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8168598 |
Optimised formulation of tobramycin for aerosolization
The invention provides a tobramycin formulation for delivery by aerosolization in the form of additive-free, isotonic solution whose pH has been optimised to ensure adequate shelf-life at room...
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8158763 |
Sugar chain asparagine derivatives, sugar chain asparagine, sugar chain and processes for producing these
An asparagine-linked α2,3-oligosaccharide having undeca- to hepta-saccharides, an asparagine-linked α2,6-oligosaccharide having undeca- to hepta-saccharides and containing fluorine and an a...
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8153440 |
Methods for altering surface characteristics of microspheres
Various methods for altering surface characteristics of a microsphere are provided. One method includes coupling an enolic acid to the microsphere to modify the surface characteristics of the...
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8110677 |
Microwave-assisted extraction of polysaccharide from Artemisia sphaerocephala
This invention relates to a method of extracting crude polysaccharide by microwave-assisted from Artemisia sphaerocephala seed de-oiling dregs. In particular, the invention comprising:...
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8106184 |
Nicotinoyl riboside compositions and methods of use
The invention relates to compositions of nicotinoyl ribosides and nicotinamide riboside derivatives and their methods of use. In some embodiments, the invention relates to methods of making...
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8101393 |
Cellulolytic enzymes, nucleic acids encoding them and methods for making and using them
The invention provides polypeptides having any cellulolytic activity, e.g., a cellulase activity, a endoglucanase, a cellobiohydrolase, a beta-glucosidase, a xylanase, a mannanse, a β-xylosidase, ...
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8080641 |
Process for the production of multiple cross-linked hyaluronic acid derivatives
The present invention relates to a process for the production of cross-linked hyaluronic acid (HA) derivatives, in particular multiple, e.g. double cross-linked hyaluronic acid derivatives. The...
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8071756 |
Polysaccharide pseudo-sponge
A photocrosslinked polysaccharide pseudo-sponge exhibiting a low swelling property and a high degradation ability in vivo while retaining a suitable strength. The polysaccharide pseudo-sponge is...
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8063202 |
Process for preparing glycopeptides having asparagine-linked oligosaccharides, and the glycopeptides
Glycopeptide having at least one asparagine-linked oligosaccharide at a desired position of the peptide chain obtained by: (1) esterifying hydroxyl of a resin and carboxyl of ah amino acid having...
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8058424 |
Synthesis of 5-azacytidine
The present invention provides a method for the preparation of 5-azacytidine, wherein 5-azacytidine is represented by the structure: The method involves the silylation of 5-azacytosine, followed by...
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8049002 |
Processes for chemical synthesis of lipochitooligosaccharides
Processes for the synthesis of lipochitooligosaccharides were developed. A fully acylated oligoglucosamine precursor is prepared and reacted with a glucosamine monomer that has an amine protecting...
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8034767 |
Method for producing purine nucleosides and nucleotides by fermentation using a bacterium belonging to the genus Escherichia or Bacillus
A method is provided for producing a purine nucleoside, such as inosine and guanosine, and a method for producing a 5′-purine nucleotide such as 5′-inosinic acid or 5′-guanylic acid, using a bacte...
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8034925 |
Glucosamine and method of making glucosamine from microbial biomass
Glucosamine suitable for human or animal consumption is disclosed. The glucosamine is derived from fungal biomass containing chitin. Various methods of producing glucosamine by acid hydrolysis of...
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8026356 |
Process for the large scale production of Stavudine
The present invention provides a method for preparing pure Stavudine having purity more than 99.5% comprises: i) Converting 3′,5′-anhydrothymidine to crude Stavudine, ii) Converting crude Sta...
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8012942 |
Carba-nucleoside analogs for antiviral treatment
Provided are thieno[3,4-d]pyrimidin-7-yl and furo[3,4-d]pyrimidin-7-yl ribosides, riboside phosphates and prodrugs thereof as well as intermediates and methods of preparation. The compounds,...
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7993678 |
Hyaluronic acid derivatives
The present invention relates to the modification of hyaluronic acid (HA) with aryl/alkyl succinic anhydrides (ASA) to produce aryl/alkyl succinic anhydride HA derivatives, to the derivatives as...
