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6187754 |
Sialyl-Lewisa and sialyl-Lewisx epitode analogues
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6169077 |
Sialyl-Lewisa and sialyl-Lewisx epitope analogues
Sialyl-Lewis x and sialyl-Lewis a epitope analogues in which the naturally occurring N-acetyl group of the N-acetylglucosamine monomer is replaced by various aliphatic or aromatic substituents...
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6162797 |
Derivatives of K5 polysaccharide having high anticoagulant activity
Derivatives of the K5 polysaccharide having anticoagulant activity higher than heparin, obtained by a process including the steps of reacting: with an organic base a solution of K5 polysaccharide...
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6150342 |
Heparin derivatives for treatment of angina pectoris
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6136790 |
Carbohydrate mimetics having antiadhesive properties
The invention relates to carbohydrate mimetics, which inhibit the binding of selectin to carbohydrate ligands, of the formula I ##STR1## excluding the compounds sialyl-Lewis-X and -A and their...
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6133239 |
Carbohydrate ligands (myelorollin) that cause E-selectin dependent cell rolling and adhesion under dynamic flow system
An unbranched polylactosamine comprising at least 6 monosaccharides and having terminal α2➝3 sialylation and internal α1➝3 fucosylation at various N-acetylglucosamine residues except for...
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6103704 |
Therapeutic methods using hyaluronic acid
A method of accumulating a drug and a form of hyaluronic acid in the skin and/or exposed tissue of a human includes topically administering a therapeutically effective dosage amount of a...
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6087339 |
Saccharide derivatives
Disclosed are novel saccharide derivatives which inhibit binding of toxins, such as heat-labile enterotoxin or cholera toxin, to their receptors either in vitro or in vivo. Additionally, disclosed...
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6080589 |
Neisseria meningitidis capsular polysacchride conjugates
Capsular polysaccharides containing multiple sialic acid residues, particularly the Group B polysaccharide of Neisseria meningitidis, are modified by chemical reaction to randomly introduce pendant...
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6069135 |
Use of hyaluronic acid or its derivatives to enhance delivery of therapeutic agents
A pharmaceutical composition is provided comprising: (1) an agent selected from a medicinal agent and a therapeutic agent and combinations thereof in a therapeutically effective amount to treat...
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6051701 |
Sulfated hyaluronic acid esters
Hyaluronic acid, hyaluronate esters and salts thereof are sulfated such that the number of sulfate groups per monomeric unit is in the range of from 0.5 to 3.5. The sulfated derivatives exhibit...
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6036977 |
Drug preparations for treating sexual dysfunction
Topical gelled compositions comprising a drug for treating sexual dysfunction dispersed within a polymer matrix and methods and treatments using said compositions.
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6017901 |
Heavy metal salts of succinic acid hemiesters with hyaluronic acid or hyaluronic acid esters, a process for their preparation and relative pharmaceutical compositions
Hyaluronic acid or hyaluronic acid ester derivatives, wherein one or more hydroxy functions of its 1,4β-D-glucuronic acid and 1,3-β-N-acetyl-D-glucosamine alternating repeating units are...
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6018035 |
Reagents for isotropic size enhancement of a peptide, protein, nucleotide or other substrate
Novel polysaccharide compounds are disclosed for decorating biomolecular surfaces to increase isotropic size and mask antigenicity. The oligosaccharides may be synthesized as repeating disaccharide...
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6017892 |
Method for accelerating marrow cell proliferation
The present invention relates to a pharmaceutical composition (a marrow cell proliferation accelerator, a radioprotective agent, a therapeutic agent for thrombocytopenia) comprising a compound...
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5985850 |
Compositions comprising hyaluronic acid and drugs
A dosage amount of a pharmaceutical composition comprising a therapeutically effective amount of an agent to treat a disease or condition involving underperfused tissue and pathological tissue in...
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5972907 |
Synthetic core 2-like branched structures containing GalNAc-lewis.sup.x and Neu5Acα2-3Galβ1-3GalNAc sequences as novel ligands for selectins
Compounds which bind to selectin receptors and thus may modulate the course of inflammation, cancer and related processes by intervening with cell-cell adhesion events. Further, such compounds can...
