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8557978 Cross-linked glycopeptide-cephalosporin antibiotics  
This invention provides cross-linked glycopeptide-cephalosporin compounds and pharmaceutically acceptable salts thereof which are useful as antibiotics. This invention also provides pharmaceutical...
8470809 Crystalline sodium salt of cephalosporin antibiotic  
The present invention relates to novel polymorph of Ceftiofur sodium as a crystalline product. The present invention also provides a process for the preparation of novel polymorphs of crystalline...
8431562 Crystalline sodium salt of cephalosporin antibiotic  
Polymorphs of Ceftiofur sodium as a crystalline product and a process for the preparation of polymorphs of crystalline Ceftiofur sodium of formula (I).
8212024 Crystalline sodium salt of cephalosporin antibiotic  
The present invention relates to novel polymorph of Ceftiofur sodium as a crystalline product. The present invention also provides a process for the preparation of crystalline Ceftiofur sodium of...
8178521 Cefazolin sodium pentahydrate crystal and its molecular assembly preparation method  
The present invention relates to cefazolin sodium pentahydrate crystal and a method for assembly and preparation of the crystal molecule. The cefazolin sodium pentahydrate crystal molecule...
8148632 Quantum dot solar cell  
Example solar cells and methods for making and using the same are disclosed. An example solar cell may include an electron conductor layer, a quantum dot layer, a bifunctional ligand layer...
7833998 Oral neurotherapeutic cephalosporin sulfoxide and sulfone-containing compositions  
The treatment of neurological disorders using cephalosporin sulfoxide-containing and/or cephalosporin sulfone-containing compositions and pharmaceutical compositions including oral dosage forms...
7741478 Salts in the preparation of cephalosporin antibiotics  
Compounds of general formula (II), wherein R1 represents R4 represents hydrogen or —CHO group, R5 represents hydrogen or trityl,R2 represents hydrogen or methoxy group,R3 represents —CH═CH2 or and...
7700581 Cephalosporin compounds comprising a C3 thio-methyl moiety substituted with N-containing heterocyclic group, and a C7 thiourea acetamido group, their preparations and uses thereof  
Disclosed herein are a cephalosporin compound of formula I, wherein R1 is selected from the following groups: wherein R2 is selected from the following groups: the preparation and uses thereof. A...
7511135 Method for manufacture of ceftiofur  
A process for preparation of ceftiofur of formula (I) having purity greater than 97% is disclosed. The process comprises reacting [2-(2-aminothiazol-4-yl)]-2-syn-methoxyimino acetic...
7488724 7-alkylidene-3-substituted-3-cephem-4-carboxylates as beta-lactamase inhibitors  
The invention provides compounds of formula (I): wherein: R1-R4 and A have any of the values defined in the specification, and their pharmaceutically acceptable salts, are useful for inhibiting...
7459550 Process for the preparation of Cefditoren  
The present invention relates to an improved process for the preparation of Cefditoren of formula (I), the said process comprising the steps of: i) converting the compound of formula (II) to a...
7452990 Intermediates for synthesis of cephalosporins and process for preparation of such intermediates  
A novel 4-halo-2-oxyimino-3-oxo butyric acid-N,N-dimethyl formiminium chloride chlorosulfate of formula (I) useful in the preparation of cephalosporin antibiotics wherein X is chlorine or bromine;...
7396926 Beta-lactamase substrates having phenolic ethers  
Provided are fluorescent substrates for β-lactamases having the general formula I: in which R is a benzyl, 2-thienylmethyl, or cyanomethyl group; R′ is selected from the group consisting of H,...
7384928 Broad spectrum cephem compounds  
A compound of the formula: (wherein, T is S, SO or O;X is halogen, CN, carbamoyl optionally substituted with lower alkyl, lower alkyl, lower alkoxy, or lower alkylthio;A is substituted lower...
7339055 Process for the preparation of cephalosporin antibiotic  
A process for the preparation of cephalosporin antibiotic of the formula (I) which comprises: (i) activating the compound of formula (III) as acid halide in an organic solvent (ii) treating the...
