Matches 101 - 150 out of 293 < 1 2 3 4 5 6 >
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5656624 4-[(heterocycloalkyl or heteroaromatic)-substituted phenyl]-2-azetidinones useful as hypolipidemic agents  
4-[(Heterocycloalkyl or heteroaromatic)-substituted phenyl]-2-azetidinone hypocholesterolemic agents of the formula ##STR1## or a pharmaceutically acceptable salt thereof, wherein: A is optionally...
5627283 Amidinophenylalanine derivatives, a process for the preparation thereof, use thereof and agents containing these as anticoagulants  
Amidinophenylalanine derivatives of the formula I ##STR1## the synthesis of these compounds, the use thereof and pharmaceutical agents which contain these compounds are described.
5627176 Substituted azetidinone compounds useful as hypocholesterolemic agents  
Substituted azetidinone hypocholesterolemic agents of the formula ##STR1## or a pharmaceutically acceptable salt thereof, wherein: Ar 1 is R 3 -substituted aryl; Ar 2 is R 4 -substituted...
5580976 Preparation of β-lactam compounds, and intermediates therefor  
A process for preparing a β-lactam compound of the formula (I): ##STR1## which comprises cyclization of an azetidinone derivative of the formula: ##STR2## is provided in which R 1 is hydrogen,...
5574152 4-(1,1-dialkoxycarbonylalkyl) azetidin-2-one derivative and process for producing 4-(1-carboxyalkyl) azetidin-2-one derivative using the same  
A process for preferentially producing a 4-(1-carboxyalkyl) azetidin-2-one derivative represented by formula (IIβ): ##STR1## wherein R 3 represents a lower alkyl group and R 4 represents a...
5571913 Process for preparing a lactam  
The invention relates to a process for preparing a lactam from an alicyclic ketoxime in the presence of a lactim-O-sulphonic acid and a solvent, the reaction being carried out in the presence of an...
5563264 Preparation of βlactam compounds  
A process for preparing a β-lactam compound of the formula (I): ##STR1## which comprises cyclization, in the presence of a catalyst, of an azetidinone derivative of the formula: ##STR2## is...
5561146 Modified guanidino and amidino thrombin inhibitors  
Thrombin inhibitors are provided which have the formula ##STR1## wherein Z is a thrombin inhibitor substructure containing distal and proximal binding site residues; and R 1 is cyano, hydroxyl,...
5550229 Alkylation process for preparing azetidinone compound and starting compound therefor  
Novel process for preparing azetidinone compound of the formula [III]: ##STR1## wherein R 1 is H or lower alkyl, R 2 and R 3 combine together with the adjacent nitrogen to form heterocyclic...
5541317 Azetidinone compounds useful in the preparation of carbapenem antibiotics and process for preparing carbapenem and penem compounds  
Compounds of formula (I): ##STR1## wherein: R 1 is hydrogen or a hydroxy-protecting group; R 2 is alkyl, alkoxy, halogen, optionally substituted phenyl or optionally substituted phenoxy; R 3 is...
5532228 Side-chain homologous vitamin D derivatives, process for their production, pharmaceutical preparations containing these derivatives and their use as pharmaceutical agents  
The invention discloses side-chain homologous vitamin D derivatives of formula I ##STR1## in which R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , B, and D have the meanings defined in the specification and...
5532255 Adhesion receptor antagonists  
Compounds of the formula ##STR1## in which R 1 , X and Y have the meanings defined herein, and their salts, inhibit the binding of fibrinogen to the fibrinogen receptor and can be used for treating...
5510477 Process for the acylation of lactams  
High quality acyl lactam imides are prepared by reacting an acyl lactam of the formula ##STR1## where 5 carbon atoms and an acylating acid of the formula R'CO 2 H or by reacting a lactam, an...
5480987 2-substituted alkyl-3-carboxy carbapenems as antibiotics and a method of producing them  
The invention provides substituted allylazetidinone compounds having the formula: ##STR1## and propargyl azetidinone compounds having the formula: ##STR2## wherein R 1 , R 2 , R 3 , R 30 , X, Y and...
5457114 Amidinophenylalanine derivatives, a process for the preparation thereof, use thereof and agents containing these as anticoagulants  
Amidinophenylalanine derivatives of the formula I ##STR1## the synthesis of these compounds, the use thereof and pharmaceutical agents which contain these compounds are described.
5424422 Beta-lactams and their production  
A beta-lactam compound of the formula: ##STR1## wherein R 1 and R 2 are, the same or different, each a hydrogen atom or a lower alkyl group, R 3 o is a lower alkyl group having a...