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5972906 |
Treatment of mucous membrane disease, trauma or condition and for the relief of pain thereof
A method for the treatment of mucous membrane trauma disease or condition for the relief of pain associated therewith comprising administering topically an effective amount of a composition...
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5962498 |
Protein kinase C modulators. C. indolactam structural-types with anti-inflammatory activity
Compounds having anti-inflammatory, anti-viral, protein kinase C-modulatory and other activities are disclosed. The compounds are derived from aromatic heterocyclic compounds of the indole, indene,...
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5955605 |
Biotinidase resistant biotin-DOTA conjugates
Biotinidase-resistant biotin-DOTA conjugates, and methods of use thereof in diagnostic and therapeutic pretargeting methods are provided. These conjugates are useful in diagnosis and treatment of...
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5952006 |
Drug preparations for treating impotency
Topical gelled compositions comprising a drug for treating impotency dispersed within a polymer matrix and treatments using the complex.
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5948904 |
Process for the preparation of aromatic carbamoyl-substituted polysaccharide derivatives
The invention relates to a process for the preparation of polysaccharide-N-arylcarbamates in suitable form as supports for chromatography, which process comprises adding to polysaccharide...
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5936076 |
αgalactosylceramide derivatives
The present invention relates to the novel α-galactosylceramide represented by the formula (A): ##STR1## wherein R represents ##STR2## where R 2 represents H or OH and X denotes an integer of...
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5922690 |
Dermatan disulfate, an inhibitor of thrombin generation and activation
A method of inhibiting thrombin generation and of inhibiting complement activation by using a dermatan sulfate having at least 2 sulfate groups per disaccharide obtained by chemical sulfation of...
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5922848 |
Method of recovering shiga-like toxins and vaccines comprising inactivated shiga-like toxin
Disclosed are methods of purifying shiga-like toxins (SLTs) from Polymyxin B sulfate extracts of Verotoxin-producing Escherichia coli. The methods are facile, efficient and reproducible. In another...
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5905071 |
Glycosylamides of 2-aminoacylamino-2-deoxy sugars
The present invention relates to (2-aminoacylamino-2-deoxy-glycosyl)-amides, which are substituted on the nitrogen atom of the amino acid, of the general formula (I) ##STR1## in which the...
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5897880 |
Topical drug preparations
Topical gelled compositions comprising an optional drug dispersed within a polymer matrix, methods of producing the same and treatments with the complex.
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5880100 |
Method for inhibiting binding of human lens cells
The present invention provide a method of inhibiting an irregular binding of human cells caused by specific adhesion of Lewis x glycolipids by administering any of an oligosaccharide having a...
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5872111 |
Compositions comprising glycosylamide surfactants
The present invention relates to novel detergent and/or personal wash compositions comprising glycosylamide surfactants.
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5861505 |
Synthetic analog of sialic Lewis antigen from bacterial capsular polysaccharide
An analog of sialic Lewis antigen prepared from native capsular polysaccharide of Klebsiella 63 bacteria.
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5856299 |
Highly reactive esters of carboxy polysaccharides and carboxy polysaccharides derived therefrom
Provided are active esters of carboxy polysaccharides and semisynthetic derivatives of carboxy polysaccharides, wherein all or part of the carboxy groups thereof are esterified with an aromatic...
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5849709 |
Saccharopeptides and derivatives thereof
Saccharopeptides and methods of using the novel saccharopeptides are described having the following structural formula I: W-- --Y--W--! m (I) wherein W is...
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5849722 |
Oligosaccharide having affinity for fibroblast growth factor and process for producing same
An oligosaccharide having an affinity for fibroblast growth factor, which is composed of 8 to 18 monosaccharide residues, wherein a principal disaccharide unit comprising L-iduronic acid 2-sulfate...
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5849716 |
Sphingoglycolipids, their preparation, and therapeutic methods of use
The present invention relates to a sphingoglycolipid represented by the following formula (I) which is effective at a small dose and has an anti-tumor activity and an immunostimulating effect with...
