|
Match
|
Document |
Document Title |
|
|
4111933 |
Protection of functional groups during reaction and their subsequent restoration
In the process for preparing an organic compound of the formula A' -- X in which X is an amino group, a hydroxyl group or a carboxyl group, and A' is the remainder of the molecule, from an...
|
|
|
4112087 |
Cephalosporin type antibacterials having a substituted propenyl group in the 3-position
Compounds of the formula ##STR1## wherein R is alkyl having 1 to 4 carbon atoms, β-haloethyl, allyl, propargyl, cyclopentyl or benzyl; R 1 is hydrogen or an α-substituted acetamido group; R 2 ...
|
|
|
4110534 |
Process for the preparation of 3-vinyl and substituted vinyl cephalosporins
The invention is concerned with the preparation of Δ 3 -4-carboxy cephalosporin antibiotics possessing a 3-vinyl group or substituted 3-vinyl group by means of phosphorous intermediates.
|
|
|
4107431 |
Δ.sup.3 -3-Vinyl or substituted vinyl-4-carboxy cephalosporins
The invention is concerned with Δ 3 -4-carboxy cephalosporin antibiotics possessing a 3-vinyl or substituted 3-vinyl groups as well as with phosphorous intermediates useful in the preparation...
|
|
|
4101658 |
Antibacterial hydrazono cephalosporins
Antibacterial cephalosporins of the following formula: ##STR1## WHEREIN A and B each is a hydrogen or an amino protecting group; X is a hydroxy or a carboxy protecting group; Y is a hydrogen,...
|
|
|
4094978 |
3-Propenyl derivatives of cephalosporin, compositions and their use
3-(3-hydroxyprop-1-(t)-enyl)-7β-(α-substituted acetamido)-ceph-3-em-4-carboxylic acids; 3-(3-carbamoyloxyprop-1-(t)-enyl)-7β-(α-substituted acetamido)-ceph-3-em-4-carboxylic acids; and...
|
|
|
4093800 |
Process for preparing cepham compounds
A novel 4-(2'-benzothiazolyldithio)-3-imidoazetidin-2-one of the formula ##STR1## in which X is chloro or bromo and R 2 is methylene or oxygen is ring-closed to the corresponding...
|
|
|
4092474 |
Cephalosporins having a metaloxy group in 3-substituent
Antibacterial cephalosporins of the formula ##STR1## wherein Acyl is an acyl group; R is a hydrogen or methoxy, R 1 is a hydrocarbyl group containing 1 to 8 carbon atoms; R 2 is a hydrogen,...
|
|
|
4089955 |
7-β-[D-2-Amino-2-(1,4-cyclo hexadienyl)-acetylamino]-3-Hal-3-cephem-4-carboxylic acids
7β-[D-2-Amino-2-(1,4-cyclohexadienyl)-acetylamino]-3-Hal-3-
cephem-4-ca rboxylic acids, wherein Hal denotes halogen with an atomic number of up to 35, and pharmaceutically acceptable salts thereof...
|
|
|
4086341 |
Cephalosporin derivatives
Penicillin and cephalosporin derivatives characterized by the presence of a nitroalkyl, nitrocycloalkyl, nitrophenylalkyl or nitroanilinoalkyl group in the side chain are antibacterial agents. The...
|
|
|
4086423 |
Process for cephem synthesis
Cephalosporin antibiotics of the formula: ##STR1## are produced by cycloaddition of a glycine derivative of the formula ##STR2## with a thiazine derivative of the formula ##STR3##
|
|
|
4084049 |
Cepham derivatives
A compound of the formula ##STR1## wherein R' is amino or a conventional, pharmaceutically acceptable acylamino, R 2 is carboxy or a conventionally protected carboxy, X is -S- or ##STR2## R 3 is...
|
|
|
4081595 |
Reduction giving 3-cephem compounds
Antibacterial cephems having the following formula: ##STR1## (WHEREIN A is amino or substituted amino; COB is carboxy or protected carboxy; R is two hydrogens, hydrogen and a monovalent...
|
|
|
4079181 |
Certain 7-oxo-4-thio-2,6-diazabicyclo-3,2,0-hept-2-ene compounds
An intermediate represented by following formula for synthesizing 3-hydroxy-3-cephem compounds. ##STR1## wherein A and B each is a hydrogen or amino substituent; R is a hydrogen or thiol...
|
|
|
4073902 |
O-Substituted 7β-amino-3-cephem-3-ol-4-carboxylic acid compounds
The invention relates to O-substituted 7β-amino-3-cephem-3-ol-4-carboxylic acid compounds of the formula ##STR1## wherein X represents amino or substituted amino, R 2 represents hydroxyl or a...
|
|
|
4071681 |
Process for preparing beta-lactam antibiotic substances
Process for preparing β-lactam antibiotic substances useful as intermediate for various cephalosporin or penicillin derivatives, which comprises oxidation of 7-benzylideneaminocephem or...
|
|
|
4067866 |
Process for preparing cephalosporins and certain novel 2β-thiohydrazo-azetidinones as intermediates
A process is disclosed for preparing cephalosporins of structure: ##STR1## where R is selected from the class consisting of hydrogen, alkyl having from 1 to 4 carbon atoms, cyano-methyl-,...
