Matches 151 - 200 out of 518 < 1 2 3 4 5 6 7 8 9 10 11 >
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5741897 Process for preparing an N-substitued aldonamide  
The present invention generally relates to a process for preparing an N-substituted aldonamide by reacting an aldonic acid in a polar organic solvent with an amine of the formula HNR 1 (X--NR 1...
5733892 Metastasis inhibitor composition comprising a phospholipid-linked glycosaminoglycan and method for inhibiting metastasis employing the same  
This invention relates to compounds prepared by linking glycosaminoglycan to phospholipid or lipid, which are expected to exert a pharmacological effect for inhibiting metastasis because of their...
5731298 Method for the treatment of scars and keloids  
A method and a pharmaceutical composition for non-topical wound, scar and keloid treatment is described which contains cross-linked glycosaminoglycans and conventional pharmaceutical auxiliary...
5714598 Sulfated acid amides having anticoagulant properties  
A sulfated acid amide having heparin-like properties of the formula: (R 1 )--NH--R--NH--(R 1 ) where R 1 is a di-, tri- or tetra-saccharide acid selected from cellobiose, cellotriose,...
5705493 Oligosaccharides having biological activity and preparation of same from supersulfated dermatan  
Oligosaccharides derived from natural or supersulphated GAGS or their mixtures, with a heparin content less than 1% by wt. having average molecular weight between 2,500 and 15,000 dalton, at least...
RE35706 Lipophila derivatives of muramylpeptides having properties of activating macrophages and compositions containing them  
The invention relates to muramyleptide derivatives resulting essentially from the conjugation or the coupling, as the case may require, through an arm, between a muramylpeptide and a group...
5677285 Derivatives of neuraminic acid  
Provided are new derivatives of neuraminic acid of formula (I), where Ac represents an acyl residue of an aliphatic, araliphatic, aromatic, alicyclic, or heterocyclic carboxylic acid, including...
5676964 Crosslinked carboxy polysaccharides  
Inter and/or intramolecular cross-linked esters of acid polysaccharides are disclosed in which a part or all of the carboxy groups are esterified with hydroxyl groups of the same molecule and/or of...
5654289 Disaccharide derivative  
A novel disaccharide derivative represented by the following formula, which is the compound of the present invention, its stereoisomers and salts and a medicinal composition comprising the same as...
5653980 Vaccine comprising part of constant region of IgE for treatment of IgE-mediated allergic reactions  
The invention relates to a vaccine, preferably for human use, against IgE-mediated allergic reactions. The vaccine contains a protein having the entire amino acid sequence of the constant CH2-CH3...
5644049 Biomaterial comprising hyaluronic acid and derivatives thereof in interpenetrating polymer networks (IPN)  
Provided is a biomaterial comprising an interpenetrating polymer network (IPN), wherein one of the polymer components is an acidic polysaccharide or a semi-synthetic derivative thereof. The...
5644042 Process for production of aldobionic acid amide  
A process for the preparation of aldobionamides directly from an aldobionic acid starting material, in which an aldobionic acid is reacted by removing water by azeotropic distillation to obtain an...
5639734 Disaccharide inflammation inhibitors and uses thereof  
The present invention provides a composition of matter comprising a biosynthetic anti-inflammatory oligosaccharide, comprising the structure of: sugar - sugar - X - R; wherein said sugar is...
5631241 Pharmaceutical compositions containing hyaluronic acid fractions  
Two pharmaceutically useful fractions of hyaluronic acid are obtained comprising a first fraction with a molecular weight between 50,000 and 100,000 which is useful for wound healing, and a second...
5624839 Process for culturing hepatocytes for formation of spheroids  
Hepatocytes spheroids can be formed by culturing hepatocytes in a culture vessel using a lipid-bound glycosaminoglycan as a culture substrate. Floating spheroids of hepatocytes can be obtained...
5621086 Sialic acid derivative and method of manufacturing it  
The present invention is drawn to methods of manufacturing a sialic acid derivative suitable for industrial production. With a method of the present invention, Tetra-O-acetylsialic acid (4a) and...
5620858 Method of removing shiga-like toxins from biological samples  
Diagnostic and therapeutic compositions which comprise the αGal(1-4)βGal subunit are described. These compositions permit the rapid diagnosis and treatment of enteric infections caused by E. coli...
