|
Match
|
Document |
Document Title |
|
|
5204458 |
Process for preparing cephem derivatives
The present invention provides a process for preparing a cephem derivative characterized in that an allenyl β-lactam compound represented by the formula (1) ##STR1## wherein R 1 is amino or...
|
|
|
5164494 |
Cephalosporin derivatives
Process for the preparation of 7β-amino-3-substituted methyl-3-cephem-4-carboxylic acid derivatives, new intermediates comprising 7β-(cyclo)alkylideneammonio-3-halomethyl-3-cephem-4-carbox ylic...
|
|
|
5162524 |
Processes for making cephems from allenylazetidinone derivatives
This invention relates to a novel process for making a cephem of formula II from a 2-(3-amino-2-oxo-azetidin-1-yl)-2,3-butadienoate intermediate of formula I using an organo-copper reagent. In...
|
|
|
5159071 |
Process for the manufacture of 7-amino-3-exomethylene-3-cepham-4-carboxylic acid ester
A one-pot process for preparing 7-amino-3-exomethylene-3-cepham-4-carboxylic acid ester (II) comprises: (a) reacting 7-acylamino-3-exomethylene-3-cepham-1-oxide-4-carboxylic acid ester (I) with a...
|
|
|
5149803 |
Intermediates for cephalosporin compounds
Cephalosporin antibiotics having a 3-position substituent of the formula: --CH 2 NR 1 --Y--A--Z--Q are described, wherein R 1 is hydrogen or certain optionally substituted alkyl groups; Y is...
|
|
|
5142040 |
Process for preparing a 3-formylcephem derivative
The present invention provides a process for preparing a 3-formylcephem derivative represented by the formula (2) ##STR1## which comprises oxidizing in the presence of oxygen a 3-halomethylcephem...
|
|
|
5142042 |
Process for preparing well crystallized alkali metal salts of 3, 7-substituted 7-aminocephalosporanic acid derivatives
A process for preparing a well crystallized alkali metal salt of 3, 7-substituted 7-aminocephalosporanic acid derivatives having the general formula: ##STR1## wherein: R1= ##STR2## R 2 =CH3 or C1...
|
|
|
5132419 |
Process for the preparation of 7-amino-3-((Z)-1-propen-1yl)-3-cephem-4-carboxylic acid
(7-APCA) having the formula (I) ##STR1## which is an important synthesis intermediate in the preparation of cephalosporin-like antibiotics, is prepared by treating a compound of the formula (II)...
|
|
|
5126444 |
Intermediates for cephalosporin compounds
Cephalosporin antibiotics having a 3-position substituent of the formula: ##STR1## are described; wherein R 1 is hydrogen or certain substituted alkyl groups, Z is CH or N, R 2 and R 3 are...
|
|
|
5126446 |
Process for 3-exomethylenecepham sulfoxide esters
3-Exomethylenecepham sulfoxide esters are obtained in improved yields via cyclization of 3-methyl-2-(4-chlorosulfinyl-2-oxo-3-amino-1-azetidinyl)-3-b
utenoic acid esters under anhydrous conditions...
|
|
|
5112967 |
Process for synthesizing antibacterial cephalosporin compounds
A process for synthesizing 3-acryloxymethyl antibacterialcephalosporin compounds of formula ##STR1## wherein R is hydrogen or a carboxylic acid protecting group; R 1 is hydrogen or an acyl group;...
|
|
|
5109132 |
Process for the preparation of 3-exomethylene cepham derivatives
A process is provided for the preparation of 3-methylene and 3-halomethylene cepham derivatives via 3-phosphoniomethyl-3-cephem derivatives, which in turn can be prepared from 3-halomethyl-3-cephem...
|
|
|
5095107 |
Process for cleavage of esters during the production of cephalosporins
Superior method for the removal of the methyl or ethyl ester group from cephalosporin and carbacephalosporin carboxylic acids.
|
|
|
5066797 |
Process for preparing cepham intermediates
There is described a process for producing exomethylene cepham intermediates useful in cephalosporin chemistry. The process comprises the preparation of a compound of the formula ##STR1## in which...
|
|
|
5053500 |
Intermediates for the preparation of beta-lactam antibiotics
Cephalosporin derivatives of the formulae ##STR1## wherein X is sulphur, oxygen, methylene or sulphinyl, R3 is hydrogen or methoxy, R54 is hydrogen or a carboxyl protecting group, R 51 is a...
|
|
|
5043439 |
Process for production of cephalosporins
Cephalosporin intermediates having a replacable organosulfonylyoxy or heterocyclothio group in the 3-position undergo a carbon alkylation process with organocopper reagents to provide 3-hydrocarbon...
|
|
|
5037975 |
Cephalosporin free radical compounds
The invention provides a free radical process for preparing 1-carba(1-dethia)cephalosporin antibiotics with 2-substituted methylcephalosporin 1,1-dioxides wherein the substituent on the 2-methylene...
