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7297682 |
Diphosphate salt of a 4″—substituted-9-deoxo-9 A—AZA—homoerythromycin derivatives and its pharmaceutical composition
This invention relates to a novel crystalline diphosphate salt of...
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7291602 |
11,12-lactone bicyclolides
The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof:
which exhibit antibacterial properties. The present invention further...
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7273853 |
6-11 bicyclic ketolide derivatives
The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof:
which exhibit antibacterial properties. The present invention further...
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RE39836 |
Macrolide antinfective agents
Compounds of the formula
wherein
R a is H; substituted or unsubstituted alkyl (1-10C); substituted or unsubstituted alkenyl (2-10C); substituted or unsubstituted alkynyl (2-10C);...
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7259170 |
Macrolides containing pharmaceutical compositions
A pharmaceutical compound comprising a compound of formula I and a pharmaceutically acceptable 2-amino-1,3-propanediol beside one or more pharmaceutically acceptable excipient(s).
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7229972 |
3,6-Bicyclolides
The present invention discloses compounds of formula (I) or pharmaceutically acceptable salts, esters, or prodrugs thereof:
which exhibit antibacterial properties. The present invention further...
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7211568 |
9-Desoxoerythromycin compounds as prokinetic agents
9-Desoxoerythromycin compounds of formula I
wherein R 1 , R 2 , R 3 , R 4 , and R 5 are as defined herein, are useful as prokinetic agents for treating disorders of gastric motility.
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RE39591 |
6-O-substituted ketolides having antibacterial activity
Antimicrobial compounds having the formula
as well as pharmaceutically acceptable salts, esters or prodrugs thereof; pharmaceutical compositions comprising such compounds; methods of treating...
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RE39531 |
9-hydrazone and 9-azine erythromycin derivatives and a process for making the same
Disclosed are 9-hydrazone erythromycin and 9-azine erythromycin derivatives and the processes for making the same. The compounds are useful intermediates for conversion into 6-O-alkyl erythromycin....
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RE39383 |
Process for 6-O-alkylation of erythromycin derivatives
A procedure for preparing 6-O-alkyl erythromycin compounds having the formula:
wherein R 1 is a loweralkyl group, R 2 and R 3 an independently hydrogen or a hydroxy-protecting group, except...
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7109176 |
Nonsteroidal anti-inflammatory substances, compositions and methods for their use
The present invention relates (a) to new compounds represented by Formula I:
wherein M represents a macrolide subunit (macrolide moiety) derived from macrolide possessing the property of...
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7101858 |
Processes for preparing clarithromycin and clarithromycin intermediate, essentially oxime-free clarithromycin, and pharmaceutical composition comprising the same
The present invention relates to processes for preparing protected silylated clarithromycin oxime, preferably 6-O-methyl-2′,4″-bis(trimethylsilyl)-erythromycin A 9-O-(2-methoxyprop-2-yl)oxime...
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7071314 |
Arylation method for the functionalization of O-allyl erythromycin derivatives
An efficient arylation technique for use in the synthesis of erythromycin derivatives, involving a modified Heck reaction which employs less than six mole percent of palladium catalyst and no...
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7071170 |
Macrolide antibiotics
This invention relates to compounds of the formula
wherein a, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 and X are each as defined above, and to pharmaceutically acceptable salts thereof, useful as...
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RE39149 |
Method of administering azithromycin
An oral dosage form of azithromycin which does not exhibit an adverse food effect; Specific azithromycin oral dosage forms including tablets, powders for oral suspensions and unit dose packets;...
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7049417 |
6,11-4-Carbon bridged ketolides
Novel 6,11-4-carbon bridged ketolides, pharmaceutically-acceptable compositions comprising a therapeutically effective amount of a compound of the invention in combination with a...
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7022825 |
Polyketides and antibiotics
Facile methods for preparing diketide and triketide thioesters are disclosed. The resulting thioesters may be used as intermediates in the synthesis of desired polyketides, and may contain...
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7015203 |
Macrolides
The invention relates to novel erythromycin analogs and azalides, particularly ones with novel C-13 substituents, and to pharmaceutically acceptable salts thereof. The compounds of this invention...
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6998390 |
Oxolide antibacterials
Antibacterial compounds having formula (I)
and formula (II)
and salts, prodrugs, and salts of prodrugs thereof, processes for making the compounds and intermediates employed in the...
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6995143 |
Macrolides with antibacterial activity
The invention provides new macrolides antibiotics of formula I with improved biological properties and having the formula
wherein R 1 , R 2 and R 3 are as herein described.
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6953782 |
11-C-substituted erythromycin derivatives
The present invention discloses compounds of formulae I, II, III or IV or pharmaceutically acceptable salts, esters, or prodrugs thereof:
which exhibit antibacterial properties. The present...
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6930092 |
Antibiotic agents
Methods of treating a microbial infection comprising administering to a patient in need of such treatment are disclosed. In one aspect the method comprises administering to a patient in need of...
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6919317 |
Pharmaceutical composition comprising squalene epoxidase inhibitor and macrolide immunomodulator
Synergistic combinations of a squalene epoxidase inhibitor such as terbinafine and a macrolide T-cell immunomodulator or immunosuppressant such as 33-epichloro, 33-desoxyascomycin are provided,...
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6916792 |
Process for preparing erythromycin compound
The present invention is to provide a process for producing a 2′-O-acetyl-4″-formyl-8,9-anhydroerythromycin A 6,9-hemiketal compound 4, and it provide a process for producing an erythromycin...
