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8067196 |
6-O sulfated polysaccharides and methods of preparation thereof
Disclosed are methods of 6-O-sulfating glucosaminyl N-acetylglucosamine residues (GlcNAc) in a polysaccharide preparation and methods of converting anticoagulant-inactive heparan sulfate to...
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8012942 |
Carba-nucleoside analogs for antiviral treatment
Provided are thieno[3,4-d]pyrimidin-7-yl and furo[3,4-d]pyrimidin-7-yl ribosides, riboside phosphates and prodrugs thereof as well as intermediates and methods of preparation. The compounds,...
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7812151 |
Low molecular weight polysaccharides having antithrombotic activity
Novel depolymerized-LMWepiK5-N,O-sulfates obtainable starting from a LMW-epiK5-N-sulfate prepared by nitrous depolymerization of an epiK5-N-sulfate or by C5-epimerization of a LMW-K5-N-sulfate...
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7812142 |
Pentose derivatives as anti-hyperglycemic drugs
The present invention relates to pentose and pentose derivatives that are effective at increasing glucose transport in a non-insulin dependent manner, and to uses thereof for a) treating and/or...
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7700763 |
3-triazolyl-galactoside inhibitors of galectins
The present invention relates to novel compounds, the use of said compounds as a medicament as well as for the manufacture of a medicament for treatment of disorders relating to the binding of...
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7687619 |
Room temperature stable agarose solutions
Room temperature stable, non-gelling polysaccharide solutions such as agaroses, dextrans and cyclodextrans are made by the present invention. It has been found that by incorporating certain...
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7666845 |
Compounds having inhibitory activity against sodium-dependent glucose transporter
The invention is directed to compounds of the formula (I) described herein, a pharmaceutically acceptable salt thereof, or a prodrug thereof, and pharmaceutical compositions and methods of treatment.
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7622575 |
Therapeutic uses of glucan
The present invention is directed to methods of using glucan compositions, comprising water insoluble microparticulate glucans, in the treatment of connective tissue injuries. The water insoluble...
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7202230 |
Use of hyaluronic acid derivatives in the preparation of biomaterials with a physical haemostatic and plugging activity
The present invention describes the use of polysaccharide derivatives for the preparation of biocompatible and biodegradable biomaterials with absorbent properties for body fluids and physical...
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7183261 |
Galactosylceramide analogs, and β-glucocerebrosidase activators, external skin preparations and method of activating β-glucocerebrosidase using the analogs
Galactosylceramide analogues represented by the following formula (1) or (2). (wherein X and Y each represent S or O, R1 and R2 each represent an alkyl group or an alkenyl group each having 9 to 35...
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7138386 |
Preventives or remedies for arthritis
The present invention relates to pharmaceuticals, foods and drinks, food additives, animal feeds and feed additives comprising an N-acylated hydroxyproline derivative or a salt thereof, and an...
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7125860 |
Cross-linked derivatives of hyaluronic acid
The present invention describes a new class of cross-linked derivatives of partially N-deacetylated hyaluronic acid or derivatives thereof, comprising at least one repeating unit of formula (I)...
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7049434 |
Derivatives of hyaluronan
The invention describes new hyaluronan derivatives where the hydroxyl groups are esterified or carbamoylated in amounts ranging from 0.01% to 100% and the carboxyl groups are either totally or...
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7033765 |
Site-specific drug delivery
Compounds and methods which are useful for the site-specific delivery and localization of drugs are provided. The compounds can be represented by the formula: A-L-D wherein A is an anchoring...
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7034127 |
Hydrophilic biopolymer-drug conjugates, their preparation and use
Disclosed are methods of conjugating biologically active substances, particularly, alpha-interferon, with a hyaluronan or a mixture of a hyaluronan with at least one other hydrophilic polymer...
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6992183 |
Highly sulfated derivatives of K5 polysaccharide and their preparation
The purification of the E.coli K5 polysaccharide by treatment with isopropyl alcohol and elimination of lipophilic substances is described. The purified product can be used to prepare, after...
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6969531 |
Sodium hyaluronate microspheres
The present invention relates to microspheres comprising hyaluronan derivatized with a bifunctional crosslinker to form microspheres. Methods of making such microspheres, comprising mixing...