7335767 Method for preparation of ceftiofur and salts thereof  
A process for preparation of ceftiofur sodium of formula (Ib) possessing high stability and having purity of more than 97% and substantially free of impurities, is disclosed. The process...
7071329 Process for preparing cephalosporins with salified intermediate  
Cephalosporins may be conveniently prepared by a process in which a benzathinium salt of formula (V) wherein: Z is benzathine; and X and R2 are as defined in the specification, is reacted with...
6919449 Process for the preparation of cephalosporin intermediate and its use for the manufacture of cephalosporin compounds  
The present invention relates to a method for the preparation of cephalosporin antibiotic of the formula (II), which comprises hydrolyzing and halogenating the ester of formula (III) by...
6916801 7-Alkylidene-3-substituted-3-cephem-4-carboxylates as β-lactamase inhibitors  
The invention provides compounds of formula (I): wherein: R1-R4 and A have any of the values defined in the specification, and their pharmaceutically acceptable salts, are useful for inhibiting...
6906187 Manufacture of cefalosporins and intermediates  
There is described a process for the preparation of 3-disubstituted cepham-4-carboxylic acid derivatives of formula I wherein R″ is 4-methoxybenzyl, X is the residue of a thioether and Z is a...
6800756 Method for the preparation of ceftiofur sodium and its intermediates  
The present invention relates to preparation of Ceftiofur acid of formula (I), and its pharmaceutically acceptable salts. The process includes the steps of(i) condensing an activated derivative of...
6794372 Nitrate salts of antimicrobial agents  
Nitrate salts of antimicrobial agents for the preparation of antimicrobial medicaments, specifically antiviral, antifungal and antibacterial medicaments.
6787649 Cephalosporin intermediates  
A process which comprises (i) acylating a compound of formula II with a compound of formula IV to obtain a compound of formula I and(ii) deformylating said compound of formula I to obtain a...
6777549 β-lactam production  
A process for the production of a compound of formula comprisingi) silylating a compound of formula then reacting a resulting with a compound of formulaR′BS—X′ IVBwherein R′B is hydrogen or...
6723716 7-acylamino-3-heteroarylthio-3-cephem carboxylic acid antibiotics and prodrugs thereof  
The present invention relates to a cephem prodrug having formula III or formula IV: or a pharmaceutically acceptable salt thereof, wherein R′1 is selected from the group consisting of hydrogen and...
6713625 Process for the preparation of cefditoren using the thioester of thiazolylacetic acid  
The present invention provides a process for the preparation of Cefditoren of the formula (I) which comprises acylating 7-amino-cephem carboxylic acids of the general formula (IV) where R3 is...
6642377 Process for the preparation of basic antibiotic-inorganic acid addition salts and intermediate oxalates  
A production process which comprises subjecting a basic antibiotic.oxalate (II) to salt-exchange with an alkali earth metal salt (III) of an inorganic acid: wherein the ring A means the basic...
6610845 Thioester derivatives of thiazolyl acetic acid and their use in the preparation of cephalosporin compounds  
The present invention provides new thioester derivatives of thiazolyl acetic acid of the general formula (I), wherein, R1 represents H, trityl, CH3, CRaRbCOOR2 (Ra and Rb independently of one...
6583133 Propenyl cephalosporin derivatives and process for the manufacture thereof  
Disclosed are cephalosporin derivatives of the general formula wherein R is an organic residue with a molecular weight not exceeding 400 bonded to the adjacent sulphur atom via carbon and...
6576761 Process for the preparation of cephem compounds  
1. A process for preparing a 3-alkenylcephem compound or 3-norcephem compound of the formula (3) characterized in that an alkenyl halide of the formula (2), a nickel catalyst, a metal up to −0.3...
6555680 Method for the preparation of ceftiofur sodium  
The present invention relates to a process for the preparation of sodium salt of Ceftiofur as given in Formula I, directly from its amine salt using sodium base.
6555679 Method for preparation of ceftiofur sodium from its hydrohalide salts  
The present invention relates to a process for preparing sodium salt of cephalosporins from their corresponding hydrohalide salt, which is neutralized with trimethylsilylating agent for the first...
