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7605242 |
Process for the physical depolymerization of glycosaminoglycanes and products obtained therefrom
The invention relates to a process for the depolymerization of glycosaminoglycanes characterized by the use of UVC radiation. The invention also relates to the intermediate depolymerized heparin...
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7601704 |
Process for synthesizing oil and surfactant-free hyaluronic acid nanoparticles and microparticles
A method for synthesizing uniformly sized hyaluronic acid (“HA”) particles that are substantially free from oil and surfactant contaminants. The method comprises crosslinking HA chains with...
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7598354 |
Campylobacter glycans and glycopeptides
Multiple strains and species of Campylobacter share a common glycan moiety which is present in a plurality of surface-exposed glycoproteins. This glycan has the formula: GalNAc-a1,...
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7553981 |
Natural semi-synthetic and synthetic lipid derivatives of ceramide and sphingosine groups, drugs and the medical use thereof in the form of therapeutic agents in particular for dermatology
The subject of the present invention is new substances which are derived from naturally occurring ceramides and sphingosine and also from synthetic compounds with principally the same structure in...
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7510657 |
Method of preparing affinity ligands
The present invention is a method of preparing affinity ligands, which method comprises to provide a cyclic scaffold comprising a thiol group, a carbonyl group and an amine group; to derivatize the...
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7507723 |
Hyaluronic acid oligosaccharide fractions and drugs containing the same
Hyaluronic acid oligosaccharides having a size selected from sizes of 4 to 60 saccharides, fractions containing the hyaluronic acid oligosaccharides and having particular physicochemical...
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7485718 |
Chemical synthesis of low molecular weight polyglucosamines and polygalactosamines
A process for the synthesis of beta linked low molecular weight polymers of galactosamine and glucosamine has been developed. Through the use of high amounts of activating agents, efficient...
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7459579 |
Method of separating optically active dihydroxy-heptenoic acid esters
An optically active dihydroxyheptenoic acid ester having an aromatic group is separated from a solution containing a mixture of optical isomers of digydroxyheptenoic acid ester by liquid...
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7445641 |
Biomaterials modified with superoxide dismutase mimics
The present invention relates to biomaterials modified with non-proteinaceous catalysts for the dismutation of superoxide, and processes for making such materials. This modification may be by...
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7414126 |
Process for the preparation of topiramate
The present invention relates to a process for the preparation of topiramate, intermediates in this process and a process for the preparation of these intermediates.
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7371738 |
Method of transdermal drug delivery using hyaluronic acid nanoparticles
The present invention relates to the development of a hyaluronic acid and hyaluronic acid hybrid nanoparticle systems for the administration of active molecules, peptides, DNA and/or other...
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7361644 |
Specific antagonist for both E- and P-selectins
Compounds and methods are provided for modulating in vitro and in vivo processes mediated by selectin binding. More specifically, selectin modulators and their use are described, wherein the...
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7348424 |
Polysaccharide containing phosphorylcholine group and process for producing the same
The present invention is a method for manufacturing a phosphorylcholine group-containing polysaccharide wherein the aldehyde derivative-containing compound obtained by the oxidative ring-opening...
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7335512 |
Marker for measuring liver cirrhosis
The invention provides methods and kits to detect liver cirrhosis in mammals. The diagnostic test is based on the profiling and identification of diagnostic carbohydrates present in a body fluid...
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7321034 |
Process for the physical depolymerization of glycosaminogylcanes and products obtained thereform
The invention relates to a process for the depolymerization of glycosaminoglycanes characterized by the use of electron beam radiation, optionally in the presence of an organic compound selected...
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7304148 |
Sugar chain asparagine derivatives, sugar chain asparagine, sugar chain, and processes for producing these
An asparagine-linked α2,3-oligosaccharide having undeca- to hepta-saccharides, an asparagine-linked α2,6-oligosaccharide having undeca- to hepta-saccharides and containing fluorine and an...
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7285661 |
Starch derivatives, starch active substance conjugates, method for the production thereof and their use as medicaments
The invention relates to starch derivatives of formula (I), in which: X represents a bromine or iodine atom; R″ represents a straight-chain or branched alkyl group, aryl group or aralkyl group,...
