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4716219 |
Adsorbent for protein purification
Adsorbents, which are suitable for the affinity chromatography of proteins, especially of interferons, and which consist of an electroneutral carrier matrix, --O--CH 2 --CH(OH)--CH 2 --NH- groups...
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4716224 |
Crosslinked hyaluronic acid and its use
Crosslinked hyaluronic acid or salts thereof prepared by crosslinking hyaluronic acid or salts thereof with a polyfunctional epoxy compound wherein a crosslinking index or number is 5 or more per...
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4716223 |
Method for preparing ganglioside derivatives and use thereof in pharmaceutical compositions
The present invention relates to a method for preparing inner ester derivatives of gangliosides and pharmaceutical compositions containing such derivatives to be used in treating disorders of the...
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4713448 |
Chemically modified hyaluronic acid preparation and method of recovery thereof from animal tissues
Disclosed is hylan, a chemically modified hyaluronic acid preparation characterized by the presence of small amounts (0.005-0.05% by weight) of aldehyde cross-linking groups covalently bonded to...
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4707471 |
Water-soluble aminated β-1,3-bound D-glucan and composition containing same
Water-soluble aminated β-1,3-bound D-glucan and macrophage-stimulating composition containing as an active constituent such glucan.
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4696980 |
Sulfone activated thioether adsorbents for the separation of proteins and the like
The adsorbent consists of a solid phase, completely or partially penetrated by or surface-coated with a hydrophilic molecular polymer netting to which has been bound substituents or cross bridges...
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4695624 |
Covalently-modified polyanionic bacterial polysaccharides, stable covalent conjugates of such polysaccharides and immunogenic proteins with bigeneric spacers, and methods of preparing such polysaccharides and conjugates and of confirming covalency
Covalently modified bacterial polysaccharides and proteins; covalent conjugates of such polysaccharides linked by a bigeneric spacer, which permits proof of covalency and facilitates purification...
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4638056 |
Opthalmic wafer
Damage to endothelial and epithelial cells subject to trauma can be substantially reduced by using a wafer of a viscoelastic material. This method is particularly useful when applied prior to...
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4532267 |
Vision correction lens made from an aminopolysaccharide compound or an ether or ester thereof
An oxygen permeable, wettable, optically acceptable vision correction lens can be made from homopolymers of aminoglycans, substituted aminoglycans, or crosslinked polymers thereof.
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4517295 |
Hyaluronic acid from bacterial culture
Hyaluronic acid, a polysaccharide, is prepared in high yield from streptococcus bacteria by fermenting the bacteria under anaerobic conditions in a CO 2 -enriched growth medium, separating the...
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4508892 |
Compositions for competitive protein binding assays inhibiting non-specific interference
Conjugates of heavy atoms containing analytes or their analogs and fluorescent molecules are covalently bonded to macromolecular supports to minimize the interference of fluorescence during assays,...
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4491660 |
Matrix polymers for binding endotoxins
An endotoxin binding material affixed to a support is disclosed. One embodiment is a matrix material capable of binding endotoxins and comprising a polar, water-insoluble, high molecular weight...
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4490525 |
Polysaccharides containing phthalocyanine nucleus
Metal-containing or metal-free phthalocyanine-polysaccharide complex defined below is used for removal of mutagens and carcinogens present in aqueous solutions, the said complex having formula of...
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4468465 |
Diagnosing cancer by observing marker glycosaminoglycans extracted from patient
A disease-specific marker for cancer and hyperplasia of the human prostate comprising hybrid and copolymer glycosaminoglycans (GAGs) extracted from the patient and methods for diagnosing and...
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4464360 |
Glycosphingalipids for inhibiting bacterial adherence
Pharmaceutical preparations containing globotetraosylceramide, globotriaozylceramide or globotetraos, and the use of said preparations or compounds for treatment, prophylaxis or diagnosis of...
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4454316 |
Heteropolysaccharide S-139
The new heteropolysaccharide S-139, prepared by fermentation of an unnamed Psuedomonas species, ATCC 31644 has valuable properties as a thickening, suspending and stabilizing agent in aqueous...
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4438108 |
Anti-thromboticum based on polysacharides, method for its preparation and pharmaceutical compositions
A new anti-thromboticum based on a mixture of oligo- and polysaccharides is provided. The invention also relates to methods for preparation thereof and to pharmaceutical compositions including the...
