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7390803 |
Tetrahydropyranyl cyclopentyl benzylamide modulators of chemokine receptor activity
The present invention is directed to compounds of the formula (I) (wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 , R 11 , R 27 , R 28 , R 29 , R 30 , R 31 , X, m, n and the...
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6306845 |
Method for treating demyelinating disease
The present invention provides a method for treating a demyelinating disease in a subject which includes administering to the subject a therapeutically effective amount of a high affinity...
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5198537 |
Digoxigenin derivatives and use thereof
The present invention provides digoxigenin derivatives of the formula: ##STR1## wherein n is a whole number of from 1 to 4 and Z is a carboxyl group or a functional derivative derived therefrom....
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5003054 |
Ouabain triacetate derivative compounds
A method for performing a diagnostic immunoassay by solid phase separation for digoxin. To a reaction mixture of a test sample and labeled anti-digoxin antibody, which forms a complex of any...
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4847246 |
Antiviral compositions derived from fireflies and their methods of use
This invention relates to antiviral organic steroid compositions and derivatives thereof; a process of producing the antiviral compositions; and a method for inhibiting viruses utilizing the...
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4788136 |
Diagnostic immunoassay by solid phase separation for digoxin
A method for performing a diagnostic immunoassay by solid phase separation for digoxin. To a reaction mixture of a test sample and labeled anti-digoxin antibody, which forms a complex of any...
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4380624 |
Novel isomers of bufalin and resibufogenin and their preparation
This invention relates to novel isomers of naturally occurring cardiotonic compounds, specifically novel isobufalins and novel isoresibufogenins. This invention also relates to a novel method of...
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4334069 |
Chemiluminescent phthalhydrazide-labeled hapten conjugates
Chemiluminescent-labeled conjugates of the formula: ##STR1## wherein one of R 1 and R 2 is hydrogen and the other is --NR 3 R 4 ; R 3 is hydrogen or straight chain alkyl containing 1-4 carbon...
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4331802 |
Organometallic reagents and their use in the synthesis of cardenolides and isocardenolides
A method for synthesizing a cardenolide or isocardenolide by subjecting an α,β-unsaturated steroidal 17-ketone to a double bond shift and hydrogenation to produce a (C/D cisoid) ketone which is...
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4259240 |
Synthesis of furyl intermediates, and cardenolides and their isomers prepared therefrom
The invention relates to furyl intermediates and the preparation thereof, said intermediates being particularly useful in the preparation of synthetic cardenolides and their isomers. The process...
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4255329 |
Double receptor fluorescent immunoassay
A novel sensitive method for determining qualitatively and quantitatively the presence of a wide variety of physiologically active organic compounds (ligand) and their receptors is provided. The...
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4218447 |
Acyl derivatives of hellebrigenin
There are prepared compounds corresponding to the general formula: ##STR1## in which R represents a 2,2-dimethylethenyl; isopropyl; nonyl; a C 3 -C 6 -cycloalkyl radical; a phenyl group...
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4175078 |
Cardenolide and bufadienolide derivatives of ajmaline and process for producing same
According to the invention, the novel substances are the cardenolide and adienolide derivatives of ajmaline of the general formula ##STR1## wherein R is cardenolide or bufadienolide of the general...
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4115539 |
Analytical or clinical derivatives, tagged derivatives and methods of analysis using such derivatives
Novel isocyanates such as, for example, blocked L-tyrosine methyl ester isocyanate, are reacted with compounds of biological, clinical interest or the like such as, for example, digoxin, to form...
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4102884 |
14 β-Hydroxy 3-deoxycardenolides
Novel compounds of the formula ##STR1## useful as pharmaceutical compounds are disclosed. Processes are also disclosed for their preparation.
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4097477 |
Steroid compounds and processes thereof
Novel steroids of the formula ##STR1## Also there are provided processes for preparing such compounds. The new compounds are useful as intermediates in the preparation of known cardenolides;...
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4030886 |
Saturation analysis
The invention provides a method and a kit for the saturation analysis of a steroid characterized by the use of a selenium-75 labelled version of the steroid to be assayed. Selenium-75 derivatives...
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4000125 |
Novel cardiotonic steroids, process for their preparation and therapeutical use
The invention relates to novel steroid compounds having the formula ##STR1## and their glycoside derivatives containing a pyridazine ring, in which particularly the substituent R 4 is a hydroxy...
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3981982 |
Radioimmunoassay for determining the digoxin content of a sample
A competitive radioimmunoassay for the measurement of digoxin in a serum sample in which the non-radioactive digoxin competes with a constant amount of a radioactively labeled digoxin tyramine...
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3954739 |
Biological reagent
Compounds of formula (VIII) wherein R 1 , r 2 , r 3 , r 4 and R 5 are each selected from hydrogen and an hydroxyl group and at least four are hydrogen; B is an alkylene chain of from 1 to 4...
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3953431 |
Derivatives of digoxigenin
Derivatives of digoxigenin which are either unlabeled or radioiodinated having the following structural formula: ##SPC1## Wherein R' is hydroxyl or acetoxy; B is succinyl, phthaloyl, maleyl or...
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3952030 |
Selenium-75 steroids
Novel dimeric and monomeric selenium-75 derivatives of steroids are made by reacting a keto steroid with selenium-75 dioxide or selenious acid-Se75. The resulting diselenide dimers can be converted...
