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7259153 |
Drug formulation and delivery using crystalline methylated cyclodextrins
The present invention is directed to pharmaceutical compositions containing crystalline methylated cyclodextrins, which enhance the solubility of the pharmaceutically active agent or agents of the...
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7115586 |
Non-inclusion cyclodextrin complexes
The invention provides a number of methods for enhancing the aqueous solubility of an active ingredient which is insoluble or sparingly soluble in water. In one preferred embodiment, solubilization...
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7091335 |
Derivatized reduced malto-oligosaccharides
Disclosed are derivatized malto-oligosaccharides and methods for the preparation thereof. In accordance with the disclosed invention, a malto-oligosaccharide is hydrogenated to thereby obtain a...
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7087709 |
Polymers for delivering nitric oxide in vivo
Disclosed are novel polymers derivatized with at least one —NO x group per 1200 atomic mass unit of the polymer. X is one or two. In one embodiment, the polymer is an S-nitrosylated polymer and...
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7030237 |
Method and equipment for continuous and selective inclusion separation
In a reaction system having at least two liquid-liquid interfaces between an organic phase of raw material containing a compound(s) to be separated and an aqueous phase of an aqueous solution of...
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7005513 |
Functionalized glycosaminoglycan polymer and medical instruments and drugs by using the same
The present invention provides a functionalized polymer which can be used extensively in the field of medical drugs as well as medical devices and which is obtainable in an organic synthetic manner...
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7005426 |
Folic acid-polysaccharide complex, its preparation method and pharmaceutical composition containing the same as active component
The present invention relates to folic acid-polysaccharide complexs and method of preparation thereof, more particularly relates to folic acid-Dextran complexs, method of preparation thereof,...
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7001893 |
Inclusion complex of Rifampicin, an anti-tubercular drug, with β-cyclodextrin or 2-hydroxypropyl β-cyclodextrin and a process thereof
The present invention relates to an inclusion complex of Rifampicin and cyclodextrin (CD) that can be used as an anti-tubercular drug. The present invention also relates to a process for...
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6998479 |
Derivatives of cyclodextrins
The present invention is directed to novel aminooxy-cyclodextrin derivatives of the formula (1): CD—(X—Y—ONH 2 ) n , wherein CD is mono- or polydeoxy α-, β-, or γ-cyclodextrin, carrying in...
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6982256 |
Tolerance of 4-(4-(2-pyrrolylcarbonyl)-1-piperazinyl)-3-trifluoromethyl-benzoylguanidine in intravenous administration
The invention relates to new formulations for improving the local tolerance of intravenously administered 4-(4-(2-pyrrolylcarbonyl)-1-piperazinyl)-3-trifluoromethyl-b
enzoylguanidine or one of the...
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6884885 |
Production of cyclodextrin complexes
The process entails increasing the concentration of cyclodextrin to 15% (w/w) and above to form complexes through a precipitation process in order to increase the yield of complexes, increase the...
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6878695 |
Compositions comprising cyclodextrin derivatives
A stable composition for removing unwanted molecules from a surface comprises low-degree of substitution cyclodextrin derivatives. The compositions are suitable for capturing unwanted molecules...
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6864246 |
Anilide and cyclodextrin complexes, their preparation and their use as medicine in particular for treating dyslipidemiae
The invention concerns more particularly dodecylthio-phenylacetanilide derivative complexes such as (S)-2′,3′,5′-trimethyl-4′-hydroxy-α-dodecylthio-phe
nylacetanilide or related...
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6858723 |
Amphiphile cyclodextrins, preparation and use thereof for solubilizing organized systems and incorporating hydrophobic molecules
The invention provides cyclodextrin derivatives that may be used to transport hydrophobic molecules for pharmaceutical or cosmetic applications, by forming organised systems in an aqueous medium,...
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6835718 |
Biocleavable micelle compositions for use as drug carriers
This invention discloses compositions and methods for preparing biocleavable or biodegradable micelle compositions for carrying and releasing drugs and other active agents for therapeutic or other...
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6818630 |
Biologically active materials
The present disclosure concerns biologically active materials, particularly materials that comprise a biodegradeable polymer linked to a biologically active agent. The disclosure further concerns...
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6699849 |
Cyclodextrin complexes of benzodiazepines
Methods for enhancing the complexation efficiency of a drug with cyclodextrin and for enhancing the availability of a drug following administration of a cyclodextrin-drug complex.