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7273934 |
Three-branched sugar-chain asparagine derivatives, the sugar-chain asparagines, the sugar chains, and processes for producing these
A 3-branched asparagine-linked oligosaccharide derivative of the formula (1) wherein the nitrogen of amino group of asparagine is modified with a lipophilic protective group, biotin group or FITC...
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7273729 |
Chondroitin synthase and DNA encoding the enzyme
A human-derived novel chondroitin synthase, which is an enzyme for synthesizing a fundamental backbone of chondroitin and has both glucuronic acid transferase activity and N-acetylgalactosamine...
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7244619 |
Serum marker for measuring liver fibrosis
The invention provides methods and kits to detect liver fibrosis or a change in the gradation of liver fibrosis in mammals. The diagnostic marker is based on the profiling and identification of...
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7183261 |
Galactosylceramide analogs, and β-glucocerebrosidase activators, external skin preparations and method of activating β-glucocerebrosidase using the analogs
Galactosylceramide analogues represented by the following formula (1) or (2).
(wherein X and Y each represent S or O, R 1 and R 2 each represent an alkyl group or an alkenyl group each having...
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7157443 |
Staphylococcus aureus exopolysaccharide and process
A high molecular weight polysaccharide intracellular adhesin (SAE) antigen having the general structure of poly-1,6,β-2-amidoglucopyranoside, which is variable substituted with N-acetyl and...
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7148260 |
Water-based emulsifier wax gels including free sphingoid bases and oil in-water emulsion including the same
Water-based emulsifier wax gels are provided that include skin-identical sphingolipids The present invention also provides a process for the preparation of such gels, the use of such gels for the...
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7132412 |
Treatment of skin diseases using a pharmaceutical preparation in colloidal form
A new use of a suitable colloidal mixture of hyaluronic acids, of different molecular weights mixed together in a proper ratio in the treatment of the cutaneous diseases is described.
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7125860 |
Cross-linked derivatives of hyaluronic acid
The present invention describes a new class of cross-linked derivatives of partially N-deacetylated hyaluronic acid or derivatives thereof, comprising at least one repeating unit of formula (I)...
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7125852 |
Geranyl compounds
This invention provides compounds having excellent antitumor activity, which are represented by the following formulae
in which R 1 , R 2 , R 3 , m, n and R 4 have the significations as given...
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7109323 |
Formulation of boronic acid compounds
The invention relates to the formulation of pharmaceutical compounds. More particularly, the invention provides stable, pharmaceutically acceptable compositions prepared from boronic acid compounds...
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7098195 |
Fluorinated glucosamine analogs useful for modulating post-translational glycosylations on cells
The present invention provides compositions and methods for inhibiting cell migration, e.g., lymphocytes and inflammation. The invention also provides an improved process for preparing fluorinated...
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7094763 |
Substituted fused heterocyclic C-glycosides
This invention relates to substituted fused heterocyclic C-glycosides, compositions containing them, and methods of using them, for example, for the treatment or prophylaxis of diabetes and...
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7091337 |
Process for the physical depolymerization of glycosaminoglycanes and products obtained therefrom
The invention relates to a process for the depolymerization of glycosaminoglycanes characterized by the use of high-energy radiation in the presence of an organic compound selected from the group...
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7091008 |
Hyaluronan synthase genes and expression thereof in Bacillus hosts
The present invention relates to a recombinant Bacillus host cell containing a recombinant vector including a nucleic acid segment having a coding region segment encoding enzymatically active...
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7067640 |
Cross-linked chiral compounds and methods of making thereof
The invention relates to a method which comprises synthesizing bifunctional compounds then chiral compounds from the bifunctional compounds, also to synthesizing supports comprising these chiral...
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7056900 |
Disaccharide derivatives for treating hyperglycaemia
The invention relates to the use of the disaccharide derivatives 3′-aminosucrose, sucrose-C6-acid and palatinose-C6′-acid and/or of an amide or alkyl ester thereof for the prevention or...
