|
Match
|
Document |
Document Title |
|
|
6358919 |
Polymer compounds comprising glycosphingosine
A polymer compound or a salt thereof which comprises a biodegradable polymer such as polyglutamic acid acetylated at N-terminal thereof containing a glycosphingolipid such as lysoganglioside GM 3 ,...
|
|
|
6299897 |
Inhibition of selectin binding
This invention provides compositions for inhibiting the binding between two cells, one expressing P- or L-selectin on the surface and the other expressing the corresponding ligand. A covalently...
|
|
|
6291435 |
Treatment of diarrhea caused by enteropathogenic Escherichia coli
This invention relates to compositions and methods useful to treat diarrhea, especially diarrhea and related conditions initiated or mediated by enteropathogenic E. coli (EPEC), using...
|
|
|
6274565 |
Inhibitor of activation of β-glucan recognition protein
The present invention relates to an inhibitor of an activation of β-glucan recognition protein in a body fluid of an insect comprising a sugar compound comprising plural member of sugar residues,...
|
|
|
6262255 |
Non-immunogenic, biocompatible macromolecular membrane compositions, and methods for making them
Non-immunogenic biocompatible macromolecular sheet composition are formed from a cellulosic membrane, a binding moiety having a plurality of functional groups, and a glycosaminoglycan (GAG). The...
|
|
|
6251876 |
Autocross-linked hyaluronic acid and related pharmaceutical compositions for the treatment of arthropathies
The present invention relates to compositions containing an autocross-linked form of hyaluronic acid as a first component in a mixture with a second component noncross-linked hyaluronic acid, and...
|
|
|
6232301 |
Remedies for bladder disorders
In order to provide an agent for treatment of bladder troubles that has vesical mucosa epithelium dilatation promoting action and/or vesical mucosa healing action, and exhibits excellent curative...
|
|
|
6232303 |
Process for preparing a hyaluronic acid fraction having a low polydispersion index
A process for preparing a hyaluronic acid fraction having an average molecular weight comprised between 5000 and 300,000 and a polydispersion index lower than 1.7, comprising treating the starting...
|
|
|
6225462 |
Conjugated polysaccharide fabric detergent and conditioning products
A polysaccharide conjugate comprises a polysaccharide with an attached entity having a molecular weight of at least 5000, the polysaccharide conjugate being capable of binding to cellulose....
|
|
|
6191271 |
Synthetic divalent sLex containing polylactosamines and methods for use
The present invention is directed to novel compositions and their use in the treatment of inflammatory responses. Specifically, the invention is directed to novel synthetic oligosaccharide...
|
|
|
6180601 |
Low molecular weight hyaluronic acid with peptide or protein
The invention relates to freeze-dried soft, flexible and continous matrix of low-molecular weight hyaluronic acid or salt thereof, in which the molecular weight of the hyaluronic acid is preferably...
|
|
|
6162910 |
Process for preparing lipophilic oligosaccharide antibiotics
Process for preparing a lipophilic oligosaccharide antibiotic containing a nitro group using oxidizing agents and catalysts such as cobalt, manganese and copper having an oxidation state of +2 are...
|
|
|
6162797 |
Derivatives of K5 polysaccharide having high anticoagulant activity
Derivatives of the K5 polysaccharide having anticoagulant activity higher than heparin, obtained by a process including the steps of reacting: with an organic base a solution of K5 polysaccharide...
|
|
|
6143883 |
Water-soluble low molecular weight beta-glucans for modulating immunological responses in mammalian system
A fractionated, water-soluble, readily absorbable, low molecular weight beta-glucan is usable as an immune-modulator in the mammalian system. A method is disclosed, which produces a fractionated...
|
|
|
6136790 |
Carbohydrate mimetics having antiadhesive properties
The invention relates to carbohydrate mimetics, which inhibit the binding of selectin to carbohydrate ligands, of the formula I ##STR1## excluding the compounds sialyl-Lewis-X and -A and their...
|
|
|
6133239 |
Carbohydrate ligands (myelorollin) that cause E-selectin dependent cell rolling and adhesion under dynamic flow system
An unbranched polylactosamine comprising at least 6 monosaccharides and having terminal α2➝3 sialylation and internal α1➝3 fucosylation at various N-acetylglucosamine residues except for...
