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7560545 Process for obtaining cefotetan with high yield  
The invention relates to a method for obtaining cefotetan acid substantially free of tautomer, by treating crude cefotetan with Al 3+ ions which cause the tautomer to precipitate. The precipitate...
7544677 Inhibitors of Akt activity  
The present invention is directed to compounds which contain substituted 5-deazapteridine moieties which inhibit the activity of Akt, a serine/threonine protein kinase. The invention is further...
7507813 Amorphous cefuroxime axetil and preparation process therefore  
A novel process for the preparation of amorphous cefuroxime axetil particles and the amorphous cefuroxime axetil particles therefrom are disclosed in the invention. Specifically, the invention is...
7045618 Cefpodixime proxetil  
The present invention relates to an improved and cost effective process for the industrial manufacture of cefpodoxime proxetil. More specifically, the present invention relates to the preparation...
6949641 Crystalline β-lactam intermediate  
The novel intermediate compound crystalline 7-[2-(2-fomylaminothiazol-4-yl)-2 -(Z)-(methoxyimino)acetamido]-3-methoxymethyl-3-cephem-4-car boxylic acid-1 -(isopropoxy/crystallization of cefpodoxime...
6835829 Purification process  
Processes for the depletion of 7-ADCA in mixtures of vinyl-ACA with 7-ADCA via novel salts of vinyl-ACA or via chromatography.
6803460 Process for the fermentative production of cephalosporin  
A method for the recovery of an N-substituted cephalosporanic acid compound of general formula (I), wherein R 2 is selected from the group consisting of adipyl (1,4-dicarboxybutane), succinyl,...
6602999 Amorphous form of cefpodoxime proxetil  
A novel process for the production of an improved amorphous form of cefpodoxime proxetil...
6552185 Process for the fermentative production of cephalosporin  
A method for the recovery of a compound formula (I) from a complex mixture, comprising the steps of: (a) acidifying the complex mixture to a pH below 6.5 and maintaining the mixture below said...
6504026 Process for production of ceftiofur  
Process for preparing ceftiofur having formula I: in the form of the sodium salt.
6489470 Process for the preparation of cefpodoxime proxetil diastereoisomers  
A process for increasing the diastereoisomeric ratio (B/A+B), wherein B is the more apolar and A is the more polar of two diastereoisomers, of a mixture of diastereoisomers of a compound of formula...
6350869 Crystalline amine salt of cefdinir  
Cefdinir in the form of a salt with dicyclohexylamine, a process for its production and its use in the purification of impure cefdinir.
6288223 Process for the selective preparation of Z-isomers of 3-2(substituted vinyl)cephalosporins  
There can be produced, at a high selectivity and in a high yield, the Z-isomer of a 7-N-unsubstituted or substituted-amino-3-[2-(4-substituted or unsubstituted-thiazol-5-yl)...
6284888 Vinyl-ACA purification process  
A process for purification of vinyl-ACA of formula ##STR1## from a mixture of vinyl-ACA and 7-ADCA of formula ##STR2## is provided. The process comprises a) producing a mixture of a salt of...
6172221 Clavulanic acid extraction process  
A back extraction process in which beta-lactam antibiotics or clavulanic acid is extracted from an organic solvent phase into an aqeous medium phase, using a mixing region in which the phases are...
6100393 Process for purifying 7-substituted aminodeacetoxy-cephalosporins through the use of filtration membranes  
Process for purifying 7-substituted aminodeacetoxycephalosporins through the use of filter membranes. A process for purification by ultrafiltration and/or nanofiltration with a cut-off for...
5874571 Process for the recovery of cephalexin  
The disclosed process is for the recovery of cephalexin from a mixture containing cephalexin and 7-aminodesacetoxy cephalosporanic acid (7-ADCA), wherein a mixture of cephalexin and 7-ADCA, with a...
5693790 Crystalline form of a cephalosporin antibiotic  
The preparation of a novel crystalline cefaclor and the conversion of such a product to cefaclor monohydrate are described. The new intermediate cefaclor is a particular crystalline form and...
5686588 Amine acid salt compounds and process for the production thereof  
A stoichiometric acid moiety transfer reaction for the preparation of an acid salt of an amine compound is disclosed. The acid moiety transfer reaction provides amine acid salts of high purity and...
