|
Match
|
Document |
Document Title |
|
|
6844329 |
Polysaccharides with antithrombotic activity comprising at least a covalent bond with biotin or a biotin derivative
The present invention relates to novel synthetic polysaccharides with antithrombotic activity exhibiting at least one covalent bond with biotin or a biotin derivative and to a process employing...
|
|
|
6838448 |
Corneal storage fluid comprised of hyaluronic acid
A solution for storing corneal tissue, especially at a temperature of 2 to 8° C., which comprises hyaluronic acid having an average molecular weight of less than 6,000,000 Da (preferably of from...
|
|
|
6835720 |
Compounds having antiviral activity
In order to provide the anti-retrovirus active compound with low anti-coagulant action and low cytotoxicity, compounds comprising glycoside or the salt thereof wherein lipid is linked to position 2...
|
|
|
6833451 |
Lipopolysaccharides (LPS) extracted from Escherichia coli
Lipopolysaccharides and processes for producting the lipopolysaccharides are provided. The lipopolysaccharide has a lipid A portion, a core oligosaccharide portion, and an O-specific chain having a...
|
|
|
6833363 |
N-sulphated hyaluronic acid compounds, derivatives thereof and a process for their preparation
The present invention is directed to novel sulphated compounds of hyaluronic acid and derivatives thereof, optionally salified, wherein the glucosamines are partially N-sulphated and partially or...
|
|
|
6831172 |
Cross-linked hyaluronic acids and medical uses thereof
Cross-linked hyaluronic acids produced by the reaction of the carboxylic acid groups of hyaluronic acid and a polyamine and the sulfated and hemisuccinylated derivates thereof. The cross-linked...
|
|
|
6770635 |
Method for medicating the inflammatory controlling system and adverse inflammatory reactions and for making compounds for treating the pathology of adverse inflammatory reactions
Adverse inflammatory reactions can be treated by administrating to an organism a composition having diglucosylamine as the active ingredient. The preferred compound is...
|
|
|
6722062 |
Capsular polysaccharides from enterococci
The present invention is directed to a method for purifying polysaccharides capable of inducing the production of high titers of opsonic antibodies that kill strains of enterococcal bacteria. In...
|
|
|
6703496 |
Starch phosphates, method for the production thereof and their use
The invention relates to starch phosphates exhibiting improved properties with regard to application techniques, to a method for the production thereof, and to their use. Based on the disadvantages...
|
|
|
6703377 |
Method of promoting bone growth with hyaluronic acid and growth factors
A bone growth-promoting composition is provided comprising hyaluronic acid and a growth factor. The composition has a viscosity and biodegradability sufficient to persist at an intra-articular site...
|
|
|
6699846 |
Mono- and disaccharides for the treatment of nitric oxide related disorders
Methods for treating diseases or conditions modulated or ameliorated by nitric oxide, particularly ischemia and reperfusion injury, are provided, using glycolipids structurally related to...
|
|
|
6693188 |
N-acetyl-D-glucosamine and process for producing N-acetyl-D-glucosamine
The present invention is directed to N-acetyl-D-glucosamine obtained from microbial biomass, and to methods of obtaining N-acetyl-D-glucosamine from microbial biomass. In particular, the present...
|
|
|
6686457 |
Material
Material characterized by that the material contains at least one biologically active saccharide which is covalently bound via at least one spacer to a crosslinked matrix.
|
|
|
6667296 |
Method for preventing and reducing radiation cystitis using hyaluronic acid
A method for preventing, reducing or treating radiation cystitis caused by external beam radiation therapy, which impinges on the urinary bladder and associated structures, comprising administering...
|
|
|
6664243 |
Benzyllactobionamides as inhibitors of smooth muscle cell proliferation
This invention provides smooth muscle cell proliferation inhibitors of formula I having the structure wherein R 1 -R 13 are as defined herein.
|
|
|
6645945 |
Method of treating diseased, injured or abnormal cartilage with hyaluronic acid and growth factors
A composition is provided for treating diseased, injured or diseased cartilage comprising hyaluronic acid and a growth factor. The composition has a viscosity and biodegradability sufficient to...
|
|
|
6632802 |
Hyaluronic acid esters, threads and biomaterials containing them, and their use in surgery
The application discloses esters of hyaluronic acid, wherein a first part of the carboxylic functions is esterified with an araliphatic alcohol and a second part is esterified with at least one...