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7973157 |
Imino and amino sugar purification
Novel processes for the purification of an imino or amino sugar, such as D-1-deoxygalactonojirimycin (DGJ). Particularly, there are described processes for the purification of multi-kilogram scale...
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7960523 |
Processes for the production of aminoalkyl glucosaminide phosphate and disaccharide immunoeffectors, and intermediates therefor
This invention relates to processes for production of alkylamino glucosaminide phosphate compounds, and of disaccharide compounds, including various novel intermediates and intermediate processes....
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7951936 |
Crosslinked polysaccharide sponge
A process for producing a polysaccharide sponge comprises the steps of (A) freezing a photoreactive polysaccharide solution, and (B) irradiating the frozen photoreactive polysaccharide solution...
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7947824 |
Process for preparing purine nucleosides
The present invention for the stereoselective preparation of 2-deoxy-β-D-adenine nucleosides wherein a blocked 2-deoxy-α-D-arabinofuranosyl halide is coupled with the salt of an adenine derivative.
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7943763 |
Process for preparing glycopeptides having asparagine-linked oligosaccharides, and the glycopeptides
Glycopeptide having at least one asparagine-linked oligosaccharide at a desired position of the peptide chain which is obtained by: (1) esterifying hydroxyl of a resin and carboxyl of an amino acid...
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7939502 |
Optimised formulation of tobramycin for aerosolization
The invention provides a tobramycin formulation for delivery by aerosolization in the form of additive-free, isotonic solution whose pH has been optimised to ensure adequate shelf-life at room...
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7939655 |
Process for preparing a sterile high molecular weight hyaluronic acid formulation
A process for preparing a sterile ready-to-use aqueous pharmaceutical formulation comprises a high molecular weight hyaluronic acid salt (HA) at a specified concentration, comprising the steps of:...
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7927830 |
Modified carbocyanine dyes and their conjugates
Chemically reactive carbocyanine dyes incorporating an indolium ring moiety that is substituted at the 3-position by a reactive group or by a conjugated substance, and their uses, are described....
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7893225 |
Crosslinked polysaccharide sponge
A process for producing a polysaccharide sponge comprises the steps of (A) freezing a photoreactive polysaccharide solution, and (B) irradiating the frozen photoreactive polysaccharide solution...
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7888500 |
Preparation and uses of locked-ring sugar C-glycoside derivatives
“Locked-ring” C-glycoside derivatives may be prepared wherein the ring of the sugar molecule remains intact without the need for any protecting groups. These C-glycoside derivatives may be pro...
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7871987 |
Ester derivatives of ascorbic and 2-keto acid saccharides
Novel ester derivatives of ascorbic acid and 2-keto-acid saccharides are provided wherein the ester is introduced by ester bond formation between at least one hydroxy-functionality on the ascorbic...
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7867774 |
Methods for altering surface characteristics of microspheres
Various methods for altering surface characteristics of a microsphere are provided. One method includes coupling an enolic acid to the microsphere to modify the surface characteristics of the...
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7868166 |
Continuous process for the production and/or workup of polysaccharide derivatives
A process is described for the continuous preparation and/or workup of polysaccharide derivatives by reaction and/or conditioning in a suspension with liquid reaction partners, in which, in...
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7858774 |
Synthesis of 5-azacytidine
The present invention provides a method for the preparation of 5-azacytidine, wherein 5-azacytidine is represented by the structure: The method involves the silylation of 5-azacytosine, followed by...
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7838644 |
Epimerized derivatives of K5 polysaccharide with a very high degree of sulfation
A new method is described for the oversulfation of epiK-N sulfate to obtain an epiK5-amine-O-oversulfate with very high sulfation degree which, by subsequent N-sulfation, provides new...
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7834173 |
Esters of hyaluronic acid with rhein, process for their preparation and compositions comprising the same
The present invention relates to esters of hyaluronic acid with rhein, more particularly to a compound based on hyaluronic acid, wherein alcohol groups of hyaluronic acid are esterified with rhein,...
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7816514 |
Glucosamine and method of making glucosamine from microbial biomass
Glucosamine suitable for human or animal consumption is disclosed. The glucosamine is derived from fungal biomass containing chitin. Various methods of producing glucosamine by acid hydrolysis of...