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6906039 |
Process for preparation of erythromycin compounds
The present invention is to provide a process for producing a 2′-O-acetyl-4″-O-formyl-8,9-anhydroerythromycin A 6,9-hemiketal compound 4 , and it provide a process for producing an...
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6900296 |
Cost effective method for selective methylation of erythromycin A derivatives
The invention relates to a cost effective and industrially advantageous process for the selective methylation of a hydroxy group at the 6 position of erythromycin A derivative which comprised...
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6900183 |
Macrolide antibiotics
11,12 γ lactone ketolides of the following formula:
and pharmaceutically acceptable salts and solvates thereof, wherein R, R 1 , R 2 , and R 3 are as described herein. The disclosure also...
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6897299 |
Process for producing erythromycin derivative
A method for preparing a fumarate salt of a compound represented by Formula (II):
(wherein R 1 represents a hydrogen atom or a lower alkyl group, and R 2 represents a lower alkyl group),...
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6861412 |
Diphosphate salt of A 4″-substituted-9-deoxo-9A-AZA-9A-homoerythromycin derivative and its pharmaceutical composition
This invention relates to a novel crystalline diphosphate salt of...
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6849608 |
Macrolide antibiotics
A macrolide antibiotic of the formula
wherein the variables are defined as described herein.
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6843854 |
Method and apparatus for separating a component from a mixture
The present invention comprises the optimization of a four zone simulated moving bed system configured to separate a first component from a mixture containing the first component and a second...
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6812216 |
11-C-substituted derivatives of clarithromycin
There are described 11-C-substituted derivatives of clarithromycin and pharmaceutically acceptable compositions comprising a therapeutically effective amount of a compound of the invention in...
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6809188 |
Method of preparing clarithromycin
Clarithromycin can be easily prepared by reacting erythromycin A N-oxide with a methylating agent to obtain 6-O-methylerythromycin A N-oxide; and treating 6-O-methylerythromycin A N-oxide obtained...
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6794366 |
Macrolide antiinfective agents
Compounds of the formula or the 10,11-anhydro forms therefor, wherein R a is H or OH; R b is H or halogen; R c is H or a protecting group; R d is methyl; unsubstituted alkyl (3-10C);...
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6790835 |
Bicyclic macrolide derivatives
The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further...
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6777543 |
13-methyl erythromycin derivatives
The invention relates to compounds of the formula and to pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 17 , R f , A, X, and Y are as...
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6777393 |
4″-substituted-9-deoxo-9a-aza-9a homoerythromycin a derivative
The invention relates to a method of preparing compounds of the formula and to pharmaceutically acceptable salts thereof. The compounds of formula 1 are antibacterial agents that may be used to...
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6774115 |
6-O-substituted bicyclic ketolides
The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further...
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6767998 |
Method for preparing purified erythromycin
The object of the present invention is to prepare purified erythromycin by removing erythromycin F from erythromycin. The present invention provides a method for preparing purified erythromycin...
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6764998 |
6,11-4C-bicyclic 9a-azalide derivatives
The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further...
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6756359 |
C12 modified erythromycin macrolides and ketolides having antibacterial activity
Antimicrobial macrolide compounds are provided having formulas II: as well as pharmaceutically acceptable salts, esters or prodrugs thereof; pharmaceutical compositions comprising such...
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6753318 |
6,11-4-carbon bridged erythromycin derivatives
Novel 6,11-4-carbon bridged erythromycin derivatives and pharmaceutically-acceptable compositions comprising a therapeutically effective amount of a compound of the invention in combination with a...
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6750205 |
Motilide compounds
The present invention provides novel macrolide compounds of the formulas wherein: R is hydroxyl or methoxy; R 1 is selected from the group consisting of hydrogen, hydroxyl, halide, NH 2 , OR 9...
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6750204 |
11-C-substituted ketolides
There are described 11-C-substituted derivatives of erythromycin and pharmaceutically acceptable compositions comprising a therapeutically effective amount of a compound of the invention in...
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6740642 |
Macrolides with antibacterial activity
The invention provides new macrolides antibiotics of formula I with improved biological properties and improved stability of the formula wherein R 1 is hydrogen, cyano, —S(L) m R 2 ,...
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RE38520 |
Erythromycin derivatives, method for preparing same, and use thereof as drugs
A subject of the invention is the compounds of formula (I): in which: X represents a CH 2 or SO 2 radical or an oxygen atom, Y represents a (CH 2 ) m —(CH═CH) n (CH 2 ) o radical, with...
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6734292 |
Pseudoerythromycin derivatives
The present invention is to obtain novel anti-inflammatory agents having decreased antibacterial activity and increased anti-inflammatory action, and is psedoerythromycin derivatives represented by...
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6727229 |
11,12-substituted lactone ketolide derivatives having antibacterial activity
Novel 11-12 substituted lactone ketolide derivatives and pharmaceutically-acceptable compositions comprising a therapeutically effective amount of a compound of the invention in combination with a...
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6720308 |
Anhydrolide derivatives having antibacterial activity
Novel 11-12 substituted lactone anhydrolide derivatives and pharmaceutically-acceptable compositions comprising a therapeutically effective amount of a compound of the invention in combination with...
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6716820 |
6-O-substituted bicyclic macrolides
The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further...
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