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6960344 |
Use of imine-forming polysaccharides as adjuvants and immunostimulants
The present invention relates to polysaccharide conjugates that comprise: a polysaccharide that binds to surface-receptors present on Antigen Presenting Cells, conjugated to one or more compounds...
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6924273 |
Chondroprotective/restorative compositions and methods of use thereof
The instant invention provides a method of treating or preventing osteoarthritis, joint effusion, joint inflammation and pain, synovitis, lameness, post operative arthroscopic surgery,...
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6919316 |
Immunosuppressive agent
An immunosuppressive agent comprising, as an effective ingredient, at least one compound selected from the group consisting of compounds represented by general formula (1) below and...
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6916919 |
Isolation of DNA molecules
The present invention relates to a process for separating nucleic acid molecules, preferably open circular and supercoiled plasmid DNA and RNA molecules from each other, comprising the steps of...
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6844329 |
Polysaccharides with antithrombotic activity comprising at least a covalent bond with biotin or a biotin derivative
The present invention relates to novel synthetic polysaccharides with antithrombotic activity exhibiting at least one covalent bond with biotin or a biotin derivative and to a process employing...
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6759522 |
Sulforhamnosylacyglycerol derivatives and use thereof as medicaments
Novel sulforhamnosylacylglycerol derivatives represented by General Formula (1): where R101 represents an acyl residue of a higher fatty acid and R102 represents a hydrogen atom or an acyl residue...
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6740640 |
Sulfofucosylacylglycerol derivatives and administration thereof as medicaments
Sulfofucosylacylglycerol derivatives represented by General Formula (1): where R101 represents an acyl residue of a higher fatty acid and R102 represents a hydrogen atom or an acyl residue of a...
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6660853 |
Method for purifying high molecular weight hyaluronic acid
A method for purifying high molecular weight hyaluronic acid, comprising the steps of providing one or more raw hyaluronic acid sources; extracting hyaluronic acid from the source; precipitating...
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6608044 |
Inhibition of TNF activity
The bioactivity of TNF is inhibited by administering heparin or a derivative thereof along with a soluble TNF receptor. The heparin or derivative thereof can be administered simultaneously with the...
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6608042 |
Pharmaceutical compositions containing oligosaccharides, the novel oligosaccharides and preparation thereof
The present invention relates to pharmaceutical compositions containing as an active ingredient at least one oligosaccharide of formula: to novel oligosaccharides of formula (I), to mixtures...
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6528629 |
Malto-oligosaccharide derived glycosides
Disclosed is a method for preparing a malto-oligosaccharide derived glycoside. Generally, the method comprises providing a malto-oligosaccharide and glycosylating the malto-oligosaccharide with an...
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6518302 |
Remedies
Compounds represented by general formula (I) wherein X represents OH or OSO3H; and R represents a substituent other than OH which allows, after leaving, the induction of unsaturated bonds into the...
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6518410 |
Sulfoquinovosylacylglycerol derivative, and use thereof as medicaments
A method for immunosuppression in a subject comprising administering to the subject in need thereof, a pharmaceutically effective amount of at least one sulfoquinovosylacylglycerol derivative...
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6495678 |
Immunosuppressant containing glucopyranose derivative as active ingredient
An immunosuppressant comprising Glucopyranose derivatives of the formula (I): wherein R is H, OH etc; G is —CH2CH(R1—R2)(R3—R4), in which R1 is a single bond, OCO-alkyl; R2, R4 is H, phenyl which...
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6486137 |
Oligosaccharide mixtures having antithrombotic activity
A mixture of linear oligosaccharides containing different numbers of repeating sulphated disaccharide units derived from L-iduronic acid (IdoA) and N-acetyl-D-galactosamine (Gal-NAc) and having the...
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6444795 |
1-0-(2-propenyl)-6-0-sulfonylpyranosides
1-O-(2-propenyl)-6-O-sulfonylpyranoside represented by the formula wherein R1, R2 and R3 each independently represents an alkyl or substituted silyl group, and R4 represents an alkylsulfonyl or...
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6395886 |
1-O-(2-propenyl)-6-deoxy-6-carbonylthiopyranosides
1-O-(2-propenyl)-6-deoxy-6-carbonylthiopyranoside represented by the formula wherein R1, R2 and R3 each independently represents an alkyl or a substituted silyl group, and R5 represents a hydrogen...
