|
Match
|
Document |
Document Title |
|
|
6951932 |
Synthesis of 2-aralkoxyadenosines and 2-alkoxyadenosines
The invention provides new methods for synthesis of 2-aralkyloxyadenosines and 2-alkoxyadenosines. The invention is particularly useful for synthesis of 2-[2-(4-chlorophenyl)ethoxy]adenosine....
|
|
|
6949640 |
Method for synthesizing 2-chloro-9-(2-fluoro-β-D-arabinofuranosyl)-9H-purin-6-amine
2-Chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purin
-9-amine is synthesized by reacting a 2-chloro-6-substituted purine with a protected and activated 2-deoxy-2-fluoro-D-arabinofuranose;...
|
|
|
6946551 |
Preparation of hyaluronic acid from eggshell membrane
Compositions and methods of preparing compositions containing hyaluronic acid derived from eggshell membrane are disclosed. The compositions can contain essentially pure hyaluronic acid or...
|
|
|
6933372 |
Method to produce a solid form of heparin
The present invention provides a new method to process a solution containing heparin; heparin salts or heparin complexes in a solvent or a mixture of solvents to a solid form of heparin products...
|
|
|
6933381 |
Method of preparing modified cellulose ether
Process for the production of polysaccharide ethers, e.g. cellulose ethers, are disclosed wherein salts formed during the process, e.g., sodium nitrate or sodium acetate, are converted to their...
|
|
|
6921819 |
Polysaccharide crosslinking, hydrogel preparation, resulting polysaccharide(s) and hydrogel(s), uses thereof
The invention relates to a process for the crosslinking of polysaccharides. The process of the invention is a process for the crosslinking of at least one polymer selected from polysaccharides and...
|
|
|
6916920 |
Process for producing hydrazinomonosaccharide derivatives and use thereof
A process for producing hydrazinomonosaccharide derivatives and use of hydrazines in determining the structures of aldose and ketose monosaccharides located at the reducing ends of saccharides.
|
|
|
RE38743 |
Mixtures of particular LMW heparinic polysaccharides for the prophylaxis/treatment of acute thrombotic events
Heterogeneous intimate admixtures of sulfated heparinic polysaccharides, well suited for the prophylaxis/treatment of acute thrombotic episodes in a human patient, comprise immixture of sulfated...
|
|
|
6894160 |
Catalytic process for the modification of carbohydrates, alcohols, aldehydes or polyhydroxy compounds
The invention relates to the industrial conversion of carbohydrates, alcohols, aldehydes or polyhydroxy compounds in aqueous phase. According to the invention a catalytic method is used for the...
|
|
|
6884882 |
2′-deoxyuridine derivatives and hydrogels formed therewith
A 2′-deoxyuridine derivative of formula I is bioavailable and thermally stable and forms a gel in water at a low concentration; and, can be employed as a drug delivery vehicle:
|
|
|
6884880 |
Process for the preparation of 9-β-anomeric nucleoside analogs
A process for substantially enhancing the regio and stereoselective synthesis of 9-β-anomeric nucleoside analogs is described. The introduction of the sugar moiety onto a 6-substituted purine base...
|
|
|
6884788 |
Thiol-modified hyaluronan
The present invention relates to biscarbodiimides, thiourea derivatives, urea derivatives, and cross-linked hyaluronan derivatives having at least one intramolecular disulfide bond, and methods of...
|
|
|
6878819 |
Fucosylated oligosaccharides and process for their preparation
The present invention relates to a process for the preparation of oligosaccharides or oligosaccharide containing compounds, especially N-acetyl-chitooligosaccharides having a fucosylated...
|
|
|
6872819 |
Biomaterials containing hyaluronic acid derivatives in the form of three-dimensional structures free from cellular components or products thereof for the in vivo regeneration of tissue cells
Biomaterials are disclosed comprised of biodegradable, biocompatible, and bioabsorbable non-woven fabric materials for use in surgery for the guided regeneration of tissues. The non-woven fabric...
|
|
|
6867296 |
Recovery and purification of anhydro sugar alcohols from a vapor stream
This invention concerns a process for recovering and purifying dianhydro sugar alcohols from a vapor stream comprising dianhydro sugar alcohols, such as isosorbide, and water vapor.
|
|
|
6864244 |
Anhydrous crystalline 1-[4(S)-azido-2(S),3(R)-dihydroxy-4-(hydroxymethyl)-1(R)-cyclopentyl]cytosine hemisulfate as useful as an antiviral agent
The present invention relates to the hemisulfate salt of 1-[4(S)-azido-2(S),3(R)-dihydroxy-4-(hydroxymethyl)-1(R)-cyc
lopentyl]cytosine (Ia) with improved stability and physical properties which...
