|
Match
|
Document |
Document Title |
|
|
8173609 |
Macrolides useful against inflammatory and allergic diseases
New macrolide general compounds of formula I with improved activity making them useful for inhibiting human phosphodiesterase 4 and treating chronic obstructive pulmonary disease (COPD).
|
|
|
8143227 |
Azithromycin for treatment of skin disorders
Azithromycin has increased efficacy in treating acne and other skin conditions when administered systemically at low doses, below those previously known to produce a clinical antibiotic effect.
|
|
|
8124744 |
Macrolide derivatives
Compounds represented by formula (I) and the formula (IV) have an inhibitory activity of MMP-9 production, therefore, are useful as a medicine agent with fewer side effects than conventional MMP...
|
|
|
8097594 |
Macrolides and ketolides having antimicrobial activity
The present invention provides compounds having antimicrobial activity for preventing and treating diseases caused by microbial infections. Thus, the present invention relates to novel...
|
|
|
8097708 |
10a-Azalide compound
[Object]: To provide a compound having a novel structure effective against Hemophilus influenzae and erythromycin resistant bacteria (for example, resistant pneumococci and streptococci) as well as...
|
|
|
8080529 |
Macrolides with anti-inflammatory activity
The present invention relates to novel semi-synthetic macrolides having anti-inflammatory activity. More particularly, the invention relates to 14- and 15-membered macrolides substituted at the...
|
|
|
8076301 |
10-substituted macrolide antibiotics
Disclosed herein are 10-desmethyl, 10 substituted-macrolides, their preparation, pharmaceutical compositions containing them, their use and methods of treatment using them. The 10-desmethyl...
|
|
|
8063021 |
Ketolide anti-infective compounds
Compounds according to formula I wherein m is 0 or 1; X is and R1, R2, R3 R4, and R5 are as defined herein, are useful as anti-infective agents.
|
|
|
8030282 |
Motilide polymorphs
The invention provides polymorphs of a motilide having a structure represented by formula Ia
|
|
|
8012943 |
Antibacterial agents
Described herein are novel macrolides, the preparation of novel macrolides, the use of novel macrolides for preventing, treating, or ameliorating various conditions, and the use of novel macrolides...
|
|
|
7989600 |
Macrolide compounds containing biotin and photo-affinity group for macrolide target identification
The present invention relates to new macrolide compounds represented by the general structure I, wherein M is a macrolide, P is a photo-affinity group bearing subunit containing biotin, and L is a...
|
|
|
7928078 |
Conjugates of immune cell specific macrolide compounds with anti-inflammatory compounds for improved cellular targeting of anti-inflammatory therapy
The present invention relates to novel compounds represented by the structure I and pharmaceutical preparations thereof for the treatment of inflammatory diseases in humans and animals.
|
|
|
7910559 |
Decladinosyl-macrolides with anti-inflammatory activity
The present invention relates to novel semi-synthetic macrolides having anti-inflammatory activity. More particularly, the invention relates to 14- and 15-membered macrolides lacking cladinose...
|
|
|
7872109 |
Motilide polymorphs
The invention provides polymorphs of a motilide having a structure represented by formula Ia
|
|
|
7767797 |
Macrocyclic compounds and methods of use thereof
The invention features novel macrocyclic compounds, methods of making the compounds, pharmaceutical compositions including the compounds, and methods of treatment using the compounds.
|
|
|
7718621 |
Macrolones—amino substituted quinolones
A compound of formula (I) or a pharmaceutically acceptable derivative thereof, having antimicrobial activity, processes for their preparation, compositions containing them and to their use in...
|
|
|
7704960 |
Macrolide compounds endowed with antiinflammatory activity
Macrolide compounds endowed with antiinflammatory activity are described, and more particularly macrolide derivatives lacking cladinose in position 3, with antiinflammatory activity,...
|
|
|
7683162 |
Process of preparing a crystalline azithromycin monohydrate
The present invention provides a process of preparing a crystalline azithromycin monohydrate. The process involves dissolving azithromycin in a solution containing ethanol, adding the dissolved...
|
|
|
7622452 |
C-9 alkenylidine bridged macrolides
The present invention discloses compounds of formulae (I), (II) or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention...
|
|
|
7608596 |
10-substituted macrolide antibiotics
Disclosed herein are 10-desmethyl, 10 substituted-macrolides, their preparation, pharmaceutical compositions containing them, their use and methods of treatment using them. The 10-desmethyl...
|
|
|
7601695 |
Antibacterial agents
Described herein are novel macrolides, the preparation of novel macrolides, to the use of novel macrolides for preventing, treating, or ameliorating various conditions, and the use of novel...
|
|
|
7595300 |
7-quinolyl ketolide antibacterial agents
15-fluoroketolides of the formula having improved activity and safety, compositions comprising them, and methods for their preparation and use in the treatment of bacterial infections.
|
|
|
7589067 |
6, 11-bridged tricyclic macrolides
The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further...
|
|
|
7582611 |
Motilide compounds
Compounds having a structure according to formula (I) where RA, RB, RC, RD, RE, and RF are as defined herein, are useful as prokinetic agents.
|
|
|
7579324 |
Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof
This invention features a compound of the following formula: T-(-L-C)m, T is a transportophore, L is a bond or a linker having a molecular weight up to 240 dalton, C is a non-antibiotic therapeutic...
|
|
|
7572773 |
Single dose fast dissolving azithromycin
The present disclosure related to a method of treating an infection by oral administration of a single dose of a fast dissolving form of azithromycin. The disclosure also relates to a method of...