|
|
|
6630457 |
Functionalized derivatives of hyaluronic acid, formation of hydrogels in situ using same, and methods for making and using same
Methods for chemical modification of hyaluronic acid, formation of amine or aldehyde functionalized hyaluronic acid, and the cross-linking thereof to form hydrogels are provided. Functionalized...
|
|
|
6627621 |
Neutrophil function inhibitors
Glucosamine salts are effective for the inhibition of neutrophil functions, and hence, are useful for the prevention and/or treatment of diseases, caused as a result of an excessive extracellular...
|
|
|
6613748 |
C-glucosyl ether lipids
A C-glucosyl ether lipid of the following formula: wherein R 1 is a C 12 -C 20 alkyl or C 12 -C 20 alkenyl; R 2 is a C 1 -C 3 alkyl or C 3 cycloalkyl; and X nitrogen-containing group.
|
|
|
6608043 |
Remedies for joint diseases
The present invention provides an agent for treatment of arthritic diseases such as rheumatoid arthritis that has for its active ingredient a complex of hyaluronic acid and zinc. This complex...
|
|
|
6608061 |
Bisaryl compound and medicament for cancer treatment comprising the same
A medicament for treatment of cancer comprising a compound represented by the following general formula (I) or a physiologically acceptable salt thereof: Ar 1 —S—R 1 —S—Ar 2 wherein R 1 ...
|
|
|
6602859 |
Photocurable hyaluronic acid derivative and process for producing the same, and photocured crosslinked-hyaluronic acid derivative and medical material using the same
A photocurable hyaluronic acid derivative of the present invention comprises hyaluronic acid and a photoreactive crosslinking group bonded thereto, wherein a 1.0 wt. % aqueous solution of the...
|
|
|
6596283 |
Meningococcal polysaccharide conjugate vaccines
The invention relates to chemically-modified group B polysaccharides of Neisseria meningitidis . The invention also provides vaccines in which the respective modified polysaccharides are...
|
|
|
6579978 |
Biomaterials comprising N-sulphated hyaluronic acid compounds or derivatives thereof
The present invention is directed to novel sulphated compounds of hyaluronic acid and derivatives thereof, optionally salified, wherein the glucosamines are partially N-sulphated or partially...
|
|
|
6562954 |
Method for producing oligosaccharide, and novel oligosaccharide and pharmaceutical composition containing the same
Oligosaccharides including those usable as anti-inflammatory agent or anti-allergy agent, represented by the following general formula (3): wherein R 10 and R 11 each independently represent a...
|
|
|
6552184 |
Process for the preparation of autocrosslinked compounds of hyaluronic acid and the derivatives thereof by the supercritical antisolvent technique
Crosslinked compounds of hyaluronic acid and the derivatives thereof, prepared by the technique of precipitation induced by supercritical antisolvent (SAS), can be used to advantage for the...
|
|
|
6541460 |
Method for use of hyaluronic acid in wound management
A method for decreasing or shortening the length of time required to complete a surgical procedure by the application of hyaluronic acid to the surgical site, and for wound management by topical...
|
|
|
6537979 |
Water-insoluble derivatives of hyaluronic acid crosslinked with a biscarbodiimide
This invention describes a method for preparing water-insoluble biocompatible gels, films and sponges by reacting hyaluronic acid, or a salt thereof, with a carbodiimide in the absence of a...
|
|
|
6534648 |
Isolated algal lipopolysaccharides and use of same to inhibit endotoxin-initiated sepsis
The isolation and purification of lipopolysaccharides from several related strains of eukaryotic algae is disclosed. These lipopolysaccharides have been shown to be structurally and functionally...
|
|
|
6528629 |
Malto-oligosaccharide derived glycosides
Disclosed is a method for preparing a malto-oligosaccharide derived glycoside. Generally, the method comprises providing a malto-oligosaccharide and glycosylating the malto-oligosaccharide with an...
|
|
|
6511965 |
Ether type lipid A 1-carboxylic acid analogs
A compound of formula (I) below, which exhibits excellent macrophage activity inhibitory action, is useful for the treatment or prophylaxis of inflammatory disorders, autoimmune diseases or...
|
|
|
6509322 |
Pharmaceutical compositions for topical use containing hyaluronic acid and its derivatives
The present invention is drawn to a pharmaceutical composition, comprising a pharmaceutically effective amount of an acidic polysaccharide and/or a derivative thereof, a gaseous vehicle, and a...
