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6911325 Process for the preparation of derivatives of Ruscus aculeatus steroid glycosides by enzymatic hydrolysis  
A process for the preparation of desglucodesrhamnoruscin which comprises the enzymatic hydrolysis of Ruscus Aculeatus steroid glycosides (ruscosaponins) by means of crude hydrolases from ...
6861410 Immunological adjuvant compositions  
The present invention is directed to novel adjuvant compositions, which target the cellular and/or humoral arms of immunity. According to an embodiment of the invention, an oil-in-water adjuvant...
6521600 Compound, WF002, production thereof and use thereof  
The present invention provides a new bioactive compound of formula (I), which has an antimicrobial activity against pathogenic microorganisms, and a process for production thereof. Also provided...
6124442 Process for extracting triterpene glycosides from botanical sources  
The process includes obtaining a liquid extract from a fresh plant source material and mixing the extract with a solution saturated with at least one element having an oxidation number of one or...
6017906 Polyamine conjugates for treatment of infection  
The present invention relates to methods of preventing or treating an infection or disease caused by an infectious agent. The present invention also relates to the augmentation of the efficacy of...
5908833 Colon or ileum-specific steroid derivatives  
Novel compounds which are a glucocorticosteroid (GCS) chemically bound to a sugar, having the general formula GCS 1 --O--Sugar 1 for colon- or ileum-specific delivery of the GCS to inflamed...
5760009 Spirostanyl glycosidal crystalline monohydrate  
A crystalline monohydrate of (3β,5α,25R)-3- (β-D-cellobiosyl)oxy!spirostan-11-one that is useful as a hypocholesterolemic or antiatherosclerosis agent.
5695738 Steroidal C-glycosides  
Compositions of sterodial glycosides are described wherein the glycoside is linked directly, or indirectly to a desired steroidal compound via a carbon, or similar stable linkage, and methods of...
5606041 Process for steroidal peracyl glycosides  
Processes for the synthesis of tigogenin beta-O-cellobioside heptaalkanoate which is an intermediate for the known hypo-cholesterolemic agent tigogenin beta-cellobioside. The process comprises...
5591836 Cholesterol lowering compounds  
Disclosed are novel saponins containing 5-C-hydroxymethylhexose and a sterol or triterpene. These materials, when consumed by humans and animals, lower the cholesterol level in the blood. These...
5583112 Saponin-antigen conjugates and the use thereof  
Saponin/antigen conjugates and the use thereof for enhancing immune responses in individuals are disclosed. The saponins may be substantially pure or mixtures of saponins.
5563250 Cleavable conjugates for the delivery and release of agents in native form  
The present invention provides cleavable conjugates whose linkers contain a labile bond that is cleavable under a variety of mild conditions, including weakly acidic. Since the agent may be bonded...
5530107 Method for making steroidal peracyl glycosides  
Processes for the synthesis of tigogenin beta-O-cellobioside heptaalkanoate which is an intermediate for the known hypocholesterolemic agent tigogenin beta-cellobioside. The process comprises...
5525480 N- and O-substituted aminophenols, method and use for diagnosis  
The present invention provides N- and O-substituted aminophenol derivatives of the general formula ##STR1## wherein R 1 , R 2 , R 3 , G and L are as hereinbefore defined. The present invention also...
5438125 Sialic acid derivatives  
Sialic acid compounds of formula ##STR1## wherein X is hydrogen, a lower alkyl group or benzyl, Y is hydrogen or acetyl, Ac is acetyl, and the wavy line represents that the compound of the formula...
5426179 Steroid compounds active on the cardiovascular system  
Steroid compounds active on the cardiovascular system of formula ##STR1## wherein X, n, R, R 1 and R 2 have the meanings mentioned in the description are described.
5294703 Process for preparing α-D-cellobiose octaacetate  
Provided is a novel improved process for the preparation of α-D-cellobiose octaacetate via the acetylative degradation of cellulose or cellulose acetate. The title compound is provided in high...
5198537 Digoxigenin derivatives and use thereof  
The present invention provides digoxigenin derivatives of the formula: ##STR1## wherein n is a whole number of from 1 to 4 and Z is a carboxyl group or a functional derivative derived therefrom....