|
|
|
7569549 |
Isostructural pseudopolymorphs of 9-deoxo-9a-aza-9a-methyl-9a-homoerythromycin A
Substantially pure isostructural pseudopolymorphs of 9-deoxo-9a-aza-9a-methyl-9a-homoerythromycin A having the Formula I: wherein S is an organic solvent which is at least partially miscible with...
|
|
|
7569550 |
14 and 15 membered ring compounds
The present invention relates to 14- or 15-membered macrolides substituted at the 4″ position of formula (I) and pharmaceutically acceptable derivatives thereof, to processes for their p...
|
|
|
7563877 |
Processes for the preparation of 0-(2-aminobenzo[d]oxazol-5-yl)methyl hydroxylamine for the synthesis of 6,11-bicyclic erythromycin derivative EDP-182
The present invention relates to processes and intermediates for the preparation of 6-11 bicyclic erythromycin derivative known as EDP-182 (IX-a). In particular, the present invention relates to...
|
|
|
7547679 |
Ether linked macrolides useful for the treatment of microbial infections
The present invention relates to 14- or 15-membered macrolides substituted at the 4″ position of formula (I) and pharmaceutically acceptable derivatives thereof, to processes for their p...
|
|
|
7524823 |
Macrolides
The present invention relates to new antibiotic macrolide compounds of the general formula I: with improved activity, to medicaments comprising such antibiotics, and to the use of such antibiotics...
|
|
|
7521428 |
Macrolide derivatives having effect of potentiating antifungal activity
Macrolide derivatives having enhancing effect for activities of azole antifungal agents, acting at low concentration and within a short time against fungal infection and reducing the frequency of...
|
|
|
7517859 |
Spirocyclic bicyclolides
The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further...
|
|
|
7507721 |
Macrolides with antiinflammatory activity
Macrolide compounds of formula (I) wherein X, R, R1, R2, R3 and R4, have the meanings as defined in the specification, pharmaceutically acceptable salts thereof, pharmaceutical compositions...
|
|
|
7468428 |
Lyophilized azithromycin formulation
The invention provides among other things a stable, sterile pharmaceutical formulation comprising lyophilized azithromycin and ethanol. The invention also provides a method of producing a stable,...
|
|
|
7462600 |
Macrolides
Macrolide compounds per se, as shown below and defined herein, and their use, e.g., as antibacterial and antiprotozoal agents in animals, including humans: Also disclosed are methods of preparing...
|
|
|
7446097 |
Conjugates of immune cell specific macrolide compounds with anti-inflammatory compounds for improved cellular targeting of anti-inflammatory therapy
The present invention relates to novel compounds represented by the structure I and pharmaceutical preparations thereof for the treatment of inflammatory diseases in humans and animals.
|
|
|
7438924 |
Dry granulated formulations of azithromycin
This invention relates to a pharmaceutical formulation, in the form of a tablet, sachet or powder for suspension dosage form, which comprises dry granulated particles of a non-dihydrate form of...
|
|
|
7435805 |
O-alkyl macrolide and azalide derivatives and regioselective process for their preparation
The present disclosure relates to new 11-O-alkyl macrolides and azalides and pharmaceutically acceptable salts and solvates thereof, and to pharmaceutical compositions thereof. The disclosure also...
|
|
|
7419961 |
9a-azalides with anti-inflammatory activity
Macrolides with anti-inflammatory activity are described. Particularly described are 9a-azalides and their anti-inflammatory activity without cladinose in position 3, the pharmaceutically...
|
|
|
7414030 |
6-11 Bicyclic erythromycin derivatives
The present invention discloses compounds of formulaes I, II, III, or IV, or a racemate, enantiomer, regioisomer, salt, ester or prodrug thereof: which exhibit antibacterial properties. The present...
|
|
|
7414114 |
Process for preparation of anhydrous azithromycin
The present invention provides a stable form of azithromycin derivatives that act as antibiotics. These compounds are in anhydrous form and have increased stability over the hydrated forms.
|
|
|
7410952 |
Derivatives of azithromycin
The invention relates to derivatives of azithromycin, processes for the manufacture thereof and pharmaceutical compositions thereof preferably together with azithromycin.
|
|
|
7407942 |
3,6-bridged 9,12-oxolides
The present invention discloses compounds of formula (I) or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further...
|
|
|
7402568 |
Bicyclic 9a-azalide derivatives
The present invention discloses compounds of formulae I and II, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention...
|
|
|
7384921 |
Polymorphic forms of 6-11 bicyclic ketolide derivatives
The present invention includes EP-13420 polymorphic crystalline forms: Form I, Form II, Form Ia, and monohydrate and amorphous EP-13420 which posses distinct physical properties. In another...
|
|
|
7384922 |
6-11 bridged oxime erythromycin derivatives
The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further...
|
|
|
7365174 |
Azalide and azalactam derivatives and method for producing the same
Compounds represented by the general formula (1) or pharmaceutically acceptable salts thereof, effective in the prevention and/or treatment of infections with microbes: (1) (a) wherein R1 is...
|
|
|
7365056 |
Substituted 9a-N-(N′-(sulfonyl)phenylcarbamoyl)derivatives of 9-deoxo-9-dihydro-9a-aza-9a-homoerithomycin A and 5-0-desosaminyl-9-deoxo-9-dihydro-9-a-aza-9a-homoerithronolide A
The invention relates to substituted 9a-N-{N′-[4-(sulfonyl)phenyl]carbamoyl} derivatives of 9-deoxo-9-dihydro-9a-aza-9a-homoerithromycin A and 5...
|
|
|
7351696 |
Compounds
The present invention relates to compounds of formula (I) and pharmaceutically acceptable derivatives thereof, to processes for their preparation and their use in therapy or prophylaxis of systemic...
|