|
|
|
5034522 |
Method for the production of 3-methyl cephem derivatives
A method for obtaining improved cophalexin monohydrate or cephradine monohydrate yields and purities in the syntheses of such materials by the acylation of silyl esters of 7-ADCA, which involves...
|
|
|
5034521 |
Process for preparing 3-substituted methyl-3-cephem-4-carboxylic acid
A novel process is disclosed for preparing a 3-substituted methyl-3-cephem-4-carboxylic acid or pharmaceutically acceptable salt thereof. The process comprises reacting a...
|
|
|
4994454 |
Cepham derivatives
A process is provided for the preparation of 3-methylene and 3-halomethylene cepham derivatives via 3-phosphoniomethyl-3-cephem derivatives, which in turn can be prepared from 3-halomethyl-3-cephem...
|
|
|
4992541 |
Process for the preparation of 1,1-dioxo-7-substituted cephems
The present invention relates to an improved process for the preparation of the compounds of formula (I) ##STR1## which involve the direct oxidation without N-protection of the compound of the...
|
|
|
4958018 |
Method for production of 3-exomethylenecepham derivatives
Disclosed is a method of producing a 3-exomethylenecepham of the formula ##STR1## wherein R 1 is amino or substituted amino and R 2 is a carboxy-protecting group comprising reacting a cephem of...
|
|
|
4950753 |
Process for 3-exomethylenecepham sulfoxide esters
3-Exomethylenecepham sulfoxide esters are obtained in improved yields via cyclization of 3-methyl-2-(4-chlorosulfinyl-2-oxo-3-acylamino-1-azetidinyl)
-3-butenoic acid esters under anhydrous...
|
|
|
4945159 |
Formation of lactams and other amides under mild conditions by action of cyanogen
A method for the formation of intramolecular amide bonds by the action of cyanogen, under mild reaction conditions, in the preparation of cyclic amides, including lactams, in biologically active...
|
|
|
4902793 |
Process for preparing 3-alkoxymethylcephalosporins
A process for preparing 3-alkoxymethylcephalosporins which are useful as an intermediate for various cephalosporin derivatives having a high antimicrobial activity is disclosed. According to the...
|
|
|
4888100 |
Photochemical conversion of cephalosporins, 1-carba(1-dethia)cephalosporins and 1-oxa(1-dethia)cephalosporins
A process for photochemically converting 3-exomethylene cephams (or 1-carba(1-dethia)cephams or and 1-oxa(1-dethia)cephams) from the corresponding 3-alkyl-3-cephem (or 1-carba(1-dethia)cephem or...
|
|
|
4855419 |
Application of 4-[1-oxoalkyl]-2,5-oxazolidinediones in selective stereospecific formation of biologically active α-lactams
The present invention relates to a method for producing novel 4-[1-oxoalkyl]-2,5-oxazolidinediones, (4-1 OOD), and their use in a stereoselective method of producing beta-lactam-containing...
|
|
|
4855418 |
Process for production of ceophalosporins
Cephalosporin and 1-carba(1-dethia)cephalosporin antibiotics substituted in the 3-position with, inter alia, alkyl, alkenyl and alkynyl, are provided via process comprising conversion of a...
|
|
|
4853468 |
Process for the preparation of cephem derivatives
This invention provides azetidinone derivatives represented by the formula ##STR1## and processes for preparing the same. The azetidinone derivatives are used as the intermediates for producing...
|
|
|
4847373 |
Production of 3-allyl- and 3-butenyl-3-cephems
There is disclosed a process for the production of certain 2-allyl- and 3-butenyl-3-cephem derivatives by coupling a 3-chloromethyl-3-cephem with a hydrocarbyltributystannane in the presence of...
|
|
|
4820832 |
Process for preparing 3-unsubstituted cephalosporins and 1-carba(dethia)cephalosporins
A process for preparing 7β-acylamino (or 7β-protected amino)-3-H-1-carba(1-dethia)-3-cephem-4-carboxylic acid esters and the corresponding cephalosporins is provided. 7β-Acylamino (or...
|
|
|
4760060 |
3-heteroaralkylthio carbacephem compounds and antibacterial pharmaceutical composition
Carbacephem and cephem compounds represented by the formula: ##STR1## [Wherein X is S or CH 2 ; n is an integer of 1 to 5; R 1 is an unsubstituted or substituted heterocyclic group (where the...
|
|
|
4735937 |
8-oxo-5-thia-1-azabicyclo(4,2,0)oct-2-ene compounds
The invention concerns 7-amino-ceph-3-em-4-carboxylic acid compounds of the formula ##STR1## wherein R 1 a represents hydrogen or an amino protective group R 1 A and R 1 b represent hydrogen or...