|
|
|
6110897 |
Antiinflammatory cell adhesion inhibitors
The invention relates to compounds of formula Ix and Ia: ##STR1## wherein (Ix) comprises the regioisomeric form sLe X and (Ia) comprises the regioisomeric form sLe A , and R 1 is a lipophilic...
|
|
|
6110692 |
Receptor for underivatized aqueous soluble β(1-3)-glucan
A preparation containing a receptor for underivatized, aqueous soluble β(1-3)-glucan is disclosed, along with characterization of the receptor for underivatized, aqueous soluble β(1-3)-glucan....
|
|
|
6090596 |
Method and means for the production of hyaluronic acid
Supercapsulated strains of group A and C streptococci are provided. The strains are used in the production of hyaluronic acid with a molecular weight exceeding 6 million.
|
|
|
6075066 |
Material to be worn on the eyeball
|
|
|
6069137 |
Treatment of traveller's diarrhea
This invention relates to treatment of traveller's diarrhea, including diarrhea caused by enterotoxigenic E. coli (ETEC), using oligosaccharide compositions which bind E. coli heat-labile toxin...
|
|
|
6051560 |
Chrondroitin sulfate/sodium hyaluronate composition
Chondroitin sulfate/soduim hyaluronate compositions exhibiting pseudo-plastic behavior and non-Newtonian flow characteristics are disclosed.
|
|
|
6037331 |
Compositions for prevention of inflammation and adhesion formation uses thereof
Pharmaceutical compositions comprising hyaluronic acid, non-steroidal inflammatory drugs, and at least one organic salt of at least one divalent metal, and methods of using these compositions for...
|
|
|
6004938 |
Inositolglycans having insulin-like action
The invention relates to inositolglycans having insulin-like action. Specific compounds are provided having the formula I A--Z--R (I) where A is...
|
|
|
5981743 |
Cyclic ester ring-opened oligomers and methods of preparation
An oligomer composed of a carbohydrate head group and an oligomer chain is disclosed. Methods for increasing the oligomerization rates of lactones and cyclic carbonates are also disclosed.
|
|
|
5977088 |
Formulations containing hyaluronic acid
Pharmaceutical compositions from which effective non-toxic (to the patient) dosage amounts may be taken and applied to the skin and/or exposed tissue of a human, each effective dosage amount...
|
|
|
5972907 |
Synthetic core 2-like branched structures containing GalNAc-lewis.sup.x and Neu5Acα2-3Galβ1-3GalNAc sequences as novel ligands for selectins
Compounds which bind to selectin receptors and thus may modulate the course of inflammation, cancer and related processes by intervening with cell-cell adhesion events. Further, such compounds can...
|
|
|
5925626 |
Hyaluronic acid fractions having pharmaceutical activity, and pharmaceutical compositions containing the same
Two pharmaceutically useful fractions of hyaluronic acid are obtained comprising a first fraction with a molecular weight between 50,000 and 100,000 which is useful for wound healing, and a second...
|
|
|
5922690 |
Dermatan disulfate, an inhibitor of thrombin generation and activation
A method of inhibiting thrombin generation and of inhibiting complement activation by using a dermatan sulfate having at least 2 sulfate groups per disaccharide obtained by chemical sulfation of...
|
|
|
5914322 |
Treatment of disease and conditions
A topically applied transdermally penetrating systemic independent acting pharmaceutical combination and formulation for the treatment of a disease or condition of the skin and exposed tissue for...
|
|
|
5891450 |
Polysaccharide derivative, and preparation process and use thereof
Disclosed herein are a polysaccharide derivative obtainable by substituting a part or the whole of hydrogen atoms of hydroxyl groups in a polysaccharide or a derivative thereof by the following...
|
|
|
5888986 |
Method for treating the urinary bladder and associated structures using hyaluronic acid
A method of treating interstitial cystitis comprising contacting the transitional epithelium lining the urinary bladder and associated structures in a mammal having interstitial cystitis with a...
|
|
|
5880091 |
Glycoprotein ligand for P-selectin and methods of use thereof
P-selectin has been demonstrated to bind primarily to a single major glycoprotein ligand on neutrophils and HL-60 cells, when assessed by blotting assays and by affinity chromatography of 3 ...
|
|
|
5880100 |
Method for inhibiting binding of human lens cells
The present invention provide a method of inhibiting an irregular binding of human cells caused by specific adhesion of Lewis x glycolipids by administering any of an oligosaccharide having a...