|
|
|
6846810 |
Antiviral nucleoside derivatives
The present invention relates to nucleoside derivatives for the treatment of Hepatitis C viral infections including compounds of formula I, pharmaceutical compositions comprising these compounds...
|
|
|
6844328 |
Polysaccharidic esters of N-derivatives of glutamic acid
The present invention is related to polysaccharide esters of N-derivatives of glutamic acid (N-GA derivatives). These polysaccharidic esters have antiproliferative activity and are characterized by...
|
|
|
6835718 |
Biocleavable micelle compositions for use as drug carriers
This invention discloses compositions and methods for preparing biocleavable or biodegradable micelle compositions for carrying and releasing drugs and other active agents for therapeutic or other...
|
|
|
6828436 |
Method for selecting a high affinity, low molecular weight displacer for oligonucleotide purification
A method for purifying oligonucleotides by displacement chromatography on anion-exchange media, using high affinity, low molecular weight (less than about 10000 Da) displacers, is disclosed....
|
|
|
6825341 |
Process for preparing functionalized polyalkyleneimines, compositions containing them and uses thereof
The present invention relates to a process for preparing functionalized polyalkyleneimines which are useful for formulating nucleic acids intended to be transfected into cells. This process...
|
|
|
6815441 |
Reaction products of taurultam and glucose
Reaction products of taurultam and glucose are useful as antineoplastic agents. They are produced by reacting an aqueous solution of taurultam and glucose at about 100 degrees Celsius for about 30...
|
|
|
6812223 |
Crystalline glucosamine sulfate metal salts and processes for preparing the same
The present invention relates to novel crystalline glucosamine sulphate metal salts for use in the treatment of acute and chronic forms of rheumatic and arthritic diseases and of all the...
|
|
|
6809086 |
Process for producing desulfated polysaccharide, and desulfated heparin
A method of increasing proliferation of cells which comprises adding to cells a cellular proliferating amount of a primary hydroxyl group of N-acetylglucosamine selectively desulfated heparin...
|
|
|
6780822 |
Anhydride-modified chitosan, method of preparation thereof, and fluids containing same
The invention provides an organic diacid anhydride-modified chitosan and a method of preparing the same under high shear conditions which eliminates the use of solvents and excessive amounts of...
|
|
|
6780988 |
Processes for producing P1,P4-diuridine-5′-tetraphosphate
The invention describes a process for producing P 1 ,P 4 -di(uridine-5′-)tetraphosphate (U 2 P 4 ) or a salt thereof from uridine 5′-monophosphate (UMP); wherein the process comprises at least...
|
|
|
6765090 |
Method for large-scale production of di(uridine 5')-tetraphosphate and salts thereof
The present invention provides new methods for the synthesis of the therapeutic dinucleotide, P 1 ,P 4 -di(uridine 5′-tetraphosphate), and demonstrates applicability to the production of large...
|
|
|
6750335 |
Nucleoside derivatives with photolabile protective groups
The invention relates to nucleoside derivatives with photolabile protecting groups of general formula (I) wherein R 1 is H, F, Cl, Br, I, or NO 2 ; R 2 is H or CN, provided that R 1 and R 2 ...
|
|
|
6740752 |
Process for preparing chitosan particles
Disclosed is a process for producing particles of the modified carbohydrate polymer chitosan. Such chitosan particles are “activated” as a consequence of the specific steps used in the process....
|
|
|
6734300 |
Acarbose purification process
An improved process for the purification of crude aqueous solutions of acarbose by passing such solutions through a strong acid cation-exchange resin, saturating such resin and recovering as an...
|
|
|
6734298 |
Cross-linking process of carboxylated polysaccharides
A process for the preparation of cross-linked polysaccharides containg carboxy groups. The process comprises a first step of activating the carboxy groups in an anhydrous aprotic solvent and then...
|
|
|
6727232 |
Nucleoside peptide antibiotics of AA-896
This invention relates to antibiotic compounds AA896 of the formula wherein: R 1 is H, aryl, alkyl (C 1 -C 20 ), —CH 2 -aryl, —C(O)alkyl(C 1 -C 20 ), —C(O)NHalkyl(C 1 -C 20 ), or...
|
|
|
6720418 |
Derivatized reduced malto-oligosaccharides
Disclosed are derivatized malto-oligosaccharides and methods for the preparation thereof. In accordance with the disclosed invention, a malto-oligosaccharide is hydrogenated to thereby obtain a...