5124441 Therapeutically active compound and its use  
Therapeutically active organic compound exhibiting at least one group comprising a structure --S'--S"--R, wherein the group --S"--R is defined by R being an organic group comprised in a...
5106963 Phospholipid conjugates and their preparation  
Phospholipid conjugate compounds derived from cardiac glycosides and sters useful in liposome immunoassays are disclosed as well as their method of preparation.
5010185 Processes for tigogenin beta-cellobioside  
Improved processes for the synthesis of tigogenin beta-cellobioside, a known hypocholesterolemic agent, using cellobiose heptaacetate and tigogenin as starting materials.
5003054 Ouabain triacetate derivative compounds  
A method for performing a diagnostic immunoassay by solid phase separation for digoxin. To a reaction mixture of a test sample and labeled anti-digoxin antibody, which forms a complex of any...
4895836 Nor-cholanic acid derivatives, a process for their preparation, their use and pharmaceutical compositions containing them  
4780314 Isolation and purification of a digitalis-like factor  
This invention relates to a novel recovery process for obtaining the small molecular weight, digitalis-like factor, and further relates to purification of the digitalis-like factor. This invention...
4603196 Process for the preparation of β-methyldigoxin  
The invention relates to a process for the preparation of β-methyldigoxin by the selective methylation of digoxin with dimethyl sulfate in the presence of a basic strontium compound and, if...
4562250 Steroidal glycosides produced by Yucca tissue culture  
Methods for the production of steroids (sapogenins) and steroidal glycosides (saponins) from cell, root-cell and shoot tissue cultures of the Yucca plant. The cultures were established and...
4546097 Saponin-based polyether polyols, pharmaceutical compositions and a method of using same  
Digitonin and digitonin-related saponins are derivatized by alkoxylation. The adducts have lower toxicity, higher solubility, and reduced ability to form insoluble complexes with cholesterol, as...
4482706 Steroid saponins  
Novel steroid saponin compounds (XR-1) and (XR-2) are extracted from Solanam aculeatissimum, a plant belonging to the Solanum genus, and 16-dehydropregnenolone is obtained by hydrolyzing the said...
4461763 Oximes of 3'"-dehydrocardenolide tridigitoxosides  
The present invention provides 3'"-dehydrocardenolide tridigitoxoside oximes of the general formula: ##STR1## in which R 1 is a hydrogen atom or an alkyl radical containing up to 3 carbon atoms, R...
4436828 Reactive asymmetrical dicarboxylic acid esters and reagents for the investigation of cardiac glycosides  
New reactive asymmetrical dicarboxylic acid ester compounds of the formula ##STR1## wherein R 1 is an alkyl radical containing up to 3 carbon atoms or is a digoxin or digitoxin residue, R 2 and R...
4436735 Ketals of 3'"-dehydrocardenolide tridigitoxosides  
The present invention provides ketals of 3'"-dehydrocardenolide tridigitoxosides of the general formula: ##STR1## in which R 1 and R 2 are identical alkyl radicals containing up to 3 carbon atoms...
4423208 Affinity gel-adsorbent  
An improved affinity gel-adsorbent for use in an improved method of purifying glucocorticoid receptor by affinity chromatography and having the formula: ##STR1## R 1 : H or OH or O R 2 : H or...
4230702 Readily enterally absorbable pharmaceutical compositions of per se poorly enterally absorbable pharmacologically active agents  
A readily enterally absorbable pharmaceutical composition of pharmacologically active agents, which per se are poorly enterally absorbable, is disclosed which comprises a pharmacologically,...
4184037 Digoxin oxidized product  
Reagent of value in the radioimmunoassay of digoxin. Also provided by the invention are a radioimmunoassay method utilizing such reagent and a test kit suitable for use in performing the assay.
4145528 Process for preparing β-methyldigoxin  
Preparation of β-methyldigoxin in the presence of dimethyl formamide, an inert solvent, methyl ester of a sulphuric acid, and strontium hydroxide.
