Patents in Class 540/230

Matches 1 - 50 out of 628

Match	Document	Document Title
1	7588913	Process for the preparation of cephradine The present invention describes a process for preparing cephradine, said process comprising reacting 7-aminodesacetoxy cephalosporanic acid (7-ADCA) with D-dihydrophenylglycine in activated form...
2	7544797	Processes for the preparation of cephem derivatives Provided is a process for preparing a compound of formula 1 or its salt, which includes reacting a compound of formula 2 with a compound of formula 3 in the presence of a base.
3	7355040	Process for the preparation of cephalosporin compounds and synthetic intermediates There is provided a process for the preparation of a compound according to Formula (II): which includes the step of cyclizing a compound of Formula (III): wherein R 1 , R 2 , R 3 , R 4 , X...
4	7273935	Process for the preparation of 3-methylcepham derivatives A process for the preparation of 3-methylcepham-4-carboxylate of the formula (I). wherein R 2 and R 3 may be same or different and represent hydrogen, halogen, amino, alkyl, phenacetamido,...
5	7264943	Method for producing cephalexin The invention relates to a process for the preparation of cephalexin with the aid of a penicillin amidase immobilized on a crosslinked hydrophilic copolymer which has binding activity for ligands...
6	6683176	Intermediates for and synthesis of 3-methylene cephams The present invention relates to novel processes for the preparation of 3-methylenecephams. More specifically, the present invention relates to the intramolecular cyclization of penicillin...
7	6620930	Process for preparing 7-amino-3-methoxymethyl-3-cephem-4-carboxylic acid 7-amino-3-methoxymethyl-3-cephem-4-carboxylic acid of formula (I) can be easily prepared by reacting 7-aminocephalosporanic acid of formula (II) with an azeotropic mixture of trimethyl borate and...
8	6458558	Process for the preparation of β-lactam derivatives A process for the preparation of Cefuroxime acid (I), which comprises the following steps: (1) Extraction of deacetyl 7-glutaryl ACA (II) aqueous solution at acid pH with organic solvents (for...
9	6437119	Compounds formed from two or three antibiotics and their processes of preparation Processes for preparing compounds having two or three antibiotic functionalities using quinolone derivatives, β-lactams and vancomycin and the like as the starting materials and chloride linking...
10	6420554	Process for preparation of 3-cephem compound A process for preparing a 3-cephem compound represented by the formula (3), the process comprising the steps of reacting a β-lactam compound represented by the formula (1) with a phosphorus halide...
11	6407091	β-lactamase inhibiting compounds The invention provides compounds of formula I and IV: wherein R 1 -R 11 and A have any of the values defined in the specification, and their pharmaceutically acceptable salts, are useful for...
12	6337396	Process for preparing crystalline cefadroxil hemihydrate from cefadroxil dimethylformamide solvate A method for preparing crystalline cefadroxil hemihydrate from cefadroxil dimethyl formamide solvate using a mixture of a lower alkanol and water.
13	6274730	Process for producing halogenated β-lactam compound A process for preparing halogenated β-lactam compounds, characterized in that a β-lactam amino compound of the formula (1) is reacted with nitrous acid or nitrite in a slurry dispersion state in...
14	6255479	Process for the preparation of α-oxolactams A method for preparing an α-oxolactam comprising, reacting a corresponding α-diazolactam with an oxygen donor, in the presence of a transition metal catalyst, to yield the corresponding...
15	6232305	Substituted amino bicyclic-β-lactam penam and cepham derivatives as cysteine protease inhibitors The present invention provides substituted amino bicyclic-β-lactam penam derivatives and substituted amino bicyclic-β-lactam cepham derivatives and their diastereoisomers of formula I, as well as...
16	6156889	Reagent useful for cleaving a protected functional group The subject matter of the present invention relates to a reagent and a process useful for cleaving a functional group protected by an alkoxycarbonyl group during an organic synthesis. This reagent...
17	6121255	Phloroglucide derivatives and their pharmceutical use A phloroglucide derivative having the following formula: ##STR1## wherein Q is halogen; X is CH 2 or CO; Y is cephalosporin having a formula of ##STR2## wherein Ph is phenyl, Ac is acetoxy, or...