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7812151 |
Low molecular weight polysaccharides having antithrombotic activity
Novel depolymerized-LMWepiK5-N,O-sulfates obtainable starting from a LMW-epiK5-N-sulfate prepared by nitrous depolymerization of an epiK5-N-sulfate or by C5-epimerization of a LMW-K5-N-sulfate...
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7790700 |
Derivatives of partially desulphated glycosaminoglycans endowed with antiangiogenic activity and devoid of anticoagulating effect
Partially desulfated glycosaminoglycan derivatives are described, particularly heparin, and more particularly formula (I) compounds where the U, R and R1 groups have the meanings indicated in the...
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7781576 |
Process for preparing a synthetic intermediate for preparation of branched nucleosides
A process is provided for the preparation of a key intermediate in the preparation of 2′-branched nucleoside compounds. The process includes contacting a protected precursor 3...
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7781416 |
Derivatives of partially desulphated glycosaminoglycans as heparanase inhibitors, endowed with antiangiogenic activity and devoid of anticoagulating effect
Partially desulphated glycosaminoglycan derivatives are described, particularly heparin, and more particularly a compound of formula (I) where the U, R and R1 groups have the meanings indicated in...
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7777027 |
Purified beta glucan composition
The invention provides methods of using beta glucans to treat conditions associated with bone loss or low bone density as well as methods for promoting bone growth in situations where enhanced bone...
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7754875 |
Halide-free glucosamine base-organic acid salt compositions
A salt of a glucosamine base having a purity of at least about 99 wt. % and a maximum halide content of about 0.01 wt. %, and an organic acid. The organic acid that is saltified with the...
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7741295 |
Sir2 products and activities
A novel compound, 2′/3′-O-acetyl-ADP-ribose, is provided. The compound is a mixture of the 2′ and 3′ regioisomers of O-acetyl-ADP ribose, and is formed nonenzymatically from 2′-O-ac...
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7728156 |
Method of performing sugar dehydration and catalyst treatment
The invention includes a method of treating a solid acid catalyst. After exposing the catalyst to a mixture containing a sugar alcohol, the catalyst is washed with an organic solvent and is then...
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7696178 |
Optimised formulation of tobramycin for aerosolization
The invention provides a tobramycin formulation for delivery by aerosolization in the form of additive-free, isotonic solution whose pH has been optimised to ensure adequate shelf-life at room...
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7683042 |
Stabilized halide-free glucosamine base and method of preparation
A stabilized glucosamine base composition comprising a glucosamine base having a purity level of at least 99.0 wt. % and a maximum halide content of about 0.01 wt. % coated with at least one...
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7683038 |
Percarboxylated polysaccharides, and a process for their preparation
The present invention relates to percarboxylated polysaccharide selected from the group consisting of gellan, carboxymethylcellulose, pectic acid, pectin and hyaluronic acid derivatives; the...
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7649099 |
Method of forming a dianhydrosugar alcohol
The invention includes methods of producing dianhydrosugars. A polyol is reacted in the presence of a first catalyst to form a monocyclic sugar. The monocyclic sugar is transferred to a second...
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7645874 |
Cellulose oxidation by nitrogen dioxide in a perfluorinated tertiary amine solvent
This invention relates to a process for preparing bioabsorbable oxidized cellulose comprising combining cellulose material, with nitrogen dioxide and a nonaqueous solvent chosen from the class of...
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7622576 |
Halide-free glucosamine base and method of preparation
A glucosamine base having a pure level of at least about 99.0 wt. % and a maximum halide content of 0.01 wt. %. The pure glucosamine base is prepared by reacting a glucosamine halide, e.g.,...
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7615652 |
Two-stage dehydration of sugars
The invention includes methods for producing dianhydrosugar alcohol by providing an acid catalyst within a reactor and passing a starting material through the reactor at a first temperature. At...
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7598372 |
Synthesis of core sugar chain structure of asparagine-linked glycoprotein
It is intended to chemically synthesize the trisaccharide moiety at the reducing end in the core sugar chain structure of an asparagine-linked glycoprotein. By using a highly inexpensive natural...
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7579460 |
Method for tagging of carbohydrates with active methylene compound
The present invention relates to the method for tagging of carbohydrates with active methylene compound. Particularly, it relates to the method for tagging of carbohydrates with active methylene...
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