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5013654 |
Production of emulsifying agents and surfactants
A novel strain of Pseudomonas aeruginosa, designated as strain SB-1, is capable of growth on hydrocarbon substrates having 10 to 32 or more carbon atoms, during which growth there is secreted into...
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5010184 |
Ionically modified agarose
Novel ionically modified polysaccharides which contain α-glycosidic linkages, the ionic groups of which are attached to the polysaccharide component through the grouping of the formula ...
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5010062 |
Therapeutic agent and method of inhibiting vascularization of tumors
A method for at least partially inhibiting vascularization of a developing solid tumor. Said method comprising parenterally administering to the patient the polysaccharide toxin produced by group B...
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4992536 |
Preparation of polycationic polysaccharides by site selective reaction
Polycationic polysaccharide derivatives containing more than one cationic substituent per substituted hydroxyl group are prepared by a site selective reaction of a cationic polysaccharide...
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4990500 |
Oxirane pseudooligosaccharides, a process for their preparation, their use and pharmaceutical preparations
Oxirane-pseudooligosaccharides of the formula I ##STR1## in which z is zero or 1, their physiologically acceptable salts with acids, a process for their preparation, pharmaceutical preparations,...
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4987222 |
Process for the controlled preparation of low molecular weight glucosaminoglycans
A process for the controlled preparation of low molecular weight glucosaminoglycans by treating conventional high molecular weight glucosaminoglycans in the solid state or in solution form with a...
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4985410 |
Quaternary ammonium salts of polysaccharides, prossessing hypocholesterolemic activity
Quaternary ammonium salts of polysaccharides possessing hypochlolesterolemic activity and having the following general formula: ##STR1## in which A represents the monomer unit of a natural...
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4975422 |
Angiogenesis inhibitor
The present invention discloses an angiogenesis inhibitor containing as an active ingredient protein-polysaccharides produced by extraction of mycelia or fruit bodies obtained from culture of a...
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4973580 |
Depolymerized dermatan sulfates endowed with an antithrombotic, fibrinolytic, antiinflammatory activity and pharmaceutical compositions containing such
Process for the preparation of oligosaccharides by a controlled chemical depolymerization of natural polysaccharides, such as heparins, heparan sulfates, dermatan sulfates, chondroitinsulfates,...
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4970150 |
Process for preparing chitosan oligosaccharides
A process for preparing a low-molecular weight chitosan which comprises adding chitosan to water containing a monobasic acid to prepare an intimate chitosan-water mixture and treating said mixture...
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4965353 |
Polysaccharide esters and their salts
The invention concerns the esters of hyaluronic acid in which all or only a portion of the carboxylic groups of the acid are esterified, and the salts of the partial esters with metals or with...
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4963666 |
Material of polysaccharides containing carboxyl groups, and a process for producing such polysaccharides
Method of crosslinking carboxyl-containing polysaccharides in that the polysaccharide is at first activated with a bi- or polyfunctional reagent, and then after removal of any potential excess of...
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4957744 |
Cross-linked esters of hyaluronic acid
Cross-linked esters of hyaluronic acid are provided which result from the esterification of polyhydric alcohols with two or more carboxy groups of the hyaluronic acid polysaccharide. These...
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4952567 |
Inhibition of lipogenesis
A process which comprises administering an antagonist of protein kinase C and/or the insulin receptor tyrosine kinase to a mammal in an amount therapeutically effective to inhibit lipogenesis in...
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4950750 |
Glycolipid containing N-glycolylneuraminic acid and method of producing the same
The present invention provides ganglioside-related compounds expressed by the following formula: ##STR1## (wherein R 1 denotes a hydrogen atom or SiR 3 R 4 R 5 (wherein R 3 and R 4 each...
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4940694 |
Therapeutic use of GM1 in severe cerebral ischemic strokes pathologies
A pharmaceutical preparation containing the ganglio-side GM 1 or an inner ester derivative thereof and a method for increasing cerebral blood flow in stroke victims by acute administration of GM 1...
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4939083 |
Carbohydrate specific to chronic myelogenous leukemia granulocytes
A substantially purified carbohydrate is provided which is isolated from chronic myelogenous leukemia cells. The carbohydrate is immunogenic and can be utilized to raise both polyclonal and...