5599914 Glycosphingolipids with a group capable of coupling in the sphingoid portion, the preparation and use thereof  
The invention relates to the chemical modification of the sphingoid portions of glycosphingolipids. It has been possible by a series of reactions to introduce an amino group in the position of the...
5593969 Lipid-A analogs: monosaccharide and dissaccharide compounds for inhibiting binding of lipid A receptors to lipid A receptors  
A compound of the formula: ##STR1## wherein: each of R 1 , R 1 ', R 2 and R 2 ' independent of each other is a substituted or unsubstituted, branched or linear C 1 -12 alkyl, alkene or alkyne...
5580858 Immunosuppressive and tolerogenic modified Lewis.sup.x compounds  
Disclosed are novel Lewis x and Lewis a analogues, pharmaceutical compositions containing such analogues, methods for their preparation and methods for their use.
5576305 Intercellular adhesion mediators  
The present invention is directed towards compositions and methods for reducing or controlling inflammation and for treating inflammatory disease processes and other pathological conditions...
5563250 Cleavable conjugates for the delivery and release of agents in native form  
The present invention provides cleavable conjugates whose linkers contain a labile bond that is cleavable under a variety of mild conditions, including weakly acidic. Since the agent may be bonded...
5559104 Procedure for the purification of hyaluronic acid and fraction of pure hyaluronic acid for ophthalmic use  
A highly pure fraction of hyaluronic acid is disclosed which is non-inflammatory and avoids post-operative complications in ocular surgery. Also disclosed is a process for the preparation of...
5559103 Bivalent sialyl X saccharides  
The present invention relates to bivalent sialyl Lewis X saccharide compounds that inhibit cellular binding to a selectin receptor. Pharmaceutical compositions containing a compound of Formula I,...
5556963 Synthesis of 4-alkoxy-N-acetylneuraminic acid  
This invention relates to an improved process for the synthesis of 4-alkoxy-N-acetylneuraminic acids. According to the process of the invention, N-acetylneuraminic acid is first alkylated at C-1...
5550155 Methods for the synthesis of monofucosylated oligosaccharides terminating in di-N-acetyllactosaminyl structures  
Monofucosylated and monosialyated derivatives of the compound βGal(1-4)βGlcNAc(1-3)βGal(1-4)βGlcNAc-OR, where R is hydrogen, a saccharide, an oligosaccharide or an aglycon moiety have been...
5550116 N,O-sulphated heparosans and pharmaceutical compositions containing them  
The invention relates to N,O-sulphated heparosans consisting of chains or of a mixture of chains of molecular mass between 1500 and 15,000 Da, characterized by a repeated disaccharide structure of...
5547944 Dermatan sulphate possessing a thrombolytic activity, and pharmaceutical forms containing it  
A natural dermatan sulphate with antithrombinic activity in excess of 220 U/mg which comprises an oligosaccharide sequence with a high degree of sulfation, having formula (III) ##STR1## in which:...
5543510 Process and intermediates for the preparation of (+)-hydantocidin and analogs thereof  
Hydantocidin is a potent non-selective herbicidal natural product. This invention provides an efficient method for the enantioselective preparation of (+)-hydantocidin, analogs thereof and...
5541166 Sulphated polysaccharides having anti-metastatic and/or anti-inflammatory activity  
A method of anti-metastatic and/or anti-inflammatory treatment of an animal or human patient comprises administration to the patient of an effective amount of at least one sulphated polysaccharide...
5523294 Di-lysoganglioside derivatives  
N-acyl-N,N'-di-lysogangliosides, N'-acyl-N,N'-di-lysogangliosides and N,N'-diacyl-N,N'-di-lysogangliosides, wherein the acyl groups are derived from an aliphatic acid having from 1 to 24 carbon...
5521293 Heteroatom containing alkyl aldonamide compounds as superior foaming, more soluble nonionic surfactants and a process for their manufacture  
The present invention relates to a process for producing amido heteroatom containing alkyl aldonamides comprising reacting an amino heteroatom containing alkyl aldonamide and an acid anhydride in...
5521164 Method for the preparation and purification of a mixture of glycosphingolipids free from contamination by non-conventional viruses  
The process of the invention relates to a process for the preparation of a ganglioside mixture, free from contaminants associated with non-conventional, life-threatening viruses, without altering...