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6590096 |
Process for the production of polysaccharide beads
The present invention relates to a method for producing porous polysaccharide beads, comprising: (a) mixing a water-based solution of a polysaccharide under stirring with an essentially...
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6528629 |
Malto-oligosaccharide derived glycosides
Disclosed is a method for preparing a malto-oligosaccharide derived glycoside. Generally, the method comprises providing a malto-oligosaccharide and glycosylating the malto-oligosaccharide with an...
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6475803 |
Cyclodextrin derivatives and measurement of water contamination degree using the same
A cyclodextrin derivative is an X-hydroxynaphthalene-Y-amidated cyclodextrin formed by subjecting a starting cyclodextrin to an addition reaction with A-hydroxyl-B-carboxyl naphthalane and used for...
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6355627 |
Branched cyclodextrin clathrate compound of hinokitiols and composition containing the same
The invention has an object of providing a hinokitiol which is not damaged in the antibacterial activity and improved in the water solubility, heat stability (anti-sublimation characteristics) and...
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6316613 |
Chiral separation of pharmaceutical compounds with charged cyclodextrins using capillary electrophoresis
The separation of enantiomeric pairs of compounds by capillary electrophoresis using highly sulfated α-, β-, and γ-cyclodextrins as chiral selectors is described herein. These charged...
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6204256 |
Acylated cyclodextrin derivatives
A cyclodextrin derivative, wherein at least 60 percent of the free hydroxy groups of said cyclodextrin are acylated with acyl groups where at least one of said acyl groups comprise a free...
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6197951 |
Starch graft copolymer blast media
The invention discloses a starch graft poly(meth)acrylate blast media which is effective in paint removal. The media is superior to a physical blend of the components (i.e., starch and acrylic...
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6127530 |
Method for the reduction of oxygenated compounds of rhenium or technetium
The present invention relates in general to a method for the reduction of oxygenated compounds of rhenium and technetium and in particular to the reduction of perrhenate or pertechnetate ions. More...
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6113880 |
Polyrotaxane derivatives for x-ray and nuclear magnetic resonance imaging
The invention relates to polyrotaxanes that contain metal complexes or iodine-containing benzene derivatives as imaging components for MRT diagnosis and x-ray diagnosis.
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6103892 |
Catalyst that oxidizes steroids and other substrates with catalytic turnover
The present invention provides a metalloporphyrin catalyst represented by the structure: ##STR1##
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6103885 |
Method of making amide modified carboxyl-containing polysaccharide and fatty amide-modified polysaccharide so obtainable
The Invention pertains to a process for the amidation of a material having at least one carboxyl-containing polysaccharide. The provided process involves a first step in which the carboxyl groups...
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6068831 |
Pseudopolyrotaxanes
The invention relates to new metal complex-containing or iodine-containing benzene derivatives that contain pseudopolyrotaxanes. They are valuable compounds for diagnosis. The pseudopolyrotaxane...
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6060597 |
Cyclic oligosaccharide, and an agent containing the same for preventing or treating retroviral diseases
A cyclic oligosaccharide or salts thereof comprising glucoses bound cyclically via α-1,6-linkages and having at least one S-oxo acid group bound, and ana gent for preventing or treating retroviral...
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5925534 |
Method for measuring LDL-cholesterol
The amount of cholesterol in low density lipoproteins in a sample can be measured by contacting the sample with one or more reagent solutions to carry out the reaction in the presence of a...
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5840881 |
Composition containing a water-insoluble or slightly water-soluble compound with enhanced water-solubility
A composition is disclosed comprising a water-insoluble or slightly water-soluble compound and a branched cyclodextrin-carboxylic acid. The branched cyclodextrin-carboxylic acid significantly...
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5840714 |
Inclusion complexes of racemic ibuproxam and of optically active ibuproxam with cyclodextrin derivatives, pharmaceutical preparations containing said inclusion complexes and methods for using same
Inclusion Complexes of Racemic Ibuproxam and of Optically Active Ibuproxam with Cyclodextrin Derivatives, Process for the Preparation Thereof, Pharmaceutical Preparations Containing these Inclusion...