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7056899 |
Disaccharide derivatives for treating hyperglycaemia
The invention relates to the use of the disaccharide derivatives 3′-aminosucrose, sucrose-C6-acid and palatinose-C6′-acid and/or of an amide or alkyl ester thereof for the prevention or...
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7033765 |
Site-specific drug delivery
Compounds and methods which are useful for the site-specific delivery and localization of drugs are provided. The compounds can be represented by the formula: A-L-D wherein A is an anchoring...
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7014857 |
Anti-sepsis conjugate vaccine
The present invention provides an immunogenic conjugate comprising biologically deacylated gram-negative bacterial moieties linked to D. discoideum proteinase 1, as well as novel subunits...
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7014847 |
Methods for preventing reovirus recognition for the treatment of cellular proliferative disorders
The present invention pertains to methods for preventing reovirus recognition in the treatment of cellular proliferative disorders, and particularly ras-mediated cellular proliferative disorders,...
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7005422 |
Derivatives of monosaccharides as cell adhesion inhibitors
This invention relates generally to compounds and processes for synthesizing derivatives of 2-3-O-isopropylidene-α-L-xylo-2-hexulofuranosonic acid. The compounds of this invention are useful,...
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7005129 |
Non-toxic mutants of pathogenic gram-negative bacteria
A method is provided for identifying, isolating, and producing htrB mutants of gram-negative bacterial pathogens. The method comprises mutating the htrB gene of a gram-negative bacterial pathogen...
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6992183 |
Highly sulfated derivatives of K5 polysaccharide and their preparation
The purification of the E.coli K5 polysaccharide by treatment with isopropyl alcohol and elimination of lipophilic substances is described. The purified product can be used to prepare, after...
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6974805 |
Configuration of glycosaminoglycans
The present invention provides stable glycosaminoglycan (GSG) structures and methods of use of such GAG structures. These structures comprise a core of free GAG, a coating of crosslinked GAG...
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6956119 |
Polysaccharide-polypeptide conjugate
Disclosed is a method of producing a polysaccharide-polypeptide conjugate by reacting a polysaccharide with a polypeptide which contains at least one free amino group, wherein a polysaccharide...
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6953784 |
Cross-linked polysaccharide drug carrier
A carrier and a method for preparing it are provided for use in the delivery of therapeutic agents. A polysaccharide is reacted with an oxidizing agent to open sugar rings on the polysaccharide to...
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6916920 |
Process for producing hydrazinomonosaccharide derivatives and use thereof
A process for producing hydrazinomonosaccharide derivatives and use of hydrazines in determining the structures of aldose and ketose monosaccharides located at the reducing ends of saccharides.
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6903208 |
Polymers and their use
A substituted polysaccharide comprising β 1-4 linkages having covalently bonded on the polysaccharide moiety thereof, at least one deposition enhancing group which undergoes a chemical change in...
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6903199 |
Crosslinked amide derivatives of hyaluronic acid and manufacturing method thereof
The present invention relates to water-insoluble, crosslinked amide derivatives of hyaluronic acid and manufacturing method thereof, where the amide derivatives of hyaluronic acid are characterized...
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6894034 |
Sebum production inhibitors
Sebum production inhibitors containing as an active ingredient a compound of general formula (1) below having a glucuronic acid derivative and a glucosamine derivative in the structure or a...
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6878819 |
Fucosylated oligosaccharides and process for their preparation
The present invention relates to a process for the preparation of oligosaccharides or oligosaccharide containing compounds, especially N-acetyl-chitooligosaccharides having a fucosylated...
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6858724 |
Non-mucin type synthetic compounds or its carrier conjugated compounds
The purposes of this invention are preparation of the non-mucin type synthetic compounds-carrier conjugated compounds which are stable against enzymes, and which have the ability of specific...
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6852708 |
Use of hyaluronic acid and forms to prevent the narrowing of the vascular walls
For the prevention of the narrowing of the tubular walls of an animal after the tubular walls have been traumatized, the administration of a therapeutically effective non-toxic amount of a form of...
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