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4937327 |
Derivative of D.25, process for its preparation, its use as an immunostimulant, and pharmaceutical compositions containing the derivative
The present invention relates to a polysaccharide derivative, which is a derivative of D.25 in which the galactofuranose (Gal f ) residues of the linear polysaccharide chain have been converted at...
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4918170 |
Process for producing gangliosides
The present invention provides a novel process for producing gangliosides such as GM 3 and GM 4 and analogues thereof. This process has the excellent characteristics in that in introduction of...
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4910142 |
Cell culture microcarrier, method for preparing same and use thereof for cultivating anchorage-dependent cells
A cell culture microcarrier having positively charged cross-linked polysaccharides and basic groups linked therewith wherein the basic groups have the formula (I) ##STR1## with Z being an...
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4886787 |
Method of preventing adhesion between body tissues, means for preventing such adhesion, and process for producing said means
The invention is concerned with a method of preventing adhesions or accretions of body tissues inter se by means of employing a degradable gel of a crosslinked carboxyl-containing polysaccharide....
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4885244 |
Method of producing hyaluronic acid
High molecular weight hyaluronic acid can be efficiently produced by incorporating one or more compounds having at least one aromatic ring to which one or more hydroxyl groups are attached into a...
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4882317 |
Covalently-modified bacterial polysaccharides, stable covalent conjugates of such polysaccharides and immunogenic proteins with bigeneric spacers and methods of preparing such polysaccharides and conjugataes and of confirming covalency
Covalently modified bacterial polysaccharides and proteins; covalent conjugates of such polysaccharides linked by a bigeneric spacer, which permits proof of covalency and facilitates purification...
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4879375 |
Preparation of hyaluronic acid from synovial fluid
A method for preparing high purity hyaluronic acid comprising treating a proteinaceous solution containing hyaluronic acid to precipitate protein and said hyaluronic acid from the solution,...
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4871839 |
Skin treatment composition
A composition suitable for topical application to human skin, particularly the scalp comprises a minoxidil glucuronide together with a cosmetically and/or physiologically acceptable vehicle. The...
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4870166 |
Process for preparing high-purity dematan sulphate, and pharmaceutical compositions which contain it
A process for preparing dermatan sulphate (DS) of pharmaceutical purity from animal organs rich in mucopolysaccharides (MPS), by: (a) stabilizing the fresh organs by freezing them either as such or...
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4859349 |
Polysaccharide/perfluoroalkyl complexes
The instant invention relates to water-soluble anionic polysaccharides bound to perfluoroalkyl cationic surfactants. Polymer complexes are formed which are especially useful for fighting fires of...
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4851338 |
Method for diagnosing the presence of bacteria
A composition for therapeutic or diagnostic use in regard to pathogenic microorganisms, containing as an active constituent a structural element having the formula: ##STR1## wherein R 1 , R 2 , R 3...
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4851395 |
Nitrogen-containing polysaccharide
Disclosed is nitrogen-containing polysaccharide substantially free of units having a molecular weight below about 5,000, said nitrogen-containing polysaccharide having been extracted from Coriolus...
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4851521 |
Esters of hyaluronic acid
The invention concerns the esters of hyaluronic acid in which all or only a portion of the carboxylic groups of the acid are esterfied, and the salts of the partial esters with metals or with...
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4849413 |
Ganglioside derivatives
New functional ganglioside derivatives comprising ester, amide and peracylated derivatives of gangliosides, preparation procedures therefor, pharmaceutical preparations containing the same, and the...
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4837313 |
Polygalactosamine PF-192 and salts thereof
A natural polymer material PF-102 and salts thereof are widely available as a convenient flocculant for fine suspended matters. PF-102 can be produced by, for example, an imperfect fungus...
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4831021 |
Ganglioside derivatives
A novel mono-sialo ganglioside derivative substantially identical chemically and physically with a product prepared by (a) concentration of an aqueous solution of a mono-sialo ganglioside and...
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4831126 |
Antigenic polysaccharide specific to Brucella abortus and Yersinia enterocolitica serotype 0:9
The antigenic O-chain polysaccharides from Brucella abortus and Yersinia enterocolitica serotype 0:9 have similar structure, i.e. 1-2 linked 4,6-dideoxy-4-formamido-α-D-mannopyranosyl units. The...