|
|
|
6489467 |
Process for purifying high molecular weight hyaluronic acid
A process for purifying high molecular weight hyaluronic acid from a biological source, including the steps of adjusting the pH of an aqueous solution containing high molecular weight hyaluronic...
|
|
|
6486137 |
Oligosaccharide mixtures having antithrombotic activity
A mixture of linear oligosaccharides containing different numbers of repeating sulphated disaccharide units derived from L-iduronic acid (IdoA) and N-acetyl-D-galactosamine (Gal-NAc) and having the...
|
|
|
6423547 |
Non-covalent bioconjugates useful for diagnosis and therapy
A composition comprising non-covalent carrier-hapten bioconjugates having the formula: HM-CM wherein HM is a hapten molecule whose molecular weight is generally, but not always, less than 1000...
|
|
|
6420552 |
Syntheses of 4-alkyl chromogenic glycosides and 7-alkyl chromogenic glycosides of N-acetylneuraminic acids
The present invention provides improved method of preparing a 4-O-alkyl chromogenic ketoside of N-acetylneuraminic acid (Neu5Ac) and a 7-O-alkyl chromogenic ketoside of N-acetylneuraminic acid...
|
|
|
6407072 |
Lysoganglioside derivatives
Novel N-acyl-lysogangliosides obtained from gangliosides by deacyation of the ceramide group, wherein the acyl group is derived from an aliphatic acid having from 2 to 24 carbon atoms, substituted...
|
|
|
6399590 |
Phosphoglycolipid and methods for its use
The invention concerns a novel phosphoglycolipid compound. The compound of the subject invention is...
|
|
|
6353095 |
Ketoaldonic acids having formed stereogenic centers of R configuration: methods and compositions
The present invention provides a ketoaldonic acid such as an octulosonic or nonulosonic acid having a formed stereogenic center of R configuration, as well as methods of synthesizing the same.
|
|
|
6342592 |
Chiral compounds, their synthesis and use as a support
The invention relates to a method which comprises synthesising bifunctional compounds then chiral compounds from the bifunctional compounds, also to synthesising supports comprising these chiral...
|
|
|
6339074 |
Sulfated hyaluronic acid and esters thereof
Hyaluronic acid, hyaluronate esters and salts thereof are sulfated such that the number of sulfate groups per monomeric unit is in the range of from 0.5 to 3.5. The sulfated derivatives exhibit...
|
|
|
6303585 |
Cross-linked polysaccharide drug carrier
A carrier and a method for preparing it are provided for use in the delivery of therapeutic agents. A polysaccharide is reacted with an oxidizing agent to open sugar rings on the polysaccharide to...
|
|
|
6299897 |
Inhibition of selectin binding
This invention provides compositions for inhibiting the binding between two cells, one expressing P- or L-selectin on the surface and the other expressing the corresponding ligand. A covalently...
|
|
|
6288043 |
Injectable hyaluronate-sulfated polysaccharide conjugates
An injectable composition is provided for promoting bone and/or cartilage growth comprising hyaluronic acid cross-linked to sulfated polysaccharide through linking groups. The linking groups are...
|
|
|
6281202 |
Pharmaceutical compositions for treatment of EGF receptor associated cancers
The present invention discloses carbohydrates and carbohydrate analogs that bind to epidermal growth factor (EGF) receptors. Methods of using such carbohydrates or analogs for a variety of uses...
|
|
|
6274568 |
Compounds for altering cell surface sialic acids and methods of use therefor
The present invention is based on the identification of compounds in the form of biosynthetic precursors which can be used to modulate neuronal growth, inhibit cellular entry by pathogens and...
|
|
|
6262255 |
Non-immunogenic, biocompatible macromolecular membrane compositions, and methods for making them
Non-immunogenic biocompatible macromolecular sheet composition are formed from a cellulosic membrane, a binding moiety having a plurality of functional groups, and a glycosaminoglycan (GAG). The...
|
|
|
6204254 |
Biocompatible surfaces and a method for their preparation
A novel group of compounds is disclosed for decorating the surface of synthetic polymeric or tissue derived prostheses to prevent adverse rejection events. The decorating molecules are obtained as...
|
|
|
6194392 |
Treatment of conditions and disease
A combination for administration to a mammal which combination employs a therapeutically effective amount of a medicinal and/or therapeutic agent to treat a disease or condition and an amount of...
|