6504026 Process for production of ceftiofur  
Process for preparing ceftiofur having formula I: in the form of the sodium salt.
6468995 Cephem compounds  
A compound of the formula: wherein R1 is amino or protected amino;R2 is hydrogen, lower alkyl or hydroxy protective group;R3 is carboxy or protected carboxy;R4 is an unsubstituted 5, 6 or...
6458949 Ceftiofur, its intermediate and a process for the preparation of the same  
A novel process for the preparation of ceftiofur, a cephalosporin antibiotic useful in the treatment of bovine respiratory disease using a novel bromo or chloro intermediate. the process comprises...
6441162 Crystalline substance of cefditoren pivoxyl and the production of the same  
A crystalline substance of Cefditoren pivoxyl is provided which has a high purity and enhanced thermal stability on storage. This crystalline Cefditoren pivoxyl may be prepared by a process...
6437119 Compounds formed from two or three antibiotics and their processes of preparation  
Processes for preparing compounds having two or three antibiotic functionalities using quinolone derivatives, β-lactams and vancomycin and the like as the starting materials and chloride linking...
6417175 Phosphonocephem derivatives, process for the preparation of the same, and use thereof  
A novel cephem compound of the formula: wherein R1 is a phosphono group or a group convertible to a phosphono group; R2 is a hydrogen atom or a group having a linkage through a carbon atom; each...
6384215 Preparation of new intermediates and their use in manufacturing of cephalosporin compounds  
The present invention provides new thioester derivatives of 4-halogeno-2-methoxyimino-3-oxo-butyric acid of the general formula (I), also, the invention provides a method by which the said...
6294668 Vinylpyrrolidinone cephalosporin derivatives  
The present invention relates to cephalosporin derivatives of the general formula ##STR1##where R1 is halogen, lower alkyl, phenyl, benzyl, styryl, naphthyl or heterocyclyl; the lower alkyl,...
6294527 Cephem compounds  
An antibacterial compound ##STR1##wherein ##STR2## represents benzene ring, pyridine ring, pyrazine ring or 5-membered aromatic neterocycle (having one oxygen or sulfur atom as ring-constituting...
6288223 Process for the selective preparation of Z-isomers of 3-2(substituted vinyl)cephalosporins  
There can be produced, at a high selectivity and in a high yield, the Z-isomer of a 7-N-unsubstituted or substituted-amino-3-[2-(4-substituted or unsubstituted-thiazol-5-yl)...
6242437 Cephem derivatives  
A compound represented by the following formula (I) is disclosed. This compound has potent antimicrobial activity against a wide spectrum of bacteria from Gram-positive bacteria to Grame-negative...
6169180 Process for the production of cephalosporines  
The invention relates to a new economical and simple process, using a new intermediate compound, for the production of 3'-substituted 7-amino-3-propenyl-4-cephem-carboxylic acid derivatives of...
6150351 Cephem compounds and pharmaceutical use thereof  
This invention relates to new cephem compound represented by the following general formula (I): ##STR1## wherein each symbol is as defined in the specification or a salt thereof, which has...
6107481 De-esterification process  
A process to prepare the E isomer of a 3-substituted (6R,7R)-7-phenyl-acetamido-ceph-3-em-4-carboxylic acid from a mixture of the E and Z-isomer of either the corresponding tert-butyl or the...
6100393 Process for purifying 7-substituted aminodeacetoxy-cephalosporins through the use of filtration membranes  
Process for purifying 7-substituted aminodeacetoxycephalosporins through the use of filter membranes. A process for purification by ultrafiltration and/or nanofiltration with a cut-off for...
6087355 Cephalosporin antibiotics  
The present invention includes novel compounds of formula ##STR1## where A, B, D, and E are selected from the group consisting of carbon, nitrogen and sulfur, R99 is selected from the group...
6063778 Cephalosporin derivatives and processes for the preparation thereof  
The invention provides novel cephalosporin derivatives of the formula (I) ##STR1## and salts thereof for use in pharmaceutical compositions. Also novel precursors for synthesis of the...