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5834446 |
Nerve process growth modulators
Nerve process growth modulation can be achieved using derivatized cyclodextrins. Processes for making sulfated and aminated β-cyclodextrin derivatives are also described in which a compound of the...
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5824798 |
Genetically engineered modification of potato to obtain amylopectin-type starch
Genetically engineered modification of potato for suppressing formation of amylose-type starch is described. Three fragments for insertion in the antisense direction into the potato genome are also...
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5814472 |
Measurement of LDL-cholesterol
Cholesterol in low density lipoproteins can be measured specifically and precisely by optically measuring a reaction product of a living sample with cholesterol oxidase or cholesterol dehydrogenase...
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5811236 |
Electrochemiluminescent rhenium moieties and methods for their use
Electrochemiluminiscent moieties having the formula Re(P) m (L 1 ) n (L 2 ) o (L 3 ) p (L 4 ) q (L 5 ) r (L 6 ) s ! t (B) u wherein P is a polydentate ligand of Re; L 1 , L 2 , L 3...
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5800602 |
Use of inclusion compounds of cyclic polysaccharides as charge control agents
Inclusion compounds consisting of a host compound, which is a cyclically linked polysaccharide having 3 to 100 monomeric saccharide units and forming a cavity in its molecular framework, and of one...
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5789569 |
Isothiocyanated cyclodextrin derivative
The present invention relates to an isothiocyanated cyclodextrin derivative which can label various kinds of organic compounds containing an amino group as their functional group. In some...
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5780619 |
Starch graft poly(meth)acrylate blast media
The invention discloses a starch graft poly(meth)acrylate blast media which is effective in paint removal. The media is superior to a physical blend of the components (i.e., starch and acrylic...
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5776914 |
Prevention of hemolysis
Disclosed are compositions and methods for preventing or substantially inhibiting the hemolytic activity of hemolysis inducing agents. The methods and compositions are based on the use of an...
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5773227 |
Bifunctional chelating polysaccharides
This invention describes bifunctional polysaccharides conjugated to both a chelating group suitable for the selective complexation of metal cations, and a targeting peptide specific for a cellular...
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5763598 |
Branched cyclodextrins and method for producing them
Disclosed are novel branched cyclodextrins having any of an N-acetylglucosamine group, a glucosaminyl group, an N-acetylgalactosaminyl group and a galactosaminyl group as bonded to the hydroxyl...
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5760017 |
Cyclodextrin derivatives usable in particular for solubilizing hydrophobic chemical compounds such as medicaments and their preparation process
The invention relates to novel cyclodextrin derivatives according to formula: ##STR1## in which R 1 represents OH or NH(CH 2 ) p OH, n is equal to 5, 6 or 7 and p is an integer from 2 to 6, it...
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5744165 |
Nimesulide salt cyclodextrin inclusion complexes
Inclusion complexes of nimesulide alkali and alkaline earth salts with cyclodextrins and cyclodextrin derivatives are disclosed. Compositions containing the inclusion complexes, processes for the...
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5731296 |
Selective vasodilation by continuous adenosine infusion
This invention is concerned with the use of adenosine as an agent for the treatment of human beings. More particularly, this invention is concerned with the administration of adenosine to human...
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5728823 |
Cyclodextrin derivatives having at least one nitrogen-containing heterocycle, their preparation and use
Reactive cyclodextrin derivatives have at least one nitrogen-containing heterocycle. The reactive cyclodextrin derivatives include at least one nitrogen-containing heterocycle having at least one...
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5698535 |
SIN-1A cyclodextrin inclusion complexes
New inclusion complexes which are stable in their so-lid state formed of SIN-1A and cyclodextrins or cyclodextrin derivatives and optionally also containing ions as catalyst or stabilizer. The...
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5631244 |
mono(6-amino-6-deoxy)cyclodextrin derivatives substituted in the 6-position by an α-amino acid residue, process for their preparation and their uses
Mono (6-amino-6-deoxy)cyclodextrin derivatives substituted in the 6-position by an α-amino acid residue. These derivatives correspond to the following general formula: ##STR1## in which: CD...
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5587466 |
Conductive polymer doped by a sulphonated cyclodextrin salt and device for obtaining and/or supplying an active substance incorporating said polymer
Conductive polymer doped by a sulphonated cyclodextrin salt and device for obtaining and/or supplying an active substance incorporating said polymer. The dopant used has the following formula (I):...
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