, topically active thiazolidine type prodrug forms of progesterone are disclosed.
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4180505 |
Novel steroidspirooxazolidines and process for their preparation
The invention relates to novel spirooxazolidines represented by the formula I ##STR1## wherein R1 is alkyl having from 1 to 4 carbon atoms; R2 is hydrogen, alkyl having from 1 to 4 carbon atoms,...
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4177269 |
Novel 17-esters of 17α-hydroxy gestogens, compositions containing such compounds, processes for their preparation and methods of treatment therewith
This invention relates to novel 17α-esters of gestogens having an antitumour activity and to the preparation thereof. The invention is also concerned with pharmaceutical compositions containing ...
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3538084 |
17-SPIRO-3'-DIAZIRIDINE STEROIDS OF THE ANDROSTANE AND ESTRANE SERIES
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3510477 |
2,2-ETHYLENE-3-OXO-STEROIDS AND INTERMEDIATES
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3499891 |
SPIRO(STEROIDAL-6,1'-CYCLOPROPANES) AND PROCESS
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3597418 |
SPIRO(3ALPHA,5ALPHA - CYCLO - 5ALPHA - ANDROSTANE-7,1'-CYCLOPROPANES),THEIR 3BETA-HYDROXY-DELTA5 AND 3-KETO-DELTA4-COUNTERPARTS,AND THE 19-NOR ANALOGUES OF THE FOREGOING
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3470162 |
3-TETRAHYDROPYRANYL ETHERS OF STEROIDAL ALDOSTERONE ANTAGONISTS
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3459739 |
3 - SPIRO - 3' - DIAZIRIDINE- AND -3'-DIAZIRINEDERIVATIVES OF THE ANDROSTANE AND ESTRANE SERIES
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3445461 |
STEROID DIAZIRINES AND DIAZIRIDINES AND A PROCESS FOR PRODUCING SAME
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3438973 |
2,2- AND 3,3-HYDRAZI-STEROIDS OF THE ANDROSTANE AND PREGNANE SERIES
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3435029 |
16 - OXYGENATED - 20 - METHYL - 21 - OIC ACIDS AND 16 - OXYGENATED - 17ALPHA,20 - METHYLENE-21-OIC ACIDS OF THE PREGNANE SERIES AND THE 21-LOWER ALKYL ESTERS THEREOF
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3409612 |
Spiro-androstane-oxazolinones and process for preparing them
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3404149 |
3-methoxyspiro[estra-1, 3, 5(10) triene-16, 1'-cyclopropan]-17beta-ols
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3338892 |
Steroidal carbamic acid-gamma-lactones
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3280156 |
17beta-hydroxyspiro(estr-4-ene-16, 1'-cyclopropan)-3-ones
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3272801 |
Steroidal spiro-oxazolidinones
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3264331 |
Androstane hydrazone derivatives and methods for their manufacture
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3261829 |
Spiro(steroidal-6,3'-1-pyrazolines) and process
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3232963 |
16,16-ethylenetestosterone derivatives
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3187022 |
17beta-amino-17alpha-pregnen-20-one compounds and the production thereof
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3094522 |
Alkanoylthio and pyrazolo androstane derivatives
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3005829 |
3-alpha-acyloxy-11-keto-dhomoetiochololactone
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3001986 |
3-oxygenated 17 - amino - 17 - carboxyethylandrostane lactams and delta4 compounds corresponding
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