4973685 Heteroannellated phenylglycine-β-lactam antibiotics  
Heteroannellated penicillins and cephalosporins of the formula ##STR1## in which R 1 --stands for a radical of the formula ##STR2##
4820833 Preparation of a highly pure, substantially amorphous form of cefuroxime axetil  
There is described a product which is a highly pure substantially amorphous form of cefuroxime axetil (cefuroxime 1-acetoxyethyl ester) which is stable, which has increased absorption via the...
4775751 Process for cephalexin hydrochloride alcoholates  
The crystalline ethanol or methanol solvates of cephalexin hydrochloride are isolated in high yield from solutions of cephalexin hydrochloride in substantially anhydrous ethanol or methanol,...
4727070 3-Propenzl cephalosporin isomer separation process and derivative  
The antibiotic 7-[D-2-amino-2-(4-hydroxyphenyl)acetamido]-3-[(Z)-1-propenyl ]ceph-3-em-4-c arboxylic acid (BMY-28100) forms imidazolidinone derivatives on reaction with ketones. These derivatives...
4719287 Higher alkyl pyrrolidone extractants for water soluble phenolic or carboxylic antibiotics  
The extraction of water soluble antibiotics containing a phenolic or carboxylic group from an aqueous solution or fermentation broth using a N--C 8 --C 14 alkyl pyrrolidone extractant and the...
4668782 Anhydrous crystalline or crystalline hemihydrate monohydrate or trihydrate of cephalosporin derivative  
An anhydrous crystalline, or crystalline hemihydrate, monohydrate or trihydrate of cephalosporin derivative of (6R,7R)-7-[(Z)-2-(2-aminothiazole-4-yl)-2-methoxy-iminoaceto amido]-3(1-qui...
4594417 Crystalline antibiotic salt  
Crystalline cephalosporin hydrochloride salt represented by the formula ##STR1## wherein the oxime is in the syn configuration, is a useful pharmaceutical form of, and tool for purification of, the...
4581166 Method for isolating and purifying antibiotics  
A process is proposed for the isolation and purification of antibiotics wherein an antibiotic containing solution is extracted with an extraction agent at a temperature of from 0° to 40° C. and...
4560749 Cephem-3-imidates and 3-amidines  
3-Azido-3-cephem esters are reacted with electron rich olefins, e.g., enamines and cyclic enol ethers, to provide C 3 amidines and imidates having antibacterial activity in the free acid form. For...
4535155 Method for separating cephalosporins  
The interseparating of desacetyl-cephalosporin C, desacetoxy-cephalosporin C and cephalosporin C can be accomplished by adsorbing these available cephalosporins on activated carbon and effecting a...
RE31730 Process for the preparation of the crystalline monohydrate of 7-(D-α-aα-(p-hydroxyphenyl)acetamido)-3-methyl-3-cephem-4-ca rboxylic acid  
A novel crystalline monohydrate of 7-[D-α-amino-α-(p-hydroxyphenyl)acetamido]-3-methyl-3-caph em-4 -carboxylic acid is prepared and found to be astable useful form of the cephalosporin antibiotic...
4477659 Cephalosporin compound  
A cephalosporin compound of the general formula (I): ##STR1## wherein X is a hydrogen atom, a chlorine atom, a methyl group, a methoxy group, an acetoxymethyl group or --CH 2 SHet wherein Het is a...
4477658 Process for the preparation of cepham and cephem compounds  
The invention concerns 7β-amino-cepham-3-one-4-carboxylic acid compounds, particularly esters thereof, and the N-substituted, especially N-acylated derivatives of such compounds. They can be used...
4456753 Process for the manufacture of highly crystalline sodium cefoperazone  
A process for the preparation of highly crystalline sodium cefoperazone comprising the controlled addition of acetone to a water/acetone/sodium cefoperazone solution and subsequent separating and...
4448958 Purification of ceforanide  
Crude cephalosporin 7-[α-(2-aminomethylphenyl)acetamido]-3-[(1-carboxymethyltet razol-5-y lthio)methyl]-3-cephem-4-carboxylic acid is purified by converting it to its salt with...
4339575 Substituted-imidazolidinyl-3-chloro-3-cephem-4-carboxylic acid  
7β-[2-(substituted or unsubstituted)-5-oxo-4-phenylimidazolidin-1-yl]-3-chloro-3-c ephem-4-carbox ylic acid represented by the formula: ##STR1## (wherein R is hydrogen or hydroxy: R 1 and R 2 ...