18	6100393	Process for purifying 7-substituted aminodeacetoxy-cephalosporins through the use of filtration membranes Process for purifying 7-substituted aminodeacetoxycephalosporins through the use of filter membranes. A process for purification by ultrafiltration and/or nanofiltration with a cut-off for...
19	6005101	Glutaryl 7-ACA derivatives and processes for obtaining them A compound having the following general formula (I): ##STR1## where R is a hydrogen atom; a linear or branched C 1 -C 4 alkyl group, unsubstituted or substituted by at least a phenyl group or at...
20	5998611	Process for producing cephem compounds in an aqueous medium An industrially excellent, novel process for producing cephem compounds which are useful as medicines, particularly, antibiotics and represented by the following formula (III): ##STR1## wherein R 1...
21	5917032	Chemical acetylation of desacetyl-cephalosporins The present invention is concerned with a chemical acetylation process for the preparation of 3'-acetylated cephalosporin from desacetyl-cephalosporin. The novel process is carried out with an...
22	5908929	Process for the manufacture of the antibiotic 7-(D-α-amino-α-phenylacetamido)-3-methyl-3-cephem-4-carboxyl ic acid (cephalexin) and pharmaceutically acceptable salts thereof A process for the manufacture of the antibiotic 7-(D-α-amino-α-phenylacetamido)-3-methyl-3-cephem-4-carbox ylic acid (cephalexin) and pharmaceutically acceptable salts thereof. It consists of...
23	5874571	Process for the recovery of cephalexin The disclosed process is for the recovery of cephalexin from a mixture containing cephalexin and 7-aminodesacetoxy cephalosporanic acid (7-ADCA), wherein a mixture of cephalexin and 7-ADCA, with a...
24	5847117	Reagent and catalytic process useful for cleaving a protected functional group The subject matter of the present invention relates to a reagent and a process useful for cleaving a functional group protected by an alkoxycarbonyl group during an organic synthesis. This reagent...
25	5847116	Process for the preparation of intermediates useful in the synthesis of cephalosporins A process is described for preparing 3-exomethylene cephalosporanic acid derivatives for use in the synthesis of cephalosporin antibiotics such as ceftibuten. The process comprises electrochemical...
26	5801241	Cyclohexanone extraction of 3-hydroxymethylcephalosporins The cephalosporin intermediates, desacetyl 7-glutaryl ACA and desacetyl cephalosporin D, are obtained in the form of a concentrated aqueous solution from an aqueous solution containing said...
27	5760027	Use of 7-alkylidene cephalosporins to inhibit elastase activity The present invention relates to the use of 7-alkylidene derivatives of cephalosporin esters, such as sulfides, sulfoxides, and sulfones, as inhibitors of human leukocyte elastase. These materials...
28	5656755	Process for preparation on 3-substituted cephem compound An object of the invention is to provide a process for preparing a 3-substituted cephem compound from an allenyl-β-lactam compound which can be easily produced from an inexpensive penicillin...
29	5637694	Preparation and use of 7-[(2-carboalkoxy-1-methylethenyl)amino]-3-hydroxymethyl-3-cephem-4-carb oxylic acids This invention relates to a method of producing 3-alkanoyloxymethyl-3-cephem-4-carboxylic acids from 3-hydroxymethyl-3-cephem-4-carboxylic acids in an aqueous medium for a practical, large-scale...
30	5631366	Process for making 3-formylcephem derivatives The present invention is concerned with a novel process for the making of a compound of formula I ##STR1## by oxidizing the corresponding 3-hydroxymethyl-cephem derivative with an inorganic...
31	5597914	Process for the production of cephalosporins A process for etherifying the hydroxymethyl group in position 3 of a cephalosporin by reaction of a 3-hydroxymethyl cephalosporin with an dioxycarbenium-tetrafluoroborate.
32	5594132	7-acylamino-3-substituted cephalosporanic acid derivatives A compound of the formula: ##STR1## in which R 2 is lower alkoxymethyl, lower alkylthiomethyl or lower alkenylthiomethyl, R 3 is carboxy or a protected carboxy group, A 5 is lower alkylene...
33	5580978	Process for the production of 7-ACA derivatives The invention provides an improved process for the production of 7-amino-3-alkoxymethlycephem-4-carboxyl acid derivatives.