5386029 Process for the manufacture of 4-acyloxy-3-hydroxyethyl-azetidinones  
The invention relates to a novel process for the manufacture of (3R,1'R)-4-acyloxy-3-(1'-hydroxyethyl)-2-azetidinones of formula ##STR1## in which R 1 represents lower alkyl or aryl, by...
5326863 Azetidin-2-one derivatives as serine protease inhibitors  
The present invention relates to new 3-guanidinoalkyl-2-azetidinones of the formula ##STR1## wherein: U and W can be the same or different and are selected from the group consisting of hydrogen and...
5322939 Process for preparing azetidin-2-one derivatives  
A process for preparing an azetidin-2-one derivative represented by formula (2): ##STR1## wherein R 4 and R 5 , which may be the same or different, each represents a hydrogen atom, an alkyl group...
5317100 Process for the preparation of optically active acyloxyazetidinones  
Compounds of the formula ##STR1## in which R 1 is hydrogen or lower alkyl, R 2 is hydrogen or a hydroxyl protective group R 2 ' and R 3 is substituted or unsubstituted phenyl or lower alkyl can...
5306816 Processes for preparing carbapenem derivatives  
The invention relates to carbapenem derivatives useful as antimicrobial agents, more particularly to intermediate compounds for the preparations thereof of the formula ##STR1##
5296595 Method of enantioselectively inserting a carbene  
A chiral catalyst is disclosed together with methods of using it for enantioselective syntheses. The chiral catalyst includes a nucleus with two metal atoms that has four bridging ligands oriented...
5284963 Method of producing 7-(substituted)-9-[(substituted glycyl)-amidol]-6-demethyl-6-deoxytetra-cyclines  
The invention provides a novel method for producing compounds of the formula I: ##STR1## wherein X and R are defined in the specifications. The invention also provides a method for making...
5283355 Benzoquinone compounds  
Compounds of the Formula (5) and processes for their preparation and use, particularly in the manufacture of unsymmetrical triphenodioxazine dyes: ##STR1## wherein: Y is H, alkyl, substituted...
5274098 Amidinophenylalanine derivatives, process for their preparation, their use and compositions containing them  
Amidinophenylalanine derivatives, a process for their preparation, their use and pharmaceutical compositions which contain these compounds are described.
5252698 Metal ion porphyrin-containing poly(azine)  
The present invention relates to porphyrin and metal ion-containing monomers and polymers. The monomers ##STR1## wherein R 1 , R 2 , R 3 , and R 4 are independently selected from H, alkyl having 1...
5250676 Process for the preparation of 3-substituted-2-azetidinones  
Provided is a process for diastereoselectively preparing compounds of the formula ##STR1## which includes the step of subjecting a compound of the formula ##STR2## to a salt whose anion is a...
5240919 Benzthiazolinonyl-substituted alkylamides  
Compounds of general formula (I): ##STR1## where R, X, A, B and p are defined in the description. Medicinal products useful for treating sleep disorders comprising the same.
5231179 Heterocyclic compounds and their production  
A compound of the formula: ##STR1## wherein R 1 , R 2 , R 3 and R 4 are each a hydrogen atom, a lower alkyl group, an ar(lower)alkyl group or an aryl group, or R 1 and R 2 may be combined...
5225552 4-cyclohexenyl azetidinone derivatives  
Compounds of formula ##STR1## in which R 1 represents a hydrogen atom or a hydroxyl protecting group; R 2 represents a hydrogen atom or a trialkylsilyl group, and --X--Y-- represents the epoxide...
5204461 Process for preparing (1'R,3S)-3-(1'-hydroxyethyl)-azetidin-2-one and derivatives thereof  
A process for preparing (1'R,3S)-3-(1'-hydroxyethyl)-azetidin-2-one or a derivative thereof represented by formula (I): ##STR1## wherein R 1 represents a hydrogen atom or a hydroxyl-protective...
5202433 Polysaccharide derivatives as separating agents  
A polysaccharide derivative prepared by replacing a part or the whole of hydrogen atoms of hydroxyl and/or amino groups of a polysaccharide with one or more atomic groups represented by the...
5196528 4-cyclohexenyl azetidinones and epoxy derivatives thereof  
Compounds of formula ##STR1## in which R 1 is hydrogen or a hydroxyl protecting group and --X--Y-- is --CHCH-- or ##STR2## useful as intermediates in the preparation of antibacterially active...
