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7579339 |
Ring-substituted diphenylazetidinones, process for their preparation, medicaments comprising these compounds, and their use
One embodiment of the invention relates to compounds of the formula I,
in which R1, R2, R3, R4, R5 and R6 have the meanings given in the specification. Other embodiments of the invention relate...
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7576200 |
Diphenylazetidinones, process for their preparation, medicaments comprising these compounds and their use
Compounds of the formula I,
in which R1, R2, R3, R4, R5, and R6 have the meanings given in the description, and their physiologically acceptable salts. The compounds are suitable for use, for...
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7563888 |
Process for the preparation of diphenyl azetidinone derivatives
The present invention is a process for the preparation of diphenylazetidinone derivatives of the formula (I) or forms thereof comprising the substituents X, R 1 and/or R 2 as defined herein. More...
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7541458 |
β-lactam synthesis
The present invention is directed to a process for the preparation of β-lactams. Generally, an imine is cyclocondensed with a ketene acetal or enolate to form the β-lactam product in a “one...
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7538212 |
Intermediate for carbapenem compound for oral administration and process for producing the same
The present invention provides a novel intermediate represented by formula (1), (3), or (4) for efficiently producing a 1β-methylcarbapenem compound for oral administration, and a process for...
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7524952 |
Process for producing carbapenem compound for oral administration
The present invention provides a process for efficiently producing a 1β-methylcarbapenem compound for oral administration. The process, which is for producing a 1β-methylcarbapenem compound...
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7504410 |
Chk-, Pdk- and Akt-inhibitory pyrimidines, their production and use as pharmaceutical agents
This invention relates to pyrimidine derivatives of general formula (I) as inhibitors of kinases, their production as well as their use as medications for treating various diseases.
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7501404 |
Substituted azetidinones
Compounds are provided which have the structure
Wherein A, B, C, D, m, Y, Ra, Rc, Rd, and Rd′ are as described herein, and which are useful as inhibitors of tryptase, thrombin, trypsin,...
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7498431 |
Process for the preparation of chiral azetidinones
Processes for preparing compounds of formula I are disclosed comprising the steps of:
(a) forming of chiral propionic acid ester compounds of formula V.
(b) reacting compounds of formula V...
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7488818 |
Method for producing 1,4-diphenyl azetidinone derivatives
The present invention is directed to the preparation of novel compounds useful in the treatment of hyperlipidemia, arteriosclerosis, hypercholesterolemia, and other related metabolic disorders....
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7482445 |
Crystalline carbapenem intermediate
This invention relates to crystals of compounds of formula (I), wherein TBS represents t-butyldimethylsilyl, and Ph represents phenyl, or its salt or solvate. Compounds of formula (I) are synthesis...
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7470678 |
Diphenylazetidinone derivatives for treating disorders of the lipid metabolism
Compounds of formula (I): (wherein variable groups are as defined within) pharmaceutically acceptable salts, solvates, solvates of such salts and prodrugs thereof and their use as cholesterol...
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7465720 |
Proteasome inhibiting β-lactam compounds
Disclosed is a total synthesis of a biologically active β-Lactam—Compound 3, which is related to Salinosporamide A and Omuralide, both structurally and by its activity as a proteasome inhibitor....
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7435727 |
Method for isolating an intestinal cholesterol binding protein
The invention describes a method for isolating an intestinal protein which is able to bind cholesterol and/or cholesterol uptake inhibitors. Methods of identifying inhibitors of cholesterol uptake...
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7407938 |
Ring-substituted diphenylazetidinones, process for their preparation, medicaments comprising these compounds, and their use
One embodiment of the invention relates to compounds of the formula I,
in which R1, R2, R3, R4, R5 and R6 have the meanings given in the specification. Other embodiments of the invention relate...
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RE40183 |
7-Substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines
The invention is drawn to 7-substituted-9-(substituted amino)-6-demethyl-6-deoxytetracycline compounds of the formula
wherein R, X, R 5 and R 6 are defined in the specification. The...
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7320972 |
4-Biarylyl-1-phenylazetidin-2-ones
4-Biarylyl-1-phenylazetidin-2-ones useful for the treatment of hypercholesterolemia are disclosed. The compounds are of the general formula
in which
represents an aryl or heteroaryl...