34	5580865	2,2-disubstituted cephem sulphones The present invention provides cephalosporin sulphones or formula (I), and pharmaceutically or veterinarily acceptable salts thereof; ##STR1## wherein n is zero, one or two; R 1 is hydrogen,...
35	5574153	Oxime derivatives of cephalosporanic structure The invention relates to oxime derivatives of cephalosporanic structure, possessing antibacterial activity.
36	5550232	Diastereomers of 1-(isopropoxycarbonyloxy) ethyl 3-cephem 4-carboxylate Enterally absorbable diastereomers of 1-(isopropoxycarbonyloxy)ethyl (6R,7R)-7-[2-(2-aminothiazol-4-yl)-2-(Z)-(methoxyimino)aceta mido]-3-(metho xymethyl)-3-cephem-4-carboxylate of the formula I...
37	5470972	Process for preparing examethylenecephem compounds The object of the invention is to provide a β-lactam compound and a 2-substituted methyl-3-cephem compound, both of which are of value as intermediates for the synthesis of cephem antibiotics. The...
38	5453504	Bicyclic β-lactams intermediates having a new amino protecting group A method for preparing a new class of protected amino intermediates is provided which utilizes reaction of an imido protected primary amine with a secondary amine. The intermediates thus provided...
39	5451675	Process for the preparatuon of 3-alkoxymethyl cephalosporin derivatives A compound of formula (I): ##STR1## or a salt thereof, is prepared by reacting 7-aminocephalosporanic acid or a salt thereof, with a solution comprising a compound of formula ROSO 3 H in a...
40	5442058	Conversion of penicillins and cephalosporins to 1-(S)-sulfoxides The present application discloses a process for the conversion of penicillin-1-(R)-sulfoxide(s) and/or cephalosporin-1-(R)-sulfoxides in solution, to their corresponding 1-(S)-sulfoxides comprising...
41	5412094	Bicyclic beta-lactam/paraben complexes The invention provides complexes of the formula: ##STR1## wherein X is chloro, hydrogen, vinyl, or --CH 3 , Z is O; is 0-5; Y is phenyl or 1,4-cyclohexadien-1-yl; R 1 and R 2 are...
42	5405955	Method for producing azetidinone and cephalosporin derivatives New compounds are disclosed having the general formulas (1) and (2): ##STR1## Also described is a process for preparing the compounds of formulas (1) and (2). Further described is a process for...
43	5403929	Process for preparing alkali salts of cephalosporin C Zinc salts of Cephalosporin C are dissolved in a solution of halides of univalent metals at a temperature of 0°-25° C. and the pH is adjusted to 1-2 prior to being ion exchanged with a sodium...
44	5359058	Cephem derivatives A cephalosporin compound substituted in the 7-position with a (cyclo)alkylideneammonio group of formula (II) ##STR1## wherein X' is an anion from an acid HX, R 1 and R 2 are individually a C 1 ...
45	5329001	Substantially anhydrous crystalline cefadroxil and method for producing it The invention relates to a substantially anhydrous crystalline cefadroxil having a water content between about 0.8% and 3.9%. Such cefadroxil is obtained slurrying a cefadroxil solvate of...
46	5317099	Process for the preparation of cephem derivatives A process for preparing B-lactam derivatives of the formula (I): ##STR1## wherein R 1 represents hydrogen or a metal salt; and R 2 represents hydrogen, acetoxy methyl,...
47	5304641	Process for the synthesis of exomethylenecephams The present invention relates to a process for the preparation of exomethylene cephams, which are useful intermediates in the production of many useful β-lactam antibiotics. More particularly...
48	5302713	Method for the preparation of Δ.sup.3 -7-substituted amino desacetoxy cephalosporanic acid A method for synthesizing Δ 3 -7-substituted amino desacetoxy cephalosporanic acid from a penicillin sulfoxide or its alkylsilylated ester derivative is provided. According to the method,...
49	5278157	Stable cephradine hydrate The invention relates to a novel stable form of cephradine, processes for its production and intermediates used therein.
50	5266691	Processes for making cephems from allenylazetidinone derivatives This invention relates to a novel process for making a cephem of formula II from a 2-(3-amino-2-oxo-azetidin-1-yl)-2,3-butadienoate intermediate of formula I using an organo-copper reagent. In...

Matches 1 - 50 out of 628

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