|
Match
|
Document |
Document Title |
|
|
6437119 |
Compounds formed from two or three antibiotics and their processes of preparation
Processes for preparing compounds having two or three antibiotic functionalities using quinolone derivatives, β-lactams and vancomycin and the like as the starting materials and chloride linking...
|
|
|
6169180 |
Process for the production of cephalosporines
The invention relates to a new economical and simple process, using a new intermediate compound, for the production of 3'-substituted 7-amino-3-propenyl-4-cephem-carboxylic acid derivatives of...
|
|
|
5801242 |
Process for making quinolonyl lactam antimicrobials and novel intermediate compounds
The present invention provides processes for making compounds of the structure (Q--L 1 )--L--(L 2 --B) wherein (I) Q is a quinolone moiety; (II) B is a lactam moiety; and (III) L, L 1 ,...
|
|
|
5760027 |
Use of 7-alkylidene cephalosporins to inhibit elastase activity
The present invention relates to the use of 7-alkylidene derivatives of cephalosporin esters, such as sulfides, sulfoxides, and sulfones, as inhibitors of human leukocyte elastase. These materials...
|
|
|
5700932 |
Process for preparing cephem derivative
The present invention relates to a process for preparing a cephem derivative represented by the following formula (I): ##STR1## useful as an intermediate for the preparation of antibiotics.
|
|
|
5580865 |
2,2-disubstituted cephem sulphones
The present invention provides cephalosporin sulphones or formula (I), and pharmaceutically or veterinarily acceptable salts thereof; ##STR1## wherein n is zero, one or two; R 1 is hydrogen,...
|
|
|
5567813 |
Process for preparing cephalosporin compounds from reactive organic acid derivatives
The present invention provides a process for preparing cephem derivatives having the following general formula (I): ##STR1## in which R 1 represents a carboxy group or a protected carboxy group...
|
|
|
5348952 |
β-lactam derivatives of the cephem sulphone type
Cephalosporins of the formula (I): ##STR1## wherein m is one or two; n is zero, one or two; A and B are organic residues; and R 1 and R 2 are halogen or hydrogen atoms or organic groups are...
|
|
|
5281703 |
Process for making antimicrobial quinolonyl lactams
The present invention provides methods of making compounds of the structure [Q-L 1 ]-L-[L 2 -B[ wherein (I) Q is a quinolone moiety; (II) B is a beta-lactam moiety; (III) L, L 1 , and...
|
|
|
4931555 |
Disulfide substituted oxazetidine derivatives
A process for producing a 2-cephem or 3-cephem derivative compound of the formula: ##STR1## wherein R 1 represents a substituted or unsubstituted amino radical and R 4 represents hydrogen or a...
|
|
|
4845088 |
Tetrazolyl derivatives of beta-lactams useful as elastase inhibitors
Tetrazolyl derivatives of β-lactams are found to be potent elastase inhibitors and thereby useful anti-inflammatory/antidegenerative agents.
|
|
|
4761409 |
Cephem derivatives
A cephem derivative represented by the general formula ##STR1## wherein R 1 represents hydrogen or methyl, R 2 represents carboxyl or esterified carboxyl, and n represents 0 or 1, or a...
|
|
|
4758558 |
N-(substituted)-[7-(2-cyanoacetamido)cephalosporanic]amide derivatives having antibiotic utility
Disclosed herein are the derivatives of substituted cephalosporanic acid represented by the formula (I): ##STR1## wherein R 1 represents a 4-pyridylthiomethyl group, an alpha-aminobenzyl group, a...
|
|
|
4735937 |
8-oxo-5-thia-1-azabicyclo(4,2,0)oct-2-ene compounds
The invention concerns 7-amino-ceph-3-em-4-carboxylic acid compounds of the formula ##STR1## wherein R 1 a represents hydrogen or an amino protective group R 1 A and R 1 b represent hydrogen or...
|
|
|
4734407 |
Alpha-aminoacyl-penicillins and cephalosporins
Antibacterially active and animal growth-regulating novel β-lactam compounds of the formula ##STR1## in which R 1 represents an optionally substituted radical of the formula ##STR2## Z represents...
|
|
|
4705784 |
Cephem compounds
A cephem compound represent by the general formula ##STR1## wherein, R 1 represents hydrogen or lower alkyl, R 2 and R 3 are the same or different and each represents hydrogen or lower alkyl, R...
|
|
|
4622394 |
Oxygen analogs of cephalosporins
In accordance with this invention, it has been found that the oxygen analog of 7-amino-cephalosporanic acid and biologically active derivatives thereof can be formed from esters of...
|
|
|
4605651 |
Antibiotic amino acid derivatives of cephalosporins
1. A cephalosporin derivatives of the general formula ##STR1## wherein R 1 is an α-, β- or γ-amino acid residue (bonded by the ester linkage), which may optionally be substituted by one or two...
