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4245088 |
Novel 3-acyloxymethyl-cephem compounds useful as intermediates for preparing cephalosporin antibiotics
Novel 3-acyloxymethyl-cephem compounds of the formula: ##STR1## wherein R 1 is hydrogen or an acyl group; W is acetonyl, or a group represented by --X--COOH or --X--OH (X is an organic residue) or...
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4239758 |
Cephalosporins
A novel cephalosporin derivative of the formula: ##STR1## [wherein X is hydrogen, hydroxyl, acyloxy, alkoxy, carbamoyloxy, quaternary ammonium or a group of the formula --SR 1 (where R 1 is a...
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4238608 |
7-[2-(2-Aminothiazol-4-yl)-2-substituted thio-acetamido] cephalosporins
A novel compound of the formula: ##STR1## wherein R is lower alkyl or a group of the formula ##STR2## where R 1 and R 2 are the same or different and each is hydrogen, carboxyl or halogen; Y is...
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4237128 |
7-[2-(2-Amino-4-thiazolyl)-2-[(1-carboxy-1, 1-dialkyl)alkoxyimino]acetamido]cephem sulfoxides
Compounds of the formula ##STR1## wherein R is hydrogen, sodium, potassium, or certain ester groups; R 1 is in the α-configuration and is hydrogen or methoxy; R 2 and R 3 are independently...
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4229574 |
Indole cephalosporin derivatives
New indole derivatives of cephalosporin compounds have been prepared which are useful as antibiotics.
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4226986 |
Process for halogenation of β-lactam compounds
Novel halogenating compounds, derived from triaryl phosphites and chlorine or bromine are employed to convert 7-acylamino-3-hydroxy-3-cephem compounds to 7-acylamino-3-halo-3-cephems and the...
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4223133 |
Cephalosporin reduction process
Cephalosporin sulfoxides are reduced to the corresponding cephalosporins in the presence of a halogen scavenger with triaryl phosphite-halogen complexes derived from the kinetically controlled...
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4223037 |
β-Lactam antibiotics and their use
New β-lactam antibiotics of the formula ##STR1## in which A is hydrogen or methoxy, B is phenyl optionally substituted by hydroxyl, halogen, methoxy, --CN and/or CH 3 --SO 2 --; thienyl;...
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4219554 |
Novel penicillins and cephalosporins and process for producing same
Novel penicillins and non-toxic salts thereof, which contain a mono- or di-oxo- or thioxo-piperazino(thio)carbonylamino group have been prepared. These compounds are valuable antibacterial...
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4217275 |
β-Lactam antibiotic esterification process using methoxymethyl methane sulfonate
Disclosed is an improved process for esterifying carboxylic acids, particularly 3-carboxylic acid groups of penicillins and 4-carboxylic acid groups of cephalosporins, to form methoxymethyl esters....
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4217348 |
Cephalosporins having an oxazolidonyloxamido substituted acyl sidechain
Cephalosporins of the formula ##STR1## wherein R is hydrogen, sodium, potassium, or certain ester groups; R 1 is in the α-configuration and is hydrogen or methoxy; R 2 is hydrogen, lower alkyl,...
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4217450 |
Imidazoledicarboxylic acid substituted cephalosporin derivatives
Compounds having the following formula: ##STR1## wherein X is a radical selected from the group consisting of hydrogen, halogen, hydroxy, mercapto, methyl and amino. Y is a radical selected from...
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4216215 |
7[(Furanyl-2-acetamido)-2-acetamido]cephalosporin derivatives
A series of novel 7-(D-α-acylaminoarylacetamido)-Δ 3 -cephem derivatives have been prepared wherein the acyl moiety contains an epoxy group immediately adjacent to the carbonyl carbon atom....
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4215118 |
2-Hetero-acetamido-penicillanates and cephalosporinates
2-Hetero-acetamido-penicillanates and cephalosporinates of the formula ##STR1## in which R is hydrogen or lower alkoxy, Z is ##STR2## R 1 and R 2 independently or together are various...