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7223859 |
Method for producing (R)-3-[4-(trifluoromethyl) phenylamino]-pentanoic acid amide derivative
The present invention provides a method for easily producing an (R)-3-[4-(trifluoromethyl)phenylamino]-pentanoic acid amide derivative useful for an intermediate for pharmaceutical products,...
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7214364 |
Inhalable aztreonam lysinate formulation for treatment and prevention of pulmonary bacterial infections
A method and a composition for treatment of pulmonary bacterial infections caused by gram-negative bacteria suitable for treatment of infection caused by Escherichia coli, Klebsiella pneumoniae,...
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7208486 |
Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
The present invention provides compounds represented by the structural formula (I):
or pharmaceutically acceptable isomers, salts, solvates or esters of the compound of Formula (I), wherein...
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7205290 |
Diphenylazetidinone with improved physiological properties, process for its preparation, medicaments comprising this compound, and its use
The invention relates to the compound of the formula 1
and to its physiologically acceptable salts. The compound is suitable, for example, as a hypolipidemic.
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7176193 |
Acid-group-substituted diphenylazetidinones, process for their preparation, medicaments comprising these compounds, and their use
One embodiment of the invention relates to compounds of the formula I:
in which R1, R2, R3, R4, R5 and R6 have the meanings given in the specification. Other embodiments of the invention relate...
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7115595 |
Carbapenem compounds
Carbapenem compounds having a substituted phenyl or a substituted thienyl directly attached to the 3 -position of carbapenem nucleus as represented by the formula:
wherein Ring E is benzene...
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7045515 |
β-lactam compounds process for reproducing the same and serum cholesterol-lowering agents containing the same
Novel β-lactam compounds represented by the following formula (I) or pharmaceutically acceptable salts thereof which are useful as serum cholesterol-lowering agents:
(I) wherein A 1 , A 3 and...
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7041836 |
Antibiotic compounds
The present invention relates to carbapenems and provides a compound of the formula (I):
or a pharmaceutically acceptable salt or in vivo hydrolysable ester thereof wherein:
R 1 is...
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7022842 |
Process for synthesizing beta-lactam
It is an object of the present invention to provide a method for synthesizing β-lactams and a method for manufacturing β-lactams in water of high-temperature and under high-pressure, and the...
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7002008 |
Process for the preparation of 1-(4-fluorophenyl)-4(S)-(4-hydroxyphenyl)-azetidin-2-one
A process for preparing a compound of the formula
comprising:
(a) formation of 3(S)-(4-hydroxyphenyl)-3-methanesulfonyloxy-propionic acid methyl ester compound of the formula
(b)...
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RE38947 |
Method of enantioselectively catalyzing a reaction
A chiral catalyst is disclosed together with methods of using it for enantioselective syntheses. The chiral catalyst includes a nucleus with two metal atoms that has four bridging ligands oriented...
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6982251 |
Substituted 2-azetidinones useful as hypocholesterolemic agents
Hypocholesterolemic substituted 2-azetidinone compounds of the formula:
are disclosed, as well as a methods of lowering cholesterol by administering said compounds, pharmaceutical compositions...
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6900312 |
Thiazole-substituted β-lactams
The present discovery consists in new thiazole-substituted β-lactams of general formula (I), as well as the method for their preparation.
R1, R2, R3, R4, R5, R6, R7, and R8 are, independently...
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6894041 |
Oxazolyl-acid amide derivatives useful as inhibitors of PDE4 isozymes
This application is directed to compounds useful as inhibitors of PDE4 in the treatment of diseases regulated by the activation and degranulation of eosinophils, especially asthma, chronic...
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6890921 |
Arylsubstituted piperazines useful in the treatment of benign prostatic hyperplasia
This invention relates to a series of arylsubstituted piperazines, of Formula I
pharmaceutical compositions containing them and intermediates used in their manufacture. The compounds of the...
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6867297 |
Process for synthesizing 4-substituted azetidinone derivatives
An azetidinone derivative represented by the general formula (1)
(wherein OR 1 is a protected hydroxyl group; R 2 is a substituted or unsubstituted alkyl group, a substituted or...
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6858727 |
Intermediate of carbapenem antibiotics and process for the preparation thereof
There is disclosed an azetidinone compound of the formula (I):
wherein R is hydrogen, or a hydroxy protecting group, R 1 and R 2 are each independently alkyl of 1-15 carbon atoms, benzyl or...