|
|
|
4604457 |
2-substituted cephem derivatives and process for preparing the same
A 2-substituted cephem derivative represented by the formula ##STR1## wherein R 1 represents a substituted or unsubstituted phenyl group, substituted or unsubstituted phenylmethyl group or...
|
|
|
4559334 |
7-Substituted-3-vinyl-3-cephem compounds and processes for production of the same
The invention relates to novel compounds of high antimicrobial activity of the formula: ##STR1## in which R 1 is amino or a protected amino group, and R 2 is carboxy or a protected carboxy...
|
|
|
4520194 |
Cephalosporins
A 7-[2-(2-aminothiazol-4-yl)-2-(syn)-methoxyiminoacetamido]cep
halosporin derivative of the formula; ##STR1## wherein R 3 is hydrogen or a residue of a nucleophilic compound; R 2 NH is an amino...
|
|
|
4496561 |
Cephalosporin derivative
A cephalosporin derivative having an antibacterial activity similar to a cephalosporin antibiotic in living bodies without affecting the intestinal bacterial colonies, a method for preparing the...
|
|
|
4477660 |
7-(S)-Acylaminocephalosporin sulfones and process
This invention encompasses 7-(S)-acylamino-3-acetoxymethyl-3-cephem-4-carboxylic acid sulfones and the epimerization process for making them. The epimerization process employs an organic nitrogen...
|
|
|
4477447 |
7-Acylaminocephalosporanic acid derivatives
This invention relates to novel 7-acylaminocephalosporanic acid derivatives of high antimicrobial activity, to processes for their preparation, and to pharmaceutical compositions comprising said...
|
|
|
4460582 |
3-Carboxybenzyl cephems
The present invention provides a compound of the formula (I): ##STR1## and pharmaceutically acceptable salts and in-vivo hydrolysable esters thereof wherein R 1 is carboxy, R 2 is hydrogen or...
|
|
|
4456755 |
7-Oxygen analogs of cephalosporins
In accordance with this invention, it has been found that the oxygen analog of 7-aminocephalosporanic acid and biologically active derivatives thereof can be formed from esters of...
|
|
|
4426520 |
3-Carbamoyloxy-cepham-4-carboxylic acid derivatives
Penicillin sulfoxide esters are reacted with an isocyanate to produce the corresponding (substituted)-2-carbamoyloxymethylpenam, the corresponding (substituted)-3-carbamoyloxycepham or the...
|
|
|
4405782 |
Process for the preparation of solutions of 7-aminocephalosporanic acids
A process for the preparation of solutions of 7-aminocephalosporanic acids wherein there is obtained a salt of the general formula III: ##STR1## where R 1 may be a group selected from among...
|
|
|
4393205 |
Cephapirine esters and salts thereof
Cephapirine esters having the formula ##STR1## wherein R is selected from the group consisting of ##STR2## Such esters and salts thereof, having antibiotic activity, are prepared by reacting 7-ACA...
|
|
|
4388460 |
Cephalosporine desacetoxy esters and salts thereof
Cephalosporine desacetoxy esters having the formula ##STR1## wherein R is selected from the group consisting of ##STR2## and R 1 is selected from the group consisting of ##STR3## Such esters and...
|
|
|
4338439 |
7-[2-[(Substituted benzoyl]amino]acetamido]cephalosporins
Cephalosporin antibiotics of the formula ##STR1## wherein R is cyclohexadienyl, phenyl or substituted phenyl, 2-thienyl, 3-thienyl, 2-furyl or 3-furyl; R 1 is a substituted phenyl having 1 to 4...
|
|
|
4322347 |
2-Carbamoyloxymethyl-penicillin derivatives
Penicillin sulfoxide esters are reacted with an isocyanate to produce the corresponding (substituted)-2-carbamoyloxymethylpenam, the corresponding (substituted)-3-carbamoyloxycepham or the...
|
|
|
4312982 |
α-Acylureidocephalosporins and salts and esters thereof
Compounds which are clinically important cephalosporins and salts and esters thereof having a wide spectrum of activity against Gram-positive bacteria but especially against Gram-negative bacteria...
|
|
|
4307230 |
3-Vinyl-cephalosporins
Novel 3-vinyl-cephalosporins of the formula ##STR1## in which n is 0 or 1, R 1 is hydrogen, a radical of the formula ##STR2## [in which R 4 is hydrogen or a protective radical and R 5 is...
|
|
|
4297489 |
7-α-Amino-substituted acylamino-3-(1-carboxymethyltetrazol-5-ylthiomethyl)-3-cephem-4-carboxyl ic acids
Certain 7-acylamido-3-(1-carboxy-loweralkyl-tetrazol-5-ylthiomethyl)
-3-cephem-4-ca rboxylic acids and their salts and easily hydrolyzed esters of the 4-carboxyl group were synthesized and found to...