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4211702 |
Process for preparation of penicillin and cephalosporin imino halides
Penicillin and cephalosporin imino halides are prepared by reacting of 6-acylaminopenicillins or 7-acylamino cephalosporins with a novel chlorinating compound derived from a triaryl phosphite and...
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4208517 |
Caphalosporin compounds having at position-7 an α-etherified hydroxyiminoarylacetamido group
Antibiotic compounds of the general formula ##STR1## [wherein R is a phenyl, thienyl or furyl group; R a and R b , which may be the same or different, are each selected from hydrogen, C 1 -4...
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4200576 |
Beta-lactam antibiotics
Antibacterially active and animal feedstuff supplement β-lactam antibiotics of the formula ##STR1## in which R is H or --UR', U is O or S, R' is optionally substituted alkyl, alkenyl,...
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4200575 |
7[(2-Thiazolyl)-2-(oxoimino)acetamido]cephalosporin derivatives
Novel [2-(syn)-carbamoyloximinoacetamido]cephalosporins of the formula: ##STR1## [wherein, Y 1 is hydrogen, hydroxyl, carbamoyloxy, acyloxy, quaternary ammonium or nitrogen-containing heterocyclic...
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4198503 |
3-Carbamoyl substituted-7-ureido substituted cephalosporins
A class of 3-carbamoyloxymethyl-7-α-acylureido cephalosporins have a broad spectrum of antibacterial activity.
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4197298 |
[3-Heterocyclic-7-(2-methoxyimino-2-aminothiazolyl) acetamido]cephalosporins
7-[2-(2-aminothiazol-4-yl)-2-(syn)-methoxyiminoacetamido]cep
halosporanic acid derivatives of the formula; ##STR1## wherein R 1 NH is an amino group which may optionally be protected; COOR 2 is a...
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4191762 |
2-Lower alkyl-7-substituted amino-2 or 3-cephem-4-carboxylic acid compounds
A compound of the formula: ##STR1## wherein R 1 is (C 1 to C 6 ) alkyl, R 2 is carboxy or a protected carboxy group, R 3 is amino or a protected amino group, and A is carbonyl or...
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4180661 |
7-[(Substituted-isothioureamethyl)phenyl]-acetamidocephalosporin derivatives
Novel cephalosporin derivatives of the following formula are useful as antibacterial agents: ##STR1##
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4179502 |
7[2-Hydroxyiminoacetamido]cephalosporins
2-Hydroxyiminoacetamide compounds of the following formula and salts thereof: ##STR1## [wherein X is S, O or an imino group which may optionally be substituted; B is a hydrogen atom or a hydroxyl,...
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4178290 |
Dithiinoacetic acid and its preparation
α-Amino(1,3-dithiin-5-yl)-acetic acid in the D-, L-, or D,L-form and in which the amino radical is free or protected by tert.-butoxycarbonyl or 2,2,2-trichloroethoxycarbonyl is a useful...
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4178444 |
Hydrazono derivatives of cephalosporins
Hydrazono derivatives of cephalosporins of the formula ##STR1## wherein R is phenyl optionally substituted, 2- or 3-thienyl optionally substituted, or 2- or 3-furyl optionally substituted, R 1 is...
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4176231 |
Process for preparing 3-exomethylenecepham sulfoxides
3-Exomethylenecepham sulfoxides are prepared by the reaction of 3-methyl-3-halocepham sulfoxides with mercuric or mercurous perchlorate.
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4172198 |
7-(N-substituted-2-phenylglycinamido)-3-sub stituted-3-cephem-4-carboxylic acid compounds and preparation thereof
New cephalosporin compounds of the formula: ##STR1## wherein R 1 is hydrogen or hydroxy, R 2 is a substituted alkanoyl group, R 3 is hydrogen, carbamoyloxy, alkanoyloxy or a heterocyclic-thio...