4298732 Crystallization process  
A process for the preparation of crystalline sodium cefuroxime (the sodium salt of (6R,7R)-3-carbamoyloxymethyl-7-[(Z)-2-(fur-2-yl)-2-methoxyim ino-acetamido] ceph-3-em-4-carboxylic acid) which...
4277601 Preparation of sodium cefuroxime  
A process for the preparation of the sodium salt of the antibiotic (6R,7R)-3-carbamoyloxymethyl-7-[Z-2-(fur-2-yl)-2-methoxyimin oacetamido]-ce ph-3-em-4-carboxylic acid (cefuroxime) which comprises...
4252951 Isolation of syn-7-(2-amino-4-thiazolyl)-(methoxyimino)acetamido-3-acetoxymethyl-3-ce phem-4-carboxylic acid  
Syn-7-(2-amino-4-thiazolyl)-(methoxyimino)-acetamido-3-aceto xymethyl-3-ceph em-4-carboxylic acid is isolated by formation of cyclic ether solvates.
4237051 Stereospecific production of 6- or 7-carbon-substituted-β-lactams  
Reaction of 6- or 7-diazo-β-lactams with allylic halides in the presence of a catalytic amount of metallic copper or a copper salt affords 6- or 7-carbon-substituted-β-lactams with the desired...
4224371 Sodium 3-acetoxylmethyl-7-[2-(2-amino-4-thiazolyl)-2-methoxyimino-acetamido]-ce ph-3-eme-4-carboxylate  
Novel stable crystalline hydrate of D form of the syn isomer of sodium 3-acetoxymethyl-7-[2-(2-amino-4-thiazolyl)-2-methoxyimino-ac etamido]-ceph- 3-eme-4-carboxylate having the formula ##STR1##...
4217275 β-Lactam antibiotic esterification process using methoxymethyl methane sulfonate  
Disclosed is an improved process for esterifying carboxylic acids, particularly 3-carboxylic acid groups of penicillins and 4-carboxylic acid groups of cephalosporins, to form methoxymethyl esters....
4211702 Process for preparation of penicillin and cephalosporin imino halides  
Penicillin and cephalosporin imino halides are prepared by reacting of 6-acylaminopenicillins or 7-acylamino cephalosporins with a novel chlorinating compound derived from a triaryl phosphite and...
4205165 Processing of cephalosporin C  
A process for the recovery of cephalosporin C comprises (a) contacting a fermentation broth containing cephalosporin C with an anion exchange resin which is either a weak-base resin in the weak...
4204058 Process for obtaining cephalosporin C and the salts and derivatives thereof from culture filtrates or culture solutions  
A novel process for obtaining cephalosporin C and the salts and derivatives thereof from culture filtrates or culture solutions is provided which comprises drying the culture filtrate or culture...
4196285 Antibiotic purification process  
Cephamycin C is concentrated and purified by subjecting a fermentation broth which contains Cephamycin C to the following sequence of steps: filtration at acidic pH, passage through a methylene...
4168375 Process for the recovery of cephalosporin C and derivatives thereof  
A process for the recovery of cephalosporin C from an aqueous medium, including the steps of treating the medium with a sulphonyl chloride of formula R--SO 2 Cl, in which R is a substituted or...
4167630 Process for epimerizing beta-lactam antibiotic compounds, and related products  
Through total synthesis methods developed in the assignee's laboratories, new as well as old penicillin and cephalosporin compounds (all containing the beta-lactam functional group) have been...
4145539 Process for isolation and purification of cephalosporin compound  
A process for the isolation and purification of cephalosporin from a solution containing impurities which includes treating the solution with macroporous non-ionic adsorption resin to adsorb the...
4137405 Isolation of antibiotic Cephamycin C  
Fermentation broths or impure solutions containing Cephamycin C, a substance having antibiotic activity against gram-negative and gram-positive microorganisms, are isolated using liquid anion...
4115645 Decolorizing process for 7-amino-3-(((2-methyl-1,3,4-thiadiazol-5-yl)thio)methyl)-3-cephem-4-carb oxylic acid  
The present invention is directed to the use of sodium sulfite and sodium dithionite for the decolorization of 7-amino-3-(((2-methyl-1,3,4-thiadiazol-5-yl)thio)methyl)-3-c ephem-4-carbox ylic acid.
Matches 1 - 50 out of 125 1 2 3 >