|
|
|
4278793 |
Cephem derivative
Cephem derivatives of the general formula ##STR1## in which the R 2 O group is in the syn-position, a process for their manufacture and pharmaceutical formulations which are active against...
|
|
|
4275062 |
Aminothiazolyl ureido sulfoxide cephalosporins
Cephalosporins of the formula ##STR1## R represents hydrogen, sodium, potassium, or certain ester groups, R 1 is in the α-configuration and is hydrogen or methoxy, X represents hydrogen ##STR2##...
|
|
|
4271157 |
Imidazole derivatives of 7-[(2-amino-4-thiazolyl)-oximino] cephalosporins
A compound of the formula ##STR1## wherein R is hydrogen, alkali metal, ##STR2## R 1 is hydrogen or methyl; R 2 is hydrogen or methyl; R 3 is hydrogen or methyl; R 4 is hydrogen, --OCONH...
|
|
|
4269977 |
Process for the manufacture of 8-oxo-5-thia-1-azabicyclo [4,2,0]oct-2-ene or 3-ene compounds
The invention concerns the decarbonylation of the formyl group in 7-amino-3-formyl-ceph-2-em-4-carboxylic acid compounds and 7-amino-3-formyl-ceph-3-em-4-carboxylic acid compounds by treatment with...
|
|
|
4252802 |
Hydroxamic acid derivatives of 7-[(2-amino-4-thiazolyl)-oximino] cephalosporins
A compound of the formula ##STR1## wherein R is hydrogen, alkali metal, ##STR2## or ##STR3## R 1 is hydrogen or methyl; R 2 is hydrogen or methyl; R 3 is hydrogen, lower alkyl or lower...
|
|
|
4248868 |
Cephem carbonylmethyl derivatives
The invention comprises carbonylmethyl derivatives of the formula IA and corresponding carbonylmethylene derivatives of the formula IB ##STR1## in which R 1 a represents a member of the group...
|
|
|
4237128 |
7-[2-(2-Amino-4-thiazolyl)-2-[(1-carboxy-1, 1-dialkyl)alkoxyimino]acetamido]cephem sulfoxides
Compounds of the formula ##STR1## wherein R is hydrogen, sodium, potassium, or certain ester groups; R 1 is in the α-configuration and is hydrogen or methoxy; R 2 and R 3 are independently...
|
|
|
4211702 |
Process for preparation of penicillin and cephalosporin imino halides
Penicillin and cephalosporin imino halides are prepared by reacting of 6-acylaminopenicillins or 7-acylamino cephalosporins with a novel chlorinating compound derived from a triaryl phosphite and...
|
|
|
4202817 |
Process for the production of penam and cephem derivatives
A process for the preparation of penam and cephem derivatives by reacting a phosphite amide of a 6-aminopenicillanic acid or 7-aminocephalosporanic acid with an acyl halide in an aprotic solvent in...
|
|
|
4145538 |
3-Carbamyloxymethyl-cephalosporins
The present invention is directed to 7-amino-3-carbamoyloxymethyl-3-cephem-4-carboxylic acid: ##STR1## and to precursors and derivatives. The compound, its precursors, and its derivatives exhibit...
|
|
|
4129732 |
4(Tetrazol-5-yl)-Δ.sup.3 -cephem compounds
Certain novel antibacterial 7-acylamino-3-substituted-4-(tetrazol-5-yl)-Δ 3 -cephem derivatives, and salts thereof, and intermediates useful in their preparation.
|
|
|
4113940 |
7-Amino 2-lower alkyl-2 or 3-cephem-4-carboxylic acid derivatives and processes for preparation thereof
A compound of the formula ##STR1## wherein R 1 is amino or substituted amino, R 2 is carboxy or protected carboxy, R 3 is lower alkyl and X is --S-- or ##STR2## or a pharmaceutically acceptable...
|
|
|
4112228 |
7-(D-α-Hydroxy-2-arylacetamido)-3-(2-carboxyalkyl-2,3-dihydro-s-tri azolo-[4,3-b]pyridazin-3-on-6-ylthiomethyl)-3-cephem-4-carboxylic acids and derivatives
7-(D-α-Hydroxy-2-arylacetamido)-3-(2-carboxyalkyl-2,3-dihyd
ro-s-triaz olo[4,3-b]pyridazin-3-on-6-ylthiomethyl)-3-cephem-4-carboxyl
ic acids and derivatives containing blocking groups on the...
|
|
|
4107432 |
7-Diacylimido cephalosporins
New 7-diacylimido cephalosporins are produced by reacting 7-acylamido cephalosporins with an acylating agent in the presence of a silyl reagent. The 7-diacylimido cephalosporins are cleaved to...
|
|
|
4098999 |
Certain 2-substituted cephalosporins
Disclosed herein are novel analogs of cephalosporins. They differ from prior art compounds in that they are substituted in the 2-position and can be prepared by reacting known cephalosporins with...
|