|
|
|
4066641 |
Method for cyclization to give cephem ring
A compound represented by ##STR1## is treated with a base to give an antibacterial cephem compound represented by ##STR2## (wherein A is amino or substituted amino; Cob is carboxy or protected...
|
|
|
4066664 |
Intermediates for preparing α-carboxy-α-(3-thienyl)penicillin and cephalosporin derivatives
A new process is disclosed for the preparation of alpha-carboxy-alpha-phenyl(or 3-thienyl)penicillin and cephalosporin derivatives. The process comprises reacting a 1.3-dioxane-4.6-dione derivative...
|
|
|
4065620 |
3-(Substituted) vinyl cephalosporins
New 3-(substituted) vinyl cephalosporin compounds, e.g., 3-(2'-ethoxycarbonylvinyl)-7-phenoxyacetamido-3-cephem-4-car
boxylic acid, which are useful as antibiotics, and 3-(substituted) vinyl...
|
|
|
4065618 |
Process for 3-H-3-cephem esters
7-Amino-(or 7-acylamido)-3-(disubstituted-amino)-3-cephem-4-carboxylic acid esters are prepared with the corresponding 3-chloro-3-cephem ester or 3-alkyl-(or aryl)-sulfonyloxy-3-cephem esters and a...
|
|
|
4065621 |
Process for 3-alkyl and 3-phenyl cephalosporins
7-Amino-(or 7-acylamido)-3-(disubstituted-amino)-3-cephem-4-carboxylic acid esters are prepared with the corresponding 3-chloro-3-cephem ester or 3-alkyl-(or aryl)-sulfonyloxy-3-cephem esters and a...
|
|
|
4064122 |
Hydroxy-substituted cephalosporins
Hydroxy-substituted cephalosporins, particularly 7-(α-hydroxy-arylacetamido)-3-substituted-3-cephem-4-carbox
ylic acids of the formula: ##STR1## wherein R is a hydrogen atom, an esterified carboxy...
|
|
|
4061630 |
7-Substituted-ureido-3-carbamoyloxymethyl cephalosporin antibiotics
Cephalosporin compounds represented by the formula ##STR1## wherein R is an acylamino group ##STR2## and R' is for example phenyl or furyl, R" is H or CH 3 ; or R is a substituted ureido group...
|
|
|
4061628 |
Intermediates for producing semi-synthetic penicillins and cephalosporins and methods of production
Novel 6-APA, 7-ACA, and 7-ADCA derivatives are described which comprise phosphorylated derivatives of 6-APA, 7-ACA, or 7-ADCA and the corresponding acylated derivatives thereof. The novel compounds...
|
|
|
4060611 |
3-Carbamylbenzyl-7-(phenylglycyl)amino cephalosporin derivatives
Antibacterial 3-carbamoylbenzyl cephems and 3-(carbamoylpyridylmethyl) cephems, pharmaceutically acceptable salts and in vivo hydrolyzable esters thereof; pharmaceutical compositions containing...
|
|
|
4060686 |
Cephalosporins having a 7-(carboxy substituted α-etherified oximinoarylacetamido) group
3-Carbamoyloxymethyl and 3-N-methylcarbamoyloxymethyl cephalosporin antibiotics in which the 7β-acylamido group has the structure ##STR1## where R is thienyl, furyl or phenyl; R a is C 1 -4...
|
|
|
4060687 |
Cephalosporins having a 3-α substituted alkyl grouping
Novel cephalosporin compounds having a 3'-α-methyl, a 3-aryl or 3-heterocycle substituent are prepared by total synthesis. The novel cephalosporin compounds are active against gram-negative and...
|
|
|
4058661 |
7-Diacyl cephalosporins
New 7-diacylimido cephalosporins are produced by reacting 7-acylamido cephalosporins with an acylating agent in the presence of a silyl reagent. The 7-diacylimido cephalosporins are cleaved to...
|
|
|
4058521 |
2-Halomethyl-2-nucleophilic substituted methyl penicillins
Antibacterial compounds of the formula ##STR1## (where COB is carboxy or protected carboxy; Hal is halogen; R is amino or protected amino; R' is mercapto-protecting group; and X is...
|
|
|
4053597 |
Hydroxy-phenylacetamido cephalosporin compositions and method of use
Cephalosporan compounds of the formula ##STR1## in the form of racemic mixtures or optically active isomers or in the form of their cis or trans isomers or mixtures thereof wherein R is selected...
|
|
|
4053469 |
Intermediates for the preparation of 7-acylamino-3-oxyiminomethyl-3-cephem-4-carboxylic acids
An antibacterial 7-protected amino-3-oxyiminomethyl-3-cephem-4-carboxylic acid is prepared by the reaction of a 7-protected amino-3-formyl-3-cephem-4-carboxylic acid or its reactive derivatives...
|
|
|
4052408 |
Oxyacetic acid compounds and process for their manufacture
α-Hydroxy-2-oxo-1-azetidinemethane-carboxylic acid compounds of formula ##STR1## wherein R 1 represents a hydrogen atom or the organic residue of an alcohol, R 2 represents a hydrogen atom or an...