5191074 β-lactam compounds and production process thereof  
A process for producing a β-lactam compound of the formula ##STR1## wherein OR 1 is a protected or unprotected hydroxyl group; R 2 is a C 1 to C 7 alkyl or aryl group; from an azetidinone...
5177201 Nitrogen deprotected 4-acyloxyazetidin-2-ones  
The 4-acyloxyazetidin-2-ones, which are intermediates in the production of carbapenems and penems, are produced from nitrogen deprotected 4-furanylazetidin-2-ones.
5149802 Process for producing azetidinone derivatives  
A process for producing 2-azetidinone derivatives represented by formula ##STR1## wherein R 1 denotes a protecting group of a hydroxyl group, Z denotes a hydrogen atom or a protecting group of...
5145957 Stereoselective synthesis of a chiral cis 3-beta hydrogen (3R) 4-aroyloxy azetidinone  
A process is described for the stereocontrolled synthesis of (3R,4R)-3-[(1R)-1-hydroxyethyl]-4-benzoyloxyazetidin-2-ones and their derivatives by cycloaddition involving an imine and a ketone,...
5142038 Process of enantiomeric separation of carbacephem intermediates  
Enantiomerically pure β-lactam intermediates of the formula (I) ##STR1## are isolated from a haloalkane solvent through precipitation with methyl-t-butyl ether or methanol. The products thus...
5138048 4-(2-Oxo-cyclohexyl) azetidinones  
Compounds of the general formula (I) ##STR1## in which: R 1 represents a hydroxyl protecting group; and R 2 represents a hydrogen or halogen atom, an azido group, a C 1 -3 alkyl group, a group...
5134231 3(1-hydoxyethyl)azetidinone compounds and their production  
An amino acid compound of the formula: ##STR1## wherein R is a lower alkyl group, R 1 is a hydrogen atom or a protecting group for carboxyl, R 2 is a hydrogen atom, a protecting group for amino,...
5112966 Beta-lactams  
A beta-lactam compound of the formula: ##STR1## wherein R 1 is a hydrogen atom, a lower alkyl group or a 1-hydroxy(lower)alkyl group wherein the hydroxyl group is optionally protected, R 2 is a...
5106475 Process for preparing 4-substituted azetidinones  
A process for preparing 3-4-cis-β,β-(4)-substituted and 3-4-trans,β,α-(4)-substituted azetidinones is provided. Also provided are novel 4,4-disubstituted azetidinones.
5104984 Enantioselective process for producing 1-beta-methyl carbapenem antibiotic intermediates  
A process is described for the stereochemically controlled synthesis of intermediates useful in producing 1-betamethylcarbapenem antibiotic intermediates involving reacting a beta lactam with a...
5089609 4-benzoyl azetidinones  
Compounds of the formula ##STR1## wherein each R' is independently hydrogen, one, two or three of halogen, lower alkyl or lower alkoxy and R" is methyl, ethyl, allyl or a phenyl, are described....
5081237 3-alkenyl-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid compounds  
The invention relates to novel intermediate compounds for preparation of compounds of high antimicrobial activity, said intermediate compounds being of one of the formulas: ##STR1## wherein R 1 is...
5081238 βmethyl azetidinone derivatives and stereoselective process for preparing the same  
An azetidinone derivative having the general formula (I): ##STR1## wherein R 1 and R 2 are hydrogen atom or a protective group and R 3 is an alkyl group or hydrogen atom, a process for preparing...
5075435 Beta-lactams and their production via stereospecific hydrogenation  
A beta-lactam compound of the formula: ##STR1## wherein R 1 is a hydrogen atom, a lower alkyl group or a 1-hydroxy(lower)alkyl group wherein the hydroxyl group is optionally protected, R 2 is a...
5075437 3,4-disubstituted-2-azetidinone derivatives and processes for preparation using tin enolates  
The invention relates to the preparation of 3,4-disubstituted-2-azetidinone compounds of the formula: ##STR1## in which R 1 is hydrogen or amido-protective group, R 2 is hydroxy(lower)alkyl or...
5075436 Chiral 1-β-methyl-carbapenem intermediates  
A multistep process is described for selectively obtaining 1-β-methylcarbapenem intermediates in high overall yield. The desired 1-β-methyl chirality is obtained through the hydrogenation of...
5047526 Dehydrogenative silylation process of organic compounds having active hydrogen  
A dehydrogenative silylation process of organic compounds having active hydrogen which comprises reacting an organic compound having active hydrogen with t-butyldimethylsilane in the presence of a...
Matches 101 - 150 out of 293 < 1 2 3 4 5 6 >