|
|
|
4727070 |
3-Propenzl cephalosporin isomer separation process and derivative
The antibiotic 7-[D-2-amino-2-(4-hydroxyphenyl)acetamido]-3-[(Z)-1-propenyl
]ceph-3-em-4-c arboxylic acid (BMY-28100) forms imidazolidinone derivatives on reaction with ketones. These derivatives...
|
|
|
4705851 |
Process for the preparation of 3-phosphoniummethyl-3-cephem compounds
The invention relates to a process for the preparation of 3-phosphoniummethyl-3-cephem compounds of the formula: ##STR1## wherein R 3 is aryl, or a salt thereof, which is characterized by reacting...
|
|
|
4703118 |
Synthesis of 3-iodomethyl cephalosporins
The present invention provides a process for preparing a 3-iodomethyl cephalosporin by treating a bis(trialkylsilyl)-7-amino-4-carboxylic acid-3-substituted cephalosporin derivative with a...
|
|
|
4699979 |
7-amino-3-propenylcephalosporanic acid and esters thereof
This invention provides novel cephalosporin intermediates, 7β-amino-3-[(Z)-1-propen-1-y1]-3-cephem-4-carboxylic acid and esters thereof having the general formula ##STR1## wherein the...
|
|
|
4695627 |
Cephalosporin deoxygenation process
A process for the preparation of 7β-acylamino-3-substituted-3-cephem-4-carboxylic acid compounds comprising reacting at -70° C. to 0° C. in an inert organic solvent phosphorus pentachloride with...
|
|
|
4694079 |
3-propenyl cephalosporin solvates
7-[(D)-2-Amino-2-(4-hydroxyphenyl)acetamido]-3-[(Z)-1-propen
yl]ceph-3-em-4- carboxylic acid in the form of its crystalline dimethylformamide solvate (1/1.5) has been provided.
|
|
|
4668781 |
Ceph-3-one compounds and process for their manufacture
The invention concerns 7β-amino-cepham-3-one-4-carboxylic acid compounds, particularly esters thereof, and the N-substituted, especially N-acylated derivatives of such compounds. They can be used...
|
|
|
4666899 |
3-(Optionally substituted-but-1-en-3-ynyl) cephalosporins
Compounds of general formula I ##STR1## (wherein R represents NH 2 -- or an acylated or silylated amino group; R 2 represents a hydrogen, halogen, alkyl, aryl, carboxyl or lower alkoxycarbonyl...
|
|
|
4661590 |
Substituted vinyl cephalosporins
3-[(Z)-1-Propen-1-yl]-7-acylamido cephalosporins in which the 7-acyl group is phenylglycyl or substituted phenylglycyl are orally active antibiotics against Gram+ and Gram- bacteria.
|
|
|
4656264 |
Bicyclic azetidinone intermediates
An azetidinone compound represented by the formula ##STR1## wherein R 1 represents a substituted or unsubstituted phenyl group, R 2 represents a carboxyl-protecting group, X represents a hydrogen...
|
|
|
4647658 |
Process for preparing aminohydroxycephamcarboxylates
A useful synthetic intermediate, 7-amino-3-acyloxycepham-4-carboxylic acid aralkyl ester, is prepared by reducing 7-amido-3-oxocepham-4-carboxylic acid aralkyl ester with alkali metal borohydride...
|
|
|
4640798 |
Intermediates for the preparation of penicillin and cephalosporin compounds
There is described a process for preparing a sulphoxide of the formula ##STR1## in which R 1 , R 2 , R 3 and R 4 , taken individually, are alkyl, alkoxy or aryl groups, X is an alkylene group, R 5...
|
|
|
4637999 |
Substituted cephalosporins as anti-inflammatory and antidegenerative agents
Substituted cephalosporins are found to be potent elastase inhibitors and thereby useful antiinflammatory/antidegenerative agents.
|
|
|
4631274 |
Halovinyl cephem compounds
The invention relates to novel halovinyl cephem derivatives of high antimicrobial activity of the formula: ##STR1## wherein R 1 is a group of the formula: R 4 --A--CONH-- in which R 4 is...
|
|
|
4629542 |
Process for preparing 3-exomethylenecepham derivatives
This invention provides a process for preparing 3-exomethylenecepham derivatives represented by the formula ##STR1## wherein R 1 is arylacetylamino, aryloxyacetylamino, heterocyclic acetylamino or...
|
|
|
4625021 |
High yield process for preparing beta-lactam antibiotics having a high purity degree
A high yield process for preparing beta-lactam antibiotics having a high purity degree, in particular derivatives of the cephalosporanic and penicillanic acids, of the formula: ##STR1## by...
|
|
|
4623645 |
Substituted cephalosporin sulfoxides as anti-inflammatory and antidegenerative agents
Substituted cephalosporin sulfoxides are found to be potent elastase inhibitors and thereby useful anti-inflammatory/antidegenerative agents.
|