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4169947 |
7β-[[[2-Acylamino]-1,2-dioxoethyl]amino]acyl cephalosporins
7β-[[[2-Acylamino]-1,2-dioxoethyl]amino]acyl cephalosporins of the formula ##STR1## wherein R is hydrogen, lower alkyl, phenyl-lower alkyl, diphenyl-lower alkyl, tri(lower alkyl)silyl,...
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4168309 |
Cephalosporins having a 7-(carboxy substituted α-etherified oximinoarylacetamido) group
Antibiotic compounds of the general formula ##STR1## [wherein R is a phenyl, thienyl or furyl group; R a and R b which may be the same or different, are each selected from hydrogen, C 1 -4 alkyl,...
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4166178 |
3-Acyloxymethyl-cephem compounds
Novel 3-acyloxymethyl-cephem compounds of the formula: ##STR1## wherein R 1 is hydrogen or an acyl group; X is a divalent group consisting of a carbon chain having 2 to 3 carbon atoms and a...
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4165430 |
Cephalosporins having a 7-carboxy substituted α-etherified oximinoarylacetamido) group
Cephalosporin antibiotics having the formula: ##STR1## (where R is thienyl, furyl or phenyl; R a is hydrogen, C 1 -4 alkyl, C 2 -4 alkenyl, C 3 -7 cycloalkyl or phenyl, and R b is hydrogen, C 1...
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4162360 |
3-Carbamoyloxymethyl-7-substituted oximino acetamido cephalosporanic acid derivatives
3-Carbamoyloxymethyl and 3-N-methylcarbamoyloxymethyl cephalosporin antibiotics in which the 7β-acylamido group has the structure ##STR1## where R is thienyl, furyl or phenyl; R a is C 1 -4...
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4160829 |
Antibacterial 1,2,4-oxadiazolylacetamido cephalosporins
1,2,4-Oxadiazolylacetic acid derivatives. The derivatives include penicillin and cephalosporin amides which have antibiotic properties.
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4150156 |
7-(Substituted methyl)-3-(substituted thio)-cephalosporins, derivatives and pharmaceutical compositions containing them
Disclosed are antibiotic 3-(substituted thio)-7-(substituted methyl) cephalosporins, derivatives and analogues thereof; wherein the methyl substituent is, inter alia, hydroxyl, ketonic oxygen,...
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4150223 |
Cephalosporin phosphonic acid, sulfonic acid and sulfonamide compounds
Novel antibiotics of the formula: ##STR1## and its salts, esters and amides wherein R is acyl; B is H, OCH 3 , CH 3 or SR" wherein R" is lower alkyl; A is hydrogen, hydroxy, or an organic group;...
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4147864 |
Process for the manufacture of 7β-amino-3-cephem-3-ol-4 carboxylic acid compounds
7β-amino-3-cephem-3-ol-4-carboxylic acid compounds of the formula ##STR1## wherein R 1 a represents hydrogen or an amino protective group R 1 A and R 1 B represents hydrogen or an acyl group...
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4147863 |
7-D-(-)-mandelamido-3-(1-methyl-1H-tetrazol-5-yl)vinyl- 3-cephem-4-carboxylic acid
Novel cephalosporin derivatives having a (1-alkyl-1H-tetrazol-5-yl)vinyl group at the 3-position of the cephem nucleus and showing an excellent antibacterial activity are disclosed. A process for...
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4145538 |
3-Carbamyloxymethyl-cephalosporins
The present invention is directed to 7-amino-3-carbamoyloxymethyl-3-cephem-4-carboxylic acid: ##STR1## and to precursors and derivatives. The compound, its precursors, and its derivatives exhibit...