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6274144 |
Method for generating antibodies to saccharide fragments
A method for depolymerizing polysaccharides containing into saccharide fragments using ozonolysis is described.
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6262255 |
Non-immunogenic, biocompatible macromolecular membrane compositions, and methods for making them
Non-immunogenic biocompatible macromolecular sheet composition are formed from a cellulosic membrane, a binding moiety having a plurality of functional groups, and a glycosaminoglycan (GAG). The...
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6225450 |
DNA sequencing by mass spectrometry
The invention describes a new method to sequence DNA. The improvements over the existing DNA sequencing technologies are high speed, high throughput, no electrophoresis and gel reading artifacts...
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6162797 |
Derivatives of K5 polysaccharide having high anticoagulant activity
Derivatives of the K5 polysaccharide having anticoagulant activity higher than heparin, obtained by a process including the steps of reacting: with an organic base a solution of K5 polysaccharide...
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6136790 |
Carbohydrate mimetics having antiadhesive properties
The invention relates to carbohydrate mimetics, which inhibit the binding of selectin to carbohydrate ligands, of the formula I ##STR1## excluding the compounds sialyl-Lewis-X and -A and their...
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6121430 |
Regiospecific synthesis of glucose-based surfactants
New glucose-based surfactants and methods of their synthesis are described. The surfactants are synthesized through the preparation of an intermediate glucose 4,6-cyclic sulfate. The surfactants...
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6106866 |
In vivo agents comprising cationic drugs, peptides and metal chelators with acidic saccharides and glycosaminoglycans, giving improved site-selective localization, uptake mechanism, sensitivity and kinetic-spatial profiles, including tumor sites
A drug carrier composition comprising a drug complexed with dermatan sulfate is disclosed. The drug is preferably an anti tumor drug and may be taxol, a peptide onco-agent or vincristine. The most...
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6087339 |
Saccharide derivatives
Disclosed are novel saccharide derivatives which inhibit binding of toxins, such as heat-labile enterotoxin or cholera toxin, to their receptors either in vitro or in vivo. Additionally, disclosed...
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6084081 |
Lewis X derivatives
A novel fluorine-containing Lewis X derivative represented by the following formula (I): ##STR1## wherein R represents hydrogen, a hydroxyl-protective group, --PO(OH)2, --SO3 H or sialylate; R1...
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RE36385 |
Glucopyranose derivatives
This invention relates to glucopyranose compounds of formula (I) and (IA) ##STR1## and the non-toxic salts thereof wherein the substituents are as defined herein. Such materials possess enhancing...
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5972907 |
Synthetic core 2-like branched structures containing GalNAc-lewisx and Neu5Acα2-3Galβ1-3GalNAc sequences as novel ligands for selectins
Compounds which bind to selectin receptors and thus may modulate the course of inflammation, cancer and related processes by intervening with cell-cell adhesion events. Further, such compounds can...
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5948405 |
Fucans with low molecular weight having anticoagulant, antithrombinic and antithromobic activity
Fucans with low molecular weight having anticoagulant, antithrombinic and antithrombotic activity.Fucan sulfates having molecular weight between 14000 and 29000 Dalton show a remarkable...
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5925626 |
Hyaluronic acid fractions having pharmaceutical activity, and pharmaceutical compositions containing the same
Two pharmaceutically useful fractions of hyaluronic acid are obtained comprising a first fraction with a molecular weight between 50,000 and 100,000 which is useful for wound healing, and a second...
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5922690 |
Dermatan disulfate, an inhibitor of thrombin generation and activation
A method of inhibiting thrombin generation and of inhibiting complement activation by using a dermatan sulfate having at least 2 sulfate groups per disaccharide obtained by chemical sulfation of...
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5908837 |
Methods of using low molecular weight heparins for prevention or treatment of pathological processes
The present invention relates to pharmaceutical compositions for the prevention and/or treatment of pathological processes involving the induction of TNF-α secretion comprising a pharmaceutically ...
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5837695 |
Fluorescent chlamydia antigen substrate
The present invention relates to a unique fluorescently labeled Chlamydial antigen. This fluorescently labeled Chlamydial antigen is useful in immunoassay-type formatted systems for the detection...
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