4107299 Cardioactive 12-epi-digoxin and derivatives thereof  
12-Epi-digoxins of the formula ##STR1## wherein R 1 and R 2 each independently is hydrogen or a lower alkanoyl or alkyl radical, R 3 is hydrogen or a lower alkanoyl radical, and R 4 is...
4021546 Pro-drug forms of digoxin and method of preparing and using same  
There is provided, a novel pro-drug form of digoxin having the following formula: ##STR1## wherein R represents a member selected from the group consisting of a hydrogen atom, a residue of any...
4003998 α-Acyl derivatives of digitoxin  
Compounds of the formula ##STR1## wherein R 1 is ##STR2## R 2 is alkyl of 2 to 15 carbon atoms; mono-substituted alkyl of 1 to 4 carbon atoms, the substituent being halogen, cyano, carbethoxy,...
4001402 Cardenolide glycosides and method of making the same, and therapeutic composition  
Cardioactive glycosides of the formula ##STR1## are disclosed, wherein R 1 is saturated aliphatic hydrocarbon having 1 - 4 carbon atoms or unsaturated aliphatic hydrocarbon having 2 - 4 carbon...
4000125 Novel cardiotonic steroids, process for their preparation and therapeutical use  
The invention relates to novel steroid compounds having the formula ##STR1## and their glycoside derivatives containing a pyridazine ring, in which particularly the substituent R 4 is a hydroxy...
3981862 Preparation of C22-alkyl derivative of digoxin  
A process for the preparation of a C22-alkyl-derivative of digoxin of the formula ##SPC1## In which R 1 is an alkyl radical containing up to 4 carbon atoms, R 2 and R 3 are selected from...
3951946 Cardioglycoside derivatives of the strophanthidin type, a process for their manufacture and medicinal preparations containing these compounds  
Cyclic acetals or ketals of cardioglycosides derived from k-strophanthidin or strophanthidol are more readily absorbed by the stomach and intestine than the parent cardioglycoside. The acetals are...
3950323 Digoxigenine-3-[2',3'-didesoxy-glycosides] and a process for their manufacture  
Digoxigenine-3-[2', 3'-didesoxy-glycosides] of the formula ##SPC1## In which R 1 is the digoxigenine radical and R 2 is hydrogen, methyl or --CH 2 OH, which are prepared by a reaction of a...
3947404 Dihydrodigoxin compounds and therapeutic compositions  
New dihydrodigoxin derivatives of the formula ##SPC1## Wherein one of R 1 and R 2 represents a methyl or ethyl radical and the other represents hydrogen, methyl, ethyl or acetyl (i.e. alkanoyl;...
3937697 12-Dehydro digoxin-4'"-and 3'"-alkyl ethers  
12-Dehydro digoxin mono-4'" and 3'"-alkyl ethers and a process for their manufacture. The compounds have a cardiotonic and diuretic activity.
3936438 Aromatic cardenolide acetals  
The present invention is concerned with new cardenolide acetals of the general formula: ##SPC1## Wherein R 1 is an unsubstituted or substituted glycosyl radical and Ar is an unsubstituted or...
3933791 Obtention of digitoxigenin from neriifolin and 2'-acetylneriifolin  
Process for degrading the glycoside neriifolin and its acetate to the cardenolide digitoxigenin. Novel intermediates are also described.
3932626 Pharmaceutical compositions containing a carboxylic acyl derivative of digoxin and method of use  
Pharmaceutical dosage unit compositions containing as an active ingredient a compound of the formula ##SPC1## Wherein R 1 is alkyl of 2 to 12 carbon atoms, halo-(alkyl of 1 to 4 carbon atoms),...
3924017 SWEETNESS INDUCER  
A composition containing salts of chlorogenic acid, caffeic acid, cynarine and isomers thereof capable of inducing a pleasant sweet taste in non-sweet foodstuffs.
3919191 14,15β-Epoxycardenolide- and 14,15β-epoxybufadienolide-glycosides and process for their preparation  
Cardioactive 3β-hydroxy-14,15β-epoxy-5β-cardenolide-or -5β-bufadienolide-glucosides and rhamnosides. A method for making these compounds by reacting the corresponding 14-anhydrocardenolides or...
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