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4138554 |
7-[D-α-(4-Hydroxy-1,5-naphthyridine-3-carboxamido)-α-phenyl (and p-hydroxyphenyl)acetamido]-3-carbamoyloxymethyl-3-cephem-4-carboxylic acids
7-[D-α-(4-hydroxy-1,5-naphthyridine-3-carboxyamido)-α-phen
yl (and p-hydroxyphenyl) acetamido]-3-carbamoyloxymethyl-3-cephem-4-carboxylic acids were synthesized and found to have potent...
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4138555 |
(6R,7R)-7-[2-aryl-2-(etherified oximino)acetamido]-3-carbamoyloxymethylceph-3-em-4-carboxylic acid 1-oxides
Cephalosporin antibiotics in which the 7β-acylamido group has the structure ##STR1## where R 1 is a furyl, thienyl or phenyl group and R 2 is a C 1 -C 4 alkyl, C 3 -C 7 cycloalkyl or phenyl...
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4137312 |
Epoxy substituted cephalosporin derivatives
A series of novel 7-(D-α-acylaminoarylacetamido)-Δ 3 -cephem derivatives have been prepared wherein the acyl moiety contains an epoxy group immediately adjacent to the carbonyl carbon atom....
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4132789 |
7-[2-(2-Imino-4-thiazolin-4-yl)-2-sulfoacetamido]cephalosporins and antibacterial compositions containing them
Novel cephalosporins shown by the general formula: ##STR1## wherein Y is an acyloxy group, a quaternary ammonium group or a group of the formula: --S--R in which R is a nitrogen-containing...
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4128715 |
Cephalosporin antibiotics
A special crystalline form of the L-lysine salt of the antibiotic cefuroxime is described. The salt has improved properties that permit it to be used in areas where cefuroxime itself and known...
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4122259 |
7β-[2-Aryl-2-(etherified oximino)acetamido]-3-N-substituted carbamoyloxymethylceph-3-em-4-carboxylic acids
Cephalosporin antibiotics in which the 7β-acylamido group is syn 2-aryl-2-(etherified imino) acetamido and in which the 3-position substituent is an alkyl-, alkenyl-etc. substituted...
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4115566 |
7α Ureido cephem-4-carboxylic acid derivatives
6-Acylamino-penam-3-carboxylic acids and 7-acylamino-3-cephem-4-carboxylic acids in which the acyl group has the formula ##STR1## in which R 1 is hydrogen, R 2 is optionally substituted phenyl,...
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4113940 |
7-Amino 2-lower alkyl-2 or 3-cephem-4-carboxylic acid derivatives and processes for preparation thereof
A compound of the formula ##STR1## wherein R 1 is amino or substituted amino, R 2 is carboxy or protected carboxy, R 3 is lower alkyl and X is --S-- or ##STR2## or a pharmaceutically acceptable...
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4112087 |
Cephalosporin type antibacterials having a substituted propenyl group in the 3-position
Compounds of the formula ##STR1## wherein R is alkyl having 1 to 4 carbon atoms, β-haloethyl, allyl, propargyl, cyclopentyl or benzyl; R 1 is hydrogen or an α-substituted acetamido group; R 2 ...
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4110327 |
2,3 Diketo-piperazinocarbonylamino alkanoic acids and derivatives
Novel penicillins and cephalosporins and non-toxic salts thereof, which contain a mono- or di-oxo- or thioxo-piperazino(thio)carbonylamino group in molecule. These compounds are valuable...
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4107431 |
Δ.sup.3 -3-Vinyl or substituted vinyl-4-carboxy cephalosporins
The invention is concerned with Δ 3 -4-carboxy cephalosporin antibiotics possessing a 3-vinyl or substituted 3-vinyl groups as well as with phosphorous intermediates useful in the preparation...
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4107433 |
Phthalidyl ester of 3-carbomoyloxy cephalosporin derivatives
Phthalidyl and substituted phthalidyl esters of certain cephalosporins are absorbed by the oral route into the serum, where they are hydrolyzed to the parent antibacterially active cephalosporin.
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