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4415733 |
Ganglioside derivatives, their preparation and their application
This invention has for its object new ganglioside derivatives, their preparation and their application.
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4411832 |
Polysaccharide matrices comprising macromolecular spacer arms for use as adsorbents in affinity chromatography techniques
Polysaccharide matrices, including polyfunctional macromolecular spacer "arms" coupled to the backbones of such matrices in multipoint attachment, are useful as adsorbents in affinity...
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4411891 |
Cationized dextran and salts thereof and manufacturing process and utilization thereof
A cationized dextran of the following formula ##STR1## wherein R represents a group selected from the class consisting of a hydrogen atom, hydroxy lower alkyl groups, and quaternary...
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4380504 |
ψ-Emulsans
Growth of Acinetobacter Sp. ATCC 31012 on various substrates and under varying conditions has been used to produce two classes of extracellular microbial protein-associated lipopolysaccharides (the...
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4359459 |
O-α-D-Multigalactopyranosyl-O-α-D-multiglucopyranosyl-O-β- D
O-α-D-Galactopyranosyl(1➝6)-O-α-D-galactopyranosyl(1.fwd
arw.6)-O-α-D-glucopyranosyl(1➝2)-O-β-D-fructofuranosyl(1
. fwdarw.6)-O-α-D-glucopyranosyl(1➝4)-O-α-D-glucopyranosyl
...
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4359460 |
6'-(1-Adamanta necarboxylate)-6-O-α-D-galactopyranosyl-α-D-glucopyranose sulfate salts
6'-(1-Adamantanecarboxylate)-6-O-α-D-galactopyranosyl-α-D-
gluco pyranose sulfate salts, useful as complement inhibitors, and the process for making such compounds.
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4359461 |
Mono-, di- and tri-adamantylcarbonyl- digalactopyranosyl- glucopyranosyl- fructofuranose sulfate salts
Mono-, di- and tri-adamantylcarbonyl- digalactopyranosyl- glucopyranosyl- fructofuranose sulfate salts, useful as complement inhibitors and the process of making such compounds.
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4359458 |
O-β. -D (and O-α.. -D) Multigalactopyranosyl, xylopyranosyl and glucopyranosyl sulfate salts
O-β-D (and O-α-D) multi-galactopyranosyl (or xylopyranosyl or glucopyranosyl) 1α,1α' galactopyranosyl (or xylopyranosyl or glucopyranosyl) sulfate salts, useful as complement inhibitors, the...
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4357323 |
Polysaccharide RBS substance and antitumor agent containing same
A polysaccharide RBS substance having the ultraviolet absorption spectrum depicted in FIG. 1 and the infrared absorption spectrum depicited in FIG. 2 is obtained from rice bran by extraction with...
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4322524 |
Cyanoethylpullulan
The present invention provides a novel compound cyanoethylpullulan which is a cyanoethylation product of pullulan. Pullulan is readily cyanoethylated by the reaction with acrylonitrile in the...
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4321363 |
Adsorbent for urokinase containing agarose
Highly pure urokinase can be produced by affinity chromatography on a novel adsorbent which comprises a water insoluble carrier and a ligand united to the carrier. The ligand is shown by the...
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4311829 |
Apo-β-emulsans
Growth of Acinetobacter Sp. ATCC 31012 on various substrates and under varying conditions has been used to produce two classes of extracellular microbial protein-associated lipopolysaccharides (the...
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4311832 |
Proemulsans
Growth of Acinetobacter Sp. ATCC 31012 on various substrates and under varying conditions has been used to produce two classes of extracellular microbial protein-associated lipopolysaccharides (the...
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4311830 |
Apo-α-emulsans
Growth of Acinetobacter Sp. ATCC 31012 on various substrates and under varying conditions has been used to produce two classes of extracellular microbial protein-associated lipopolysaccharides (the...
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4311831 |
Apo-ψ-emulsans
Growth of Acinetobacter Sp. ATCC 31012 on various substrates and under varying conditions has been used to produce two classes of extracellular microbial protein-associated lipopolysaccharides (the...
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4280995 |
Oral suspension of phenytoin
The invention comprises a 5,5-diphenyl-2,4-imidazolidinedione-guaran complex formed by reacting an aqueous solution of guaran with an organic solvent solution of...