|
|
|
5874417 |
Functionalized derivatives of hyaluronic acid
A composition of matter comprising a hyaluronate functionalized with a hydrazide at glucuronic acid sites of said hyaluronate, wherein the hydrazide is chosen from a group consisting of:...
|
|
|
5871772 |
Sodium hyaluronate viscous solutions for use as masking fluid in therapeutic photokeratectomy by means of excimer laser
Sodium hyaluronate viscous aqueous solutions of molecular weight from 1,200,000 to 2,200,000 Daltons at concentrations from 0.10% to 0.40% by weight are proposed for use as masking fluid in...
|
|
|
5872109 |
Anti-inflammatory agent
Use of a polysaccharide selected from the group consisting of sulfated acid mucopolysaccharides and sulfated dextrans, and physiologically acceptable salts thereof for prophylaxis or treatment of...
|
|
|
5861505 |
Synthetic analog of sialic Lewis antigen from bacterial capsular polysaccharide
An analog of sialic Lewis antigen prepared from native capsular polysaccharide of Klebsiella 63 bacteria.
|
|
|
5858994 |
Carbohydrate conjugates as inhibitors of cell adhesion
The invention relates to novel conjugates of tetrasaccharides, preferably of sialyl-Lewis X (SLeX) and sialyl-Lewis A (SLeA), having improved activity as inhibitors of cell adhesion, a process for...
|
|
|
5856299 |
Highly reactive esters of carboxy polysaccharides and carboxy polysaccharides derived therefrom
Provided are active esters of carboxy polysaccharides and semisynthetic derivatives of carboxy polysaccharides, wherein all or part of the carboxy groups thereof are esterified with an aromatic...
|
|
|
5834444 |
Hyaluronic acid and salts thereof inhibit arterial restenosis
A method is provided of preventing arterial restenosis of an animal after the arteries have been traumatized. The method comprises the administration of a therapeutically effective non-toxic amount...
|
|
|
5830882 |
Compositions containing a form of hyaluronic acid and a medicinal agent for treating acne in mammals and methods for administration of such composition
A combination for administration to a mammal which combination employs a therapeutically effective amount of a medicinal and/or therapeutic agent to treat a disease or condition and an amount of...
|
|
|
5817642 |
Clearing of atherosclerosis
A method of clearing atherosclerosis comprising the step of administering to a patient, at least one dosage amount of a pharmaceutical composition comprising an effective non-toxic amount of each...
|
|
|
5811410 |
Method of administering of a hyaluronic acid and an NSAID to decrease side effects of the NSAID
A method of administering a medicinal agent and an effective amount of a form of hyaluronic acid for decreasing side effects associated with using the agent alone in treating a disease or condition...
|
|
|
5811404 |
Sialyl Le.sup.x analogues as inhibitors of cellular adhesion
The present invention relates to analogues of sialyl Le x the inhibit cellular adhesion between a selectin and cell that express sialyl Le x on their surfaces, as well as methods and compositions...
|
|
|
5801162 |
Dermatan sulfate compositions and antithrombotic compositions containing same
Dermatan sulfate compositions having certain characteristics have been found to have thrombolytic activity. Dermatan sulfate combined with tissue plasminogen activator (t-PA) enhances the...
|
|
|
5795860 |
Analogs for specific oligosaccharide-protein interactions and uses therefor
Disclosed are (1) methods for identifying natural and synthetic sequences having binding specificity for glycan-binding proteins, including proteins that act as effectors of biological activity,...
|
|
|
5783691 |
Crosslinked hyaluronate gels, their use and method for producing them
The present invention relates to a crosslinked hyaluronic acid derivative in which the crosslinking has been achieved by means of reaction with a phosphorus-containing reagent, especially a...
|
|
|
5783570 |
Organic solvent-soluble mucopolysaccharide, antibacterial antithrombogenic composition and medical material
The present invention relates to an organic solvent-soluble mucopolysaccharide consisting of an ionic complex of at least one mucopolysaccharide (preferably heparin or heparin derivative) and a...
|
|
|
5763413 |
Lewis-associated compound, process for producing the same, and anti-inflammatory
A Lewis-associated compound, represented by general formula (I), a process for producing the same, and an anti-inflammatory, wherein R 1 and R 3 represent each hydrogen, m SO 3 H or CH 2 COOH;...
|