|
|
|
4043991 |
Preparation of peptides and cephalosporins
An improved process for producing a peptide and a cephalosporin which comprises treating a phosphoramide derivative of the formula: ##STR1## wherein R 1 and R 2 are each an alkyl group, a...
|
|
|
4044002 |
Reduction process for cephalosporin sulfoxides
Cephalosporin sulfoxides are reduced to the corresponding cephalosporin with acyl bromides, e.g., acetyl bromide, in the presence of a bromine scavenger, e.g., an olefin, acetylene, phenol, phenol...
|
|
|
4042585 |
Process for preparation of 3-halomethylcephems
3-Halomethyl-3-cephems are provided by reacting a 3-methylenecepham with an alkali metal salt of a lower alcohol or a bicyclic amidine base in the presence of a positive halogenating agent at a...
|
|
|
4038275 |
Process for preparation of 3-hydroxymethylcephems
3-Hydroxymethyl-2-cephems are provided by (1) reacting a 2-halomethylcephem compound with a γ-hydroxycarboxylic acid salt or a δ-hydroxycarboxylic acid salt and (2) reacting the novel γ or...
|
|
|
4036835 |
Process for preparing cephalosporins
A process for preparing cephalosporins of structure: ##STR1## where R is hydrogen, C 1 to C 4 alkyl, cyano-methyl-, thienyl-methyl, furyl-methyl-, naphthyl-methyl-, phenyl-methyl-,...
|
|
|
4031084 |
Process for cephalosporin antibiotic intermediates
7-Acylamido-3-exomethylenecepham ester sulfoxides are reacted with ozone to provide the corresponding 3-hydroxy-3-cephem ester sulfoxides, intermediates for 3-methoxy and 3-halo substituted...
|
|
|
4029806 |
Nitro-β-lactam antibiotics and processes for their preparation and use
Penicillin and cephalosporin derivatives characterized by the presence of a nitroalkyl, nitrocycloalkyl, nitrophenylalkyl or nitroanilinoalkyl group in the side chain are antibacterial agents. The...
|
|
|
4021426 |
Process for preparing 6-aminopenicillanic acid, 7-aminocephalosporanic acid and its derivatives at the 3-position
A process for preparing 6-APA and 7-ACA and derivatives therefore is disclosed wherein a penicillin or cephalosporin substrate is reacted with a molar excess of an oxalyl halide of the formula...
|
|
|
4018776 |
Process for the preparation of cephalosporins from the corresponding azetidinone-thiazoline derivatives
A process is disclosed for preparing a cephalosporin of structure: ##STR1## where R is selected from the class consisting of hydrogen, alkyl having from 1 to 4 carbon atoms, cyano-methyl,...
|
|
|
4014869 |
Cephalosporin derivatives
Novel antibiotic compounds which are 7β-acrylamidoceph-3-em-4-carboxylic acids, and 6β-acrylamidopenam-3-carboxylic acids and non-toxic derivatives thereof wherein the acrylamido group has the...
|
|
|
4014872 |
Substituted 3-hydroxy- or 3-oxo-cephams
The invention relates to novel semisynthetic intermediates or relay compounds of use in the production of cephalosporins and related β-lactam antibiotic compounds. The novel compounds are...
|
|
|
4014868 |
Preparation of β-lactam antibiotics
The sodium salt of amoxycillin or other β-lactam antibiotic is prepared by slurrying the antibiotic in zwitterionic form in a lower alkanol-containing organic solvent system, causing dissolution...
|
|
|
4013650 |
Process for the manufacture of 3-methylene-cepham compounds
Compounds of the formula ##STR1## wherein R 1 a represents hydrogen or an amino protective group R 1 A and R 1 b represents hydrogen or an acyl group Ac, or R 1 a and R 1 b together represent...
|
|
|
4013651 |
3-Substituted amino-cephalosporins
7-Amino-(or 7-acylamido)-3-(disubstituted-amino)-3-cephem-4-carboxylic acid esters are prepared with the corresponding 3-chloro-3-cephem ester or 3-alkyl-(or aryl)-sulfonyloxy-3-cephem esters and a...
|
|
|
4012380 |
7-Acylamino-3-acyl-2(or 3)cephems
Intermediate C-3 1-hydroxyalkyl or 1-hydroxyarylalkyl cephems, prepared by reacting Grignard reagents at low temperature with 3-formyl-2-cephem compounds, are oxidized to the corresponding...
|
|
|
4011214 |
3-(Morpholinoalkoxyiminomethyl)cephem compounds
Novel cephalosporin compounds of the formula ##STR1## wherein R 1 is an acyl group and R 2 is an alkylene group which may be substituted with a lower alkoxyl group, or pharmaceutically acceptable...
|
|
|
4010156 |
Process for the rearrangement of penicillins to cephalosporins and intermediate compounds thereof
Penicillin sulfoxides are converted to 3-halo-3-methyl-cepham-4-carboxylic acid esters and amides or the corresponding cephem derivatives by heating the penicillin sulfoxide precursor in a...
|