5514654 N-acyldipeptides, processes for the preparation thereof and pharmaceutical compositions containing the same  
N-acyldipeptides of formula I ##STR1## wherein R represents a rest of formula ##STR2## and R 4 , Y, m, n and Z have the meaning as defined in the description, R 1 represents hydrogen, a 1-10 C....
5512470 Method for inhibiting sialidase activity  
Novel NeuAc-Gal dissacharide sialidase substrates and inhibitors which are locked into rigid conformation by the attachment of an alkyl group at the C-6 arm of the galactose core are provided. Also...
5508392 Use of vitamin D glycosides, vitamin D orthoester glycosides, vitamin D analog glycosides and vitamin D analog orthoester glycosides for the treatment of osteoporosis  
The present invention relates to methods for the treatment of prevention of osteoporosis by the administration of a vitamin D glycoside or vitamin D orthoester glycoside, or an analog thereof.
5498604 Lewis-type sugar chain derivative  
The object of the present invention is to provide a new SLe-type sugar chain derivative represented by the following formula (I), which is useful as a pharmaceutical and which contains moranoline:...
5489675 Disaccharide sialidase substrates and inhibitors  
Novel NeuAc-Gal dissacharide sialidase substrates and inhibitors which are locked into rigid conformation by the attachment of an alkyl group at the C-6 arm of the galactose core are provided. Also...
5489578 Sulfated ligands for l-selectin and methods of treating inflammation  
Sulfated oligosaccharides which bind to L-selectin receptors and act as agonists are formulated into pharmaceutical formulations and administered by injection to treat inflammation. Compounds which...
5484775 Semisynthetic ganglioside analogues  
N-acyl-N,N'-dilysogangliosides, wherein the acyl groups are derived from unsubstituted aliphatic acids having from 1 to 11 carbon atoms, and N'-acyl-N,N'-dilysogangliosides and...
5470842 Carbohydrate-based anti-inflammatory agents  
Ligands in the form of N-acetyllactosamines which bind to endothelial leukocyte adhesion molecule-1 (ELAM-1) are disclosed. The ligand compounds can be formulated into pharmaceutical compositions...
5464942 Phospholipid- or lipid-linked glycosaminoglycan and process for producing the same  
This invention relates to compounds prepared by linking glycosaminoglycan to phospholipid or lipid, which are expected to exert a pharmacological effect for inhibiting metastasis because of their...
5463034 Polysaccharides, process for their preparation and their use  
New polysaccharides have recurring units I or a salt thereof. ##STR1##
5441932 Sugar compounds for inhibition of the biosynthesis of sugar chains containing sialic acid  
An inhibitor of the biosynthesis of sugar chains containing sialic acid that is excellent in the suppression of inflammation or allergy, which comprises as an active ingredient a sugar compound of...
5438125 Sialic acid derivatives  
Sialic acid compounds of formula ##STR1## wherein X is hydrogen, a lower alkyl group or benzyl, Y is hydrogen or acetyl, Ac is acetyl, and the wavy line represents that the compound of the formula...
5424294 Modified gangliosides and the functional derivatives thereof  
N-acyl-N,N'-di-lysogangliosides, N'-acyl-N,N'-di-lysogangliosides and N,N'-diacyl-N,N'-di-lysogangliosides, in which the acyl groups are derived from an organic acid of the aliphatic, aromatic,...
5386018 Process of preparing N-substituted aldonamides  
N-substituted aldonamides are synthesized by the reaction of alkylamines and aldonolactone. Commercially available sources of aldonolactones (e.g., lactobiono-1,5-lactone) include aldonic acid...
5380832 Ganglioside GM3 analogs  
Disclosed are ganglioside GM 3 analogs represented by the formula ##STR1## in which X represents a radical of the following formula ##STR2## wherein at least one of R 1 , R 2 , R 3 and R 4 is...
5380829 Thioglycoside analogs of gangliosides  
Disclosed are thioglycoside analogs of gangliosides represented by the formula ##STR1## in which Y represents a radical of the following formula ##STR2## and X represents a radical of the formula...
5366963 Gangliosides with immunosuppressive ceramide moieties  
A method for suppressing immune responses in animals by administering a mixture of gangliosides to the animal where the gangliosides have heterogeneous ceramide structures containing fatty acid...
Matches 151 - 200 out of 518 < 1 2 3 4 5 6 7 8 9 10 11 >