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4830852 |
Covalently-modified neutral bacterial polysaccharides, stable covalent conjugates of such polysaccharides and immunogenic proteins and methods of preparing such polysaccharides and conjugates
Covalently-modified neutral bacterial polysaccharides; covalent conjugates of such polysaccharides linked by a bigeneric spacer, with immunogenic bacterial membrane or other proteins, which...
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4814437 |
Method for preparation of sulfated polysaccharides by treating the polysaccharide with a reducing agent before sulfation
A new method for preparation of sulfated polysaccharides by means of pyridine-chlorosulfonic acid reagents. The polysaccharide is before sulfation treated with a reducing agent, e.g. sodium...
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4810784 |
Process for covalent coupling for the production of conjugates, and products hereby obtained
A process to produce by covalent binding conjugates of a substance containing a 2-amino-2-deoxyglycopyranosyl residue the NH 2 -function of which in its most stable conformation is equatorially...
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4808576 |
Remote administration of hyaluronic acid to mammals
The present disclosure is concerned with the discovery that hyaluronic acid, an agent well known to reduce the sequelae of trauma in mammalian joint tissue when applied directly to the traumatized...
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4801619 |
Hyaluronic acid preparation to be used for treating inflammations of skeletal joints
Hyaluronic acid preparation containing an effective amount of hyaluronic acid of a molecular weight exceeding 3×10 6 dalton, for intra-articular administration in the treatment of steroid...
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4801539 |
Fermentation method for producing hyaluronic acid
Streptolysin-free hyaluronic acid is produced by cultivating a microorganism belonging to a genus Steptococcus which is anhemolytic and is capable of producing hyaluronic acid (e.g., Streptococcus...
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4784990 |
High molecular weight sodium hyaluronate
A novel mutant microorganism Streptococcus zooepidemicus HA-116 ATCC 39920, has been produced. The microorganism produces large amounts of high molecular weight hyaluronic acid. The invention...
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4782046 |
Ultrapure hyaluronic acid and method of making it
Hyaluronic acid having controlled molecular weight and substantially free of protein and nucleic acids can be prepared from a hyaluronidase-negative or hyaluronidase inhibited microbiological...
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4772419 |
Shaped article and processes for its preparation
A shaped article based upon cross-linked, possibly derivatized hyaluronic acid or a salt thereof is characterized in that it has a dry matter content of at least 65 percent by weight and a tensile...
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4764507 |
Polysaccharide RDP substance
A polysaccharide RDP substance having the ultraviolet absorption spectrum depicted in FIG. 1, the infrared absorption spectrum depicted in FIG. 2 and the 13 C-NMR spectrum depicted in FIG. 3 is...
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4762825 |
Polysaccharide RON substance
A polysaccharide RON substance having the ultraviolet absorption spectrum depicted in FIG. 1, the infrared absorption spectrum depicted in FIG. 2 and the 13 C-NMR spectrum depicted in FIG. 3 is...
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4761401 |
Oligosaccharides
Esterified oligosaccharides particularly estersified disaccharides containing a uronic acid residue and a hexosamine residue joined through a glycosidic linkage. Such as useful in cosmetic and...
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4740589 |
Capsular polysaccharide metal complex vaccines
Complexes comprising a metal constituent and a bacterial capsular polysaccharide constituent, wherein the polysaccharide contains sialic acid, are useful in the prophylaxis and treatment of...
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4734403 |
Membrane polysaccharides which are useful as immunostimulants
The present invention relates to a membrane polysaccharide of bacterial origin having the following quantitative analytical composition: TBL ______________________________________ galactose...
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4727136 |
Modified meningococcal group B polysaccharide for conjugate vaccine
The group B polysaccharide of Neisseria meningitidis is chemically modified to enhance the immune response thereto, thereby providing cross-reactive antibodies of high affinity. The N-acetyl group...
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4725585 |
Method of enhancing the host defense
The invention relates to a method of enhancing or regulating the host defense of a mammal, said method comprising administering to a mammal a therapeutically effective amount of hyaluronic acid.
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