|
|
|
6693188 |
N-acetyl-D-glucosamine and process for producing N-acetyl-D-glucosamine
The present invention is directed to N-acetyl-D-glucosamine obtained from microbial biomass, and to methods of obtaining N-acetyl-D-glucosamine from microbial biomass. In particular, the present...
|
|
|
6693180 |
Composite sponge wound dressing made of β-Chitin and Chitosan and method for producing the same
The present invention relates to a composite sponge wound dressing and method for producing the same. Chitosan and β-Chitin is mixed in a specific ratio for forming the sponge for wound repairing....
|
|
|
6673919 |
Chemically modified hyaluronic acid or salts thereof, and a process for producing thereof
This invention relates to a chemically modified hyaluronic acid and salts thereof, which are obtained by O-acylating, alkoxylating or crosslinking a complex consisting of hyaluronic acid or a salt...
|
|
|
6673544 |
Method for the light-controlled synthesis of biochips
The present invention relates to a method for the photolithographic synthesis of biochips in which photolabile protective groups of the 2-(2-nitrophenyl)ethyl type are used, whereby the irradiation...
|
|
|
6660854 |
Processes for preparing β-D-ribofuranose derivatives
Provided are a process for preparing β-D-ribofuranose derivatives, which are useful as an intermediate for the preparation of ribavirin. The process can be performed under a mild condition, in the...
|
|
|
6656885 |
Anhydride-modified chitosan, method of preparation thereof, and fluids containing same
The invention provides an organic diacid anhydride-modified chitosan containing a polar additive comprising water soluble compounds containing one or more hydroxyl groups or one or more amino...
|
|
|
6653457 |
Method of covalent coupling
A method of preparing conjugates by means of covalent coupling of a polysaccharide selected from heparin, heparin derivatives, at least partially deacerylated dermatan sulphate and dextran sulphate...
|
|
|
6649755 |
Process for preparing acarbose with high purity
Disclosed herein is a process for preparing highly pure acarbose of formula (I) useful as medicine for the treatment of diabetes. The disclosed process comprises prepurifying an acarbose-containing...
|
|
|
6639067 |
Continuous process for the production of anhydrosugar alcohols
A process is described for continuous production of anhydrosugar alcohol by continuous introducing of sugar alcohols and/or monoanhydrosugar alcohols into a reaction vessel and dehydration in the...
|
|
|
6596859 |
Process to prepare pyrimidine nucleosides
A process for the production of a compound of the formula: wherein R 1 is hydrogen, alkyl, C 1 -C 16 substituted alkyl, aryl, substituted aryl, aralkyl, substituted aralkyls, alkenyl,...
|
|
|
6593467 |
Process for the preparation of a deoxyuridine derivative
A process for the preparation of 5′-deoxy-5-fluorouridine, which comprises the transformation of 2′,3′-O-isopropylidene-5-fluorouridine in the corresponding 5′-O-sulfonyl derivative,...
|
|
|
6569840 |
Low-molecular heparin modification and remedy for skin ulcer
The invention is direct to modified heparins, especially low-molecular weight modified heparins that are adapted for used in preparing an agent for treating a skin ulcer. The low-molecular weight...
|
|
|
6566346 |
Oral skin improving agent, skin improving method, and food composition for improving skin
There are provided an oral skin improving agent that exhibits good skin improving effects when orally ingested, suppresses problems of discoloration and generation of unpleasant odor during...
|
|
|
6562961 |
Aminoalkyl trialkyl silyl cellulose and a method for coating surfaces
The invention relates to polysaccharide derivatives comprising a) at least one hydrophobic and b) at least one nitrogen-containing substituent; in particular, the derivative is a cellulose ether...
|
|
|
6562762 |
Method of and composition for reducing the loss of fluid during well drilling, completion or workover operations
Disclosed is a composition for and method of reducing the loss of fluid from well drilling, completion, or workover fluids during well drilling, completion, or workover operations, particularly for...
|
|
|
6552184 |
Process for the preparation of autocrosslinked compounds of hyaluronic acid and the derivatives thereof by the supercritical antisolvent technique
Crosslinked compounds of hyaluronic acid and the derivatives thereof, prepared by the technique of precipitation induced by supercritical antisolvent (SAS), can be used to advantage for the...
|
|
|
6537979 |
Water-insoluble derivatives of hyaluronic acid crosslinked with a biscarbodiimide
This invention describes a method for preparing water-insoluble biocompatible gels, films and sponges by reacting hyaluronic acid, or a salt thereof, with a carbodiimide in the absence of a...
|