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6733744 |
Indole compounds as minimally invasive physiological function monitoring agents
Highly hydrophilic indole and benzoindole derivatives that absorb and fluoresce in the visible region of light are disclosed. These compounds are useful for physiological and organ function...
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6703386 |
Diphenylazetidinone derivatives, process for their preparation, medicaments comprising these compounds and their use
Compounds of the formula I, for example, are disclosed, in which R1, R2, R3, R4, R5, and R6 independently of one another are (C 0 -C 30 )-alkylene-L or are the meanings given in the description,...
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6608070 |
2,3-substituted indole compounds as anti-inflammatory and analgesic agents
This invention provides a compound of the following formula: or the pharmaceutically acceptable salts thereof wherein Z is OH, C1-6 alkoxy, —NR2R3 or heterocycle; Q is selected from the...
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6605716 |
Process for the preparation of hydroxy and amino compounds
A process for the preparation of hydroxy and amino compounds, in which, in a first step, an aldehyde, ketone or imine is reacted in a Reformatsky reaction with a reactive halogen compound and zinc,...
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6562962 |
Preparation of substituted isoserine esters using metal alkoxides and β-lactams
A process for preparing N-acyl, N-sulfonyl and N-phosphoryl substituted isoserine esters in which a metal alkoxide is reacted with a β-lactam.
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6559140 |
Cyclic and bicyclic diamino histamine-3 receptor antagonists
Compounds of formula (I) compounds of formula (II) compounds of formula (III) and compounds of formula (IV) or pharmaceutically acceptable salts thereof are useful as H 3 receptor...
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6544976 |
Neurotrophic 2-azetidinecarboxylic acid derivatives, and related compositions and methods
This invention provides compounds having the following general structure: This invention also provides pharmaceutical compositions comprising same and methods of using these compositions to...
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6509463 |
Isocyanoalkylcarbonic acid derivatives, the reaction thereof in isocyanide multicomponent reactions to form sec-amido-alkylcarbonic acid derivatives, and those sec-amidoalkyl-carbonic acid derivatives
The present invention relates to compounds of the general formula I wherein A is a group of the formula and Z is an O or S atom, to the further processing thereof to form novel...
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6509359 |
Pyrrolidin-2-one compounds and their use as neuraminidase inhibitors
A compound having the formula: wherein all variables are as defined in the specification, for use as a neuramninidase inhibitor.
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6492553 |
Methods for preparing N-&lsqb (aliphatic or aromatic)carbonyl)&rsqb -2-aminoaetamide compounds and for cyclizing such compounds
A method for preparing a N-[(aliphatic or aromatic)carbonyl)]-2-aminoacetamide compound, and for preparing a cyclized compound therefrom, as well as novel resin bound intermediate compounds that...
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6395895 |
Butenyl substituted β-lactams
Taxane derivatives having a 3′ butenyl substituted C13 side chain.
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6395894 |
Process for the synthesis of carbapenem intermidiates, and compounds produced
A process of synthesizing a compound of structural formula 6 is disclosed wherein R 1 represents H or a suitable protecting group for an alcohol; R 2 represents a benzyl, C 1-6 alkyl or aryl;...
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RE37721 |
Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents
Hydroxy-substituted azetidinone hypocholesterolemic agents of the formula or a pharmaceutically acceptable salt thereof, wherein: Ar 1 and Ar 2 are aryl or R 4 -substituted aryl; Ar 3 is aryl...
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6350760 |
Substituted piperidines as melanocortin-4 receptor agonists
Certain novel substituted piperidine compounds are agonists of the human melanocortin receptor(s) and, in particular, are selective agonists of the human melanocortin-4 receptor (MC-4R). They are...
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6340751 |
Process for the preparation of 4-substituted azetidinone derivatives
Disclosed is a process for the preparation of a 4-substituted azetidinone derivative, which comprises reacting an azetidinone derivative and an amide compound in the presence of a magnesium...
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6335324 |
Beta lactam compounds and their use as inhibitors of tryptase
Compounds of the formulas: are disclosed. These compounds inhibit tryptase as well as other enzyme systems or are selective tryptase inhibitors and are useful as antiinflammatory agents...
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