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3939187 |
15α,-Sulfonyloxy-12β-hydroxypregnanes and process for the preparation thereof
15α-Sulfonyl-12β-hydroxypregnanes of the formula ##SPC1## Wherein Ac is lower-acyl and R is alkyl, cycloalkyl, aralkyl or aryl, which are useful as intermediates for the production of...
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3939156 |
Cardenolides
Novel cardenolides having desirable cardiac activity and which are readily reabsorbed internally, a process for their preparation and therapeutic compositions containing said cardenolides are...
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3895008 |
Digoxigenin-12-formiate and process for its manufacture
Digoxigenin-12-formiate prepared by a selective acylation of digoxigenin with a mixed anhydride of formic acid and acetic acid in the presence of a tertiary organic base. The product is suitable...
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3879379 |
3-Amino-cardenolides and process for their manufacture
Cardioactive 3-amino-cardenolides and a method for preparing them by reacg a 3-oxo-cardenolide with hydroxylamine or its salts to form a cardenolide-3-oxime and then catalytically hydrogenating...
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3859272 |
19-ALKYLENE-14- β-HYDROXY-CARDENOLIDE DERIVATIVES AND PROCESS FOR PREPARING THEM
Cardiotonically active 19-alkylene-14 β-hydroxy-cardenolides of the mula ##SPC1## Wherein R 1 taken alone is --CH, --CO 2 R 5 , --CON(R 6 ) 2 , --CH(OR 6 ) 2 , --C 6 H 5 , --CH=CH 2 , or --SCH...
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3687944 |
PROCESS FOR THE PREPARATION OF BUFALIN AND RELATED COMPOUNDS
There is provided a novel method of preparing the cardiac active agents bufalin and its immediate precursor resibufogenin from the well known cardenolide, digitoxigenin. The method comprises...
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3684801 |
REMOTE OXIDATION OF UNACTIVATED STEROID METHYLENE GROUPS
There is provided a method of activating inactive methylene groups of the 5α-steroid nucleus. This method comprises forming a 3α-m- or p-benzoylphenyl 5α-steroid alkanoate and irradiating said...
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3681344 |
CERTAIN CARDIOACTIVE OXIDO-BUFADIENOLIDES
Cardioactive oxido-bufadienolides of the formula ##SPC1## Wherein R is hydrogen or lower acyl. Methods of making such compounds.
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3674779 |
4-CHLORO-3-OXO-14-HYDROXY-OR 4-CHLORO-3,14-DIHYDROXY-CARDA-4,20-DIENOLIDES AND PROCESS FOR THEIR MANUFACTURE
Process for the manufacture of 4-chloro-3-oxo-14β-hydroxy- or 4-chlo3,14β -dihydroxy-carda-4,20(22)dienolides wherein 3-oxo-carda-4,14,20(22)-trienolides are at first treated with chlorine, the...
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3621015 |
PROCESS FOR THE MANUFACTURE OF (ANDROST-17β-Y1)-α-PYRONES
The method of making androst-(17β-α y1)-α -pyrones havingnotropic, cardiovascular, and diuretic activity by Wittig reaction of a 20-keto-21-acetal pregnene with a methyl-triphenyl-phosphonium...
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3543307 |
DECOMPOSITION PRODUCTION OF DELTA4,20,22-BUFATRIENOLIDES AND PROCESS FOR THEIR SEPARATION
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3535314 |
PROCESS FOR THE PREPARATION OF 14BETA-HYDROXY-3-KETO-5BETA-CARD-20(22)-ENOLIDES
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3531475 |
PROCESS FOR THE OXIDATION OF ALCOHOLS AND OXIDIZING AGENT UTILIZED THEREIN
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3510478 |
15ALPHA - HALOGENO - 14BETA - HYDROXY-CARD-20(22) - ENOLIDES AND PROCESS FOR THEIR MANUFACTURE
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3455910 |
UNSATURATED LACTONES OF THE STEROID SERIES AND PROCESS FOR THEIR MANUFACTURE
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3454563 |
PROCESS FOR THE MANUFACTURE OF 14BETA-HYDROXY-CARD-20(22)-ENOLIDES
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3451994 |
14BETA-HYDROXY-16BETA,21-OXIDONORCHOLAN-23-OIC ACID LACTAMS AND DERIVATIVES
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3420820 |
UNSATURATED LACTONES OF THE STEROID SERIES AND PROCESS FOR PREPARING THEM
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3398138 |
Novel cardenolides and derivatives
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3325484 |
Process for preparing periplogenia and intermediates secured therein
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3318789 |
Process for the manufacture of 19-nor-steroids
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3287377 |
19-oxygenated steroids from 5alpha-halogen-6beta:19-oxido-steroids
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3264328 |
10alpha-steroids and process for their manufacture
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3256274 |
Process for the introduction of a double bond into the alpha, beta-position of the carbonyl of a steroid lactone
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3211719 |
19-norcardenolides
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3194804 |
19-norcard-20(22)-enolides, derivatives thereof, and intermediates thereto
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3178419 |
19-nor-steroids and process for their manufacture
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3177200 |
Process for the manufacture of cardioactive monoglycosides
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