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5837830 |
Stereodirected process for synthesis of α-N-acetylgalactosaminides
A stereodirected process for synthesizing α-N-acetylgalactosaminides from N-acetylgalactosamine which, in a preferred embodiment, comprises: reacting N-acetylgalactosamine with a dialkyl acetal...
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5837862 |
Sialyl Lewis X mimetics incorporating mannopeptides
Sialyl Lewis X mimetics based on mannose glycosides are synthesized and shown to mimic the configuration and essential functional groups of sialyl Lewis X in space. The mannose based mimetics...
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5834444 |
Hyaluronic acid and salts thereof inhibit arterial restenosis
A method is provided of preventing arterial restenosis of an animal after the arteries have been traumatized. The method comprises the administration of a therapeutically effective non-toxic amount...
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5831079 |
Method of preparing ganglioside
A method of preparing Ganglioside G M3 which comprises converting Ganglioside G D3 into Ganglioside G M3 in an alkaline condition is disclosed. The conversion of Ganglioside G D3 into...
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5830882 |
Compositions containing a form of hyaluronic acid and a medicinal agent for treating acne in mammals and methods for administration of such composition
A combination for administration to a mammal which combination employs a therapeutically effective amount of a medicinal and/or therapeutic agent to treat a disease or condition and an amount of...
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5817800 |
Inhibitors of β-glucuronidase and their use in the treatment of carcinamatosis and inflammation
Compounds of the formulae I and II ##STR1## are suitable for the suppression of tumor growth and of tumor metastasis.
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5811410 |
Method of administering of a hyaluronic acid and an NSAID to decrease side effects of the NSAID
A method of administering a medicinal agent and an effective amount of a form of hyaluronic acid for decreasing side effects associated with using the agent alone in treating a disease or condition...
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5811404 |
Sialyl Le.sup.x analogues as inhibitors of cellular adhesion
The present invention relates to analogues of sialyl Le x the inhibit cellular adhesion between a selectin and cell that express sialyl Le x on their surfaces, as well as methods and compositions...
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5801162 |
Dermatan sulfate compositions and antithrombotic compositions containing same
Dermatan sulfate compositions having certain characteristics have been found to have thrombolytic activity. Dermatan sulfate combined with tissue plasminogen activator (t-PA) enhances the...
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5795869 |
Sulfated lyso-ganglioside derivatives
Semisynthetic analogues of gangliosides selected from the group consisting of N-sulfo-, N-hydrocarbyl-sulfonyl- and N-hydrocarbyloxy-sulfonyl-N,N'-dilyso-gangliosides and the N'-acyl derivatives...
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5792753 |
Compositions comprising hyaluronic acid and prostaglandin-synthesis-inhibiting drugs
A topically administrable pharmaceutical composition is disclosed which comprises a therapeutically effective amount of a drug which inhibits prostaglandin synthesis, and an amount of a form of...
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5792842 |
Ganglioside GM3 derivative having fluorine atom at 9-position of sialic acid and intermediates therefor
A ganglioside GM3 derivative having a fluorine atom at the 9-position of sialic acid represented by the formula: ##STR1## wherein R is an aliphatic lower acyl group, R 1 is a hydrogen atom or a...
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5780606 |
Neisseria meningitidis capsular polysaccharide conjugates
Capsular polysaccharides containing multiple sialic acid residues, particularly the Group B polysaccharide of Neisseria meningitidis, are modified by chemical reaction to randomly introduce pendant...
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5773605 |
Sulfated glycosaminoglycanoid derivatives of the heparin sulfate type
The invention relates to sulfated glycosaminoglycanoid derivatives of the heparin and heparan sulfate type, of which N-sulfate, N-acetate, and hydroxy groups, are replaced by alkoxy, aryloxy,...
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5756712 |
Peptidodisaccharides as oligosaccharide mimetics
Methods are provided to replace the ether oxygen linkage of oligosaccharides with a peptide link, --NHC(O)--, where the nitrogen atom is linked to the anomeric carbon atom of the sugar. A new...
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5753631 |
Intercellular adhesion mediators
The present invention is directed towards compositions and methods for reducing or controlling inflammation and for treating inflammatory disease processes and other pathological conditions...
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