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4273765 |
Amino sugar derivatives containing trehalose
This invention relates to Trestatin A, Trestatin B and Trestatin C salts thereof and mixtures thereof as well as compositions containing at least one of the Trestatins A, B or C or a salt thereof....
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4268505 |
Pharmaceutical composition comprising a nitrogen-containing polysaccharide and an antibiotic agent, and a method of treating an infectious disease therewith
A nitrogen-containing polysaccharide, which is obtainable by extracting mycelia of a fungus belonging to the genus Coriolus of Polyporaceae of Basidiomycetes with an aqueous solvent, is effectively...
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4254257 |
Amine salts of acidic microbial polysaccharides and their use in recovery of such polysaccharides
Acidic polysaccharides of the type obtainable by microbial fermentation of an organic material such as a carbohydrate (e.g., xanthan gum) form novel amine salts with aliphatic or alicyclic...
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4243662 |
Plant-virus controlling agent
A novel product comprising nitrogen-containing polysaccharides is produced by bringing a culture product of fungi Basidomycetes into reaction with an aqueous ammoniacal solution at a temperature of...
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4242501 |
Purification of pneumococcal capsular polysaccharides
A multivalent pneumococcal vaccine of the group consisting of immunogenic amounts of purified pneumococcal capsular polysaccharide (substantially absent "C" polysaccharide) of pneumococcal types...
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4235994 |
High molecular weight meningococcal group C vaccine and method for preparation thereof
A vaccine against Group C meningococcal meningitis consisting of a polysaccharide of which at least 80% by weight has a molecular weight in excess of 1,000,000 daltons is prepared. The...
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4229570 |
Method of producing nitrogen-containing polysaccharides
The fungi belonging to the Coriolus genus is first extracted with water or a dilute alkaline solution and then further extracted stepwise by using alkaline solutions with gradually increased...
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4228275 |
Nitrogen containing polysaccharide and process for preparing same
A novel product comprising nitrogen-containing polysaccharides is produced by bringing a culture product of fungi Basidiomycetes into reaction with an aqueous ammoniacal solution at a temperature...
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4202885 |
Process for the preparation of anti-transplanted sarcoma 180 tumorigenic substances
Extraction of a fungus of the class Basidiomycetes belonging to the Coriolus genus with an aqueous solvent under pressure and at a temperature of 120° C. to 200° C. gives an anti-transplanted...
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4183847 |
Enzymatically hydrolyzable, serum-soluble cholesterol compounds and method for their preparation
Water and serum soluble cholesterol compounds are prepared by reactively combining certain esters of cholesterol with a solubilizing agent selected from the group consisting of peptides, proteins,...
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4169923 |
High polymers containing nicotinic acid, process for their preparation and their use
Polymers having molecular weight between 1,000 and 1,500,000 characterized in that they contain radicals of nicotinic acid bound to the macromolecular structure by covalent bonds that are gradually...
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4167623 |
Pullulan aminoalkyl ether
Pullulan aminoalkyl ether is obtained by reacting pullulan with an aminoalkylating agent in a solvent in the presence of an alkali. This ether may be used as a cationic polymer of considerable...
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4141973 |
Ultrapure hyaluronic acid and the use thereof
An ultra-pure, high molecular weight hyaluronic acid fraction which is characterized by the absence of significant cellular infiltration of the vitreous and anterior chamber, absence of significant...
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4140578 |
Method of producing polysaccharides
A fungus belonging to genus Coriolus of the class Basidiomycetes is subjected to submerged culture in a liquid medium and the obtained culture is dried and extracted with an aqueous solvent, and...
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4090919 |
Water-insoluble tannin preparation for immobilization of proteins
A water-insoluble tannin preparation is obtained by covalent binding or physical adsorption of tannin onto a water-insoluble, hydrophilic carrier. The preparation has a specific affinity for...
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4075405 |
β-1,3-Glucan derivatives
β-1,3-Glucan derivatives, which are produced by reacting a water-insoluble β-1,3-glucan with a cyanogen halide, are a useful water-insoluble carrier of high reactivity for the production of...
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4053459 |
Antibody specific to methaqualone and its metabolites
A sensitive radioimmunoassay for methaqualone and its major metabolites is described. Included within this disclosure is the preparation of novel methaqualone haptens, the preparation of antigens...
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